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ClinicalTrials.gov public records Last synced Oct 6, 2026, 1:06 AM EDT

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Showing 73–96 of 300 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: vagal nerve stimulation Clear all
Withdrawn Phase 3 Interventional

Vagal Nerve Stimulation as an Alternative Therapy for Premature Ventricular Contractions

NCT06110364
View directory record Official record
Conditions
Premature Ventricular Contraction
Interventions
Low-Level Tragus Stimulation, Heart Rate Variability- Biofeedback, Conventional Medical Therapy
Device · Behavioral · Other
Lead sponsor
Hunter Holmes Mcguire Veteran Affairs Medical Center
Federal
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Oct 26, 2024 · Synced Oct 6, 2026, 1:06 AM EDT
Not yet recruiting Not applicable Interventional

taVNS Treatment for Fibromyalgia

NCT04777500
View directory record Official record
Conditions
Fibromyalgia
Interventions
Auricular transcutaneous electrical nerve stimulation device
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Charlestown, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 17, 2026 · Synced Oct 6, 2026, 1:06 AM EDT
Not listed Not applicable Interventional

Respiratory-gated Auricular Vagal Afferent Nerve Stimulation (RAVANS) Study in Ulcerative Colitis

NCT05662059
View directory record Official record
Conditions
Ulcerative Colitis
Interventions
RAVANS, RAVANS-sham
Device
Lead sponsor
Cala Health, Inc.
Industry
Eligibility
10 Years to 39 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Lake Success, New York
Source: ClinicalTrials.gov public record
Updated Mar 17, 2023 · Synced Oct 6, 2026, 1:06 AM EDT
Withdrawn Phase 2Phase 3 Interventional

Vagus Nerve Stimulation to Augment Recovery From Minimally Conscious or Persistently Vegetative States After Traumatic Brain Injury

NCT01260090
View directory record Official record
Conditions
Minimally Conscious States Due to Traumatic Brain Injury, Persistently Vegetative States Due to Traumatic Brain Injury
Interventions
Vagus nerve stimulation;, No stimulation
Device
Lead sponsor
VA New York Harbor Healthcare System
Federal
Eligibility
18 Years to 60 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 27, 2023 · Synced Oct 6, 2026, 1:06 AM EDT
Completed Not applicable Interventional Results available

VNS During Rehabilitation for Improved Upper Limb Motor Function After Stroke

NCT02243020
View directory record Official record
Conditions
Stroke, Upper Limb Deficits
Interventions
Vagus Nerve Stimulation (VNS)
Device
Lead sponsor
MicroTransponder Inc.
Industry
Eligibility
30 Years to 80 Years
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2022
U.S. locations
3
States / cities
Minneapolis, Minnesota • Dallas, Texas • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 15, 2022 · Synced Oct 6, 2026, 1:06 AM EDT
Not yet recruiting Early Phase 1 Interventional

Understanding Non-invasive Vagus Nerve Stimulation Effects in PTSD

NCT06953388
View directory record Official record
Conditions
PTSD - Post Traumatic Stress Disorder
Interventions
transcutaneous auricular vagus nerve stimulation, sham transcutaneous auricular vagus nerve stimulation
Device
Lead sponsor
Wayne State University
Other
Eligibility
18 Years to 80 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2031
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Jul 13, 2026 · Synced Oct 6, 2026, 1:06 AM EDT
Completed Not applicable Interventional

Systematic Evaluation of VNS Parameters

NCT05395026
View directory record Official record
Conditions
Epilepsy
Interventions
electrical stimulation of vagus nerve
Other
Lead sponsor
Duke University
Other
Eligibility
18 Years to 65 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 9, 2026 · Synced Oct 6, 2026, 1:06 AM EDT
Completed Early Phase 1 Interventional Results available

taVNS Paired With Bottle Feeding in Infants Failing Oral Feeds

NCT04643808
View directory record Official record
Conditions
Poor Feeding, Infant Development, Vagus Nerve Stimulation
Interventions
transcutaneous auricular vagus nerve stimulation
Device
Lead sponsor
Medical University of South Carolina
Other
Eligibility
3 Weeks to 5 Months
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Oct 30, 2023 · Synced Oct 6, 2026, 1:06 AM EDT
Recruiting Not applicable Interventional

Non-invasive Vagus Nerve Stimulation (nVNS) for Post-Traumatic Stress Disorder (PTSD)

