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ClinicalTrials.gov public records Last synced Oct 9, 2026, 4:36 AM EDT

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Showing 49–72 of 96 matching trials from the live ClinicalTrials.gov search.
Filters: Sponsor: Prisma Health-Upstate Clear all
Terminated Phase 4 Interventional Results available

Amniotic Membrane Allograft Application in the Management of Venous Leg Ulcerations

NCT02929056
View directory record Official record
Conditions
Varicose Ulcer, Venous Insufficiency
Interventions
AmnioExCel dressing and compression therapy, SOC alginate dressing and compression therapy
Biological · Procedure
Lead sponsor
Prisma Health-Upstate
Other
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Greenville, South Carolina
Source: ClinicalTrials.gov public record
Updated Dec 16, 2021 · Synced Oct 9, 2026, 4:36 AM EDT
Completed No phase listed Observational

Pelvic Ring Injury

NCT01821339
View directory record Official record
Conditions
Pelvic Ring Injury
Interventions
Not listed
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 27, 2016 · Synced Oct 9, 2026, 4:36 AM EDT
Completed No phase listed Observational

Body Composition During Cancer Treatment

NCT03784911
View directory record Official record
Conditions
Cancer
Interventions
SOZO Device, DEXA Scan
Device
Lead sponsor
Prisma Health-Upstate
Other
Eligibility
18 Years and older
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
1
States / cities
Greenville, South Carolina
Source: ClinicalTrials.gov public record
Updated Oct 28, 2024 · Synced Oct 9, 2026, 4:36 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Mindfulness-Based Relapse Prevention for Opioid and Alcohol Use Disorders

NCT04278352
View directory record Official record
Conditions
Opioid-use Disorder, Opioid Abuse, in Remission, Alcohol Use Disorder, Alcohol Use Disorder, in Remission
Interventions
Mindfulness Based Relapse Prevention
Behavioral
Lead sponsor
Clemson University
Other
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
3
States / cities
Clemson, South Carolina • Greenville, South Carolina
Source: ClinicalTrials.gov public record
Updated Mar 8, 2024 · Synced Oct 9, 2026, 4:36 AM EDT
Terminated Phase 1 Interventional Results available

Trial of Famotidine & N-Acetyl Cysteine for Outpatients With COVID-19

NCT04545008
View directory record Official record
Conditions
Covid19
Interventions
Famotidine, N-Acetyl cysteine
Drug
Lead sponsor
Prisma Health-Upstate
Other
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
3
States / cities
Easley, South Carolina • Greenville, South Carolina • Greer, South Carolina
Source: ClinicalTrials.gov public record
Updated Feb 18, 2022 · Synced Oct 9, 2026, 4:36 AM EDT
Completed Not applicable Interventional

An Integrated Intervention Involving Recovery Coaching and Cognitive Behavioral Therapy for Opioid Use Disorder

NCT06102200
View directory record Official record
Conditions
Standard of Care, Standard of Care + CBT4CBT, Standard of Care + CBT4CBT + RC
Interventions
CBT4CBT, RC, Sandard of care
Behavioral
Lead sponsor
Prisma Health-Upstate
Other
Eligibility
18 Years and older
Enrollment
92 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Greenville, South Carolina
Source: ClinicalTrials.gov public record
Updated Feb 6, 2026 · Synced Oct 9, 2026, 4:36 AM EDT
Completed No phase listed Observational

Effects of E-Cigarette Flavors on Adult E-Cigarette Users With Opioid Use Disorder

NCT07594717
View directory record Official record
Conditions
Nicotine Use Disoder, Opioid Use Disorder
Interventions
Sweet-cooling, Sweet non-cooling EC flavor, Tobacco flavor EC
Drug
Lead sponsor
Prisma Health-Upstate
Other
Eligibility
21 Years and older
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Greenville, South Carolina
Source: ClinicalTrials.gov public record
Updated Aug 3, 2026 · Synced Oct 9, 2026, 4:36 AM EDT
Active, not recruiting No phase listed Observational

Dietary Insights and Nutrition Experiences in Adults on GLP-1 Therapy - A Study on Diet Quality Changes in Adults on GLP-1 Therapy

NCT07313384
View directory record Official record
Conditions
Obesity Type 2 Diabetes Mellitus, Obesity (Disorder)
Interventions
GLP-1 Therapy
Drug
Lead sponsor
University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
2
States / cities
Columbia, South Carolina • Greenville, South Carolina
Source: ClinicalTrials.gov public record
Updated Jul 23, 2026 · Synced Oct 9, 2026, 4:36 AM EDT
Completed Not applicable Interventional

