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ClinicalTrials.gov public records Last synced Oct 2, 2026, 1:04 PM EDT

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Showing 1–24 of 39 matching trials from the live ClinicalTrials.gov search.
Filters: Sponsor: OrthoCarolina Research Institute, Inc. Clear all
Completed Phase 4 Interventional

Anatomic Reconstruction of the Patellofemoral Joint

NCT01375231
View directory record Official record
Conditions
Knee Replacement Surgery
Interventions
Measured Resection of patellofemoral joint, Measured resection of patella
Procedure
Lead sponsor
OrthoCarolina Research Institute, Inc.
Other
Eligibility
Not listed
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 30, 2014 · Synced Oct 2, 2026, 1:04 PM EDT
Completed Phase 4 Interventional

Chronic Insertional Achilles Tendonitis Treated With or Without Flexor Hallucis Longus Tendon Transfer

NCT00950053
View directory record Official record
Conditions
Chronic Insertional Achilles Tendonitis
Interventions
Achilles decompression & debridement, Achilles decompression and debridement with FHL transfer
Procedure
Lead sponsor
OrthoCarolina Research Institute, Inc.
Other
Eligibility
50 Years and older
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 13, 2013 · Synced Oct 2, 2026, 1:04 PM EDT
Not yet recruiting Phase 4 Interventional

Mochida ReFeel for Digital Nerve Injuries

NCT07524465
View directory record Official record
Conditions
Digital Nerve Injury, Nerve Reconstruction
Interventions
ReFeel
Device
Lead sponsor
OrthoCarolina Research Institute, Inc.
Other
Eligibility
18 Years to 69 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 24, 2026 · Synced Oct 2, 2026, 1:04 PM EDT
Enrolling by invitation Phase 4 Interventional Accepts healthy volunteers

Can Intraosseous Antibiotics Improve the Results of Irrigation & Debridement and Prosthetic Retention for PJI?

NCT03713528
View directory record Official record
Conditions
Joint Infection
Interventions
Intraoperative Intraosseous Vancomycin
Drug
Lead sponsor
OrthoCarolina Research Institute, Inc.
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2027
U.S. locations
10
States / cities
San Francisco, California • Gainesville, Florida • Weston, Florida + 5 more
Source: ClinicalTrials.gov public record
Updated Apr 6, 2026 · Synced Oct 2, 2026, 1:04 PM EDT
Active, not recruiting Not applicable Interventional

Clinical Trial for Surgery of the Ulnar Nerve (SUN) at the Elbow

NCT04254185
View directory record Official record
Conditions
Neuropathy Ulnar
Interventions
Simple decompression, Subcutaneous anterior transposition
Procedure
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
378 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2027
U.S. locations
10
States / cities
Atlanta, Georgia • Louisville, Kentucky • Baltimore, Maryland + 6 more
Source: ClinicalTrials.gov public record
Updated Sep 4, 2026 · Synced Oct 2, 2026, 1:04 PM EDT
Completed Not applicable Interventional

Efficacy and Patient Satisfaction With AQUACEL® Ag Surgical Dressing Compared to Standard Surgical Dressing

NCT01258270
View directory record Official record
Conditions
Wound Healing
Interventions
Postop Dressing
Procedure
Lead sponsor
OrthoCarolina Research Institute, Inc.
Other
Eligibility
18 Years to 90 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 10, 2013 · Synced Oct 2, 2026, 1:04 PM EDT
Active, not recruiting Not applicable Interventional

Lymphedema Following Hand/Wrist Surgery in Women Post Axillary Node Dissection

NCT00984269
View directory record Official record
Conditions
Lymphedema
Interventions
Tourniquet Use
Procedure
Lead sponsor
OrthoCarolina Research Institute, Inc.
Other
Eligibility
18 Years and older · Female only
Enrollment
67 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2025
U.S. locations
2
States / cities
Ann Arbor, Michigan • Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 28, 2025 · Synced Oct 2, 2026, 1:04 PM EDT
Completed Phase 4 Interventional Results available

Reinfusion Drains vs Tranexamic Acid in Total Joint Arthroplasty

NCT01636414
View directory record Official record
Conditions
Total Joint Arthroplasty
Interventions
Hemovac drain, Re-infusion drain, Tranexamic drain
Procedure
Lead sponsor
OrthoCarolina Research Institute, Inc.
Other
Eligibility
18 Years and older
Enrollment
204 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 22, 2016 · Synced Oct 2, 2026, 1:04 PM EDT
Terminated Phase 4 Interventional

