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ClinicalTrials.gov public records Last synced Oct 10, 2026, 10:19 PM EDT

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Showing 25–48 of 309 matching trials from the live ClinicalTrials.gov search.
Filters: Sponsor: National Institute of Dental and Craniofacial Research (NIDCR) Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available

BEhavioral EConomics for Oral Health iNnovation Trial

NCT03576326
View directory record Official record
Conditions
Toothbrushing, Dental Plaque, Parent-Child Relations, Oral Hygiene, Dental Caries
Interventions
Drawing Incentive
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
6 Months to 47 Months
Enrollment
244 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
1
States / cities
Santa Monica, California
Source: ClinicalTrials.gov public record
Updated Sep 19, 2025 · Synced Oct 10, 2026, 10:19 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Probiotics That Moderate pH and Antagonize Pathogens to Promote Oral Health

NCT02999230
View directory record Official record
Conditions
Dental Caries
Interventions
Caries Free 1.5% Arginine, Caries Free Placebo Sodium Fluoride, Caries Active 1.5% Arginine, Caries Active- Placebo Sodium Fluoride
Other
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 65 Years
Enrollment
170 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Oct 1, 2024 · Synced Oct 10, 2026, 10:19 PM EDT
Completed Phase 1 Interventional

Safety of a Single Administration of AAV2hAQP1, an Adeno-Associated Viral Vector Encoding Human Aquaporin-1 to One Parotid Salivary Gland in People With Irradiation-Induced Parotid Salivary Hypofunction

NCT02446249
View directory record Official record
Conditions
Squamous Cell Head and Neck Cancer, Radiation Induced Xerostomia, Salivary Hypofunction
Interventions
AAV2hAQP1
Biological
Lead sponsor
MeiraGTx, LLC
Industry
Eligibility
18 Years and older
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2026
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 24, 2026 · Synced Oct 10, 2026, 10:19 PM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

Safety and Preliminary Efficacy of Lipoxin Analog BLXA4-ME Oral Rinse for the Treatment of Gingivitis

NCT02342691
View directory record Official record
Conditions
Gingival Inflammation
Interventions
BLXA4, Placebo oral rinse
Drug
Lead sponsor
The Forsyth Institute
Other
Eligibility
18 Years to 65 Years
Enrollment
127 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2019
U.S. locations
1
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 20, 2023 · Synced Oct 10, 2026, 10:19 PM EDT
Recruiting Phase 1 Interventional

Resiniferatoxin to Treat Severe Pain Associated With Advanced Cancer

NCT00804154
View directory record Official record
Conditions
Intractable Pain, Palliative Care
Interventions
Intrathecal Resiniferatoxin
Drug
Lead sponsor
National Institute of Dental and Craniofacial Research (NIDCR)
NIH
Eligibility
18 Years to 99 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2027
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 31, 2026 · Synced Oct 10, 2026, 10:19 PM EDT
Completed Not applicable Interventional

Evaluation of Patients With Unusual Diagnostic or Treatment Considerations

NCT00001182
View directory record Official record
Conditions
Healthy, Tooth Disease
Interventions
current standard of care treatments
Procedure
Lead sponsor
National Institute of Dental and Craniofacial Research (NIDCR)
NIH
Eligibility
Not listed
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1982 – 2002
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 4, 2008 · Synced Oct 10, 2026, 10:19 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Implementing a Participatory, Multi-level Intervention to Improve Asian American Health Study

NCT03438045
View directory record Official record
Conditions
Oral Disease, Dental Caries
Interventions
Partnered intervention
Behavioral
Lead sponsor
NYU College of Dentistry
Other
Eligibility
18 Years to 100 Years
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 13, 2021 · Synced Oct 10, 2026, 10:19 PM EDT
Completed Phase 2 Interventional

