- Conditions
- Radiation Exposure
- Interventions
- Prone hyperpolarized 3 helium gas scan, Supine hyperpolarized 3 helium gas scan, Vitals, Pulmonary Function Tests, Initial protocol MRI scan
- Drug · Diagnostic Test
- Lead sponsor
- Eric A. Hoffman
- Other
- Eligibility
- 18 Years to 90 Years
- Enrollment
- 18 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2008 – 2012
- U.S. locations
- 1
- States / cities
- Iowa City, Iowa
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- Conditions
- Metabolic Syndrome, Diabetes Mellitus, Type 2, Obesity
- Interventions
- Not listed
- Lead sponsor
- Eric Hoffman
- Other
- Eligibility
- 18 Years to 35 Years
- Enrollment
- 700 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2007 – 2016
- U.S. locations
- 1
- States / cities
- Washington D.C., District of Columbia
- Conditions
- Pulmonary Disease, Chronic Obstructive
- Interventions
- Pulmonary Function Test, CT Scans, Questionnaires, MRI, Xenon gas
- Diagnostic Test · Behavioral · Biological
- Lead sponsor
- Eric A. Hoffman
- Other
- Eligibility
- 20 Years to 89 Years
- Enrollment
- 341 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 1997 – 2015
- U.S. locations
- 1
- States / cities
- Iowa City, Iowa
- Conditions
- Emphysema
- Interventions
- Sildenafil study group
- Drug
- Lead sponsor
- Eric A. Hoffman
- Other
- Eligibility
- 30 Years to 60 Years
- Enrollment
- 22 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2011 – 2014
- U.S. locations
- 1
- States / cities
- Iowa City, Iowa
- Conditions
- Emphysema
- Interventions
- Sildenafil
- Drug
- Lead sponsor
- Eric A. Hoffman
- Other
- Eligibility
- 25 Years to 65 Years
- Enrollment
- 17 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2017 – 2025
- U.S. locations
- 1
- States / cities
- Iowa City, Iowa
- Conditions
- Emphysema
- Interventions
- Sildenafil 20 MG, Placebo Oral Tablet, Pulse wave velocity, Carotid artery compliance and stiffness, Pressure wave reflection
- Drug · Diagnostic Test
- Lead sponsor
- Eric A. Hoffman
- Other
- Eligibility
- 21 Years to 65 Years
- Enrollment
- 162 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2018 – 2024
- U.S. locations
- 1
- States / cities
- Iowa City, Iowa