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ClinicalTrials.gov public records Last synced Oct 19, 2026, 12:01 PM EDT

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Showing 985–1008 of 1,663 matching trials from the live ClinicalTrials.gov search.
Filters: Sponsor: Brigham and Women's Hospital Clear all
Completed Phase 1 Interventional Accepts healthy volunteers

A Study on Hydroxocobalamin Given to Healthy Individual to Monitor Symptoms

NCT07469189
View directory record Official record
Conditions
Hydroxocobalamin Adverse Reaction
Interventions
Hydroxocobalamin
Drug
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 70 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 13, 2026 · Synced Oct 19, 2026, 12:01 PM EDT
Completed Not applicable Interventional Results available

Cook Balloon vs Dilapan-S for Outpatient Cervical Ripening

NCT05062343
View directory record Official record
Conditions
Induced; Birth
Interventions
Dilapan-S, Cook Cervical Ripening Balloon
Device
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 27, 2023 · Synced Oct 19, 2026, 12:01 PM EDT
Completed Phase 1Phase 2 Interventional Results available

Oral Clofarabine for Relapsed/Refractory Non-Hodgkin Lymphoma

NCT00644189
View directory record Official record
Conditions
Follicular Lymphoma, Marginal Zone Lymphoma, Mantle Cell Lymphoma, Small Lymphocytic Lymphoma, Lymphoplasmacytic Lymphoma, Low Grade B-cell Lymphoma, Not Otherwise Specified, Diffuse Large B-cell Lymphoma, Peripheral T-cell Lymphoma, Angioimmunoblastic T-cell Lymphoma, Anaplastic Large-cell Lymphoma
Interventions
Clofarabine
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2021
U.S. locations
2
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 15, 2023 · Synced Oct 19, 2026, 12:01 PM EDT
Completed Phase 2 Interventional Results available

Dose-Dense MVAC With Pegfilgrastim Support in Subjects With Muscle-Invasive Urothelial Carcinoma

NCT00808639
View directory record Official record
Conditions
Bladder Cancer, Muscle-invasive Bladder Cancer
Interventions
Methotrexate, Doxorubicin, vinblastine, cisplatin, Pegfilgrastim
Drug
Lead sponsor
Dana-Farber Cancer Institute
Other
Eligibility
18 Years and older
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2016
U.S. locations
4
States / cities
Boston, Massachusetts • Burlington, Massachusetts • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 24, 2016 · Synced Oct 19, 2026, 12:01 PM EDT
Completed Not applicable Interventional

Computerized Decision Support to Increase Detection of Chronic Thromboembolic Pulmonary Hypertension in Patients With Prior Pulmonary Embolism

NCT03729544
View directory record Official record
Conditions
Chronic Thromboembolic Pulmonary Hypertension
Interventions
On-screen computerized decision support alert
Behavioral
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 25, 2026 · Synced Oct 19, 2026, 12:01 PM EDT
Completed Phase 2 Interventional Results available

LBH589 in Relapsed or Relapsed and Refractory Waldenstrom's Macroglobulinemia

NCT00936611
View directory record Official record
Conditions
Waldenstrom's Macroglobulinemia
Interventions
LBH589
Drug
Lead sponsor
Dana-Farber Cancer Institute
Other
Eligibility
18 Years and older
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
2
States / cities
Denver, Colorado • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 28, 2021 · Synced Oct 19, 2026, 12:01 PM EDT
Withdrawn Not applicable Interventional

Initiating Substance Use Disorder Treatment for Hospitalized Alcohol Use Disorder Patients

NCT04223011
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
In-Hospital Recovery Coach Intervention
Behavioral
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 75 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 14, 2020 · Synced Oct 19, 2026, 12:01 PM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

Examining the Genetic Factors That May Cause Chronic Obstructive Pulmonary Disease (COPD)

NCT00608764
View directory record Official record
Conditions
Pulmonary Disease, Chronic Obstructive, Emphysema, Bronchitis, Chronic
Interventions
Not listed
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
45 Years to 80 Years
Enrollment
10,718 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2028
U.S. locations
20
States / cities
Birmingham, Alabama • San Diego, California • Torrance, California + 14 more
Source: ClinicalTrials.gov public record
Updated Sep 17, 2025 · Synced Oct 19, 2026, 12:01 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Surveying Parents About Genome Screening of Newborns

NCT01736501
View directory record Official record
Conditions
Parents of Healthy Newborns
Interventions
Genetics education at baseline, Hypothetical genomic scenarios at follow-up
Other
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
Not listed
Healthy volunteers
Accepts healthy volunteers
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 12, 2025 · Synced Oct 19, 2026, 12:01 PM EDT
Not yet recruiting Phase 4 Interventional

Use of Fidaxomicin Compared to Vancomycin for Decolonization of C. Difficile in Patients With Inflammatory Bowel Disease

NCT06794944
View directory record Official record
Conditions
Inflammatory Bowel Disease (IBD), Clostridioides Difficile Infection
Interventions
Vancomycin (POC), Fidaxomicin
Drug
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2031
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 3, 2025 · Synced Oct 19, 2026, 12:01 PM EDT
Recruiting Not applicable Interventional

Brain Connectivity in Depression

NCT03276793
View directory record Official record
Conditions
Depression
Interventions
MRI scan, Behavioral testing
Other · Behavioral
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Enrollment
260 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2027
U.S. locations
4
States / cities
Boston, Massachusetts • Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Apr 21, 2025 · Synced Oct 19, 2026, 12:01 PM EDT
Completed Not applicable Interventional Results available

Predicting Successful Sleep Apnea Treatment With Acetazolamide in Heart Failure Patients