NCT07523685
View directory record Official record
Conditions
PTSD, Post Traumatic Stress Disorder PTSD, PTSD - Post Traumatic Stress Disorder, Post Traumatic Stress Disorder, Post Traumatic Stress Disorders, Post-traumatic Stress Disorder (PTSD), Post-Traumatic Stress Disorder, PTSD
Interventions
non-invasive vagus nerve stimulation
Device
Lead sponsor
Acacia Clinics
Industry
Eligibility
18 Years to 70 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Sunnyvale, California
Source: ClinicalTrials.gov public record
Updated Apr 27, 2026 · Synced Oct 6, 2026, 1:06 AM EDT
Recruiting Not applicable Interventional

A Pilot Trial of taVNS for SRNS in Children (kidNEY-VNS)

NCT05583942
View directory record Official record
Conditions
Nephrotic Syndrome in Children, Minimal Change Disease, Focal Segmental Glomerulosclerosis
Interventions
trascutaneous auricular vagus nerve stimulation, Sham device
Device
Lead sponsor
Northwell Health
Other
Eligibility
3 Years to 17 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
2
States / cities
New Hyde Park, New York • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 17, 2026 · Synced Oct 6, 2026, 1:06 AM EDT
Active, not recruiting Not applicable Interventional

Leverage Noninvasive Transcutaneous Vagus Nerve Stimulation to Reduce Suicidal Behaviors in Vulnerable Adolescents

NCT05602779
View directory record Official record
Conditions
Self Harm, Suicidal Ideation
Interventions
tVNS Program, Phone App Program, tVNS and Phone App Program, Sham tNVS and Control App
Device · Other · Combination Product
Lead sponsor
University of Notre Dame
Other
Eligibility
13 Years to 17 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
2
States / cities
South Bend, Indiana • Rochester, New York
Source: ClinicalTrials.gov public record
Updated Apr 17, 2026 · Synced Oct 6, 2026, 1:06 AM EDT
Completed Not applicable Interventional Results available

Transcutaneous Electrical Vagus Nerve Stimulation to Suppress Atrial Fibrillation

NCT02548754
View directory record Official record
Conditions
Atrial Fibrillation, Inflammation
Interventions
Parasym device
Device
Lead sponsor
University of Oklahoma
Other
Eligibility
21 Years to 90 Years
Enrollment
53 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Feb 16, 2022 · Synced Oct 6, 2026, 1:06 AM EDT
Recruiting No phase listed Observational

Vivistim Registry for Paired VNS Therapy (GRASP)

NCT05301140
View directory record Official record
Conditions
Upper Extremity Problem
Interventions
Vivistim System
Device
Lead sponsor
MicroTransponder Inc.
Industry
Eligibility
22 Years and older
Enrollment
1,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
15
States / cities
Orlando, Florida • Elk Grove Village, Illinois • Evanston, Illinois + 11 more
Source: ClinicalTrials.gov public record
Updated Jun 29, 2026 · Synced Oct 6, 2026, 1:06 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Effect of Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) on Plasma Insulin Levels

NCT06597149
View directory record Official record
Conditions
Healthy
Interventions
Transcutaneous Auricular Vagus Nerve Stimulation, Sham Procedure (No Stimulation)
Device
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 70 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Oct 1, 2026 · Synced Oct 6, 2026, 1:06 AM EDT
Completed Not applicable Interventional

Vagus Nerve Stimulation in Treatment of Postural Orthostatic Tachycardia Syndrome

NCT03930914
View directory record Official record
Conditions
Postural Orthostatic Tachycardia Syndrome
Interventions
Parasym (TM) Transcutaneous Electrical Nerve Stimulation (TENS) Device
Device
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years to 80 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Dec 18, 2023 · Synced Oct 6, 2026, 1:06 AM EDT
Completed No phase listed Observational Results available

Vagus Nerve Stimulation Titration Protocol to Improve Tolerance and Accelerate Adaptation

NCT02385526
View directory record Official record
Conditions
Epilepsy, Seizures
Interventions
Vagus Nerve Stimulation Therapy
Device
Lead sponsor
Cyberonics, Inc.
Industry
Eligibility
12 Years and older
Enrollment
67 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
15
States / cities
Phoenix, Arizona • Loma Linda, California • Los Angeles, California + 11 more
Source: ClinicalTrials.gov public record
Updated Jul 23, 2018 · Synced Oct 6, 2026, 1:06 AM EDT
Recruiting Early Phase 1 Interventional Accepts healthy volunteers

