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Showing 1–24 of 560 matching trials from the live ClinicalTrials.gov search.
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Filters: "deep brain stimulation" Clear all
Completed No phase listed Observational Results available

Intraoperative Investigation of a Directional Lead and Local Field Potentials for the Optimization of Stimulation Efficacy

NCT03630302
View directory record Official record
Conditions
Parkinson
Interventions
DBS
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years to 70 Years
Enrollment
10 participants
Timeline
2018 – 2020
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 27, 2021 · Synced Jul 24, 2026, 2:49 AM EDT
Recruiting Not applicable Interventional

Deep Brain Stimulation Effects In Patients With Opioid Use Disorder

NCT04354077
View directory record Official record
Conditions
Opioid-use Disorder
Interventions
DBS of the NAc
Device
Lead sponsor
Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
Other
Eligibility
22 Years to 65 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2030
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 17, 2026 · Synced Jul 24, 2026, 2:49 AM EDT
Recruiting Not applicable Interventional

Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)

NCT06423430
View directory record Official record
Conditions
Treatment Resistant Depression
Interventions
Sham-stimulation, Active-stimulation
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
22 Years to 70 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
24
States / cities
Birmingham, Alabama • Los Angeles, California • Sacramento, California + 18 more
Source: ClinicalTrials.gov public record
Updated Jun 28, 2026 · Synced Jul 24, 2026, 2:49 AM EDT
Completed Not applicable Interventional

Identification of Clinically Relevant Markers of Deep Brain Stimulation Electrode Impedance

NCT02794233
View directory record Official record
Conditions
Parkinson Disease
Interventions
Impedance measurements
Other
Lead sponsor
University of Florida
Other
Eligibility
25 Years to 80 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated May 14, 2018 · Synced Jul 24, 2026, 2:49 AM EDT
Recruiting Not applicable Interventional

Neocortical Microarchitecture of Executive Function

NCT06778135
View directory record Official record
Conditions
Parkinson Disease
Interventions
Temporary implatation of large-scale intracranial electrode., brain electrode
Procedure · Device
Lead sponsor
University of Colorado, Denver
Other
Eligibility
45 Years to 85 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Sep 16, 2025 · Synced Jul 24, 2026, 2:49 AM EDT
Completed Not applicable Interventional

Deep Brain Stimulation with LIFUP for Mild Cognitive Impairment and Mild Alzheimer's Disease

NCT03347084
View directory record Official record
Conditions
Brain Imaging, Mild Cognitive Impairment, Alzheimer Disease, Deep Brain Stimulation
Interventions
Excitation, Inhibition
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
55 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Sep 4, 2024 · Synced Jul 24, 2026, 2:49 AM EDT
Recruiting Not applicable Interventional

Globus Pallidus Stimulation to Treat Insomnia

NCT04116996
View directory record Official record
Conditions
Parkinson Disease
Interventions
DEEP BRAIN STIMULATION
Device
Lead sponsor
Mayo Clinic
Other
Eligibility
40 Years to 80 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2029
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Nov 30, 2025 · Synced Jul 24, 2026, 2:49 AM EDT
Recruiting Not applicable Interventional

Low-Intensity Focused Ultrasound Pulsation (LIFUP) for the Treatment of Generalized Anxiety Disorder (GAD)

NCT04557891
View directory record Official record
Conditions
Generalized Anxiety Disorder
Interventions
Active LIFUP Treatment, Sham LIFUP Treatment
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 65 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
3
States / cities
Los Angeles, California • Boston, Massachusetts • Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Feb 9, 2026 · Synced Jul 24, 2026, 2:49 AM EDT
Enrolling by invitation Not applicable Interventional

Spatiotemporal Dynamics of the Human Emotion Network

NCT05152992
View directory record Official record
Conditions
Epilepsy, Depression, Anxiety, Emotions
Interventions
Viewing visual stimuli and electrical stimulation of the brain
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 80 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2026
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jun 22, 2026 · Synced Jul 24, 2026, 2:49 AM EDT
Terminated Not applicable Interventional Results available

Burst-Type Deep Brain Stimulation of the Subthalamic Nucleus in Parkinson's Disease

NCT05753449
View directory record Official record
Conditions
Parkinson Disease, Deep Brain Stimulation
Interventions
Baseline (or standard of care) DBS programming, Burst-type DBS electrical stimulation programming
Device
Lead sponsor
Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
Other
Eligibility
18 Years to 85 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 27, 2025 · Synced Jul 24, 2026, 2:49 AM EDT
Completed Phase 2 Interventional Results available

A Comparison of an Implanted Neuroprosthesis With Sensory Training for Improving Airway Protection in Chronic Dysphagia

NCT00376506
View directory record Official record
Conditions
Chronic Dysphagia, Multiple Sclerosis, Parkinson Disease
Interventions
Neurostimulation device for dysphagia, External vibrotactile device
Device
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
18 Years to 90 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2011
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 25, 2012 · Synced Jul 24, 2026, 2:49 AM EDT
Recruiting Not applicable Interventional

Neurophysiological Investigation of the Approach-avoidance Axis in OCD: Applications to Neuromodulation

NCT06596447
View directory record Official record
Conditions
Obsessive Compulsive Disorder (OCD), Neuromodulation
Interventions
Deep Brain Stimulation
Device
Lead sponsor
Baylor College of Medicine
Other
Eligibility
22 Years to 64 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 22, 2026 · Synced Jul 24, 2026, 2:49 AM EDT
Completed Not applicable Interventional

