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ClinicalTrials.gov public records Last synced Oct 8, 2026, 9:06 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 578 matching trials from the live ClinicalTrials.gov search.
Filters: "deep brain stimulation" Clear all
Completed No phase listed Observational Results available

Effects of IV Administration of Ketamine on the Analgesia Nociception Index (ANI) Measured With the PhysioDoloris

NCT01717521
View directory record Official record
Conditions
Monitoring, Intraoperative
Interventions
Not listed
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older · Female only
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Aug 5, 2019 · Synced Oct 8, 2026, 9:06 PM EDT
Completed Not applicable Interventional Results available

The Effects of Dexmedetomidine and Propofol on Cerebral Blood Flow and Brain Oxygenation During Deep Brain Stimulation

NCT01200433
View directory record Official record
Conditions
Intracranial Neurosurgery
Interventions
dexmedetomidine, propofol
Drug
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 80 Years
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 14, 2016 · Synced Oct 8, 2026, 9:06 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Long-term Brain Stimulation of the Motor Ventral Thalamus (VOP/VIM) to Improve Motor Function

NCT07056348
View directory record Official record
Conditions
Traumatic Brain Injury, Stroke, Brain Disease, Movement Disorders (Incl Parkinsonism), Central Nervous System Disease, Essential Tremor, Movement Disorders, Essential Tremor of Voice
Interventions
Deep Brain Stimulation (DBS) of the Motor Thalamus
Device
Lead sponsor
Jorge Gonzalez-Martinez
Other
Eligibility
18 Years to 80 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2030
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 18, 2026 · Synced Oct 8, 2026, 9:06 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effects of Gamma-tACS on Memory and Sleep

NCT05907707
View directory record Official record
Conditions
Transcranial Alternating Current Stimulation, Aging, Cognitive Decline, Memory, Sleep
Interventions
Gamma transcranial alternating current stimulation, Control transcranial alternating current stimulation, EEG headband, Actigraphy wristband
Device
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
50 Years and older
Enrollment
11 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 2, 2025 · Synced Oct 8, 2026, 9:06 PM EDT
Recruiting Not applicable Interventional

Neurophysiology of Reward Signaling in Parkinson's Disease

NCT07409207
View directory record Official record
Conditions
Parkinson Disease
Interventions
Neurophysiology recordings, Neural stimulation
Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
40 Years and older
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jun 12, 2026 · Synced Oct 8, 2026, 9:06 PM EDT
Enrolling by invitation No phase listed Observational Accepts healthy volunteers

Non-Invasive Bioelectronic Analytics

NCT04100486
View directory record Official record
Conditions
Autonomic Dysfunction, Autonomic Imbalance, Autonomic Nervous System Diseases, Vagus Nerve Autonomic Disorder
Interventions
Standing-Squatting-Standing Test, Deep Breathing Test, Cold Pressor Test, Cold Face Test, Valsalva Maneuver, Transcutaneous Auricular Vagus Nerve Stimulation (taVNS)
Other · Device
Lead sponsor
Northwell Health
Other
Eligibility
18 Years to 60 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2027
U.S. locations
1
States / cities
Manhasset, New York
Source: ClinicalTrials.gov public record
Updated Jun 9, 2026 · Synced Oct 8, 2026, 9:06 PM EDT
Recruiting Not applicable Interventional

Use of CereGate Therapy for Freezing of Gait in PD

NCT05292794
View directory record Official record
Conditions
Parkinson Disease, Freezing of Gait, Deep Brain Stimulation
Interventions
CereGate Software; BSN cDBS Programmer; BSN Burst Programmer
Device
Lead sponsor
CereGate Inc.
Industry
Eligibility
21 Years to 80 Years
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
7
States / cities
Redwood City, California • Aurora, Colorado • Miami, Florida + 4 more
Source: ClinicalTrials.gov public record
Updated May 28, 2026 · Synced Oct 8, 2026, 9:06 PM EDT
Recruiting Not applicable Interventional

