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Showing 1–24 of 36 matching trials from the live ClinicalTrials.gov search.
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Completed Not applicable Interventional

Creating Live Interactions to Mitigate Barriers

NCT03317769
View directory record Official record
Conditions
Schizophrenia
Interventions
Computerized Plasticity-Based Adaptive Cognitive Training, Commercially available computerized training, Optimized social skills training, Unstructured support group sessions
Other
Lead sponsor
Posit Science Corporation
Industry
Eligibility
18 Years to 60 Years
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jul 22, 2019 · Synced Sep 1, 2026, 9:11 PM EDT
Completed Not applicable Interventional

STATE Trial: SusTained Attention Training to Enhance Sleep

NCT02921074
View directory record Official record
Conditions
Insomnia
Interventions
Computerized Plasticity-Based Adaptive Cognitive Training, Commercially available computerized training
Other
Lead sponsor
Posit Science Corporation
Industry
Eligibility
55 Years to 80 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated May 10, 2018 · Synced Sep 1, 2026, 9:11 PM EDT
Completed Not applicable Interventional

Cognitive Remediation for HIV-associated Neurocognitive Dysfunction

NCT02671526
View directory record Official record
Conditions
HIV-associated Neurocognitive Dysfunction
Interventions
Computerized plasticity-based adaptive cognitive training
Other
Lead sponsor
Posit Science Corporation
Industry
Eligibility
25 Years to 60 Years
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Nov 22, 2016 · Synced Sep 1, 2026, 9:11 PM EDT
Completed Phase 1 Interventional

Computer-Based Therapy for Mild Cognitive Impairment

NCT00319943
View directory record Official record
Conditions
Mild Cognitive Impairment
Interventions
Computer-based training for Mild Cognitive Impairment (MCI)
Procedure
Lead sponsor
Posit Science Corporation
Industry
Eligibility
65 Years to 90 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2006
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Apr 26, 2006 · Synced Sep 1, 2026, 9:11 PM EDT
Completed Phase 1 Interventional

Computer-Based Training in Patients With Post-Chemotherapy Cognitive Impairment

NCT00387062
View directory record Official record
Conditions
Breast Cancer, Cognitive Symptoms, Memory Disorders
Interventions
Computer-based Cognitive Training
Device
Lead sponsor
Posit Science Corporation
Industry
Eligibility
21 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jun 23, 2008 · Synced Sep 1, 2026, 9:11 PM EDT
Completed Not applicable Interventional

Attention Training for Learning Enhancement and Resilience Trial

NCT02416401
View directory record Official record
Conditions
Age-related Cognitive Decline
Interventions
Computerized Plasticity-Based Adaptive Cognitive Training, Commercially available computerized training
Other
Lead sponsor
Posit Science Corporation
Industry
Eligibility
65 Years and older
Enrollment
83 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
2
States / cities
Iowa City, Iowa • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 8, 2018 · Synced Sep 1, 2026, 9:11 PM EDT
Completed Phase 1 Interventional

Computerized Attention Training for Individuals With Acquired Brain Injury

NCT01641432
View directory record Official record
Conditions
Acquired Brain Injury, Stroke, Hemispatial Neglect
Interventions
Tonic and Phasic Attention Training, Active Comparator
Behavioral
Lead sponsor
Posit Science Corporation
Industry
Eligibility
21 Years to 80 Years
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2011
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jul 21, 2014 · Synced Sep 1, 2026, 9:11 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Computer-Based Training for Cognitive Enhancement: In Home Study

NCT00337974
View directory record Official record
Conditions
Aging
Interventions
Computerized Plasticity-Based Adaptive Cognitive Training, Educational DVDs
Other
Lead sponsor
Posit Science Corporation
Industry
Eligibility
60 Years and older
Enrollment
182 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2006
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Nov 1, 2015 · Synced Sep 1, 2026, 9:11 PM EDT
Completed Not applicable Interventional

Remediation of Spatial Neglect Trial

NCT01965951
View directory record Official record
Conditions
Stroke, Acquired Brain Injury, Hemispatial Neglect
Interventions
Computerized Plasticity-based Adaptive Cognitive Training, Commercially available computerized training
Other
Lead sponsor
Posit Science Corporation
Industry
Eligibility
18 Years and older
Enrollment
96 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 6, 2020 · Synced Sep 1, 2026, 9:11 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Brain Enhancement Training Towards Elders Resilience to Aging

NCT03197454
View directory record Official record
Conditions
Age-related Cognitive Decline
Interventions
Computerized Plasticity-Based Adaptive Cognitive Training, Commercially available computerized training
Other
Lead sponsor
Posit Science Corporation
Industry
Eligibility
65 Years and older
Enrollment
147 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
2
States / cities
Iowa City, Iowa • Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Oct 30, 2023 · Synced Sep 1, 2026, 9:11 PM EDT
Completed Not applicable Interventional

HeartMapp: Assessment and Treatment for Heart Failure

NCT03827954
View directory record Official record
Conditions
Heart Failure, Cognitive Impairment
Interventions
HeartMapp+CT
Other
Lead sponsor
Posit Science Corporation
Industry
Eligibility
40 Years and older
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Aug 23, 2021 · Synced Sep 1, 2026, 9:11 PM EDT
Completed Not applicable Interventional

The Mental Activity and eXercise Trial for Seniors

NCT00522899
View directory record Official record
Conditions
Cognitive Impairment
Interventions
Group 1, Group 2, Group 3, Group 4
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
65 Years and older
Enrollment
126 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
2
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Apr 8, 2012 · Synced Sep 1, 2026, 9:11 PM EDT
Completed Not applicable Interventional Results available

