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ClinicalTrials.gov public records Last synced Oct 17, 2026, 1:17 AM EDT

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Showing 25–48 of 230 matching trials from the live ClinicalTrials.gov search.
Filters: Sponsor: Mclean Hospital Clear all
Suspended Not applicable Interventional Accepts healthy volunteers

Smoked Nicotine Induced Changes in Hormone Function, Mood States and Behaviors

NCT01636323
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Nicotine
Other
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years to 40 Years · Female only
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2016
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 15, 2013 · Synced Oct 17, 2026, 1:17 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Families With Substance Use and Psychosis: A Pilot Study

NCT04284813
View directory record Official record
Conditions
Psychosis, Substance Use, Substance Use Disorders, Family, Tobacco Use, Nicotine Use Disorder, Cigarette Smoking, Cannabis, Marijuana, Alcohol Use Disorder, Alcohol, Schizophrenia, Schizoaffective Disorder, Bipolar Disorder, Mental Disorder
Interventions
CRAFT-FT
Behavioral
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years to 70 Years
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 12, 2022 · Synced Oct 17, 2026, 1:17 AM EDT
Active, not recruiting Early Phase 1 Interventional

Cannabidiol Solution for the Treatment of Behavioral Symptoms in Older Adults With Mild Cognitive Impairment or Alzheimer's Dementia

NCT04075435
View directory record Official record
Conditions
Alzheimer Disease, Anxiety, Agitation,Psychomotor, Mild Cognitive Impairment (MCI) Due to Alzheimer's Disease
Interventions
high CBD/low THC sublingual solution
Drug
Lead sponsor
Mclean Hospital
Other
Eligibility
55 Years to 90 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 30, 2026 · Synced Oct 17, 2026, 1:17 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Magnetic Resonance Spectroscopy Studies of Acute Hypoxic and Hyperoxic Breathing in Healthy Volunteers

NCT03106376
View directory record Official record
Conditions
Healthy
Interventions
16% O2 gas in breathed air, 26% O2 gas in breathed air
Other
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years to 40 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 30, 2023 · Synced Oct 17, 2026, 1:17 AM EDT
Not listed Phase 1 Interventional

Families Coping With Mental Illness Program

NCT00435721
View directory record Official record
Conditions
Schizophrenia, Schizoaffective Disorder
Interventions
Psychoeducation
Behavioral
Lead sponsor
North Suffolk Mental Health Association
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2005
U.S. locations
2
States / cities
Belmont, Massachusetts • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 15, 2007 · Synced Oct 17, 2026, 1:17 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Generalized Anxiety and Seroquel

NCT01066143
View directory record Official record
Conditions
Generalized Anxiety Disorder, Seroquel XR
Interventions
Seroquel XR
Drug
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years to 55 Years
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2013
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 17, 2017 · Synced Oct 17, 2026, 1:17 AM EDT
Recruiting Not applicable Interventional

Computer - Based Treatment for Social Anxiety Disorder

NCT04663724
View directory record Official record
Conditions
Social Anxiety Disorder
Interventions
Computer-Based Treatment
Behavioral
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
18 Years to 60 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 24, 2026 · Synced Oct 17, 2026, 1:17 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Cerebral GABA and Fear Conditioning in PTSD

NCT01800383
View directory record Official record
Conditions
Stress Disorders, Post-Traumatic
Interventions
Not listed
Lead sponsor
Isabelle Rosso
Other
Eligibility
20 Years to 50 Years
Enrollment
126 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2022
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 4, 2023 · Synced Oct 17, 2026, 1:17 AM EDT
Completed Not applicable Interventional

Building an Outcomes Assessment Infrastructure to Assess Anxiety Treatment

NCT02305537
View directory record Official record
Conditions
Social Anxiety Disorder, Specific Phobia, Separation Anxiety Disorder, Panic Disorder, Agoraphobia, Obsessive-Compulsive Disorder
Interventions
McLean Anxiety Mastery Program
Behavioral
Lead sponsor
Mclean Hospital
Other
Eligibility
6 Years to 19 Years
Enrollment
559 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2024
U.S. locations
1
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 20, 2025 · Synced Oct 17, 2026, 1:17 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Sex, Hormones and Gamma-Aminobutyric Acid (GABA) in Stress Induced Anhedonia in Depression

NCT03031665
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Not listed
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years to 25 Years
Enrollment
251 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2022
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 13, 2024 · Synced Oct 17, 2026, 1:17 AM EDT
Completed Not applicable Interventional

Effectiveness of HabitWorks and Symptom Tracking for Anxiety and Depression

NCT07025486
View directory record Official record
Conditions
Anxiety, Depression, Anxiety
Interventions
HabitWorks, Symptom TRacking
Behavioral
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years and older
Enrollment
340 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 17, 2025 · Synced Oct 17, 2026, 1:17 AM EDT
Terminated Phase 1 Interventional

