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Showing 1–24 of 46 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: very low calorie diet Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Promoting Long-term Behavior Change to Reduce CVD Risk

NCT00227006
View directory record Official record
Conditions
Obesity
Interventions
Behavioral lifestyle/weight-loss intervention
Behavioral
Lead sponsor
Stanford University
Other
Eligibility
25 Years and older
Enrollment
163 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1999 – 2004
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated May 19, 2015 · Synced Sep 25, 2026, 9:12 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Giving a Low Carbohydrate Diet to Overcome Hypertension

NCT04230928
View directory record Official record
Conditions
Hypertension, African Americans, Diet, Carbohydrate-Restricted, Risk Reduction Behavior
Interventions
Very low carbohydrate diet, Standard DPP-GLB diet, Standard DPP-GLB program modules
Other · Behavioral
Lead sponsor
Baylor Research Institute
Other
Eligibility
18 Years to 74 Years
Enrollment
64 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Mar 1, 2026 · Synced Sep 25, 2026, 9:12 AM EDT
Completed Not applicable Interventional

Low-Carbohydrate Diabetes Prevention Program Among Veterans With Prediabetes

NCT04881890
View directory record Official record
Conditions
PreDiabetes
Interventions
Low-Carbohydrate Diabetes Prevention Program
Behavioral
Lead sponsor
VA Ann Arbor Healthcare System
Federal
Eligibility
18 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 7, 2022 · Synced Sep 25, 2026, 9:12 AM EDT
Completed Not applicable Interventional Results available

Metabolic Changes Induced by a Very Low Carbohydrate Diet in Youth With Type 1 Diabetes

NCT04955691
View directory record Official record
Conditions
Type1diabetes, Low Carbohydrate Diet
Interventions
low carbohydrate diet, standard carbohydrate diet
Other
Lead sponsor
Yale University
Other
Eligibility
12 Years to 21 Years
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Oct 15, 2025 · Synced Sep 25, 2026, 9:12 AM EDT
Completed Not applicable Interventional

Intermittent Fasting for the Treatment of Type 2 Diabetes Mellitus

NCT05860413
View directory record Official record
Conditions
Type 2 Diabetes
Interventions
Intermittent energy restriction (IER), Time Restricted Eating (TRE)
Behavioral
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
21 Years to 65 Years
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Nov 9, 2025 · Synced Sep 25, 2026, 9:12 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Time Restricted Eating (TRE) Among Native Hawaiian/Pacific Islander Women at Risk for Endometrial Cancer

NCT04763902
View directory record Official record
Conditions
Endometrial Neoplasms
Interventions
Time Restricted Eating (TRE) Schedule, Control Schedule
Behavioral
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older · Female only
Enrollment
39 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jul 28, 2026 · Synced Sep 25, 2026, 9:12 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of a Very Low Calorie and Low Calorie Diet on Moderate to Severe Obstructive Sleep Apnea in Obese Adults

NCT02251574
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
Low Calorie Diet, Very Low Calorie Diet, Standard Care
Other
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
21 Years to 75 Years
Enrollment
37 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Apr 4, 2018 · Synced Sep 25, 2026, 9:12 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Healthy Eating for Reproductive Health: Greenville

NCT01716429
View directory record Official record
Conditions
Polycystic Ovarian Syndrome, Infertility, Obesity, Overweight
Interventions
Vegan diet, Low calorie diet
Behavioral
Lead sponsor
University of South Carolina
Other
Eligibility
18 Years to 35 Years · Female only
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
1
States / cities
Greenville, South Carolina
Source: ClinicalTrials.gov public record
Updated Apr 17, 2019 · Synced Sep 25, 2026, 9:12 AM EDT
Completed Not applicable Interventional

Improving Maintenance Following Very Low Calorie Diet: The Sustain Lost Weight (SLW) Intervention

NCT01222988
View directory record Official record
Conditions
Obesity
Interventions
Optifast Products
Dietary Supplement
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 80 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Jan 16, 2013 · Synced Sep 25, 2026, 9:12 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Fasting-Mimicking Diet on Skin Health

NCT05564624
View directory record Official record
Conditions
Skin
Interventions
Fasting mimicking diet (FMD)
Other
Lead sponsor
L-Nutra Inc
Industry
Eligibility
35 Years to 60 Years · Female only
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Richardson, Texas
Source: ClinicalTrials.gov public record
Updated Oct 25, 2023 · Synced Sep 25, 2026, 9:12 AM EDT
Completed Not applicable Interventional

A Study of Ketogenic Diet in Newly Diagnosed Overweight or Obese Endometrial Cancer Patients

NCT03285152
View directory record Official record
Conditions
Endometrial Cancer
Interventions
Ketogenic Diet (KD), Standard Diet (SD)
Other
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
18 Years and older · Female only
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2026
U.S. locations
8
States / cities
Basking Ridge, New Jersey • Middletown, New Jersey • Montvale, New Jersey + 4 more
Source: ClinicalTrials.gov public record
Updated Jun 28, 2026 · Synced Sep 25, 2026, 9:12 AM EDT
Completed Not applicable Interventional

Global Profiling of Gene and Protein Expression Associated With Coronary Heart Disease Reversal

NCT01805492
View directory record Official record
Conditions
Heart Diseases, Cardiovascular Diseases
Interventions
Dr. Dean Ornish Program for Reversing Heart Disease
Behavioral
Lead sponsor
Windber Research Institute
Other
Eligibility
21 Years and older
Enrollment
422 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2000 – 2009
U.S. locations
1
States / cities
Windber, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 5, 2013 · Synced Sep 25, 2026, 9:12 AM EDT
Active, not recruiting Not applicable Interventional

