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ClinicalTrials.gov public records Last synced Oct 15, 2026, 7:45 AM EDT

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Showing 481–504 of 779 matching trials from the live ClinicalTrials.gov search.
Filters: Sponsor: Children's Hospital of Philadelphia Clear all
Active, not recruiting Phase 1 Interventional

PHOX2B PC-CAR T Cells for Relapsed Neuroblastoma

NCT07007117
View directory record Official record
Conditions
Refractory Neuroblastoma, Relapsed Neuroblastoma, High-Risk Neuroblastoma
Interventions
PHOX2B PC-CAR T Cells
Biological
Lead sponsor
Stephan Grupp MD PhD
Other
Eligibility
1 Year and older
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2035
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 1, 2026 · Synced Oct 15, 2026, 7:45 AM EDT
Recruiting Phase 1 Interventional

CART123 Cells With or Without Ruxolitinib in Relapsed/Refractory Acute Myeloid Leukemia

NCT07464951
View directory record Official record
Conditions
Acute Myeloid Leukemia (AML)
Interventions
Anti-CD123 LV redirected T cells (CART123), Ruxolitinib (JAKAVI®)
Biological · Drug
Lead sponsor
Stephan Grupp MD PhD
Other
Eligibility
0 Years to 29 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 7, 2026 · Synced Oct 15, 2026, 7:45 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Treatment to Improve Sleep in Caregivers With Insomnia and a Child With Autism

NCT05373537
View directory record Official record
Conditions
Autism Spectrum Disorder, Insomnia Chronic, Caregiver Burden
Interventions
Cognitive behavioral therapy for Insomnia
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
3 Years to 100 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
2
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 8, 2026 · Synced Oct 15, 2026, 7:45 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Automated Harness Tightener for Child Safety Seat

NCT04408417
View directory record Official record
Conditions
Child Passenger Safety
Interventions
Prototype child safety seat with tension indicator lights, Control child safety seat
Device
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
18 Years to 75 Years
Enrollment
92 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 1, 2022 · Synced Oct 15, 2026, 7:45 AM EDT
Enrolling by invitation Not applicable Interventional

A Comparison of Two Brief Suicide Prevention Interventions Tailored for Youth on the Autism Spectrum

NCT05398250
View directory record Official record
Conditions
Suicidal Ideation, Suicidal and Self-injurious Behavior, Suicide, Autism Spectrum Disorder
Interventions
Safety Planning Intervention tailored for Autistic Individuals, Safety Planning Intervention Tailored for Autistic Individuals Plus Structured Follow-Up Contacts
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
12 Years to 99 Years
Enrollment
1,665 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
5
States / cities
Baltimore, Maryland • Chapel Hill, North Carolina • Columbus, Ohio + 2 more
Source: ClinicalTrials.gov public record
Updated Feb 10, 2026 · Synced Oct 15, 2026, 7:45 AM EDT
Completed Phase 4 Interventional Results available

Continuous Levalbuterol for Treatment of Status Asthmaticus in Children

NCT00124176
View directory record Official record
Conditions
Asthma
Interventions
Racemic albuterol (R+S albuterol), Levalbuterol (R albuterol)
Drug
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
6 Years to 18 Years
Enrollment
81 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2006
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 14, 2013 · Synced Oct 15, 2026, 7:45 AM EDT
Completed Phase 1 Interventional

Safety and Efficacy Study of Ursodeoxycholic Acid Therapy in Pediatric Primary Sclerosing Cholangitis

NCT01088607
View directory record Official record
Conditions
Primary Sclerosing Cholangitis
Interventions
ursodeoxycholic acid (UDCA)
Drug
Lead sponsor
University of Tennessee
Other
Eligibility
5 Years to 21 Years
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2017
U.S. locations
12
States / cities
Phoenix, Arizona • Los Angeles, California • San Francisco, California + 9 more
Source: ClinicalTrials.gov public record
Updated Oct 26, 2017 · Synced Oct 15, 2026, 7:45 AM EDT
Completed Not applicable Interventional

