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ClinicalTrials.gov public records Last synced Oct 6, 2026, 10:17 AM EDT

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Showing 1–19 of 19 matching trials from the live ClinicalTrials.gov search.
Withdrawn Early Phase 1 Interventional Accepts healthy volunteers

tFUS to Enhance Alertness and Performance

NCT06461221
Conditions
Reaction Time, Alertness
Interventions
Transcranial Focused Ultrasound
Device
Lead sponsor
Medical University of South Carolina
Other
Eligibility
22 Years to 55 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Charleston, South Carolina
Conditions
Parkinson Disease
Interventions
Gen0Bh Transcranial Focused Ultrasound System (Active), Gen0Bh Transcranial Focused Ultrasound System (Sham)
Device
Lead sponsor
Sanmai Technologies PBC dba Sanmai
Industry
Eligibility
22 Years to 80 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
4
States / cities
Tucson, Arizona • Santa Monica, California • Gainesville, Florida + 1 more
Conditions
Cranial Neurosurgery
Interventions
Brain imaging using transcranial focused ultrasound (tFUS)
Device
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Minneapolis, Minnesota
Conditions
Bipolar
Interventions
BrainSonix Pulsar 1002
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 64 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Conditions
Impulsive Behavior
Interventions
tFUS, Sham tFUS
Device
Lead sponsor
Mary Phillips, MD MD (Cantab)
Other
Eligibility
18 Years to 35 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Conditions
Healthy
Interventions
Transcranial Focused Ultrasound
Device
Lead sponsor
Medical University of South Carolina
Other
Eligibility
22 Years to 55 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Charleston, South Carolina
Completed Not applicable Interventional Accepts healthy volunteers

Wearable Neural Interfacing System for REM Sleep Restoration and Enhancement

NCT07190287
Conditions
Sleep Disturbance, Stress, Psychological, REM Sleep Measurement
Interventions
NEUSleeP system (FUS-EEG wearable device), BrainSonix Pulsar 1002
Device
Lead sponsor
University of Texas at Austin
Other
Eligibility
18 Years to 50 Years
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Austin, Texas
Recruiting Not applicable Interventional Accepts healthy volunteers

Olfactory Transcranial Focused Ultrasound

NCT07658365
Conditions
Healthy, Olfaction
Interventions
transcranial focused ultrasound (tFUS)
Device
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 65 Years
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
Charleston, South Carolina
Conditions
Healthy Volunteers, no Condition, Basic Science
Interventions
Transcranial Focused Ultrasound Stimulation, Electroencephalography, Magnetic Resonance Imaging
Device
Lead sponsor
Massachusetts Institute of Technology
Other
Eligibility
21 Years to 55 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Cambridge, Massachusetts
Conditions
Mild Cognitive Impairment, Amnestic Mild Cognitive Disorder, Deep Brain Stimulation, Mild Alzheimer's Disease
Interventions
Low-Intensity Focused Ultrasound Pulsation (LIFUP)
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
50 Years to 90 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Los Angeles, California
Enrolling by invitation Phase 1 Interventional Accepts healthy volunteers

tFUS for Memory in mNCD and Healthy Adults

NCT06718140
Conditions
Mild Neurocognitive Disorder, Healthy Aging
Interventions
Transcranial Focused Ultrasound
Device
Lead sponsor
Medical University of South Carolina
Other
Eligibility
50 Years to 85 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Charleston, South Carolina
Recruiting Not applicable Interventional Accepts healthy volunteers

tFUS Induced Transient Scotoma for Individual Dosing

NCT06426498
Conditions
Healthy
Interventions
Brainsonix Bx Pulsar machine tFUS
Device
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 70 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Charleston, South Carolina
Conditions
Anxiety Disorders
Interventions
Active transcranial focused ultrasound (tFUS), Sham transcranial focused ultrasound (tFUS)
Device
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Charleston, South Carolina
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Safety, Parameterization, and Mechanism of Transcranial Focused Ultrasound

NCT05792020
Conditions
Healthy
Interventions
Focused Ultrasound Stimulation
Device
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 55 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
Charleston, South Carolina
Conditions
Essential Tremor
Interventions
Low Intensity Focused Ultrasound (LIFU)
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 90 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Los Angeles, California
Withdrawn Not applicable Interventional Accepts healthy volunteers

tFUS Imaging & LIFU

NCT07222865
Conditions
Brain Imaging
Interventions
Feasibility of imaging using tFUS
Device
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
18 Years to 65 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
Roanoke, Virginia
Completed Not applicable Interventional Accepts healthy volunteers

Examination of Transcranial Focused Ultrasound on Brain Activity in Adults

NCT06477029
Conditions
Impulsive Behavior
Interventions
tFUS, Sham tFUS
Device
Lead sponsor
Mary Phillips, MD MD (Cantab)
Other
Eligibility
18 Years to 45 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Conditions
Cocaine Use Disorder (CUD)
Interventions
tFUS, Sham tFUS
Device
Lead sponsor
Mary Phillips, MD MD (Cantab)
Other
Eligibility
18 Years to 45 Years
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Completed Not applicable Interventional Accepts healthy volunteers Results available

Transcranial Focused Ultrasound (tFUS) Modulation of Reward Network

NCT05986019
Conditions
Healthy
Interventions
transcranial focused ultrasound (tFUS)
Device
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 65 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Charleston, South Carolina