NCT01377987
View directory record Official record
Conditions
Heart Failures
Interventions
Acetazolamide, Placebo
Drug
Lead sponsor
David Andrew Wellman
Other
Eligibility
18 Years to 89 Years
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 13, 2018 · Synced Oct 19, 2026, 12:01 PM EDT
Enrolling by invitation Phase 4 Interventional

Comparative Effectiveness of ECT vs. KETAMINE Over the Lifespan

NCT06034821
View directory record Official record
Conditions
Acute Suicidal Depression (ASD)
Interventions
Subanesthetic dose intravenous ketamine (KET), Electroconvulsive therapy (ECT)
Drug · Device
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 90 Years
Enrollment
1,500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2030
U.S. locations
9
States / cities
San Francisco, California • Baltimore, Maryland • Belmont, Massachusetts + 6 more
Source: ClinicalTrials.gov public record
Updated Dec 15, 2025 · Synced Oct 19, 2026, 12:01 PM EDT
Not yet recruiting Not applicable Interventional

A Device to Prevent Sudden Unexpected Death in Epilepsy: Detecting Peri-Ictal Body Position

NCT06135285
View directory record Official record
Conditions
Epilepsy
Interventions
Study Subjects
Device
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 27, 2026 · Synced Oct 19, 2026, 12:01 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

RCT Superior Hypogastric Block During LH

NCT03283436
View directory record Official record
Conditions
Hysterectomy
Interventions
Bupivacaine Hydrochloride 0.25% Injection Solution
Drug
Lead sponsor
Jon I. Einarsson
Other
Eligibility
18 Years and older · Female only
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
2
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 27, 2020 · Synced Oct 19, 2026, 12:01 PM EDT
Active, not recruiting No phase listed Observational

Fertility, Hypercoagulability, and Inflammation (FREYA) Registry

NCT04537416
View directory record Official record
Conditions
Thrombophilia
Interventions
No intervention
Other
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 40 Years · Female only
Enrollment
1,000 participants
Timeline
2018 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 1, 2026 · Synced Oct 19, 2026, 12:01 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Searching for Masses and Calcifications at the Same Time in Breast Cancer Screening

NCT05975736
View directory record Official record
Conditions
Mammography, Breast Cancer, Radiology
Interventions
Search only for masses, Search only for calcifications, Search for both together, Search for one after the other
Behavioral
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2028
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 19, 2026 · Synced Oct 19, 2026, 12:01 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Multimodal, Task-Aware Movement Assessment and Control: Clinic to the Home

NCT04675307
View directory record Official record
Conditions
Frailty
Interventions
Not listed
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 14, 2026 · Synced Oct 19, 2026, 12:01 PM EDT
Recruiting Not applicable Interventional

Effect of Endoscopic Sleeve Gastroplasty in Patients With Obesity and MASH: A Randomized Controlled Trial

NCT06138821
View directory record Official record
Conditions
Obesity, Liver Diseases, Liver Fibrosis, Liver Fat, Metabolic Dysfunction-Associated Steatotic Liver Disease, Metabolic Dysfunction-Associated Steatohepatitis, MASLD, MASH, Weight Loss, Insulin Resistance, Insulin Sensitivity, Insulin Sensitivity/Resistance, Metabolic Disease, Diabetes, Diabetes Mellitus, Type 2, NASH With Fibrosis, Non-Alcoholic Fatty Liver Disease, Non Alcoholic Fatty Liver, Non-alcoholic Steatohepatitis
Interventions
ESG + lifestyle modification, Lifestyle modification
Device · Behavioral
Lead sponsor
Pichamol Jirapinyo, MD, MPH
Other
Eligibility
18 Years and older
Enrollment
132 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
2
States / cities
Boston, Massachusetts • Morgantown, West Virginia
Source: ClinicalTrials.gov public record
Updated Jun 25, 2026 · Synced Oct 19, 2026, 12:01 PM EDT
Recruiting Not applicable Interventional

OsteoPorotic fracTure preventION System (OPTIONS) Research Study

NCT06731608
View directory record Official record
Conditions
Osteoporosis, Lower Limb Fracture
Interventions
OPTIONS, Enhanced usual care
Behavioral
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
65 Years and older
Enrollment
1,344 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
2
States / cities
Baltimore, Maryland • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 29, 2026 · Synced Oct 19, 2026, 12:01 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

The Role of Endothelin in Pulmonary Hypertension

NCT00759408
View directory record Official record
Conditions
Pulmonary Hypertension
Interventions
BQ-123
Drug
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 85 Years
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1999 – 2011
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 27, 2018 · Synced Oct 19, 2026, 12:01 PM EDT
Recruiting No phase listed Observational

Burnout and Safety Assessment in Home Hospital Versus Brick-and-Mortar Hospital

NCT07773168
View directory record Official record
Conditions
Burnout, Healthcare Workers, Workplace Violence
Interventions
Not listed
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 20, 2026 · Synced Oct 19, 2026, 12:01 PM EDT
Completed No phase listed Observational

Dual-Source Computed Tomography to Improve Prediction of Response to Cardiac Resynchronization Therapy

NCT01097733
View directory record Official record
Conditions
Heart Failure - NYHA II - IV, Wide QRS Complex
Interventions
Randomization of Pre-knowledge of CT coronary venography
Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 3, 2022 · Synced Oct 19, 2026, 12:01 PM EDT
Not listed No phase listed Observational

Characterization and Prediction of Atrial Fibrillation-caused Adverse Events After Hospital Discharge for Cardiac Surgery

NCT03466125
View directory record Official record
Conditions
Atrial Fibrillation, Stroke, Acute, Death
Interventions
Cardiac surgery
Procedure
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
20 Years to 99 Years
Enrollment
25,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 8, 2023 · Synced Oct 19, 2026, 12:01 PM EDT