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ClinicalTrials.gov public records Last synced Oct 17, 2026, 2:41 AM EDT

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Showing 73–96 of 230 matching trials from the live ClinicalTrials.gov search.
Filters: Sponsor: Mclean Hospital Clear all
Not yet recruiting Not applicable Interventional

Digital Coach to Support Exposure Therapy Homework for Anxious Youth

NCT07666672
View directory record Official record
Conditions
Anxiety Disorders, OCD
Interventions
BraveBot, Self-Guided Exposure Therapy Homework
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
12 Years to 22 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027
U.S. locations
3
States / cities
Belmont, Massachusetts • Boston, Massachusetts • Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 7, 2026 · Synced Oct 17, 2026, 2:41 AM EDT
Not yet recruiting Not applicable Interventional

Pilot Study of Sensor-Informed Smartphone-based Mental Health Interventions for Mood in Early Psychosis

NCT07503093
View directory record Official record
Conditions
Psychosis, Anxiety, Depression, Rumination
Interventions
Smartphone-based Mindfulness Exercise, Smartphone-based Psychoeducation, Neutral Control Message
Behavioral
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years to 50 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 5, 2026 · Synced Oct 17, 2026, 2:41 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Effect of Nicotine on Brain Reward Pathways

NCT02346539
View directory record Official record
Conditions
Depressive Disorder
Interventions
Nicotine polacrilex
Drug
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years to 45 Years
Enrollment
46 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 22, 2018 · Synced Oct 17, 2026, 2:41 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Recovery Inspired Support Engagement (RISE) Pilot

NCT07519759
View directory record Official record
Conditions
Support Persons, Family Members, Chosen Family, Romantic Partners, Friends, Caregivers, Substance Use Disorders
Interventions
ITC
Behavioral
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years and older
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 15, 2026 · Synced Oct 17, 2026, 2:41 AM EDT
Completed Not applicable Interventional

A Project to Test the Efficacy and Safety of An Innovative Treatment for Opiate Use Disorders.

NCT05995873
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
Sham unilateral transcranial photobiomodulation, transcranial photobiomodulation at 810 nm at 250 mW/cm2 for 4 minutes
Other · Device
Lead sponsor
MindLight, LLC
Industry
Eligibility
18 Years to 65 Years
Enrollment
130 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Newton Highlands, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 22, 2026 · Synced Oct 17, 2026, 2:41 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

CoQ10 in Geriatric Bipolar Depression

NCT00720369
View directory record Official record
Conditions
Bipolar Depression
Interventions
CoEnzyme Q10
Drug
Lead sponsor
Mclean Hospital
Other
Eligibility
55 Years to 89 Years
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2010
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 13, 2014 · Synced Oct 17, 2026, 2:41 AM EDT
Completed Not applicable Interventional Results available

Sleep Loss and Mechanisms of Impaired Glucose Metabolism

NCT00555750
View directory record Official record
Conditions
Primary Insomnia
Interventions
eszopiclone, placebo
Drug
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
25 Years to 55 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 10, 2013 · Synced Oct 17, 2026, 2:41 AM EDT
Completed Phase 3 Interventional Results available

The Effects of Wellbutrin (Bupropion) on Residual and Cognitive Symptoms in SSRI-treated Depression

NCT00125957
View directory record Official record
Conditions
Depression, Major Depressive Disorder, Unipolar Depression
Interventions
Wellbutrin, Placebo
Drug
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years to 70 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2011
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 6, 2014 · Synced Oct 17, 2026, 2:41 AM EDT
Completed Not applicable Interventional Results available

Internet Based Cognitive Behavioral Therapy Effects on Depressive Cognitions and Brain Function

NCT01598922
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Internet Cognitive Behavioral Therapy
Behavioral
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years to 45 Years
Enrollment
77 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 25, 2021 · Synced Oct 17, 2026, 2:41 AM EDT
Withdrawn No phase listed Observational

Study of Dronabinol Treatment for Depression and/or Anxiety in Older Patients

NCT03369639
View directory record Official record
Conditions
Depression, Anxiety
Interventions
Not listed
Lead sponsor
Mclean Hospital
Other
Eligibility
50 Years to 89 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 31, 2019 · Synced Oct 17, 2026, 2:41 AM EDT
Enrolling by invitation Phase 4 Interventional

Comparative Effectiveness of ECT vs. KETAMINE Over the Lifespan

NCT06034821
View directory record Official record
Conditions
Acute Suicidal Depression (ASD)
Interventions
Subanesthetic dose intravenous ketamine (KET), Electroconvulsive therapy (ECT)
Drug · Device
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 90 Years
Enrollment
1,500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2030
U.S. locations
9
States / cities
San Francisco, California • Baltimore, Maryland • Belmont, Massachusetts + 6 more
Source: ClinicalTrials.gov public record
Updated Dec 15, 2025 · Synced Oct 17, 2026, 2:41 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Understanding Brain Reward Responses in Individuals With Major Depressive Disorder

NCT00183755
View directory record Official record
Conditions
Depression
Interventions
Not listed
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years to 64 Years
Enrollment
87 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2009
U.S. locations
3
States / cities
Boston, Massachusetts • Cambridge, Massachusetts • Charlestown, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 21, 2014 · Synced Oct 17, 2026, 2:41 AM EDT
Not yet recruiting Phase 1Phase 2 Interventional Accepts healthy volunteers

