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ClinicalTrials.gov public records Last synced Oct 2, 2026, 5:49 AM EDT

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Showing 1–24 of 3,129 matching trials from the live ClinicalTrials.gov search.
Filters: Sponsor: Massachusetts General Hospital Clear all
Recruiting Not applicable Interventional

Healthy Aging as Black Adults, In It Together: a Comparative Effectiveness Study of Chronic Pain and Cognitive Decline

NCT06246929
View directory record Official record
Conditions
Chronic Pain, Physical Activity, Older Adults, Mild Cognitive Impairment
Interventions
MBCT+w, ALED
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
50 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 7, 2026 · Synced Oct 2, 2026, 5:49 AM EDT
Withdrawn Phase 1 Interventional

Validation of Aspiration Markers

NCT02301845
View directory record Official record
Conditions
Pneumonia, Aspiration
Interventions
Diatoms Shells
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 16, 2016 · Synced Oct 2, 2026, 5:49 AM EDT
Terminated Phase 2 Interventional Results available

Study of the Combination of DKN-01 and Nivolumab in Previously Treated Patients With Advanced Biliary Tract Cancer (BTC)

NCT04057365
View directory record Official record
Conditions
Biliary Tract Cancer
Interventions
Nivolumab, DKN-01
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
2
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 13, 2025 · Synced Oct 2, 2026, 5:49 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Testing Effects of Melatonin on Uterine Contractions in Women

NCT05358834
View directory record Official record
Conditions
Pregnant Women
Interventions
Melatonin, Placebo
Dietary Supplement
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 35 Years · Female only
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 18, 2026 · Synced Oct 2, 2026, 5:49 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Investigating the Effects of Social Stress on Brain Imaging

NCT05591404
View directory record Official record
Conditions
Social Stress
Interventions
Trier Social Stress Test (TSST)
Behavioral
Lead sponsor
Massachusetts Institute of Technology
Other
Eligibility
18 Years to 55 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 11, 2026 · Synced Oct 2, 2026, 5:49 AM EDT
Completed Not applicable Interventional Results available

Researching Emotions And Cardiac Health: Phase III

NCT03220204
View directory record Official record
Conditions
Congestive Heart Failure, Emotions, Patient Compliance
Interventions
PP-based health behavior intervention, MI-based educational control condition
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 30, 2021 · Synced Oct 2, 2026, 5:49 AM EDT
Not listed No phase listed Observational

Concurrent Electronic Order Entry Variation Reporting Impact on Ordering Behavior

NCT00907816
View directory record Official record
Conditions
Behavior
Interventions
Not listed
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
Not listed
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 25, 2009 · Synced Oct 2, 2026, 5:49 AM EDT
Completed Not applicable Interventional

MGH Trauma-related Nightmares SDI Study

NCT05195684
View directory record Official record
Conditions
Posttraumatic Stress Disorder
Interventions
imaginal probe
Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 60 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Charlestown, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 6, 2022 · Synced Oct 2, 2026, 5:49 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Use of 99mTc Tilmanocept for Imaging Arterial Inflammation

NCT02542371
View directory record Official record
Conditions
HIV
Interventions
Arterial Imaging
Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 80 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 6, 2022 · Synced Oct 2, 2026, 5:49 AM EDT
Not yet recruiting No phase listed Observational

Quantification of Change in MG Disease Activity in Individuals With Generalized Myasthenia Gravis (gMG) After Administration of VYVGART® or VYVGART Hytrulo® Using BioDigit MG

NCT07226830
View directory record Official record
Conditions
Myasthenia Gravis Generalized
Interventions
Not listed
Lead sponsor
BioSensics
Industry
Eligibility
18 Years to 80 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 12, 2025 · Synced Oct 2, 2026, 5:49 AM EDT
Terminated Phase 2 Interventional Results available

A Study of the Use of IV Scopolamine to Augment the Efficacy of Electroconvulsive Therapy (ECT)

NCT01312844
View directory record Official record
Conditions
Depression
Interventions
Scopolamine
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 50 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 30, 2017 · Synced Oct 2, 2026, 5:49 AM EDT
Completed Not applicable Interventional Results available

The PediQUEST Response Intervention Study

NCT03408314
View directory record Official record
Conditions
Advanced Cancer
Interventions
PediQUEST Response, Usual Cancer Care
Other
Lead sponsor
Joanne Wolfe, MD, MPH
Other
Eligibility
2 Years and older
Enrollment
194 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
6
States / cities
Chicago, Illinois • Boston, Massachusetts • Philadelphia, Pennsylvania + 2 more
Source: ClinicalTrials.gov public record
Updated Aug 7, 2026 · Synced Oct 2, 2026, 5:49 AM EDT
Completed Phase 3 Interventional

