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ClinicalTrials.gov public records Last synced Oct 14, 2026, 4:46 AM EDT

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Showing 145–168 of 411 matching trials from the live ClinicalTrials.gov search.
Filters: Sponsor: University of Missouri-Columbia Clear all
Completed Phase 3 Interventional Accepts healthy volunteers

Exercise and Physical Fitness for Persons With Knee Osteoarthritis

NCT00265447
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Strength training, Aerobic conditioning, Delayed exercise
Behavioral
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
50 Years and older
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2011
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Sep 28, 2016 · Synced Oct 14, 2026, 4:46 AM EDT
Active, not recruiting Phase 1 Interventional Accepts healthy volunteers

This Study Consists of Two Study Parts Conducted Under a Single IRB. Part I: Short Term ApoE-dependent Cerebral Blood Flow Response to Sirolimus in Cognitively Normal Adults Part II: Short Term ApoE-dependent Cerebral Blood Flow and Lung Perfusion Response to Sirolimus in Cognitively Normal Adults

NCT05386914
View directory record Official record
Conditions
Genetic Predisposition to Disease, Healthy Volunteers
Interventions
Sirolimus
Drug
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
45 Years to 65 Years
Enrollment
205 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Mar 6, 2026 · Synced Oct 14, 2026, 4:46 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Hormone Replacement and Neural Cardiovascular Control in Postmenopausal Women

NCT01633814
View directory record Official record
Conditions
Menopause, Aging, Blood Pressure
Interventions
Transdermal estradiol, Placebo
Drug
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years to 80 Years · Female only
Enrollment
4 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2015
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Aug 10, 2017 · Synced Oct 14, 2026, 4:46 AM EDT
Terminated Not applicable Interventional

Studying Warmed Lidocaine for Increased Analgesic Effect During Intravitreal Injections

NCT06962709
View directory record Official record
Conditions
Pain Intensity Assessment, Pain Management
Interventions
Warmed lidocaine
Other
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
Not listed
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Sep 14, 2026 · Synced Oct 14, 2026, 4:46 AM EDT
Terminated Not applicable Interventional Results available

Optimal Dose of Proton Pump Inhibitors Following an Upper Gastrointestinal Bleed

NCT02235311
View directory record Official record
Conditions
Upper Gastrointestinal Bleed
Interventions
Pantoprazole
Drug
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 31, 2017 · Synced Oct 14, 2026, 4:46 AM EDT
Completed Not applicable Interventional Results available

Role of Vacuum Assisted Closure (VAC) Device in Postoperative Management of Pelvic and Acetabular Fractures

NCT00635479
View directory record Official record
Conditions
Pelvic Fractures, Acetabular Fractures, Hip Fractures
Interventions
VAC device, Gauze dressing
Device · Other
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years and older
Enrollment
115 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2013
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Dec 11, 2017 · Synced Oct 14, 2026, 4:46 AM EDT
Terminated No phase listed Observational

Behavioral Effects of Kuvan in Children With Mild Phenylketonuria

NCT00827762
View directory record Official record
Conditions
Phenylketonuria
Interventions
Kuvan
Drug
Lead sponsor
Washington University School of Medicine
Other
Eligibility
6 Years to 18 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
4
States / cities
Chicago, Illinois • Columbia, Missouri • St Louis, Missouri + 1 more
Source: ClinicalTrials.gov public record
Updated Dec 5, 2013 · Synced Oct 14, 2026, 4:46 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Leucine, mTOR and Athero

NCT05470218
View directory record Official record
Conditions
Atherosclerosis
Interventions
Meal
Other
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years to 95 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated May 11, 2026 · Synced Oct 14, 2026, 4:46 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Epidural Anesthesia /Analgesia Versus PCA for Laparoscopic Complex Ventral Hernia Repair: A Randomized Controlled Trial

NCT00529074
View directory record Official record
Conditions
Analgesia
Interventions
Epidural Catheter for Analgesia
Device
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years to 80 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2006
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Aug 16, 2016 · Synced Oct 14, 2026, 4:46 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Alcohol Impaired Driving: From the Laboratory to the Natural Environment

NCT03846050
View directory record Official record
Conditions
Drinking and Driving
Interventions
BAC feedback/warning, No BAC feedback/warning
Behavioral
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
21 Years to 35 Years
Enrollment
230 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2024
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 18, 2024 · Synced Oct 14, 2026, 4:46 AM EDT
Completed Phase 1 Interventional

Evaluation of Miricorilant on Liver Fat in Patients With MASLD

NCT06947304
View directory record Official record
Conditions
Nonalcoholic Steatohepatitis (NASH), Metabolic Dysfunction-Associated Steatohepatitis (MASH), Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), Non-alcoholic Fatty Liver Disease (NAFLD)
Interventions
Miricorilant
Drug
Lead sponsor
Corcept Therapeutics
Industry
Eligibility
18 Years to 75 Years
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Sep 30, 2026 · Synced Oct 14, 2026, 4:46 AM EDT
Completed No phase listed Observational

Airway Epithelium Gene Expression in the Diagnosis of Lung Cancer: AEGIS CLIA

NCT01309087
View directory record Official record
Conditions
Lung Cancer
Interventions
Not listed
Lead sponsor
Allegro Diagnostics, Corp.
Industry
Eligibility
21 Years and older
Enrollment
756 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
12
States / cities
Birmingham, Alabama • Austell, Georgia • Indianapolis, Indiana + 7 more
Source: ClinicalTrials.gov public record
Updated Mar 26, 2014 · Synced Oct 14, 2026, 4:46 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Promoting the Well Being of Caregivers Via Telehealth