Pharyngeal Electrical Stimulation Evaluation for Dysphagia After Stroke

NCT03358810
View directory record Official record
Conditions
Dysphagia Following Cerebral Infarction
Interventions
PES
Device
Lead sponsor
Phagenesis Ltd.
Industry
Eligibility
18 Years to 90 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Wheaton, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 19, 2024 · Synced Jul 24, 2026, 2:49 AM EDT
Completed Phase 2 Interventional

Electrical Stimulation of the Internal Capsule for Intractable Obsessive-compulsive Disorder (OCD)

NCT01061983
View directory record Official record
Conditions
Obsessive-Compulsive Disorder
Interventions
Medtronic Activa Deep Brain Stimulation
Device
Lead sponsor
Butler Hospital
Other
Eligibility
18 Years to 55 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2012
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Feb 24, 2013 · Synced Jul 24, 2026, 2:49 AM EDT
Withdrawn No phase listed Observational

Optimizing DBS Electrode Placement and Programming

NCT01820390
View directory record Official record
Conditions
Parkinson's Disease, Essential Tremor
Interventions
Not listed
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 70 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
2
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Feb 19, 2014 · Synced Jul 24, 2026, 2:49 AM EDT
Active, not recruiting No phase listed Observational

Brain Recordings in Patients Undergoing Deep Brain Stimulation (DBS) for Severe Obsessive-Compulsive Disorder (OCD)

NCT05915741
View directory record Official record
Conditions
Obsessive-Compulsive Disorder
Interventions
Not listed
Lead sponsor
Baylor College of Medicine
Other
Eligibility
18 Years to 64 Years
Enrollment
8 participants
Timeline
2021 – 2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 19, 2025 · Synced Jul 24, 2026, 2:49 AM EDT
Completed Not applicable Interventional

Mobile Decision Support System for Nurse Management of Neuromodulation Therapy

NCT02474459
View directory record Official record
Conditions
Parkinson's Disease
Interventions
iPad-Based Clinical Support Care, Standard Clinical Care
Device · Other
Lead sponsor
University of Utah
Other
Eligibility
30 Years to 75 Years
Enrollment
123 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
6
States / cities
San Francisco, California • Gainesville, Florida • New York, New York + 3 more
Source: ClinicalTrials.gov public record
Updated Jun 4, 2020 · Synced Jul 24, 2026, 2:49 AM EDT
Completed No phase listed Observational

Deep Brain Stimulation of the Subthalamic Nucleus (STN) and Cognitive Control

NCT00917722
View directory record Official record
Conditions
Parkinson's Disease
Interventions
Not listed
Lead sponsor
Washington University School of Medicine
Other
Eligibility
Not listed
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2013
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Nov 9, 2016 · Synced Jul 24, 2026, 2:49 AM EDT
Recruiting Phase 4 Interventional

Personalized Real-Time DBS and PD Mechanisms

NCT06013956
View directory record Official record
Conditions
Parkinson Disease
Interventions
Neurostimulation, Carbidopa 25/Levodopa 100Mg Tab
Device · Drug
Lead sponsor
David Escobar
Other
Eligibility
18 Years to 80 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated May 13, 2026 · Synced Jul 24, 2026, 2:49 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

SeeMe: Using Automated Facial Tracking to Detect Voluntary Behavior in Brain Injury

NCT07560631
View directory record Official record
Conditions
Traumatic Brain Injury (TBI) Patients, Severe Traumatic Brain Injury
Interventions
SeeMe Multimodal Auditory Command Protocol
Diagnostic Test
Lead sponsor
Stony Brook University
Other
Eligibility
22 Years to 85 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2029
U.S. locations
1
States / cities
Stony Brook, New York
Source: ClinicalTrials.gov public record
Updated May 4, 2026 · Synced Jul 24, 2026, 2:49 AM EDT
Completed No phase listed Observational

Circuit-Based Deep Brain Stimulation for Parkinson's Disease; Udall Project 1 Aim 2 and 3

NCT03079037
View directory record Official record
Conditions
Parkinson Disease
Interventions
Stimulation
Device
Lead sponsor
University of Minnesota
Other
Eligibility
22 Years to 85 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 15, 2024 · Synced Jul 24, 2026, 2:49 AM EDT
Completed No phase listed Observational

Parkinstep: Automated PD Gait and Balance Assessment for Optimizing DBS

NCT02080572
View directory record Official record
Conditions
Parkinson's Disease With Deep Brain Stimulation
Interventions
Not listed
Lead sponsor
Great Lakes NeuroTechnologies Inc.
Industry
Eligibility
21 Years and older
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2014
U.S. locations
2
States / cities
Cincinnati, Ohio • Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 4, 2015 · Synced Jul 24, 2026, 2:49 AM EDT
Completed Not applicable Interventional Results available

Development of a FES Device for Hand Use During Arm Activities Following Stroke

NCT03986216
View directory record Official record
Conditions
Stroke, Hand Function
Interventions
ReIn-Hand device assisted home-based practice
Device
Lead sponsor
Northwestern University
Other
Eligibility
21 Years to 80 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 6, 2024 · Synced Jul 24, 2026, 2:49 AM EDT
Completed Not applicable Interventional

Next-Generation Pre-Operative Targeting for Thalamic DBS in the Treatment of Tremor

NCT03875404
View directory record Official record
Conditions
Essential Tremor
Interventions
Functional MRI
Diagnostic Test
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Sep 16, 2021 · Synced Jul 24, 2026, 2:49 AM EDT