PRIME: PReservIng Memory in Epilepsy

NCT05608408
View directory record Official record
Conditions
Mesial Temporal Lobe Epilepsy
Interventions
Low Frequency Stimulation (LFS) of site with the Medtronic Percept PC system, Standard of Care (SOC) High Frequency Stimulation of the Anterior Nucleus of the Thalamus (ANT) with the Medtronic Percept PC system
Device
Lead sponsor
Nitin Tandon
Other
Eligibility
18 Years to 65 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2029
U.S. locations
2
States / cities
Rochester, Minnesota • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 27, 2026 · Synced Oct 8, 2026, 9:06 PM EDT
Recruiting Not applicable Interventional

Tele-CE in Severe Stroke

NCT07652970
View directory record Official record
Conditions
Stroke
Interventions
Tele-CE, Tele-Control
Other
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
18 Years to 80 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 17, 2026 · Synced Oct 8, 2026, 9:06 PM EDT
Completed Not applicable Interventional Results available

Deep Brain Stimulation for Treatment Resistant Depression

NCT00367003
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Deep Brain Stimulation
Device
Lead sponsor
Emory University
Other
Eligibility
18 Years to 70 Years
Enrollment
37 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2024
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Jun 23, 2026 · Synced Oct 8, 2026, 9:06 PM EDT
Completed No phase listed Observational

Deep Brain Stimulation in Patients With LUTS

NCT03202251
View directory record Official record
Conditions
Bladder Dysfunction, Neurogenic Bladder
Interventions
It's is a cohort
Other
Lead sponsor
The Methodist Hospital Research Institute
Other
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 5, 2021 · Synced Oct 8, 2026, 9:06 PM EDT
Active, not recruiting Phase 1 Interventional

Cont. of a Study to Evaluate Implanting Peripheral Nerve Grafts Into Subjects With Parkinson's Disease (PD) During DBS

NCT02369003
View directory record Official record
Conditions
Parkinson's Disease
Interventions
Autologous Peripheral Nerve Graft
Procedure
Lead sponsor
Craig van Horne, MD, PhD
Other
Eligibility
40 Years to 75 Years
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2027
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Aug 31, 2026 · Synced Oct 8, 2026, 9:06 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Electrical Synchronization of Slow Oscillations to Enhance Deep Sleep

NCT04461769
View directory record Official record
Conditions
Sleep, Sleep Hygiene
Interventions
Transcranial Electrical Stimulation
Device
Lead sponsor
Brain Electrophysiology Laboratory Company
Industry
Eligibility
18 Years to 80 Years
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated Jul 8, 2020 · Synced Oct 8, 2026, 9:06 PM EDT
Active, not recruiting Not applicable Interventional Results available

Tourette Deep Brain Stimulation (DBS) Target Detection & Suppression

NCT05371041
View directory record Official record
Conditions
Tourette Syndrome
Interventions
Medtronic Percept Neurostimulator
Device
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 85 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Sep 25, 2026 · Synced Oct 8, 2026, 9:06 PM EDT
Completed Not applicable Interventional Results available

Deep Brain Stimulation as a Novel Treatment for Refractory Opioid Use Disorder

NCT05903495
View directory record Official record
Conditions
Opioid-Related Disorders
Interventions
Deep Brain Stimulation
Device
Lead sponsor
West Virginia University
Other
Eligibility
22 Years to 50 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Morgantown, West Virginia
Source: ClinicalTrials.gov public record
Updated Mar 6, 2026 · Synced Oct 8, 2026, 9:06 PM EDT
Completed Not applicable Interventional

Vagal Approaches on Long COVID-19

NCT07190105
View directory record Official record
Conditions
Long COVID Symptoms
Interventions
Sonocea Sonic Augmentation Technology (SAT), Truvaga Electrical Vagus Nerve Stimulator
Other
Lead sponsor
Leidos Life Sciences
Industry
Eligibility
18 Years and older
Enrollment
546 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
Frederick, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 7, 2026 · Synced Oct 8, 2026, 9:06 PM EDT
Recruiting Not applicable Interventional