Study of the Effects of Glycine on Symptoms and Memory in Patients With Schizophrenia

NCT00575848
View directory record Official record
Conditions
Schizophrenia, Schizoaffective Disorder
Interventions
Glycine, Placebo
Dietary Supplement
Lead sponsor
North Suffolk Mental Health Association
Other
Eligibility
18 Years to 65 Years · Male only
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
2
States / cities
Belmont, Massachusetts • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 26, 2009 · Synced Oct 17, 2026, 1:17 AM EDT
Recruiting Phase 1Phase 2 Interventional

Assessing the Mechanisms and Impact of a Novel Cannabinoid Product for Gynecologic Pain

NCT07728695
View directory record Official record
Conditions
Endometriosis, Adenomyosis, Chronic Pelvic Inflammatory Disease
Interventions
Custom-formulated, high-CBD study product, Placebo
Drug
Lead sponsor
Staci Gruber, Ph.D.
Other
Eligibility
21 Years and older · Female only
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 27, 2026 · Synced Oct 17, 2026, 1:17 AM EDT
Not listed Not applicable Interventional

College Mental Health Project

NCT03345459
View directory record Official record
Conditions
Depression
Interventions
ICare Prevent (internet-based treatment for depression in college students)
Other
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years to 25 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 24, 2020 · Synced Oct 17, 2026, 1:17 AM EDT
Active, not recruiting No phase listed Observational

Attention and Interpretation Modification (AIM) for Fear of Cancer Recurrence: An Intervention Development Study

NCT01517945
View directory record Official record
Conditions
Breast Cancer, Rare Cancer
Interventions
AIM materials and assessments
Behavioral
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
18 Years and older
Enrollment
252 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 24, 2026 · Synced Oct 17, 2026, 1:17 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Magnetic Resonance Spectroscopic and Diffusion Tensor Imaging of Adolescents with Autism Spectrum Disorders

NCT01361503
View directory record Official record
Conditions
Autism Spectrum Disorders
Interventions
Not listed
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
6 Years to 17 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2014
U.S. locations
2
States / cities
Belmont, Massachusetts • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 13, 2024 · Synced Oct 17, 2026, 1:17 AM EDT
Not listed No phase listed Observational

Functional Brain Imaging Study of Response to Repetitive TMS (rTMS) Treatment of Major Depression

NCT01768052
View directory record Official record
Conditions
Major Depression
Interventions
functional Near Infrared Spectroscopy
Device
Lead sponsor
Mclean Hospital
Other
Eligibility
21 Years to 45 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
2
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 4, 2015 · Synced Oct 17, 2026, 1:17 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Neural Changes Associated With a Mindfulness-based Intervention for Young Adults With Childhood Maltreatment

NCT02447744
View directory record Official record
Conditions
Depression, Anxiety, PTSD, Trauma, Psychological
Interventions
Mindfulness based intervention
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
19 Years to 35 Years
Enrollment
43 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 23, 2021 · Synced Oct 17, 2026, 1:17 AM EDT
Recruiting Not applicable Interventional

Using Transcranial Magnetic Stimulation (TMS) to Understand Hallucinations in Schizophrenia

NCT05343598
View directory record Official record
Conditions
Schizophrenia, Schizo Affective Disorder
Interventions
Repetitive Transcranial Magnetic Stimulation (rTMS), Sham Repetitive Transcranial Magnetic Stimulation (rTMS)
Device
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years to 55 Years
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 22, 2026 · Synced Oct 17, 2026, 1:17 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Novel Cross-Species Neurophysiological Assays of Reward and Cognitive Domains

NCT02855229
View directory record Official record
Conditions
Translational Electrophysiology
Interventions
Methylphenidate
Drug
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years to 45 Years
Enrollment
222 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 30, 2024 · Synced Oct 17, 2026, 1:17 AM EDT
Completed Not applicable Interventional

Assessing Models of Exposure Therapy

NCT01679457
View directory record Official record
Conditions
Obsessive-compulsive Disorders and Symptoms
Interventions
ACT-Focused ERP, TAU-ERP
Behavioral
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years and older
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2019
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 25, 2022 · Synced Oct 17, 2026, 1:17 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Brain GABA Levels and Treatment Response in Major Depressive Disorder

NCT00464711
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Escitalopram
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2009
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 4, 2017 · Synced Oct 17, 2026, 1:17 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Neuroimaging Studies of Reward Processing in Depression

NCT03026036
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
PET Scan with Raclopride
Radiation
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years to 45 Years
Enrollment
123 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2021
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 3, 2023 · Synced Oct 17, 2026, 1:17 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Imaging Dopamine Release in Depression

NCT02033369
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Pramipexole
Drug
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
18 Years to 50 Years
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2017
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 1, 2019 · Synced Oct 17, 2026, 1:17 AM EDT