Increasing Water Access and Appeal in Community Recreation Centers

NCT03637465
View directory record Official record
Conditions
Health Behavior
Interventions
Hydrate Philly
Behavioral
Lead sponsor
Philadelphia Department of Public Health
Government
Eligibility
3 Years to 100 Years
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 2, 2019 · Synced Oct 15, 2026, 7:45 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

A Pilot Study of Teacher-Child Interaction Training - Universal in Head Start

NCT04075071
View directory record Official record
Conditions
Child Behavior, Child Development, Child Behavior Problem
Interventions
Teacher-Child Interaction Training - Universal
Behavioral
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
3 Years and older
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 31, 2020 · Synced Oct 15, 2026, 7:45 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Assessing Fertility Potential in Female Cancer Survivors

NCT01143844
View directory record Official record
Conditions
Effects of Chemotherapy
Interventions
Not listed
Lead sponsor
University of Pennsylvania
Other
Eligibility
11 Years to 50 Years · Female only
Enrollment
391 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2020
U.S. locations
2
States / cities
Philadelphia, Pennsylvania • Radnor, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 13, 2021 · Synced Oct 15, 2026, 7:45 AM EDT
Completed Not applicable Interventional Results available

Sleep in Pediatric HSCT

NCT04106089
View directory record Official record
Conditions
Sleep, Stem Cell Transplant Complications
Interventions
Extended time between vitals check
Behavioral
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
8 Years to 21 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 18, 2024 · Synced Oct 15, 2026, 7:45 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

BrighT STAR LIBRA: Leveraging Implementation Science for Blood Culture Reduction Approaches

NCT06187662
View directory record Official record
Conditions
Blood Culture Rates, Antibiotic Stewardship, Implementation Science
Interventions
Checklist, Targeted Messaging
Behavioral
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
18 Years and older
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
8
States / cities
Los Angeles, California • San Francisco, California • Wilmington, Delaware + 4 more
Source: ClinicalTrials.gov public record
Updated Oct 31, 2025 · Synced Oct 15, 2026, 7:45 AM EDT
Completed No phase listed Observational

Telemedicine Approaches to Evaluating Acute-phase ROP

NCT01264276
View directory record Official record
Conditions
Retinopathy of Prematurity
Interventions
Not listed
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
32 Weeks to 40 Weeks
Enrollment
269 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
11
States / cities
Louisville, Kentucky • Baltimore, Maryland • Boston, Massachusetts + 8 more
Source: ClinicalTrials.gov public record
Updated Feb 4, 2015 · Synced Oct 15, 2026, 7:45 AM EDT
Completed Not applicable Interventional Results available

Improving Medication Adherence in Adolescents Who Had a Liver Transplant

NCT03691220
View directory record Official record
Conditions
Transplant
Interventions
Telemetric Intervention
Behavioral
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
12 Years to 19 Years
Enrollment
148 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2025
U.S. locations
12
States / cities
Los Angeles, California • San Francisco, California • Miami, Florida + 7 more
Source: ClinicalTrials.gov public record
Updated Sep 30, 2026 · Synced Oct 15, 2026, 7:45 AM EDT
Not yet recruiting Not applicable Interventional

From Kitchen to Clinic

NCT07454902
View directory record Official record
Conditions
Pediatric Cancer, Malnutrition, Child, Caregiver Burden
Interventions
Medically Tailored Meals, Caregiver Coaching
Other · Behavioral
Lead sponsor
Drexel University
Other
Eligibility
5 Years to 21 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 9, 2026 · Synced Oct 15, 2026, 7:45 AM EDT
Completed Phase 2 Interventional Results available

Vitamin D Dose Finding Study

NCT01092338
View directory record Official record
Conditions
HIV Infections, AIDS
Interventions
Cholecalciferol (Vit D3)
Drug
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
5 Years to 24 Years
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 18, 2013 · Synced Oct 15, 2026, 7:45 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Neurocognitive Outcomes and Quality of Life in Adults With Maple Syrup Urine Disease (MSUD)

