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Showing 1–24 of 3,097 matching trials from the live ClinicalTrials.gov search.
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Filters: Sponsor: Massachusetts General Hospital Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Dietary Intake and Circulating Levels of Branched Chain Amino Acids

NCT02110602
View directory record Official record
Conditions
Dietary Intake of Branched Chain Amino Acids
Interventions
Diet high in amino acid levels, Diet low in amino acid levels
Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
20 Years to 40 Years · Male only
Enrollment
5 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 6, 2016 · Synced Jul 24, 2026, 1:55 AM EDT
Terminated Not applicable Interventional Results available

Evaluation of Hand Assessments in Children With Severe Hand Burns

NCT00363675
View directory record Official record
Conditions
Burns
Interventions
Functional hand tests
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
5 Years to 18 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2011
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 27, 2012 · Synced Jul 24, 2026, 1:55 AM EDT
Completed Not applicable Interventional

Galantamine-CR and Cognitive Dysfunction in Bipolar Disorder

NCT00181636
View directory record Official record
Conditions
Bipolar Disorder
Interventions
Galantamine-CR
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Ends 2006
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 23, 2007 · Synced Jul 24, 2026, 1:55 AM EDT
Recruiting Not applicable Interventional

A One-Arm Open Trial of a Smartphone Delivered Treatment for Suicidal Thoughts and Behavior

NCT06967545
View directory record Official record
Conditions
Suicide Attempt, Suicide Ideation
Interventions
Smartphone-delivered Therapeutic Evaluative Conditioning for Suicide (TEC-S)
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 9, 2026 · Synced Jul 24, 2026, 1:55 AM EDT
Terminated Phase 4 Interventional Results available

DAA Treatment in Donor HCV-positive to Recipient HCV-negative Heart Transplant

NCT03208244
View directory record Official record
Conditions
End Stage Heart Disease, Hepatitis C
Interventions
Clinically prescribed direct acting antiviral
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 21, 2022 · Synced Jul 24, 2026, 1:55 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Eliminating Barriers to Colorectal Cancer Screening Using Rapid Cycle Testing: A Pilot Study

NCT05524428
View directory record Official record
Conditions
Colo-rectal Cancer
Interventions
Implementation Science Strategy
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
4
States / cities
Boston, Massachusetts • Brockton, Massachusetts • East Boston, Massachusetts + 1 more
Source: ClinicalTrials.gov public record
Updated Nov 13, 2025 · Synced Jul 24, 2026, 1:55 AM EDT
Completed Not applicable Interventional Results available

Genomic Sequencing for Childhood Risk and Newborn Illness

NCT02422511
View directory record Official record
Conditions
Hereditary Disease, Genetic Predisposition to Disease
Interventions
Genomic sequencing, Family history report
Genetic · Other
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
Not listed
Enrollment
1,205 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2021
U.S. locations
2
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 2, 2024 · Synced Jul 24, 2026, 1:55 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Exploring Biomarkers for Depression

NCT01424111
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Escitalopram, Healthy Control
Drug · Other
Lead sponsor
Wyss Institute at Harvard University
Other
Eligibility
18 Years to 65 Years
Enrollment
51 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2017
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 30, 2018 · Synced Jul 24, 2026, 1:55 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

A Randomized Controlled Trial of a Video Decision Making Aid to Obtain Informed Consent in the Surgical Intensive Care Unit

NCT01589107
View directory record Official record
Conditions
Surgery, Trauma
Interventions
video decision aid
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
21 Years and older
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2011
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 17, 2020 · Synced Jul 24, 2026, 1:55 AM EDT
Completed Not applicable Interventional Results available

Androgen Effects in HIV-infected Women

NCT00095212
View directory record Official record
Conditions
HIV Infection
Interventions
1 Transdermal Testosterone (Patch), 2 Placebo Patch
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 55 Years · Female only
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2009
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 13, 2010 · Synced Jul 24, 2026, 1:55 AM EDT
Completed No phase listed Observational

Early Detection and Prediction of Chemotherapy Induced Cardiac Toxicity in Breast Cancer Patients

NCT00806507
View directory record Official record
Conditions
Breast Cancer
Interventions
Echocardiograms, Blood Test
Procedure
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
2
States / cities
Boston, Massachusetts • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 22, 2012 · Synced Jul 24, 2026, 1:55 AM EDT
Completed Phase 4 Interventional Results available

A Clinical Trial Via Telepsychiatry of Treatments for the Management of Emotional Dysregulation in Youth

NCT03911414
View directory record Official record
Conditions
Mood Disturbance, Mood Disorders, Natural Supplements, Alternative Treatment
Interventions
Open-label Treatment with Omega-3 Fatty Acids + Inositol, Open-label Treatment with N-acetylcysteine
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
5 Years to 17 Years
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 17, 2026 · Synced Jul 24, 2026, 1:55 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Recruitment Messages for Current Smokers Recently Diagnosed With Cancer

