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ClinicalTrials.gov public records Last synced Oct 17, 2026, 7:16 AM EDT

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Showing 49–72 of 397 matching trials from the live ClinicalTrials.gov search.
Filters: Sponsor: Alcon Research Clear all
Completed Phase 2 Interventional

Dose Response Study of AL-37807 Ophthalmic Solution in Patients With Open-Angle Glaucoma or Ocular Hypertension

NCT00465621
View directory record Official record
Conditions
Open-Angle Glaucoma, Ocular Hypertension
Interventions
Xalatan
Drug
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2007
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Jul 29, 2008 · Synced Oct 17, 2026, 7:16 AM EDT
Completed Phase 3 Interventional

Nepafenac Opthalmic Suspension 0.1% Compared to Acular LS for Treatment of Inflammation After Cataract Surgery

NCT00333255
View directory record Official record
Conditions
Cataract
Interventions
Nepafenac Ophthalmic Suspension, 0.1%
Drug
Lead sponsor
Alcon Research
Industry
Eligibility
10 Years and older
Enrollment
267 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2005
U.S. locations
1
States / cities
Nacogdoches, Texas
Source: ClinicalTrials.gov public record
Updated Jul 8, 2009 · Synced Oct 17, 2026, 7:16 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Long Term Outcomes of Vivity Intra Ocular Lens(IOL) Versus Control

NCT04561570
View directory record Official record
Conditions
Cataract
Interventions
Vivity ACRYSOF IQ IOL Group, ACRYSOF IQ IOL Control Group
Device
Lead sponsor
John Berdahl, MD
Other
Eligibility
Not listed
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Sioux Falls, South Dakota
Source: ClinicalTrials.gov public record
Updated Aug 1, 2023 · Synced Oct 17, 2026, 7:16 AM EDT
Completed Phase 3 Interventional

Safety of NGOIS Compared to BSS Plus in Pediatric Patients

NCT00346528
View directory record Official record
Conditions
Cataract
Interventions
Next Generation Ophthalmic Irrigating Solution (NGOIS), BSS Plus
Drug
Lead sponsor
Alcon Research
Industry
Eligibility
1 Week to 17 Years
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Mar 5, 2012 · Synced Oct 17, 2026, 7:16 AM EDT
Recruiting Not applicable Interventional

Contoura With Phorcides Compared to Wavefront Optimized LASIK

NCT05486546
View directory record Official record
Conditions
Myopia, Astigmatism
Interventions
Contoura with Phorcides, WaveLight Wavefront Optimized
Procedure · Device
Lead sponsor
Daniel Terveen
Other
Eligibility
21 Years to 38 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
4
States / cities
Bozeman, Montana • Omaha, Nebraska • Fargo, North Dakota + 1 more
Source: ClinicalTrials.gov public record
Updated Apr 26, 2023 · Synced Oct 17, 2026, 7:16 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Bioavailability of Nutrients Contained in Softgel Capsules vs Tablets

NCT01057966
View directory record Official record
Conditions
Vision
Interventions
ICAPS Eye Vitamin and Mineral Supplement - Softgel (full strength), ICAPS Eye Vitamin and Mineral Supplement - Softgel (half strength), ICAPS Eye Vitamin and Mineral Supplement - Coated Tablets (full strength)
Dietary Supplement
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2011
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Feb 2, 2012 · Synced Oct 17, 2026, 7:16 AM EDT
Completed Not applicable Interventional Results available

ACRYSOF® Toric NATURAL T9 Intraocular Lens (IOL)

NCT00967473
View directory record Official record
Conditions
Bilateral Cataract
Interventions
ACRYSOF® Single-Piece NATURAL Toric IOL Model SN60T9 and Model SN60T8.
Device
Lead sponsor
Alcon Research
Industry
Eligibility
21 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Jan 9, 2017 · Synced Oct 17, 2026, 7:16 AM EDT
Completed Not applicable Interventional Results available

Ocular Comfort and OCT Observation of Post Lens Clearance and Ocular Tissue Compression

NCT01423773
View directory record Official record
Conditions
Ocular Comfort
Interventions
Lotrafilcon A test contact lens, Lotrafilcon A control contact lens, Ultra-High Resolution Optical Coherence Tomographer (OCT)
Device
Lead sponsor
CIBA VISION
Industry
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Jun 28, 2013 · Synced Oct 17, 2026, 7:16 AM EDT
Not yet recruiting Phase 4 Interventional