Mapping Auricular Vagus Nerve Circuitry

NCT00200889
View directory record Official record
Conditions
Healthy
Interventions
active TEAS
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2028
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 24, 2025 · Synced Oct 6, 2026, 1:06 AM EDT
Active, not recruiting No phase listed Observational

VNS-REHAB At-Home - Post-Market Study for Using the Vivistim System® at Home

NCT05691023
View directory record Official record
Conditions
Ischemic Stroke, Upper Extremity Problem
Interventions
Vivistim System
Device
Lead sponsor
MicroTransponder Inc.
Industry
Eligibility
19 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 9, 2025 · Synced Oct 6, 2026, 1:06 AM EDT
Recruiting Not applicable Interventional

Transcutaneous Auricular Vagus Nerve Stimulation Treatment for Rosacea

NCT07600424
View directory record Official record
Conditions
Rosacea, Rosacea, Erythematotelangiectatic, Flushing
Interventions
Transaricular vagus nerve stimulation (taVNS)
Device
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 14, 2026 · Synced Oct 6, 2026, 1:06 AM EDT
Completed No phase listed Observational

Registry of Subjects With Drug Resistant Epilepsy and Treated With the VNS Therapy System.

NCT03529045
View directory record Official record
Conditions
Epilepsy, Seizures, Drug Resistant Epilepsy
Interventions
Vagus Nerve Stimulation (VNS) Therapy
Device
Lead sponsor
LivaNova
Industry
Eligibility
Not listed
Enrollment
827 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
19
States / cities
Grand Junction, Colorado • Washington D.C., District of Columbia • Orlando, Florida + 15 more
Source: ClinicalTrials.gov public record
Updated Nov 22, 2024 · Synced Oct 6, 2026, 1:06 AM EDT
Terminated Not applicable Interventional

Paired Vagus Nerve Stimulation Mechanisms

NCT06716112
View directory record Official record
Conditions
Chronic Stroke
Interventions
Vagus Nerve Stimulation (VNS) Device, Sham VNS Device, Upper Extremity Rehabilitation
Device · Behavioral
Lead sponsor
NYU Langone Health
Other
Eligibility
22 Years to 79 Years
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
2
States / cities
New York, New York • Richardson, Texas
Source: ClinicalTrials.gov public record
Updated Jun 12, 2026 · Synced Oct 6, 2026, 1:06 AM EDT
Recruiting Not applicable Interventional

Mindfulness in Chronic Kidney Disease

NCT04099992
View directory record Official record
Conditions
Chronic Kidney Diseases
Interventions
Mindfulness-based stress reduction (MBSR), Health enhancement program (HEP), Transcutaneous Vagus Nerve Stimulation (tVNS), Sham-transcutaneous Vagus Nerve Stimulation (tVNS)
Behavioral · Device
Lead sponsor
Emory University
Other
Eligibility
40 Years to 80 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2026
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Oct 21, 2025 · Synced Oct 6, 2026, 1:06 AM EDT
Recruiting Phase 2 Interventional Accepts healthy volunteers

Role of Sympathetic Overactivity and Angiotensin II in PTSD and CV

NCT02560805
View directory record Official record
Conditions
Stress Disorders, Post-Traumatic
Interventions
Microneurography, Combat virtual reality video clip, Handgrip Exercise, Cold Pressor Test (CPT), Sodium Nitroprusside (SNP), Phenylephrine, Losartan, Atenolol, Transcutaneous Vagal Nerve Stimulation (tVNS), Sham Transcutaneous Vagal Nerve Stimulation (tVNS)
Procedure · Behavioral · Drug + 1 more
Lead sponsor
Emory University
Other
Eligibility
18 Years to 65 Years
Enrollment
134 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2027
U.S. locations
1
States / cities
Decatur, Georgia
Source: ClinicalTrials.gov public record
Updated May 18, 2026 · Synced Oct 6, 2026, 1:06 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Pupil-Indexed Noninvasive Neuromodulation

NCT06282406
View directory record Official record
Conditions
Paresis
Interventions
Transcutaneous Electrical Stimulation, Sham
Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 75 Years
Enrollment
110 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 24, 2026 · Synced Oct 6, 2026, 1:06 AM EDT