NCT05999448
View directory record Official record
Conditions
Caregivers, Parents
Interventions
Acceptance and Commitment Therapy (ACT), Culturally Informed Cognitive Behavioral Therapy (CICBT), Individual, Culturally Informed Cognitive Behavioral Therapy (CICBT), Group, Dialectical Behavioral Therapy (DBT), Durand Sleep Intervention, RUBI Intervention, Naturalistic Communication Intervention (NCI), Self-Guided Resources, Participation Enhancement Intervention (PEI)
Behavioral
Lead sponsor
Purdue University
Other
Eligibility
18 Years to 70 Years
Enrollment
800 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
West Lafayette, Indiana
Source: ClinicalTrials.gov public record
Updated Aug 21, 2023 · Synced Oct 14, 2026, 4:46 AM EDT
Completed Phase 2 Interventional Results available

Sex-related Differences in Arterial Stiffness in Type 2 Diabetics: Role of Uric Acid

NCT03648996
View directory record Official record
Conditions
Diabetes Mellitus, Type 2, Hyperuricemia
Interventions
Low-fructose diet, isocaloric, Allopurinol, Placebo, Low-fructose, hypocaloric
Other · Drug
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
40 Years to 75 Years
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 3, 2023 · Synced Oct 14, 2026, 4:46 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Ketone Ester and Salt (KEAS) in Young Adults

NCT05545501
View directory record Official record
Conditions
Salt; Excess, Hypertension
Interventions
No Salt, No β-OHB, High Salt, No β-OHB, High Salt, High β-OHB
Dietary Supplement
Lead sponsor
Indiana University
Other
Eligibility
19 Years to 39 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Bloomington, Indiana
Source: ClinicalTrials.gov public record
Updated Aug 19, 2026 · Synced Oct 14, 2026, 4:46 AM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Biometabolic Outcomes After Weight Loss Surgery: An Individualized Approach

NCT04841057
View directory record Official record
Conditions
Obesity, Morbid, Metabolic Syndrome, NASH - Nonalcoholic Steatohepatitis
Interventions
50 cm BP limb length, 100 cm BP limb length, 150 cm BP limb length
Procedure
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years to 80 Years
Enrollment
750 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2031
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Sep 10, 2026 · Synced Oct 14, 2026, 4:46 AM EDT
Terminated No phase listed Observational

Screening for Sacral Agenesis in Offspring of Mothers With Diabetes in Pregnancy

NCT05033275
View directory record Official record
Conditions
Infant of Diabetic Mother, Sacral Agenesis
Interventions
Not listed
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
Not listed
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 18, 2025 · Synced Oct 14, 2026, 4:46 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Investigating Phenotypic, Epigenetic, and NeuroGenetic Traits in Rare and Ultra-rare Neurodevelopmental Disorders (Project PENGUIN)

NCT07329257
View directory record Official record
Conditions
Baker Gordon Syndrome, Rare Neurodevelopmental Conditions, Rare Neurogenetic Conditions, Syt-1 Disorder, Epilepsy, Seizure, Genetic Mutations, Autism in Children, Developmental Delay (Disorder)
Interventions
No Intervention: Observational Cohort
Other
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
Up to 99 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Jan 9, 2026 · Synced Oct 14, 2026, 4:46 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Animal and Plant Proteins and Glucose Metabolism

NCT03994367
View directory record Official record
Conditions
Metabolic Syndrome, Metabolic Syndrome, Protection Against, Glucose Metabolism Disorders
Interventions
High animal protein isolate, High animal protein whole food, High plant protein isolate, High plant protein whole food
Other
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
21 Years to 70 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2028
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated May 8, 2026 · Synced Oct 14, 2026, 4:46 AM EDT
Completed Phase 3 Interventional Results available

Dornase Alfa for ARDS in Patients With Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2)

NCT04402970
View directory record Official record
Conditions
SARS-CoV 2, ARDS
Interventions
Dornase Alfa Inhalation Solution
Drug
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 14, 2021 · Synced Oct 14, 2026, 4:46 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Sex-specific Effect of Restricted Sleep on Brain Health

NCT05920759
View directory record Official record
Conditions
Cerebrovascular Circulation
Interventions
Cerebral blood flow
Diagnostic Test
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years to 45 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Nov 26, 2025 · Synced Oct 14, 2026, 4:46 AM EDT
Completed Not applicable Interventional Results available

Combined Effects of Early Behavioral Intervention and Propranolol on ASD

NCT02428205
View directory record Official record
Conditions
Autism
Interventions
Propranolol, Placebo
Drug
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
3 Years to 10 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2022
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Mar 4, 2024 · Synced Oct 14, 2026, 4:46 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Physical Exercise to Reduce Anxiety in Underserved Children With ASD

NCT02902952
View directory record Official record
Conditions
Physical Exercise Condition, Control Condition
Interventions
Physical Exercise, Control Intervention
Behavioral
Lead sponsor
University of California, Irvine
Other
Eligibility
6 Years to 12 Years
Enrollment
148 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2020
U.S. locations
2
States / cities
Santa Ana, California • Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 4, 2023 · Synced Oct 14, 2026, 4:46 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Work Interventions to Improve Employment Outcomes for Persons With Rheumatoid Arthritis and Osteoarthritis

NCT00485914
View directory record Official record
Conditions
Osteoarthritis, Rheumatoid Arthritis
Interventions
On-site work evaluation, Educational material
Behavioral
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years to 60 Years
Enrollment
89 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2009
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Oct 4, 2016 · Synced Oct 14, 2026, 4:46 AM EDT