Barriers to Substance Use Disorder Recovery

NCT04098614
View directory record Official record
Conditions
Substance Use Disorders
Interventions
Recovery Coach Intervention
Behavioral
Lead sponsor
Prisma Health-Upstate
Other
Eligibility
18 Years to 60 Years
Enrollment
99 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Greenville, South Carolina
Source: ClinicalTrials.gov public record
Updated Nov 4, 2024 · Synced Oct 9, 2026, 4:36 AM EDT
Completed Not applicable Interventional

Effects of Upper Extremity Immobilization and Use of a Steering Wheel Spinner Knob Following Distal Radius Fracture

NCT02105038
View directory record Official record
Conditions
Distal Radius Fracture
Interventions
Spinner knob, No Knob
Other
Lead sponsor
Prisma Health-Upstate
Other
Eligibility
18 Years to 80 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Greenville, South Carolina
Source: ClinicalTrials.gov public record
Updated Feb 11, 2016 · Synced Oct 9, 2026, 4:36 AM EDT
Completed Not applicable Interventional Results available

Pregnancy-Related Hypertension: Adherence to a New Type of Monitoring

NCT04823949
View directory record Official record
Conditions
Gestational Hypertension, Preeclampsia, Chronic Hypertension With Pre-Eclampsia Complicating Childbirth, HELLP Syndrome
Interventions
Home blood pressure monitoring
Device
Lead sponsor
Prisma Health-Upstate
Other
Eligibility
18 Years and older · Female only
Enrollment
202 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
2
States / cities
Charleston, South Carolina • Greenville, South Carolina
Source: ClinicalTrials.gov public record
Updated May 18, 2023 · Synced Oct 9, 2026, 4:36 AM EDT
Completed Phase 4 Interventional

Mepivacaine vs Bupivacaine Spinal Anesthesia for TKA

NCT06291727
View directory record Official record
Conditions
Anesthesia, Spinal, Arthroplasty, Replacement, Knee
Interventions
Mepivacaine, Bupivacaine
Drug
Lead sponsor
Prisma Health-Upstate
Other
Eligibility
18 Years and older
Enrollment
138 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Greenville, South Carolina
Source: ClinicalTrials.gov public record
Updated Aug 28, 2025 · Synced Oct 9, 2026, 4:36 AM EDT
Completed Not applicable Interventional

Use of Continuous Passive Motion in the Post-Operative Treatment of Intra-articular Knee Fractures

NCT00591929
View directory record Official record
Conditions
Intra-articular Knee Fractures
Interventions
Continuous Passive Motion
Other
Lead sponsor
Prisma Health-Upstate
Other
Eligibility
18 Years to 85 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2013
U.S. locations
1
States / cities
Greenville, South Carolina
Source: ClinicalTrials.gov public record
Updated Mar 12, 2013 · Synced Oct 9, 2026, 4:36 AM EDT
Completed Not applicable Interventional

Pannus Retraction for Ultrasound Evaluation of the Obese Gravida: A Pilot Study

NCT05527327
View directory record Official record
Conditions
Obesity, Pregnancy Complications, Fetal Anomaly, Pannus
Interventions
traxi® Panniculus Retractor
Device
Lead sponsor
Prisma Health-Upstate
Other
Eligibility
16 Years and older · Female only
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
Greenville, South Carolina
Source: ClinicalTrials.gov public record
Updated Feb 1, 2023 · Synced Oct 9, 2026, 4:36 AM EDT
Terminated Phase 2 Interventional

Durvalumab in Combination With Tremelimumab in Subjects With Advanced Rare Solid Tumors

NCT02938793
View directory record Official record
Conditions
Cancer, Rare Disease
Interventions
Durvalumab, Tremelimumab
Drug
Lead sponsor
Prisma Health-Upstate
Other
Eligibility
18 Years and older
Enrollment
92 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2025
U.S. locations
1
States / cities
Greenville, South Carolina
Source: ClinicalTrials.gov public record
Updated Sep 23, 2025 · Synced Oct 9, 2026, 4:36 AM EDT
Withdrawn Phase 4 Interventional

VAPorized Administration of Bumetanide for Outpatient Relief in Heart Failure

NCT07375212
View directory record Official record
Conditions
Heart Failure Congestive
Interventions
Bumetanide, intranasal 4mg
Drug
Lead sponsor
Prisma Health-Upstate
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Greenville, South Carolina
Source: ClinicalTrials.gov public record
Updated Jan 29, 2026 · Synced Oct 9, 2026, 4:36 AM EDT
Recruiting Not applicable Interventional

A Peer Recovery Coaching Intervention for Hospitalized Alcohol Use Disorder Patients

NCT06479681
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
Peer recovery coaching (PRC), Brief Intervention (SBIRT)
Behavioral
Lead sponsor
Clemson University
Other
Eligibility
18 Years to 75 Years
Enrollment
750 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
2
States / cities
Greenville, South Carolina • Seneca, South Carolina
Source: ClinicalTrials.gov public record
Updated Aug 27, 2025 · Synced Oct 9, 2026, 4:36 AM EDT
Completed Not applicable Interventional

Randomized Controlled Trial of Virtual Reality Assisted Guided Imagery (VRAGI) for Pain in Advanced Cancer Patients.