Effect of Acoltremon Ophthalmic Solution 0.003% on Tear Production and Symptoms in Patients With Tear Deficiency and Concurrent Neuropathic Corneal Pain

NCT07849803
View directory record Official record
Conditions
Ocular Pain, Dry Eye
Interventions
acoltremon ophthalmic solution 0.003%
Drug
Lead sponsor
University of South Florida
Other
Eligibility
18 Years and older
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Oct 6, 2026 · Synced Oct 17, 2026, 7:16 AM EDT
Completed Not applicable Interventional Results available

Clinical Comparison of 4 Daily Disposable Soft Contact Lenses

NCT03349632
View directory record Official record
Conditions
Refractive Error
Interventions
verofilcon A contact lenses, senofilcon A contact lenses, stenfilcon A contact lenses, etafilcon A contact lenses
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
3
States / cities
Maitland, Florida • Pensacola, Florida • Johns Creek, Georgia
Source: ClinicalTrials.gov public record
Updated Feb 22, 2019 · Synced Oct 17, 2026, 7:16 AM EDT
Withdrawn Not applicable Interventional

Clinical Comparison of Toric Contact Lenses Fit Characteristics

NCT05805345
View directory record Official record
Conditions
Astigmatism, Refractive Errors
Interventions
Delefilcon A toric soft contact lens, Lehfilcon A toric soft contact lens, Lotrafilcon B toric soft contact lens, Verofilcon A toric soft contact lens
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
7
States / cities
Los Angeles, California • Longwood, Florida • Maitland, Florida + 4 more
Source: ClinicalTrials.gov public record
Updated May 19, 2023 · Synced Oct 17, 2026, 7:16 AM EDT
Completed No phase listed Observational

Collection of Blood Specimens From Patients in AL-3789 Studies for Elevated Intraocular Pressure (IOP)

NCT00691639
View directory record Official record
Conditions
Open-Angle Glaucoma
Interventions
Blood Collection Only
Other
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
1,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2008
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Oct 1, 2009 · Synced Oct 17, 2026, 7:16 AM EDT
Completed Not applicable Interventional

Visual Outcomes With a Trifocal IOL in Subjects With Open-angle Glaucoma

NCT04619654
View directory record Official record
Conditions
Cataract, IOL, Glaucoma, Open-Angle
Interventions
Cataract surgery with implantation of trifocal IOL combined with trabecular scaffold
Procedure
Lead sponsor
Vold Vision P.L.L.C
Other
Eligibility
45 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Fayetteville, Arkansas
Source: ClinicalTrials.gov public record
Updated Nov 8, 2022 · Synced Oct 17, 2026, 7:16 AM EDT
Completed Not applicable Interventional Results available

Clinical Evaluation of a Daily Wear Frequent Replacement Silicone Hydrogel Lens

NCT03920280
View directory record Official record
Conditions
Refractive Errors
Interventions
LID015385 contact lenses, Comfilcon A soft contact lenses, CLEAR CARE
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
8
States / cities
Maitland, Florida • Orlando, Florida • Pensacola, Florida + 5 more
Source: ClinicalTrials.gov public record
Updated Jul 28, 2022 · Synced Oct 17, 2026, 7:16 AM EDT
Completed Not applicable Interventional Results available

Acute Comfort of Lubricant Eye Drops FID 112903

NCT00673855
View directory record Official record
Conditions
Dry Eye
Interventions
Lubricant Eye Drops FID 112903, Optive Lubricant Eye Drops
Other
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008
U.S. locations
1
States / cities
Mansfield, Texas
Source: ClinicalTrials.gov public record
Updated Feb 2, 2012 · Synced Oct 17, 2026, 7:16 AM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Physiologic Phacofluidics: Ghost Protocol

NCT06904404
View directory record Official record
Conditions
Cataract
Interventions
Cataract surgery at high IOP, Cataract surgery at low IOP
Procedure
Lead sponsor
Wolfe Eye Clinic
Other
Eligibility
55 Years to 95 Years
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Hiawatha, Iowa
Source: ClinicalTrials.gov public record
Updated Aug 12, 2025 · Synced Oct 17, 2026, 7:16 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Comparison of Two Multi-Purpose Solution and Lens Material Combinations on Corneal Barrier Function