Multimodal Analgesia vs. Routine Care Pain Management for Lumbar Spine Fusion Surgery: A Prospective Randomized Study

NCT02202369
View directory record Official record
Conditions
Single Level Lumbar Decompression and Fusion Spine Surgery
Interventions
Multimodal Analgesia Treatment, Standard of Care Pain Management Protocol
Other
Lead sponsor
OrthoCarolina Research Institute, Inc.
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated May 22, 2026 · Synced Oct 2, 2026, 1:04 PM EDT
Completed Not applicable Interventional

Comparison of 3 Techniques for Recreation of Anterior Cruciate Ligament Anatomic Footprint

NCT02795247
View directory record Official record
Conditions
Anterior Cruciate Ligament Reconstruction
Interventions
Anterior Cruciate Ligament Reconstruction
Procedure
Lead sponsor
OrthoCarolina Research Institute, Inc.
Other
Eligibility
Not listed
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2023
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 2, 2024 · Synced Oct 2, 2026, 1:04 PM EDT
Terminated Phase 4 Interventional Results available

Motorized Continuous Cold Therapy Versus Standard Post-op Icing Protocol for Two Foot and Ankle Procedures

NCT00950183
View directory record Official record
Conditions
Narcotic Consumption, Pain, Wound Healing, Patient Satisfaction
Interventions
Iceman® Cold Therapy unit (djOrtho), Ice
Device · Other
Lead sponsor
OrthoCarolina Research Institute, Inc.
Other
Eligibility
Not listed
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 22, 2016 · Synced Oct 2, 2026, 1:04 PM EDT
Completed Not applicable Interventional

Anterior Capsulectomy vs. Repair in Direct Anterior THA

NCT01621932
View directory record Official record
Conditions
Total Hip Arthroplasty
Interventions
Direct anterior approach with capsulectomy, Direct anterior approach without capsulectomy
Procedure
Lead sponsor
OrthoCarolina Research Institute, Inc.
Other
Eligibility
18 Years and older
Enrollment
82 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 26, 2021 · Synced Oct 2, 2026, 1:04 PM EDT
Completed Not applicable Interventional

Opioid-Free Orthopaedic Surgery

NCT04176783
View directory record Official record
Conditions
Pain Management
Interventions
Opioids, Opioid-Free
Drug
Lead sponsor
OrthoCarolina Research Institute, Inc.
Other
Eligibility
18 Years and older
Enrollment
511 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 20, 2025 · Synced Oct 2, 2026, 1:04 PM EDT
Terminated No phase listed Observational

Acetabular Bone Vascularity in Metal-on-Metal Revisions

NCT02239406
View directory record Official record
Conditions
Failure of Total Hip
Interventions
Not listed
Lead sponsor
OrthoCarolina Research Institute, Inc.
Other
Eligibility
18 Years and older
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 22, 2016 · Synced Oct 2, 2026, 1:04 PM EDT
Enrolling by invitation No phase listed Observational

Multicenter Prospective Cohort Study on Current Treatments of Legg-Calvé-Perthes Disease

NCT02040714
View directory record Official record
Conditions
Legg Calve Perthes Disease
Interventions
Osteotomy + Long Term Non-Weight Bearing, Osteotomy + Short Term Non-Weight Bearing, Nonoperative Observation, Multiple Epiphyseal Drilling
Procedure
Lead sponsor
Texas Scottish Rite Hospital for Children
Other
Eligibility
1 Year to 18 Years
Enrollment
1,500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2032
U.S. locations
28
States / cities
Birmingham, Alabama • Los Angeles, California • San Diego, California + 23 more
Source: ClinicalTrials.gov public record
Updated May 6, 2025 · Synced Oct 2, 2026, 1:04 PM EDT
Enrolling by invitation Not applicable Interventional

Prophylactic TBR on Phantom Limb Pain

NCT06956508
View directory record Official record
Conditions
Phantom Limb Pain After Amputation
Interventions
Targeted Brain Rehabilitation
Other
Lead sponsor
OrthoCarolina Research Institute, Inc.
Other
Eligibility
13 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 6, 2026 · Synced Oct 2, 2026, 1:04 PM EDT
Enrolling by invitation Phase 4 Interventional

