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ClinicalTrials.gov public records Last synced Oct 17, 2026, 11:37 AM EDT

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Showing 1–24 of 95 matching trials from the live ClinicalTrials.gov search.
Filters: Sponsor: Hennepin Healthcare Research Institute Clear all
Completed No phase listed Observational

Olanzapine, Haloperidol, Ziprasidone, Midazolam for Acute Undifferentiated Agitation

NCT03211897
View directory record Official record
Conditions
Agitation,Psychomotor
Interventions
Haloperidol Injection, Ziprasidone Injection, OLANZapine Injection, Midazolam injection
Drug
Lead sponsor
Hennepin Healthcare Research Institute
Other
Eligibility
18 Years and older
Enrollment
737 participants
Timeline
2017
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 16, 2018 · Synced Oct 17, 2026, 11:37 AM EDT
Recruiting No phase listed Observational

International Device Assisted Controlled Sequential Elevation CPR Registry

NCT05588024
View directory record Official record
Conditions
Cardiac Arrest, Out-Of-Hospital
Interventions
Head Up CPR based bundle of care
Device
Lead sponsor
Hennepin Healthcare Research Institute
Other
Eligibility
18 Years and older
Enrollment
5,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2027
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jun 12, 2025 · Synced Oct 17, 2026, 11:37 AM EDT
Not listed Phase 4 Interventional Accepts healthy volunteers

ASPREE Cancer Endpoints Study

NCT01968798
View directory record Official record
Conditions
Cancer
Interventions
Aspirin, Placebo
Drug
Lead sponsor
Hennepin Healthcare Research Institute
Other
Eligibility
65 Years and older
Enrollment
14,500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2024
U.S. locations
40
States / cities
Birmingham, Alabama • Palo Alto, California • Washington D.C., District of Columbia + 32 more
Source: ClinicalTrials.gov public record
Updated Apr 5, 2021 · Synced Oct 17, 2026, 11:37 AM EDT
Completed Phase 2 Interventional

Comparison Between Different Types of Oxygen Treatment Following Traumatic Brain Injury

NCT00170352
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Hyperbaric Oxygen Treatment (HBOT), Enhanced Oxygen Treatment (Enhanced FiO2)
Procedure
Lead sponsor
Hennepin Healthcare Research Institute
Other
Eligibility
16 Years to 65 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2008
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 28, 2015 · Synced Oct 17, 2026, 11:37 AM EDT
Terminated No phase listed Observational

Olanzapine Versus Midazolam for Agitation

NCT03899506
View directory record Official record
Conditions
Agitation,Psychomotor
Interventions
Olanzapine, Midazolam
Drug
Lead sponsor
Hennepin Healthcare Research Institute
Other
Eligibility
18 Years and older
Enrollment
206 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated May 13, 2019 · Synced Oct 17, 2026, 11:37 AM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

Sex-specific Risk Factors and Trajectories of Blood Biomarkers for Alzheimer's Disease and Related Dementias

NCT07224139
View directory record Official record
Conditions
Alzheimer Disease, Dementia, Cognitive Dysfunction
Interventions
Not listed
Lead sponsor
Anne Murray
Other
Eligibility
65 Years and older
Enrollment
13,435 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
4
States / cities
Decatur, Georgia • Minneapolis, Minnesota • Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 4, 2025 · Synced Oct 17, 2026, 11:37 AM EDT
Completed Phase 2 Interventional Results available

Losartan to Reduce Inflammation and Fibrosis Endpoints in HIV Trial

NCT02049307
View directory record Official record
Conditions
Inflammation, Fibrosis
Interventions
Losartan 100mg daily, Matching placebo
Drug
Lead sponsor
Hennepin Healthcare Research Institute
Other
Eligibility
50 Years and older
Enrollment
108 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
4
States / cities
San Francisco, California • Bethesda, Maryland • Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Dec 10, 2019 · Synced Oct 17, 2026, 11:37 AM EDT
Recruiting Phase 2 Interventional