Wiring Adolescents With Social Anxiety Via Behavioral Interventions

NCT03990870
View directory record Official record
Conditions
Social Anxiety
Interventions
dCBGT + WASABI, dCBGT Only
Other
Lead sponsor
Posit Science Corporation
Industry
Eligibility
14 Years to 18 Years
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated May 31, 2023 · Synced Sep 1, 2026, 9:11 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Piloting a Novel, Mobile Cognitive Training Tool for Patients With Major Depressive Disorder (MDD)

NCT02922556
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Computerized Plasticity-Based Adaptive Cognitive Training, Commercially available computerized training
Other
Lead sponsor
Posit Science Corporation
Industry
Eligibility
18 Years to 85 Years
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2019
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jun 24, 2019 · Synced Sep 1, 2026, 9:11 PM EDT
Completed Not applicable Interventional

Broad-spectrum Cognitive Remediation: Effects of a Brain Plasticity-based Program in Mild Traumatic Brain Injury

NCT01640158
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Computerized Plasticity-based Adaptive Cognitive Training, Commercially available computerized training
Other
Lead sponsor
Posit Science Corporation
Industry
Eligibility
18 Years to 50 Years
Enrollment
86 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Apr 15, 2019 · Synced Sep 1, 2026, 9:11 PM EDT
Completed Not applicable Interventional

A Closed-loop Assessment and Treatment Platform for Unipolar Depression and Anxiety

NCT02948036
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Mobile-device, plasticity-based adaptive cognitive treatment
Other
Lead sponsor
Posit Science Corporation
Industry
Eligibility
18 Years to 60 Years
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jun 4, 2023 · Synced Sep 1, 2026, 9:11 PM EDT
Completed Not applicable Interventional Results available

Care Improving Cognition for ADolescents on the Autism Spectrum

NCT04562688
View directory record Official record
Conditions
Autism Spectrum Disorder
Interventions
CICADAS only, PEERS + CICADAS and then no-contact, PEERS + Active Comparator and then no-contact
Other
Lead sponsor
Posit Science Corporation
Industry
Eligibility
11 Years to 18 Years
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jun 14, 2026 · Synced Sep 1, 2026, 9:11 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Improvement in Memory With Plasticity-Based Adaptive Cognitive Training (IMPACT)

NCT00283010
View directory record Official record
Conditions
Aging
Interventions
Computerized Plasticity-Based Adaptive Cognitive Training, Educational DVDs
Other
Lead sponsor
Posit Science Corporation
Industry
Eligibility
65 Years and older
Enrollment
487 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2008
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Nov 1, 2015 · Synced Sep 1, 2026, 9:11 PM EDT
Completed Phase 2 Interventional

Evaluation of a Cognitive Adaptive E-treatment in Schizophrenia-diagnosed Adults

NCT01422902
View directory record Official record
Conditions
Schizophrenia
Interventions
Plasticity-based Cognitive Training, Non-plasticity-based Training
Other
Lead sponsor
Posit Science Corporation
Industry
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
2
States / cities
Palo Alto, California • San Francisco, California
Source: ClinicalTrials.gov public record
Updated Feb 7, 2016 · Synced Sep 1, 2026, 9:11 PM EDT
Recruiting Not applicable Interventional

ME/CFS Brain Fog: Cognitive Rehabilitation Trial

NCT07523113
View directory record Official record
Conditions
ME/CFS, ME/CFS Following EBV-associated Infectious Mononucleosis, ME/CFS Following COVID-19, Chronic Fatigue, Chronic Fatigue Syndrome (CFS), Brain Fog, Cognitive Impairment, Cognitive Dysfunction
Interventions
Processing Speed Training, In-session Instrumental Activities of Daily Living Training, Transfer Package, Follow Up Phone Calls, Trans-auricular Vagus Nerve Stimulation: High Intensity, In-session Brain Health Training, Reaction Time Training, Trans-auricular Vagus Nerve Stimulation: Low Intensity
Behavioral · Procedure
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Aug 13, 2026 · Synced Sep 1, 2026, 9:11 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Computer-Based Training for Cognitive Enhancement: Classroom Study

NCT00337909
View directory record Official record
Conditions
Aging
Interventions
Computerized Plasticity-Based Adaptive Cognitive Training, Educational DVDs
Other
Lead sponsor
Posit Science Corporation
Industry
Eligibility
60 Years and older
Enrollment
94 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2006
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Nov 1, 2015 · Synced Sep 1, 2026, 9:11 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Randomized Clinical Trial of Intensive Computer-based Cognitive Remediation in Recent-onset Schizophrenia

NCT01773239
View directory record Official record
Conditions
Schizophrenia
Interventions
TARA computer-based exercises
Behavioral
Lead sponsor
Posit Science Corporation
Industry
Eligibility
18 Years to 35 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
2
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Sep 29, 2016 · Synced Sep 1, 2026, 9:11 PM EDT
Completed Not applicable Interventional

STATE Trial: SusTained Attention Training to Enhance Sleep - Remote

NCT03604380
View directory record Official record
Conditions
Insomnia Chronic
Interventions
Computerized Plasticity-Based Adaptive Cognitive Training, Active Comparator
Other
Lead sponsor
Posit Science Corporation
Industry
Eligibility
55 Years and older
Enrollment
134 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Dec 1, 2020 · Synced Sep 1, 2026, 9:11 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Brain Enhancement Training Towards Elders Resilience to Aging, Phase IIB

NCT05599490
View directory record Official record
Conditions
Age-related Cognitive Decline
Interventions
Computerized Plasticity-Based Adaptive Cognitive Training
Other
Lead sponsor
Posit Science Corporation
Industry
Eligibility
70 Years and older
Enrollment
135 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
2
States / cities
Iowa City, Iowa • Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Feb 18, 2026 · Synced Sep 1, 2026, 9:11 PM EDT