Effect of VLCD on the Reduction of Liver Steatosis and Fibrosis in Subjects With Obesity and NAFLD

NCT04861571
View directory record Official record
Conditions
NAFLD
Interventions
Dietary intervention with very low calorie diet (VLCD), Control Arm
Dietary Supplement · Other
Lead sponsor
University of Iowa
Other
Eligibility
18 Years to 70 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Mar 9, 2026 · Synced Sep 25, 2026, 9:12 AM EDT
Not listed Not applicable Interventional

Acceptability and Feasibility of a Preoperative Very Low Calorie Diet Intervention on Surgical Weight Loss Outcomes (SAFETY)

NCT06183034
View directory record Official record
Conditions
Obesity
Interventions
Very Low Calorie Diet
Other
Lead sponsor
Hartford Hospital
Other
Eligibility
18 Years to 70 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Feb 27, 2024 · Synced Sep 25, 2026, 9:12 AM EDT
Completed Not applicable Interventional

The Effects of an Intensive Lifestyle Intervention on Reproductive Outcomes

NCT01894074
View directory record Official record
Conditions
Subfertility, Anovulatory, Obese
Interventions
Intensive Dietary Intervention, Placebo
Behavioral
Lead sponsor
Amy E Rothberg
Other
Eligibility
18 Years to 35 Years · Female only
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Dec 3, 2015 · Synced Sep 25, 2026, 9:12 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Changes in Insulin Sensitivity After Weight Loss

NCT00627484
View directory record Official record
Conditions
Obesity, Type 2 Diabetes Mellitus, Insulin Resistance
Interventions
Gastric bypass, Gastric banding, Sleeve gastrectomy, Very low calorie diet
Procedure · Behavioral
Lead sponsor
Columbia University
Other
Eligibility
18 Years to 75 Years
Enrollment
119 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2018
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 18, 2019 · Synced Sep 25, 2026, 9:12 AM EDT
Completed Not applicable Interventional

OPTIMIzing muScle Preservation in paTients wIth Cirrhosis

NCT05367596
View directory record Official record
Conditions
Obesity, Compensated Cirrhosis, Sarcopenia
Interventions
Continuous Energy Restriction (CER), Alternate Day Modified Fasting (ADMF), Group Health Education Sessions, Late Evening Snack, Physical activity, Self-monitoring, Remotely Supervised Exercise Sessions
Behavioral
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Feb 8, 2023 · Synced Sep 25, 2026, 9:12 AM EDT
Completed Not applicable Interventional

A Low-Carbohydrate Diabetes Prevention Program

NCT03258918
View directory record Official record
Conditions
PreDiabetes
Interventions
Low-Carbohydrate Diabetes Prevention Program
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Dec 11, 2018 · Synced Sep 25, 2026, 9:12 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Impact of Low Glycemic Index Nutritional Shake on Glucose Regulation in Overweight and Obese Adults

NCT06856460
View directory record Official record
Conditions
Hyperglycemia, Obesity Prevention
Interventions
powder shake with very low glycemic index, Ceral Breakfast
Dietary Supplement
Lead sponsor
Arizona State University
Other
Eligibility
25 Years to 65 Years
Enrollment
46 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Feb 12, 2026 · Synced Sep 25, 2026, 9:12 AM EDT
Not listed Not applicable Interventional

Roux-en-Y-Gastric Bypass vs. Lifestyle Modification and Medical Therapy in the Treatment of Type 2 Diabetes

NCT01231308
View directory record Official record
Conditions
Type 2 Diabetes
Interventions
Roux-en-Y-Gastric Bypass, Intensive lifestyle modification and Optimal medical Therapy
Procedure · Behavioral
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
21 Years to 65 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 23, 2012 · Synced Sep 25, 2026, 9:12 AM EDT
Active, not recruiting Phase 2Phase 3 Interventional

The Medically Reproducing Bariatric Surgery (MRB) II Study

NCT06363747
View directory record Official record
Conditions
Type 2 Diabetes, Obesity
Interventions
Very Low Calorie Diet
Other
Lead sponsor
Durham VA Medical Center
Federal
Eligibility
25 Years to 75 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Greenville, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 6, 2025 · Synced Sep 25, 2026, 9:12 AM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers

Muscle-Sparing Effect Of Human Chorionic Gonadotropin (hCG) During a Very Low Calorie Diet (VLCD)

NCT02427529
View directory record Official record
Conditions
HCG
Interventions
Human Chorionic Gonadotropin, Placebo, Low calorie diet
Drug · Other
Lead sponsor
Dr. Emma's Corporation
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
59 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
1
States / cities
Colts Neck, New Jersey
Source: ClinicalTrials.gov public record
Updated Apr 27, 2015 · Synced Sep 25, 2026, 9:12 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Complex Effects of Dietary Manipulation on Metabolic Function, Inflammation and Health

NCT02706262
View directory record Official record
Conditions
Obesity, Insulin Resistance
Interventions
Metabolically abnormal obese - Mediterranean diet, Metabolically abnormal obese - Low carbohydrate ketogenic diet, Metabolically abnormal obese - Plant-based, very-low-fat diet, Annual Follow-up Visits
Other · Behavioral
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 55 Years
Enrollment
180 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2027
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jan 26, 2026 · Synced Sep 25, 2026, 9:12 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Utilization of Very Low Calorie Diet in Obese General Surgery Patients

NCT03553849
View directory record Official record
Conditions
Morbid Obesity
Interventions
Very low calorie diet
Dietary Supplement
Lead sponsor
Christiana Care Health Services
Other
Eligibility
18 Years to 65 Years
Enrollment
58 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Newark, Delaware
Source: ClinicalTrials.gov public record
Updated Jan 27, 2021 · Synced Sep 25, 2026, 9:12 AM EDT