Deep Brain Stimulation Effects In Patients With Opioid Use Disorder

NCT04354077
View directory record Official record
Conditions
Opioid-use Disorder
Interventions
DBS of the NAc
Device
Lead sponsor
Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
Other
Eligibility
22 Years to 65 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2030
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 31, 2026 · Synced Oct 8, 2026, 9:06 PM EDT
Completed Not applicable Interventional Results available

Brain Stimulation for the Treatment of Tourette Syndrome

NCT01329198
View directory record Official record
Conditions
Tourette Syndrome
Interventions
NeuroPace RNS® System Deep Brain Stimulator
Device
Lead sponsor
University of Florida
Other
Eligibility
25 Years and older
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2017
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jun 8, 2018 · Synced Oct 8, 2026, 9:06 PM EDT
Completed No phase listed Observational

Deep Phenotyping in Patients With ALS

NCT02819765
View directory record Official record
Conditions
ALS, Motor Neuron Disease
Interventions
Not listed
Lead sponsor
Barrow Neurological Institute
Other
Eligibility
18 Years to 75 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
7
States / cities
Phoenix, Arizona • Grand Rapids, Michigan • New York, New York + 4 more
Source: ClinicalTrials.gov public record
Updated Dec 16, 2021 · Synced Oct 8, 2026, 9:06 PM EDT
Recruiting Not applicable Interventional

Closed-Loop Deep Brain Stimulation for Refractory Chronic Pain

NCT04144972
View directory record Official record
Conditions
Spinal Cord Injuries, Nerve Injury, Pain, Postoperative, Post Herpetic Neuralgia, Complex Regional Pain Syndromes, Post-Stroke Pain, Post Radiation Brain Injury, Post Radiation Plexopathy, Nerve Root Avulsion
Interventions
Medtronic Summit RC+S or Percept RC
Device
Lead sponsor
University of California, San Francisco
Other
Eligibility
22 Years to 80 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2030
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jul 31, 2026 · Synced Oct 8, 2026, 9:06 PM EDT
Recruiting Not applicable Interventional

Individualized Adaptive Deep Brain Stimulation in Opioid Use Disorder

NCT07214467
View directory record Official record
Conditions
Substance Use Disorder (SUD), Opioid Use Disorder (OUD)
Interventions
Deep Brain Stimulation
Device
Lead sponsor
University of California, San Francisco
Other
Eligibility
22 Years to 75 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2031
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Oct 28, 2025 · Synced Oct 8, 2026, 9:06 PM EDT
Withdrawn Not applicable Interventional

A Pilot Study of Deep Brain Stimulation of the Amygdala for Treatment-Refractory Combat Post-Traumatic Stress Disorder

NCT01658748
View directory record Official record
Conditions
Post Traumatic Stress Disorder
Interventions
Week 0 Medtronic 3387 electrodes/Activa PC amygdala DBS, Week 12 Medtronic 3387 electrodes/Activa PC amygdala DBS
Device
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
25 Years to 65 Years · Male only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 29, 2013 · Synced Oct 8, 2026, 9:06 PM EDT
Terminated Not applicable Interventional

Vibrotactile Coordinated Reset: A Non-invasive Treatment for Parkinson's Disease

NCT04877015
View directory record Official record
Conditions
Parkinson Disease
Interventions
Active Vibrotactile Coordinated Reset (vCR), Sham Vibrotactile Coordinated Reset (vCR)
Device
Lead sponsor
Synergic Medical Technologies, Inc.
Industry
Eligibility
45 Years to 85 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Dec 27, 2022 · Synced Oct 8, 2026, 9:06 PM EDT
Recruiting Not applicable Interventional

Understanding Prefrontal and Medial Temporal Neuronal Responses to Algorithmic Cognitive Variables in Epilepsy Patients

NCT05283811
View directory record Official record
Conditions
Epilepsy
Interventions
NEUROPACE RNS SYSTEM, EMU
Device · Behavioral
Lead sponsor
Baylor College of Medicine
Other
Eligibility
10 Years to 64 Years
Enrollment
205 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2028
U.S. locations
3
States / cities
Los Angeles, California • Houston, Texas • Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jul 6, 2026 · Synced Oct 8, 2026, 9:06 PM EDT