NCT05348174
View directory record Official record
Conditions
Cancer Pain, Oncology, Virtual Reality, Depression, Anxiety
Interventions
Virtual Reality Assisted Guided Imagery (VRAGI)
Behavioral
Lead sponsor
Prisma Health-Upstate
Other
Eligibility
18 Years to 65 Years
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
3
States / cities
Clemson, South Carolina • Columbia, South Carolina • Greenville, South Carolina
Source: ClinicalTrials.gov public record
Updated Mar 19, 2025 · Synced Oct 9, 2026, 4:36 AM EDT
Terminated Not applicable Interventional Results available

Efficacy Study of Raloxifene to Induce Ovulation in Polycystic Ovarian Syndrome

NCT01607320
View directory record Official record
Conditions
Polycystic Ovarian Syndrome
Interventions
Raloxifene, Clomiphene
Drug
Lead sponsor
Bruce Lessey
Other
Eligibility
18 Years to 36 Years · Female only
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Greenville, South Carolina
Source: ClinicalTrials.gov public record
Updated Sep 20, 2018 · Synced Oct 9, 2026, 4:36 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Healthy Eating for Reproductive Health: Greenville

NCT01716429
View directory record Official record
Conditions
Polycystic Ovarian Syndrome, Infertility, Obesity, Overweight
Interventions
Vegan diet, Low calorie diet
Behavioral
Lead sponsor
University of South Carolina
Other
Eligibility
18 Years to 35 Years · Female only
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
1
States / cities
Greenville, South Carolina
Source: ClinicalTrials.gov public record
Updated Apr 18, 2019 · Synced Oct 9, 2026, 4:36 AM EDT
Completed No phase listed Observational

COVID-19 on Placental Gene Expression and Pathology

NCT04585945
View directory record Official record
Conditions
COVID-19, SARS-CoV-2 Infection
Interventions
Positive for SARS-CoV-2 infection
Diagnostic Test
Lead sponsor
Prisma Health-Upstate
Other
Eligibility
18 Years and older · Female only
Enrollment
68 participants
Timeline
2020 – 2022
U.S. locations
1
States / cities
Greenville, South Carolina
Source: ClinicalTrials.gov public record
Updated Feb 27, 2026 · Synced Oct 9, 2026, 4:36 AM EDT
Recruiting Not applicable Interventional

Electronic Cigarettes as a Harm Reduction Strategy Among People With Opioid Use Disorder on Buprenorphine

NCT07202039
View directory record Official record
Conditions
Tobacco-flavored EC, Sweet-Cooling EC, Sweet Non-cooling EC
Interventions
Brief individual counseling sessions
Behavioral
Lead sponsor
Prisma Health-Upstate
Other
Eligibility
21 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Greenville, South Carolina
Source: ClinicalTrials.gov public record
Updated May 12, 2026 · Synced Oct 9, 2026, 4:36 AM EDT
Completed Not applicable Interventional

A RCT of CenteringPregnancy on Birth Outcomes

NCT02640638
View directory record Official record
Conditions
Pregnancy, Preterm Birth
Interventions
CenteringPregnancy
Behavioral
Lead sponsor
Clemson University
Other
Eligibility
14 Years to 45 Years · Female only
Enrollment
2,350 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
4
States / cities
Los Angeles, California • Atlanta, Georgia • Clemson, South Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Aug 26, 2022 · Synced Oct 9, 2026, 4:36 AM EDT
Enrolling by invitation Not applicable Interventional

Targeted Prehabilitation With Physical Exercise and Inspiratory Muscle Training for Elderly Frail Patients Prior to Ventral Hernia Repair

NCT06874413
View directory record Official record
Conditions
Frailty, Ventral Hernia
Interventions
Prehabilitation, Standard of Care (SOC)
Behavioral · Other
Lead sponsor
Prisma Health-Upstate
Other
Eligibility
65 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Greenville, South Carolina
Source: ClinicalTrials.gov public record
Updated May 27, 2026 · Synced Oct 9, 2026, 4:36 AM EDT