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Showing 1–10 of 10 matching trials from the live ClinicalTrials.gov search.
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Filters: Sponsor: On Target Laboratories, LLC Clear all
Completed Phase 2 Interventional Results available

OTL38 Injection for Intraoperative Imaging of Folate Receptor Positive Lung Nodules

NCT02872701
View directory record Official record
Conditions
Lung Neoplasms, Lung Cancer
Interventions
OTL38 for Injection, Near infrared camera imaging system, Endoscopic or Thoracic Surgery
Drug · Device · Procedure
Lead sponsor
On Target Laboratories, LLC
Industry
Eligibility
18 Years to 85 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
5
States / cities
Boston, Massachusetts • Cleveland, Ohio • Philadelphia, Pennsylvania + 2 more
Source: ClinicalTrials.gov public record
Updated Mar 23, 2023 · Synced Sep 24, 2026, 5:54 PM EDT
Completed Phase 2 Interventional

CYTALUX™for the Intraoperative Imaging of Prostate Cancer

NCT06434909
View directory record Official record
Conditions
Prostate Cancer
Interventions
Cytalux™ (pafolacianine) for fluorescent imaging, Image Guided Surgery
Drug · Procedure
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older · Male only
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
3
States / cities
Carmel, Indiana • Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated May 31, 2026 · Synced Sep 24, 2026, 5:54 PM EDT
Completed Phase 2 Interventional Results available

Phase 2 Study of OTL38 for Intra-operative Imaging of Folate Receptor-alpha Positive Ovarian Cancer

NCT02317705
View directory record Official record
Conditions
Ovarian Cancer
Interventions
OTL38, Near infrared camera imaging system, Laparotomy
Drug · Device · Procedure
Lead sponsor
On Target Laboratories, LLC
Industry
Eligibility
18 Years and older · Female only
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
4
States / cities
Orange, California • Tampa, Florida • Rochester, Minnesota + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 20, 2022 · Synced Sep 24, 2026, 5:54 PM EDT
Recruiting Phase 4 Interventional

Intraoperative Imaging of Gastrointestinal Malignancies Using Pafolacianine (CYTALUX™)

NCT07124351
View directory record Official record
Conditions
Gastrointestinal Cancer, Gastric Cancer, Esophageal Cancer, Appendiceal Cancer
Interventions
CYTALUX™ (pafolacianine)
Drug
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Sep 14, 2025 · Synced Sep 24, 2026, 5:54 PM EDT
Completed Phase 3 Interventional Results available

ELUCIDATE: Enabling Lung Cancer Identification Using Folate Receptor Targeting

NCT04241315
View directory record Official record
Conditions
Lung Neoplasms, Lung Cancer
Interventions
OTL38 for Injection, Near infrared camera imaging system
Drug · Device
Lead sponsor
On Target Laboratories, LLC
Industry
Eligibility
18 Years and older
Enrollment
112 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
12
States / cities
Stamford, Connecticut • Iowa City, Iowa • Boston, Massachusetts + 8 more
Source: ClinicalTrials.gov public record
Updated Mar 22, 2023 · Synced Sep 24, 2026, 5:54 PM EDT
Completed Phase 2 Interventional

Phase II Trial to Investigate the Safety and Efficacy of Four Dosing Regimens of OTL78 Injection

NCT06849544
View directory record Official record
Conditions
Prostate Cancer Surgery, Prostate Cancer Metastatic Disease
Interventions
0.03mg/kg ZOPOCIANINE given day of surgery, 0.06mg/kg ZOPOCIANINE given day of surgery, 0.03mg/kg ZOPOCIANINE given day prior to surgery, 0.06mg/kg ZOPOCIANINE given days prior to surgery
Drug
Lead sponsor
Clinton Bahler
Other
Eligibility
18 Years and older · Male only
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
3
States / cities
Carmel, Indiana • Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Aug 12, 2026 · Synced Sep 24, 2026, 5:54 PM EDT
Recruiting Phase 1 Interventional

Safety and Feasibility of Intraoperative Visualization With Cytalux in Children

NCT06235125
View directory record Official record
Conditions
Osteosarcoma, Pulmonary Metastasis, Fluorescence, Metastatic Sarcoma, Pediatrics
Interventions
Cytalux
Drug
Lead sponsor
Ann & Robert H Lurie Children's Hospital of Chicago
Other
Eligibility
6 Years to 17 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 4, 2026 · Synced Sep 24, 2026, 5:54 PM EDT
Recruiting Phase 2 Interventional

Single Dose Investigator Initiated Pilot Study to Investigate CYTALUX (Pafolacianine) for Intraoperative Detection of Malignant Tissue in Subjects Undergoing Surgical Resection for Cancer.

NCT07039526
View directory record Official record
Conditions
Esophageal Cancer, Gastrointestinal Cancers, Gynecologic Cancers
Interventions
CYTALUX™ (pafolacianine) injection preoperatively
Drug
Lead sponsor
John Waters
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jun 4, 2026 · Synced Sep 24, 2026, 5:54 PM EDT
Completed Phase 3 Interventional Results available

OTL38 for Intra-operative Imaging of Folate Receptor Positive Ovarian Cancer

NCT03180307
View directory record Official record
Conditions
Ovarian Cancer
Interventions
OTL38, near infrared camera imaging system, laparotomy
Drug · Device · Procedure
Lead sponsor
On Target Laboratories, LLC
Industry
Eligibility
18 Years to 85 Years · Female only
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
10
States / cities
Phoenix, Arizona • Tucson, Arizona • Duarte, California + 7 more
Source: ClinicalTrials.gov public record
Updated Feb 3, 2022 · Synced Sep 24, 2026, 5:54 PM EDT
Not yet recruiting Phase 2Phase 3 Interventional

Safety and Efficacy of OTL78 (Zopocianine)

NCT07725523
View directory record Official record
Conditions
Prostate Cancer Surgery, Prostate Cancer Metastatic Disease
Interventions
0.06mg/kg ZOPOCIANINE given 1-7 days prior to surgery
Drug
Lead sponsor
Clinton Bahler
Other
Eligibility
18 Years and older · Male only
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
2
States / cities
Carmel, Indiana • Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Sep 9, 2026 · Synced Sep 24, 2026, 5:54 PM EDT