NCT00560898
View directory record Official record
Conditions
Contact Lens Disinfecting Solutions
Interventions
ProClear Lens Material soaked in ReNu Multiplus Multipurpose Solution, Acuvue Advance Lens Material soaked in ReNu Multiplus Multipurpose Solution, Acuvue Advance Lens Material soaked in Optifree RepleniSH Multipurpose Solution, ProClear Lens Material soaked in Optifree RepleniSH Multipurpose Solution
Drug
Lead sponsor
Southern California College of Optometry at Marshall B. Ketchum University
Other
Eligibility
18 Years to 80 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
1
States / cities
Fullerton, California
Source: ClinicalTrials.gov public record
Updated May 20, 2008 · Synced Oct 17, 2026, 7:16 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Effect of Contact Lens Wear on Immune Cell Density and Morphology of the Ocular Surface

NCT01250925
View directory record Official record
Conditions
Myopia, Refractive Error
Interventions
ReNu MultiPlus® MultiPurpose Solution, OPTI-FREE® RepleniSH®, Clear Care®
Drug
Lead sponsor
Massachusetts Eye and Ear Infirmary
Other
Eligibility
18 Years and older
Enrollment
94 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2012
U.S. locations
2
States / cities
Iowa City, Iowa • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 10, 2017 · Synced Oct 17, 2026, 7:16 AM EDT
Completed Not applicable Interventional Results available

Comparison of Clinical Performance of Two Monthly Replacement Toric Soft Contact Lenses

NCT06165627
View directory record Official record
Conditions
Ametropia, Astigmatism
Interventions
Lehfilcon A toric contact lenses, Comfilcon A toric contact lenses, CLEAR CARE
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years to 45 Years
Enrollment
67 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
5
States / cities
Los Angeles, California • Oakland, California • San Francisco, California + 2 more
Source: ClinicalTrials.gov public record
Updated May 29, 2025 · Synced Oct 17, 2026, 7:16 AM EDT
Completed Phase 3 Interventional

A Double-Masked Comparison of FID 123320 Ophthalmic Solution to Vehicle for the Reduction of Ocular Redness

NCT06444529
View directory record Official record
Conditions
Ocular Redness
Interventions
Apraclonidine Hydrochloride Ophthalmic Solution, Vehicle
Drug
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
159 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
5
States / cities
Glendale, California • Garner, North Carolina • Cranberry Township, Pennsylvania + 2 more
Source: ClinicalTrials.gov public record
Updated Oct 23, 2025 · Synced Oct 17, 2026, 7:16 AM EDT
Completed No phase listed Observational

Compliance With Once Daily Glaucoma Medication

NCT00333463
View directory record Official record
Conditions
Compliance
Interventions
Intervention
Behavioral
Lead sponsor
Alcon Research
Industry
Eligibility
Not listed
Enrollment
700 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Nov 18, 2016 · Synced Oct 17, 2026, 7:16 AM EDT
Completed Not applicable Interventional Results available

Randomized Contralateral Clinical Trial With Single-piece (SN60WF) vs. Three Piece (MA60AC) AcrySof Intraocular Lenses (IOLs) on Development of Posterior Chamber Opacification (PCO).

NCT00758745
View directory record Official record
Conditions
Cataract
Interventions
Model SN60WF, Model MA60AC
Device
Lead sponsor
Alcon Research
Industry
Eligibility
50 Years and older
Enrollment
81 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Aug 19, 2014 · Synced Oct 17, 2026, 7:16 AM EDT
Completed Not applicable Interventional

Post Market Clinical Follow-up (PMCF) Study of Clareon Vivity & Clareon PanOptix

NCT05796453
View directory record Official record
Conditions
Aphakia, Astigmatism, Presbyopia
Interventions
Clareon Vivity IOL - Non Toric, Clareon Vivity IOL - Toric, Clareon PanOptix Trifocal IOL - Non Toric, Clareon PanOptix Trifocal IOL - Toric
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
470 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
6
States / cities
Torrance, California • Jacksonville, Florida • Liverpool, New York + 3 more
Source: ClinicalTrials.gov public record
Updated Sep 2, 2026 · Synced Oct 17, 2026, 7:16 AM EDT
Completed No phase listed Observational

Post Approval Study of the AcrySof® IQ Toric Intraocular Lens (IOL) Models SN6AT6-SN6AT9

NCT01601665
View directory record Official record
Conditions
Cataracts, Astigmatism
Interventions
SN6AT6 Intraocular Lens, SN6AT7 Intraocular Lens, SN6AT8 Intraocular Lens, SN6AT9 Intraocular Lens, SN60WF Intraocular Lens
Device
Lead sponsor
Alcon Research
Industry
Eligibility
21 Years and older
Enrollment
477 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Aug 4, 2015 · Synced Oct 17, 2026, 7:16 AM EDT