Hyperbaric Oxygen Brain Injury Treatment Trial

NCT02407028
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Hyperbaric oxygen (1.5 ATA, no NBH), Hyperbaric oxygen (2.0 ATA, no NBH), Hyperbaric oxygen (2.5 ATA, no NBH), Hyperbaric oxygen (1.5 ATA + NBH), Hyperbaric oxygen (2.0 ATA + NBH), Hyperbaric oxygen (2.5 ATA + NBH), Normobaric Hyperoxia (NBH), Usual Care
Drug · Other
Lead sponsor
Gaylan Rockswold
Other
Eligibility
16 Years to 65 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2029
U.S. locations
10
States / cities
San Diego, California • West Palm Beach, Florida • Iowa City, Iowa + 7 more
Source: ClinicalTrials.gov public record
Updated Jun 2, 2026 · Synced Oct 17, 2026, 11:37 AM EDT
Completed Not applicable Interventional

ED Management of Severe Hyperglycemia: A Clinical Trial

NCT02478190
View directory record Official record
Conditions
Hyperglycemia, Diabetes Mellitus, Complications of Diabetes Mellitus, Diabetes-Related Complications, Diabetes Mellitus, Type 2
Interventions
Tight control: goal glucose 350 mg/dL or lower, Loose control: goal glucose 600 mg/dL or lower
Other
Lead sponsor
Hennepin Healthcare Research Institute
Other
Eligibility
18 Years and older
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 21, 2018 · Synced Oct 17, 2026, 11:37 AM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

BRINK (BRain In Kidney Disease) Memory Study 2.0

NCT04975464
View directory record Official record
Conditions
Chronic Kidney Diseases, Dementia, Dementia, Vascular, Stroke, Alzheimer Disease, Cognitive Decline, Cognitive Impairment, Cognitive Dysfunction, Kidney Diseases, Diabetes, Cerebral Atrophy, Small Vessel Ischemic Disease
Interventions
Not listed
Lead sponsor
Anne Murray
Other
Eligibility
50 Years and older
Enrollment
600 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2026
U.S. locations
2
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Nov 4, 2025 · Synced Oct 17, 2026, 11:37 AM EDT
Completed Phase 2Phase 3 Interventional

EXHIT ENTRE Comparative Effectiveness Trial

NCT04345718
View directory record Official record
Conditions
Substance Use Disorder, Opioid Use Disorder, Moderate, Opioid Use Disorder, Severe
Interventions
Extended Release Buprenorphine, Treatment as Usual
Drug
Lead sponsor
Gavin Bart
Other
Eligibility
18 Years and older
Enrollment
344 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
6
States / cities
New Haven, Connecticut • Baltimore, Maryland • Boston, Massachusetts + 2 more
Source: ClinicalTrials.gov public record
Updated Dec 9, 2025 · Synced Oct 17, 2026, 11:37 AM EDT
Terminated Not applicable Interventional

Assessing Accuracy of the Freestyle Libre Pro Glucose Monitoring in Patients With Diabetes in a Critical Care Setting

NCT06800365
View directory record Official record
Conditions
Diabetes Mellitus, Critical Illness, Continuous Glucose Monitoring
Interventions
Sensor
Device
Lead sponsor
Hennepin Healthcare Research Institute
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 30, 2025 · Synced Oct 17, 2026, 11:37 AM EDT
Completed No phase listed Observational

Capacity to Consent in Acutely Intoxicated Emergency Department Patients

NCT02885532
View directory record Official record
Conditions
Informed Consent
Interventions
University of California, San Diego Brief Assessment of Capacity to Consent Tool
Other
Lead sponsor
Hennepin Healthcare Research Institute
Other
Eligibility
18 Years and older
Enrollment
417 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 31, 2016 · Synced Oct 17, 2026, 11:37 AM EDT
Completed No phase listed Observational

Use of MigraineBoxTM Head and Neck Cooling Bath for Treatment of Primary Headache in the Emergency Department

NCT01977001
View directory record Official record
Conditions
Primary Headache
Interventions
MigraineBoxTM
Device
Lead sponsor
Hennepin Healthcare Research Institute
Other
Eligibility
18 Years to 85 Years
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 24, 2014 · Synced Oct 17, 2026, 11:37 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Study to Understand the Natural History of HIV/AIDS in the Era of Effective Therapy (SUN Study)