Alendronate to Treat Polyostotic Fibrous Dysplasia and McCune-Albright Syndrome

NCT00001728
View directory record Official record
Conditions
Polyostotic Fibrous Dysplasia
Interventions
Fosamax (Alendronate)
Drug
Lead sponsor
National Institute of Dental and Craniofacial Research (NIDCR)
NIH
Eligibility
6 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1998 – 2011
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 2, 2017 · Synced Oct 10, 2026, 10:19 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Impact of Gum Infection on Heart Disease

NCT00093236
View directory record Official record
Conditions
Cardiovascular Disease, Periodontal Disease
Interventions
Early Periodontal Treatment, Usual Dental Hygiene
Procedure
Lead sponsor
Boston University
Other
Eligibility
20 Years and older
Enrollment
174 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2012
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 20, 2017 · Synced Oct 10, 2026, 10:19 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Adolescent Master Protocol

NCT01418014
View directory record Official record
Conditions
HIV/AIDS
Interventions
Not listed
Lead sponsor
Harvard School of Public Health (HSPH)
Other
Eligibility
7 Years and older
Enrollment
678 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2021
U.S. locations
14
States / cities
La Jolla, California • Aurora, Colorado • Fort Lauderdale, Florida + 10 more
Source: ClinicalTrials.gov public record
Updated Jun 27, 2025 · Synced Oct 10, 2026, 10:19 PM EDT
Completed Phase 2 Interventional Results available

Safety of and Immune Response to the Human Papillomavirus (HPV) Vaccine in HIV-Infected Women

NCT00604175
View directory record Official record
Conditions
HIV Infections, Sexually Transmitted Diseases
Interventions
Quadrivalent HPV vaccine
Biological
Lead sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
NIH
Eligibility
13 Years to 45 Years · Female only
Enrollment
319 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
56
States / cities
Birmingham, Alabama • Alhambra, California • La Jolla, California + 37 more
Source: ClinicalTrials.gov public record
Updated Nov 4, 2021 · Synced Oct 10, 2026, 10:19 PM EDT
Completed Phase 3 Interventional

Xylitol Adult Caries Trial (X-ACT)

NCT00393055
View directory record Official record
Conditions
Dental Caries
Interventions
xylitol, inactive lozenge
Dietary Supplement
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
25 Years to 80 Years
Enrollment
709 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
3
States / cities
Birmingham, Alabama • Chapel Hill, North Carolina • San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Sep 12, 2011 · Synced Oct 10, 2026, 10:19 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

The Importance of Periostin in Periodontal Health and Disease

NCT01180920
View directory record Official record
Conditions
Periodontal Disease, Non-diseased Patients
Interventions
Not listed
Lead sponsor
University of Michigan
Other
Eligibility
21 Years and older
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2013
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Dec 2, 2014 · Synced Oct 10, 2026, 10:19 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

CONDOR Study of Osteonecrosis of the Jaws (TMJ)

NCT01130389
View directory record Official record
Conditions
Osteonecrosis of the Jaw
Interventions
Not listed
Lead sponsor
Dental Practice-Based Research Network
Network
Eligibility
40 Years and older
Enrollment
309 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
5
States / cities
Birmingham, Alabama • Minneapolis, Minnesota • Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jun 16, 2011 · Synced Oct 10, 2026, 10:19 PM EDT
Completed Phase 2 Interventional

Local Flurbiprofen to Treat Pain Following Wisdom Tooth Extraction

NCT00001724
View directory record Official record
Conditions
Pain
Interventions
Flurbiprofen
Drug
Lead sponsor
National Institute of Dental and Craniofacial Research (NIDCR)
NIH
Eligibility
Not listed
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1997 – 2001
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 4, 2008 · Synced Oct 10, 2026, 10:19 PM EDT
Completed Phase 2 Interventional

Treating Periodontal Infection: Effects on Glycemic

NCT00016835
View directory record Official record
Conditions
Periodontal Disease, Diabetes Mellitus, Type 2
Interventions
Supra-gingival scaling and placebo, Subgingival scaling and metronidazole, Subgingival scaling and doxycycline
Procedure
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2004
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jul 19, 2017 · Synced Oct 10, 2026, 10:19 PM EDT
Completed Phase 2 Interventional