Rosiglitazone (Avandia) vs. Placebo for Androgen Dependent Prostate Cancer

NCT00182052
View directory record Official record
Conditions
Adenocarcinoma of the Prostate, Prostate Cancer
Interventions
Rosiglitazone, Placebo
Drug · Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older · Male only
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2000 – 2003
U.S. locations
2
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 23, 2013 · Synced Oct 2, 2026, 5:49 AM EDT
Not listed No phase listed Observational

The Effects of a Weight Management Program on Body Weight and Quality of Life

NCT02219763
View directory record Official record
Conditions
Overweight, Obesity
Interventions
Not listed
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 19, 2014 · Synced Oct 2, 2026, 5:49 AM EDT
Completed No phase listed Observational

CMC Arthritis - Neoprene Vs. Thermoplast Short Opponens Splinting

NCT00438763
View directory record Official record
Conditions
Carpometacarpal Thumb Arthritis
Interventions
Not listed
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2013
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 27, 2013 · Synced Oct 2, 2026, 5:49 AM EDT
Completed Phase 4 Interventional Results available

Effectiveness of Aripiprazole for Improving Side Effects of Clozapine in the Treatment of People With Schizophrenia

NCT00345033
View directory record Official record
Conditions
Schizophrenia, Insulin Resistance
Interventions
Aripiprazole, Placebo
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2010
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 23, 2014 · Synced Oct 2, 2026, 5:49 AM EDT
Recruiting Phase 2 Interventional

Cardiac Effects of Mineralocorticoid Receptor Antagonism After Preeclampsia

NCT07238400
View directory record Official record
Conditions
Hypertension
Interventions
Eplerenone 100 mg daily, Chlorthalidone 25 mg daily, Potassium Placebo, Potassium Chloride
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
2
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 10, 2026 · Synced Oct 2, 2026, 5:49 AM EDT
Recruiting Not applicable Interventional

A Nurse-Led, Coping and Supportive Intervention for Patients With Triple-Negative Breast Cancer

NCT07513311
View directory record Official record
Conditions
Triple Negative Breast Cancer (TNBC)
Interventions
RESTORE, Enhanced Usual Care
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 15, 2026 · Synced Oct 2, 2026, 5:49 AM EDT
Completed Not applicable Interventional

Androgen Replacement Therapy in Women With Hypopituitarism

NCT00027430
View directory record Official record
Conditions
Hypopituitarism
Interventions
TheraDerm
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2004
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 25, 2015 · Synced Oct 2, 2026, 5:49 AM EDT
Recruiting No phase listed Observational

ctDNA in Cutaneous Squamous Cell Carcinoma

NCT06875609
View directory record Official record
Conditions
Cutaneous Squamous Cell Carcinoma
Interventions
Blood and Tissue Collection
Diagnostic Test
Lead sponsor
Massachusetts Eye and Ear Infirmary
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 30, 2026 · Synced Oct 2, 2026, 5:49 AM EDT
Completed Phase 2 Interventional

SU011248 in Advanced Hepatocellular Carcinoma

NCT00361309
View directory record Official record
Conditions
Hepatocellular Carcinoma, Liver Cancer
Interventions
SU011248
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
3
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 18, 2014 · Synced Oct 2, 2026, 5:49 AM EDT
Completed Phase 2 Interventional Results available

Bevacizumab and Radiation Therapy for Sarcomas

NCT00356031
View directory record Official record
Conditions
Soft Tissue Sarcoma, Fibrous Histiocytoma, Liposarcoma, Leiomyosarcoma, Fibrosarcoma, Synovial Sarcoma
Interventions
Bevacizumab, Radiation Therapy, Surgery
Drug · Radiation · Procedure
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2010
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 19, 2017 · Synced Oct 2, 2026, 5:49 AM EDT
Not yet recruiting Not applicable Interventional

Digital Coach to Support Exposure Therapy Homework for Anxious Youth

NCT07666672
View directory record Official record
Conditions
Anxiety Disorders, OCD
Interventions
BraveBot, Self-Guided Exposure Therapy Homework
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
12 Years to 22 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
3
States / cities
Belmont, Massachusetts • Boston, Massachusetts • Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 24, 2026 · Synced Oct 2, 2026, 5:49 AM EDT
Completed Not applicable Interventional Results available

Transcranial Laser Therapy, Continuous and Pulsed Light, for Major Depressive Disorder (ELATED-3)

NCT02959307
View directory record Official record
Conditions
Depression, Major Depressive Disorder
Interventions
Transcranial Light Therapy, Sham Transcranial Light Therapy
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 70 Years
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
2
States / cities
Boston, Massachusetts • Orangeburg, New York
Source: ClinicalTrials.gov public record
Updated Sep 21, 2020 · Synced Oct 2, 2026, 5:49 AM EDT