Independent directory Public ClinicalTrials.gov records United States
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ClinicalTrials.gov public records Last synced Oct 5, 2026, 12:39 AM EDT

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Showing 1–16 of 16 matching trials from the live ClinicalTrials.gov search.
Conditions
Dry Eye, Dry Eye Disease (DED), Dry Eye Disease With Severe Keratitis
Interventions
TTAX03, Saline (NaCl 0,9 %) (placebo)
Biological
Lead sponsor
BioTissue Holdings, Inc
Industry
Eligibility
18 Years and older
Enrollment
74 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
9
States / cities
Berkeley, California • Deerfield Beach, Florida • Chaska, Minnesota + 6 more
Conditions
Diabetic Foot Ulcers
Interventions
NEOX®CORD 1K, standard of care
Other
Lead sponsor
BioTissue Holdings, Inc
Industry
Eligibility
18 Years and older
Enrollment
124 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
19
States / cities
Carlsbad, California • Castro Valley, California • Fair Oaks, California + 16 more
Conditions
Diabetic Foot Infection, Non-healing Wound, Non-healing Diabetic Foot Ulcer
Interventions
TTAX01, Standard Care
Biological · Other
Lead sponsor
BioTissue Holdings, Inc
Industry
Eligibility
18 Years and older
Enrollment
220 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
16
States / cities
San Francisco, California • Sylmar, California • Miami, Florida + 13 more
Conditions
Venous Leg Ulcer
Interventions
TTAX01, Profore Compression Therapy, Cadexomer Iodine dressing
Biological · Other
Lead sponsor
BioTissue Holdings, Inc
Industry
Eligibility
18 Years and older
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
6
States / cities
Carlsbad, California • Sylmar, California • North Chicago, Illinois + 3 more
Conditions
Osteoarthritis: Joint Replacement Surgery
Interventions
CLARIX FLO, Saline
Other
Lead sponsor
BioTissue Holdings, Inc
Industry
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Orange Park, Florida
Terminated Not applicable Interventional

FLO for Discogenic Pain

NCT03644251
Conditions
Discogenic Back Pain
Interventions
amniotic and umbilical cord matrix
Other
Lead sponsor
BioTissue Holdings, Inc
Industry
Eligibility
18 Years to 70 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Tampa, Florida
Conditions
Knee Osteoarthritis, Knee Pain Chronic, Knee Arthritis
Interventions
TTAX03, Saline
Biological
Lead sponsor
BioTissue Holdings, Inc
Industry
Eligibility
35 Years to 85 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
10
States / cities
Birmingham, Alabama • Tucson, Arizona • La Mesa, California + 6 more
Terminated Not applicable Interventional Results available

Management of Signs and Symptoms Associated With Dry Eye Disease

NCT04015219
Conditions
Dry Eye Syndromes
Interventions
Self retained cryopreserved amniotic membrane, lifitegrast ophthalmic solution
Device · Other
Lead sponsor
BioTissue Holdings, Inc
Industry
Eligibility
18 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Miami, Florida
Conditions
Corneal Wound Healing
Interventions
ProKera, Bandage contact lens
Device
Lead sponsor
Walter Reed National Military Medical Center
Federal
Eligibility
21 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2015
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Completed Not applicable Interventional Results available

Shunt Tube Exposure Prevention Study

NCT01551550
Conditions
Glaucoma
Interventions
GDD, Amniotic Membrane Graft, Pericardial Graft
Procedure
Lead sponsor
BioTissue Holdings, Inc
Industry
Eligibility
21 Years and older
Enrollment
82 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2019
U.S. locations
4
States / cities
Miami, Florida • New York, New York
Conditions
Diabetic Foot Infection, Non-healing Wound, Non-healing Diabetic Foot Ulcer
Interventions
TTAX01, Standard care
Biological · Other
Lead sponsor
BioTissue Holdings, Inc
Industry
Eligibility
18 Years and older
Enrollment
106 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
16
States / cities
Guntersville, Alabama • Tucson, Arizona • Los Angeles, California + 12 more
Completed Not applicable Interventional Results available

Optimizing the Ocular Surface Prior to Cataract Surgery

NCT02766907
Conditions
Corneal Dystrophy, Epithelial Basement Membrane
Interventions
cryopreserved amniotic membrane
Device
Lead sponsor
BioTissue Holdings, Inc
Industry
Eligibility
50 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Norfolk, Virginia
Conditions
Dry Eye Disease
Interventions
Cryopreserved amniotic membrane
Other
Lead sponsor
BioTissue Holdings, Inc
Industry
Eligibility
21 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Tinley Park, Illinois
Completed Phase 1 Interventional Results available

Demodex Blepharitis Treatment Study

NCT01647217
Conditions
Chronic Blepharitis
Interventions
Terpinen-4-ol, Placebo
Drug · Other
Lead sponsor
BioTissue Holdings, Inc
Industry
Eligibility
15 Years to 80 Years
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Miami, Florida
Conditions
Non-healing Wound, Non-healing Diabetic Foot Ulcer, Diabetic Foot Infection
Interventions
TTAX01, Surgical resection and debridement, Systemic antibiotics, Off-loading
Biological · Procedure · Drug + 1 more
Lead sponsor
BioTissue Holdings, Inc
Industry
Eligibility
18 Years and older
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
11
States / cities
Phoenix, Arizona • Sylmar, California • Miami, Florida + 8 more
Conditions
Herpes Simplex Dendritic Keratitis
Interventions
Prokera Slim, Standard of Care
Device · Other
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years to 100 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Portland, Oregon