NCT00146419
View directory record Official record
Conditions
HIV Infections, Sexually Transmitted Diseases
Interventions
Reduction in behaviors capable of sexually transmitting HIV
Behavioral
Lead sponsor
Centers for Disease Control and Prevention
Federal
Eligibility
18 Years and older
Enrollment
699 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2013
U.S. locations
8
States / cities
Denver, Colorado • Minneapolis, Minnesota • St Louis, Missouri + 2 more
Source: ClinicalTrials.gov public record
Updated Jul 30, 2015 · Synced Oct 17, 2026, 11:37 AM EDT
Completed Not applicable Interventional Results available

Cardiovascular Prevention for Persons With HIV

NCT00982189
View directory record Official record
Conditions
HIV Infection, Cardiovascular Disease Risk
Interventions
Pravastatin, Lisinopril
Drug
Lead sponsor
Hennepin Healthcare Research Institute
Other
Eligibility
40 Years and older
Enrollment
37 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Nov 22, 2017 · Synced Oct 17, 2026, 11:37 AM EDT
Completed No phase listed Observational

Use of High Sensitivity Cardiac Troponin In Ruling Out Emergency Patients With Acute Myocardial Injury and Infarction

NCT04280926
View directory record Official record
Conditions
Acute Myocardial Infarction, Acute Coronary Syndrome
Interventions
Cardiac Troponin Testing
Diagnostic Test
Lead sponsor
Fred Apple
Other
Eligibility
18 Years and older
Enrollment
1,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 15, 2026 · Synced Oct 17, 2026, 11:37 AM EDT
Terminated Not applicable Interventional

Insulin Degludec for the Management of Patient With Recurrent Diabetic Ketoacidosis

NCT03001323
View directory record Official record
Conditions
Diabetes Mellitus
Interventions
Degludec, Standard long-acting
Drug
Lead sponsor
Hennepin Healthcare Research Institute
Other
Eligibility
18 Years and older
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated May 17, 2021 · Synced Oct 17, 2026, 11:37 AM EDT
Completed No phase listed Observational

The Use of the USCOM Device in Addition to Cardiac Ultrasound in Patients Undergoing Treatment for Undifferentiated Shock

NCT01981629
View directory record Official record
Conditions
Shock
Interventions
USCOM
Device
Lead sponsor
Hennepin Healthcare Research Institute
Other
Eligibility
18 Years and older
Enrollment
47 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 24, 2014 · Synced Oct 17, 2026, 11:37 AM EDT
Completed Not applicable Interventional

Effect of Modality on Discharge Instruction in Patients Receiving Outpatient Antibiotic Prescriptions From the Emergency Department

NCT01775969
View directory record Official record
Conditions
Modality of Discharge Instructions
Interventions
Text Message, Voicemail
Other
Lead sponsor
Hennepin Healthcare Research Institute
Other
Eligibility
Not listed
Enrollment
2,874 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 25, 2013 · Synced Oct 17, 2026, 11:37 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

PrEP iT! Mobile App Intervention

NCT04509076
View directory record Official record
Conditions
Treatment Adherence and Compliance
Interventions
PrEP iT! (plus usual PrEP care), Usual PrEP care
Behavioral
Lead sponsor
San Diego State University
Other
Eligibility
18 Years to 29 Years · Male only
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jul 7, 2023 · Synced Oct 17, 2026, 11:37 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Non-rebreather at Flush Rate Compared to Bag Valve Mask With Assist

NCT02841592
View directory record Official record
Conditions
Acute Respiratory Failure
Interventions
Flush rate oxygen, Flush rate oxygen with assist
Other
Lead sponsor
Hennepin Healthcare Research Institute
Other
Eligibility
18 Years and older
Enrollment
27 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 30, 2018 · Synced Oct 17, 2026, 11:37 AM EDT
Completed Phase 4 Interventional

The Use of Low Molecular Weight Heparin in Traumatic Brain Injury

NCT00170378
View directory record Official record
Conditions
Brain Injury, Venous Thrombosis
Interventions
Enoxaparin
Drug
Lead sponsor
Hennepin Healthcare Research Institute
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2005
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jun 27, 2017 · Synced Oct 17, 2026, 11:37 AM EDT
Recruiting Not applicable Interventional

Depth Electrode Cortical Reverberation Monitoring After Traumatic Brain Injury

NCT07842458
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
A multi-contact depth electrode
Device
Lead sponsor
Samuel Cramer
Other
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 25, 2026 · Synced Oct 17, 2026, 11:37 AM EDT