NCT05471284
View directory record Official record
Conditions
Tobacco Smoking, Health Behavior
Interventions
Proximal, Distal, Cost, Benefit, Loss, Gain, Control
Behavioral
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years and older
Enrollment
99 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Jul 21, 2022 · Synced Jul 24, 2026, 1:55 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Pilot Study of Neuromodulation for Enhancement of Emotion Regulation in Bipolar Mood Disorders

NCT03622749
View directory record Official record
Conditions
Bipolar Disorder, Transcranial Magnetic Stimulation
Interventions
Transcranial Magnetic Stimulation (TMS)
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 55 Years
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2025
U.S. locations
1
States / cities
Charlestown, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 2, 2026 · Synced Jul 24, 2026, 1:55 AM EDT
Terminated Phase 2 Interventional Accepts healthy volunteers

A Safety and Efficacy Study of Alefacept in the Treatment of Moderate to Severe Erosive Mucosal Lichen Planus

NCT00135733
View directory record Official record
Conditions
Lichen Planus
Interventions
Amevive (Alefacept), Placebo
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 11, 2009 · Synced Jul 24, 2026, 1:55 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Clinical Trial of Ezogabine (Retigabine) in ALS Subjects

NCT02450552
View directory record Official record
Conditions
Amyotrophic Lateral Sclerosis
Interventions
Ezogabine, Placebo
Drug
Lead sponsor
Brian Wainger
Other
Eligibility
18 Years to 80 Years
Enrollment
65 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
12
States / cities
Phoenix, Arizona • Los Angeles, California • Orange, California + 8 more
Source: ClinicalTrials.gov public record
Updated Aug 27, 2019 · Synced Jul 24, 2026, 1:55 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Opioid Antagonism in Individuals Ascertained Through the Partners HealthCare Biobank

NCT04975347
View directory record Official record
Conditions
Reproductive Disorders
Interventions
Naloxone
Drug
Lead sponsor
Stephanie B. Seminara, MD
Other
Eligibility
18 Years to 60 Years
Enrollment
47 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 17, 2026 · Synced Jul 24, 2026, 1:55 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Nutrition for Brain and Body Health (BB-Health) Feasibility Trial

NCT05542199
View directory record Official record
Conditions
Cognition, Obesity
Interventions
Multicomponent nutrition supplement (MCNS), Behavioral weight loss program
Other · Behavioral
Lead sponsor
Tufts University
Other
Eligibility
55 Years to 85 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 5, 2025 · Synced Jul 24, 2026, 1:55 AM EDT
Completed Phase 2 Interventional

STA-9090 in Previously Treated Patients With Advanced Esophagogastric Cancer

NCT01167114
View directory record Official record
Conditions
Esophagogastric Cancer
Interventions
STA-9090
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2017
U.S. locations
3
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 1, 2023 · Synced Jul 24, 2026, 1:55 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Study Examining Repeat Dosing of OROS® Methylphenidate (CONCERTA®) and Immediate Release Methylphenidate in Healthy Adults

NCT00302393
View directory record Official record
Conditions
Healthy
Interventions
OROS methylphenidate hydrochloride, methylphenidate hydrochloride
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 55 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2008
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 21, 2013 · Synced Jul 24, 2026, 1:55 AM EDT
Completed Phase 1 Interventional Results available

The Effect of OASIS Ultra on Critical Sized Wound Healing

NCT01848821
View directory record Official record
Conditions
Traumatic Wound, Infective Wound, Iatrogenic Critical Sized Wound Defects, Wound Healing
Interventions
OASIS Ultra, Wound VAC Standard Therapy
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 100 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 29, 2019 · Synced Jul 24, 2026, 1:55 AM EDT
Not listed No phase listed Observational

Blood Transfusion by Boston MedFlight Registry

NCT04610814
View directory record Official record
Conditions
Hemorrhagic Shock
Interventions
Not listed
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 31, 2021 · Synced Jul 24, 2026, 1:55 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

eCEASE to Support Treatment for Parental Tobacco Use

NCT04974736
View directory record Official record
Conditions
Tobacco Smoking, Second Hand Tobacco Smoke, Smoking Cessation
Interventions
iEHR + Navigator
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
Not listed
Enrollment
817 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 14, 2025 · Synced Jul 24, 2026, 1:55 AM EDT
Not listed Phase 1Phase 2 Interventional

Endoscopic Mucosal Resection (EMR) for Diagnosis of Hirschsprung's Disease

NCT00671684
View directory record Official record
Conditions
Chronic Constipation, Hirschsprung's Disease
Interventions
Endoscopic Mucosal Resection (EMR)
Procedure
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
10 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 4, 2008 · Synced Jul 24, 2026, 1:55 AM EDT