Prospective Opioid-Free AIS Fusion

NCT06935331
View directory record Official record
Conditions
Adolescent Idiopathic Scoliosis (AIS)
Interventions
Opioid-Free/Opioid-Avoidant, Opioid-Containing
Drug
Lead sponsor
OrthoCarolina Research Institute, Inc.
Other
Eligibility
10 Years to 20 Years
Enrollment
58 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 6, 2026 · Synced Oct 2, 2026, 1:04 PM EDT
Completed Phase 4 Interventional

Betamethasone Versus Ketorolac Injection for the Treatment of DeQuervains Tenosynovitis

NCT02604537
View directory record Official record
Conditions
DeQuervain Tendinopathy
Interventions
betamethasone, Ketorolac
Drug
Lead sponsor
OrthoCarolina Research Institute, Inc.
Other
Eligibility
18 Years and older
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2024
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 1, 2026 · Synced Oct 2, 2026, 1:04 PM EDT
Terminated Not applicable Interventional

Cemented vs. Cementless TKA

NCT04597684
View directory record Official record
Conditions
Total Knee Arthroplasty (TKA)
Interventions
Cementless Total Knee Arthroplasty, Cemented Total Knee Arthroplasty
Procedure
Lead sponsor
OrthoCarolina Research Institute, Inc.
Other
Eligibility
18 Years to 65 Years
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 8, 2022 · Synced Oct 2, 2026, 1:04 PM EDT
Enrolling by invitation No phase listed Observational

Prospective Evaluation of Clinical and Radiographic Outcomes Following Total Talus Replacement (PROCLAIM)

NCT06311331
View directory record Official record
Conditions
Avascular Necrosis of the Talus, Talar Osteochondral Defect of Ankle, Talar Dysfunction
Interventions
Total Talus Replacement (TTR)
Device
Lead sponsor
Restor3D
Industry
Eligibility
22 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2031
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 8, 2026 · Synced Oct 2, 2026, 1:04 PM EDT
Completed Not applicable Interventional

Reverse Shoulder Arthroplasty With or Without Concomitant Latissimus and Teres Major Transfer for Shoulder Pseudoparalysis With Teres Minor Dysfunction

NCT01697865
View directory record Official record
Conditions
Osteoarthritis of the Shoulder
Interventions
Transfer group, Control group
Procedure
Lead sponsor
OrthoCarolina Research Institute, Inc.
Other
Eligibility
18 Years and older
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2020
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 25, 2021 · Synced Oct 2, 2026, 1:04 PM EDT
Active, not recruiting Not applicable Interventional

STaR Trial: Multiple Ligament Knee Injuries

NCT03543098
View directory record Official record
Conditions
Knee Dislocations, Multiple Ligament Knee Injuries
Interventions
Early Surgery, Delayed Surgery, Early Rehab, Delayed Rehab
Procedure
Lead sponsor
University of Pittsburgh
Other
Eligibility
16 Years to 55 Years
Enrollment
690 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2027
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 29, 2026 · Synced Oct 2, 2026, 1:04 PM EDT
Completed Phase 4 Interventional

Amniotic Membrane as an Adjunct Treatment for Hallux Rigidus

NCT01825356
View directory record Official record
Conditions
Hallux Rigidus
Interventions
Dorsal Cheilectomy without Amniotic Membrane Tissue Implantation, Dorsal Cheilectomy with Amniotic Membrane Tissue Implantation
Procedure
Lead sponsor
OrthoCarolina Research Institute, Inc.
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2020
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 9, 2023 · Synced Oct 2, 2026, 1:04 PM EDT
Completed Phase 4 Interventional Results available

Opioid-Free Shoulder Arthroplasty

NCT03540030
View directory record Official record
Conditions
Opioid Use, Shoulder Osteoarthritis, Avascular Necrosis, Rotator Cuff Tear, Arthritis;Inflammatory
Interventions
Gabapentin, Celecoxib, toradol, acetaminophen, regional block, propofol, IV lidocaine, rocuronium, vecuronium, sevoflurane, desflurane
Drug
Lead sponsor
OrthoCarolina Research Institute, Inc.
Other
Eligibility
50 Years and older
Enrollment
86 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 14, 2020 · Synced Oct 2, 2026, 1:04 PM EDT