Microbial Associations in Periodontal Health and Disease

NCT00066001
View directory record Official record
Conditions
Periodontitis, Periodontal Diseases
Interventions
metronidazole
Drug
Lead sponsor
The Forsyth Institute
Other
Eligibility
35 Years and older
Enrollment
154 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2009
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 9, 2010 · Synced Oct 10, 2026, 10:19 PM EDT
Completed No phase listed Observational

Using a Narcotic to Enhance the Numbing Effect of the Local Anesthetic Lidocaine on Inflamed Molar Teeth

NCT00001952
View directory record Official record
Conditions
Healthy, Inflammation, Mouth Disease, Pain
Interventions
Not listed
Lead sponsor
National Institute of Dental and Craniofacial Research (NIDCR)
NIH
Eligibility
Not listed
Enrollment
275 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1999 – 2002
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 4, 2008 · Synced Oct 10, 2026, 10:19 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

DPBRN Longitudinal Study of Dental Restorations Placed on Previously Un-restored Surfaces

NCT01201408
View directory record Official record
Conditions
Dental Caries
Interventions
Not listed
Lead sponsor
Dental Practice-Based Research Network
Network
Eligibility
6 Years and older
Enrollment
9,291 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2011
U.S. locations
6
States / cities
Birmingham, Alabama • Gainesville, Florida • Minneapolis, Minnesota + 1 more
Source: ClinicalTrials.gov public record
Updated Sep 20, 2011 · Synced Oct 10, 2026, 10:19 PM EDT
Completed Phase 3 Interventional

A Study of the Effects of Pegvisomant on Growth Hormone Excess in McCune-Albright Syndrome

NCT00017927
View directory record Official record
Conditions
McCune Albright Syndrome, Polyostotic Fibrous Dysplasia
Interventions
Pegvisomant
Drug
Lead sponsor
National Institute of Dental and Craniofacial Research (NIDCR)
NIH
Eligibility
Not listed
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2005
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 4, 2008 · Synced Oct 10, 2026, 10:19 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Coordinated Oral Health Promotion (CO-OP) Chicago

NCT03397589
View directory record Official record
Conditions
Dental Caries in Children, Health Behavior, Healthcare Disparities
Interventions
Community Health Worker (CHW) services
Behavioral
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
6 Months to 36 Months
Enrollment
420 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
13
States / cities
Blue Island, Illinois • Chicago, Illinois • Chicago Heights, Illinois + 5 more
Source: ClinicalTrials.gov public record
Updated Oct 18, 2022 · Synced Oct 10, 2026, 10:19 PM EDT
Completed Phase 2 Interventional

Study of Denosumab for Prevention of Skeletal Disease Progression in Children With Fibrous Dysplasia

NCT05419050
View directory record Official record
Conditions
Fibrous Dysplasia
Interventions
denosumab
Drug
Lead sponsor
National Institute of Dental and Craniofacial Research (NIDCR)
NIH
Eligibility
4 Years to 14 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 20, 2026 · Synced Oct 10, 2026, 10:19 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Improving Oral Health With Serious Games

NCT02027597
View directory record Official record
Conditions
Caries, Tooth Decay, Cavities, Gingivitis
Interventions
Attack of the S. Mutans, Follow-up, SnowWorld
Other
Lead sponsor
University of Washington
Other
Eligibility
8 Years to 12 Years
Enrollment
161 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2011
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jan 6, 2014 · Synced Oct 10, 2026, 10:19 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

DPBRN Blood Sugar Testing in Dental Patients

NCT01201460
View directory record Official record
Conditions
Diabetes Mellitus, Hyperglycemia
Interventions
Not listed
Lead sponsor
Dental Practice-Based Research Network
Network
Eligibility
19 Years and older
Enrollment
498 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2010
U.S. locations
6
States / cities
Birmingham, Alabama • Gainesville, Florida • Minneapolis, Minnesota + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 16, 2011 · Synced Oct 10, 2026, 10:19 PM EDT