Synaptic Mechanisms of Intermittent Theta Burst Stimulation for Major Depressive Disorder

NCT07593222
View directory record Official record
Conditions
Major Depression, Healthy Participants
Interventions
Sham iTBS, TMS, D-cycloserine, Dextromethophan, Placebo
Device · Drug
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2031
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 14, 2026 · Synced Oct 17, 2026, 2:41 AM EDT
Active, not recruiting Not applicable Interventional

Low Field Magnetic Stimulation: Imaging Biomarkers in Geriatric Bipolar Depression

NCT03484494
View directory record Official record
Conditions
Bipolar Disorder, Bipolar Depression, Bipolar I Disorder, Bipolar II Disorder
Interventions
Low Field Magnetic Stimulation
Device
Lead sponsor
Mclean Hospital
Other
Eligibility
50 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2026
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 23, 2026 · Synced Oct 17, 2026, 2:41 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

To Determine The Amount Of Voriconazole In The Brain After 2 Loading Doses And 3 Maintenance Doses Over 3 Days

NCT00300677
View directory record Official record
Conditions
Infections, Fungal
Interventions
voriconazole
Drug
Lead sponsor
Pfizer
Industry
Eligibility
18 Years to 55 Years · Male only
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 14, 2009 · Synced Oct 17, 2026, 2:41 AM EDT
Completed Not applicable Interventional

Developing a Low-Intensity Primary Care Intervention for Anxiety Disorders

NCT02266446
View directory record Official record
Conditions
Anxiety Disorders
Interventions
Attention & Interpretation Modification
Behavioral
Lead sponsor
Brown University
Other
Eligibility
18 Years and older
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Pawtucket, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jan 23, 2018 · Synced Oct 17, 2026, 2:41 AM EDT
Completed Phase 2Phase 3 Interventional Results available

Nabilone for Cannabis Dependence: A Pilot Study

NCT01347762
View directory record Official record
Conditions
Cannabis Dependence, Marijuana Dependence
Interventions
Nabilone, Placebo
Drug
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years to 45 Years
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2017
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 1, 2018 · Synced Oct 17, 2026, 2:41 AM EDT
Suspended Phase 1 Interventional

Low Field Magnetic Stimulation (LFMS) in Mood Disorders: 6 Treatments

NCT01557192
View directory record Official record
Conditions
Bipolar Depression, Unipolar Depression
Interventions
Low Field Magnetic Stimulation Device
Device
Lead sponsor
Mclean Hospital
Other
Eligibility
21 Years to 55 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2020
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 13, 2016 · Synced Oct 17, 2026, 2:41 AM EDT
Not listed Not applicable Interventional

Pilot Testing a Novel Remotely Delivered Intensive Outpatient Program for Individuals With OUD

NCT05817825
View directory record Official record
Conditions
Opioid Use Disorder, Serious Bacterial Infections
Interventions
Smart IOP Intervention, Peer Recovery Coach
Behavioral
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 3, 2024 · Synced Oct 17, 2026, 2:41 AM EDT
Withdrawn Not applicable Interventional

Opiate Craving Reduction Study Using Post-detox Patients on Suboxone and Use of TEAS as Adjunctive Treatment

NCT02033746
View directory record Official record
Conditions
Opioid-use Disorder
Interventions
Han's Acupoint Nerve Stimulator
Device
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years to 59 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 22, 2018 · Synced Oct 17, 2026, 2:41 AM EDT
Recruiting Phase 2 Interventional Accepts healthy volunteers

Pharmaco-Neuroimaging Studies of Approach/Avoidance Behaviors and Post-Mortem Studies: Pharmacological Manipulation

NCT05232032
View directory record Official record
Conditions
Depressive Disorder, Major, Anxiety Disorder
Interventions
Nociceptin Receptor Antagonist, Aversive stimuli
Drug · Device
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years to 45 Years
Enrollment
112 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 18, 2026 · Synced Oct 17, 2026, 2:41 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Predicting Cognitive Resilience Against Sleep Loss

NCT01651429
View directory record Official record
Conditions
Sleep Deprivation
Interventions
Sleep deprivation
Behavioral
Lead sponsor
Mclean Hospital
Other
Eligibility
20 Years to 45 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 16, 2014 · Synced Oct 17, 2026, 2:41 AM EDT
Completed Phase 2 Interventional

Treatment Efficacy for Drug Abuse and AIDS Prevention - 2

NCT00000211
View directory record Official record
Conditions
Cocaine-Related Disorders, Heroin Dependence
Interventions
Buprenorphine
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
26 Years to 41 Years · Male only
Healthy volunteers
Healthy volunteers not accepted
Timeline
1989 – 1996
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 12, 2017 · Synced Oct 17, 2026, 2:41 AM EDT
Not yet recruiting Not applicable Interventional

EEG and Actigraphy Biomarkers of Written Exposure Therapy for Posttraumatic Stress Disorder

NCT07766798
View directory record Official record
Conditions
Posttraumatic Stress Disorder (PTSD)
Interventions
Written Exposure Therapy, Neutral Writing Condition
Behavioral
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2031
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 14, 2026 · Synced Oct 17, 2026, 2:41 AM EDT