NCT04828863
View directory record Official record
Conditions
Maple Syrup Urine Disease
Interventions
Neurocognitive testing
Behavioral
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
21 Years to 80 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 4, 2024 · Synced Oct 15, 2026, 7:45 AM EDT
Recruiting Not applicable Interventional

Facilitating Access to Specialty Treatment

NCT05741411
View directory record Official record
Conditions
Mild Traumatic Brain Injury, Concussion, Mild, Concussion, Severe, Concussion, Intermediate
Interventions
RPM-assisted specialist access
Other
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
13 Years to 18 Years
Enrollment
210 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 22, 2026 · Synced Oct 15, 2026, 7:45 AM EDT
Terminated Phase 1 Interventional

Next Generation Personalized Neuroblastoma Therapy

NCT02780128
View directory record Official record
Conditions
Neuroblastoma, Cancer
Interventions
Biopsy, Next Generation Sequencing, Tumor Scans, Bone marrow Tests, Physical Exam, Eye Exam, Labs, Pregnancy Test, Interviews, ECG, Echocardiogram, Ribociclib, Ceritinib
Procedure · Genetic · Other + 2 more
Lead sponsor
Yael P Mosse
Other
Eligibility
1 Year to 21 Years
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2022
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 10, 2026 · Synced Oct 15, 2026, 7:45 AM EDT
Recruiting Not applicable Interventional

Reducing Empiric VAncomycin Use in Pediatric Suspected Sepsis

NCT05975671
View directory record Official record
Conditions
Sepsis, Sepsis Mrsa, Sepsis Bacteremia, Antimicrobial - Induced Nephropathy, Sepsis, Severe, Septic Shock, Septic Syndrome
Interventions
Multifaceted de-implementation strategy to reduce vancomycin overuse
Behavioral
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
Not listed
Enrollment
52,500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
4
States / cities
Atlanta, Georgia • Baltimore, Maryland • St Louis, Missouri + 1 more
Source: ClinicalTrials.gov public record
Updated Sep 19, 2025 · Synced Oct 15, 2026, 7:45 AM EDT
Completed Phase 3 Interventional Results available

Nitric Oxide Administration for Acute Respiratory Distress Syndrome

NCT00240487
View directory record Official record
Conditions
Acute Respiratory Distress Syndrome
Interventions
Nitric Oxide, No Intervention
Drug · Other
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
1 Month to 18 Years
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2000 – 2008
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 24, 2015 · Synced Oct 15, 2026, 7:45 AM EDT
Terminated Phase 1 Interventional Results available

Pharmacokinetic Study of Intranasal Dexmedetomidine in Pediatric Patients With Congenital Heart Disease

NCT03417999
View directory record Official record
Conditions
Dexmedetomidine, Congenital Heart Disease
Interventions
Dexmedetomidine
Drug
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
1 Month to 6 Years
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 22, 2024 · Synced Oct 15, 2026, 7:45 AM EDT
Recruiting Phase 4 Interventional

Clinical and Biomarker Effects of Depot Medroxyprogesterone Acetate in Females With Sickle Cell Disease

NCT06665997
View directory record Official record
Conditions
Sickle Cell Disease (SCD), Vaso-Occlusive Pain Episode in Sickle Cell Disease
Interventions
Depot medroxyprogesterone acetate (DMPA)
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
2
States / cities
Atlanta, Georgia • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 28, 2026 · Synced Oct 15, 2026, 7:45 AM EDT
Completed No phase listed Observational

Life After Pediatric Sepsis Evaluation

NCT01415180
View directory record Official record
Conditions
Septic Shock
Interventions
Not listed
Lead sponsor
Seattle Children's Hospital
Other
Eligibility
1 Month to 18 Years
Enrollment
389 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2018
U.S. locations
11
States / cities
Phoenix, Arizona • Los Angeles, California • Washington D.C., District of Columbia + 7 more
Source: ClinicalTrials.gov public record
Updated Dec 6, 2022 · Synced Oct 15, 2026, 7:45 AM EDT