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Duke University clinical trials

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ClinicalTrials.gov public records Last synced Oct 31, 2026, 11:27 PM EDT

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Duke University
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Showing 157–168 of 2,714 matching trials for sponsor Duke University.
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Recruiting Phase 2 Interventional

Allopregnanolone (Zuranolone) in Post-stroke Depression

NCT06759558
View directory record Official record
Conditions
Post Stroke Depression
Interventions
Zuranolone
Drug
Lead sponsor
Duke University
Other
Eligibility
21 Years to 65 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 3, 2026 · Synced Oct 31, 2026, 11:27 PM EDT
Completed Phase 2 Interventional

Ketones in Heart Failure With Reduced Ejection Fraction

NCT06195982
View directory record Official record
Conditions
Heart Failure With Reduced Ejection Fraction
Interventions
ketone ester, placebo
Dietary Supplement
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 3, 2026 · Synced Oct 31, 2026, 11:27 PM EDT
Completed No phase listed Observational

Master Protocol for Evaluating Multiple Infection Diagnostics for Ciprofloxacin-Resistant Neisseria Gonorrhoeae

NCT06815536
View directory record Official record
Conditions
Neisseria Gonorrheae Infection
Interventions
Investigational Reflex Test 1, Investigational Reflex Test 2, Investigational Reflex Test 3
Diagnostic Test
Lead sponsor
Duke University
Other
Eligibility
Not listed
Enrollment
2,627 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
8
States / cities
San Francisco, California • Indianapolis, Indiana • Jackson, Mississippi + 5 more
Source: ClinicalTrials.gov public record
Updated Sep 3, 2026 · Synced Oct 31, 2026, 11:27 PM EDT
Not yet recruiting Not applicable Interventional

Rehabilitation and Sex Therapy to Optimize Recovery After Prostate Cancer Treatment

NCT07685249
View directory record Official record
Conditions
Prostate Cancer, Urinary Incontinence, Erectile Dysfunction
Interventions
Sex Therapy, Pelvic Floor Physical Therapy, Vacuum Erection Device (VED)
Behavioral · Device
Lead sponsor
Duke University
Other
Eligibility
18 Years and older · Male only
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 3, 2026 · Synced Oct 31, 2026, 11:27 PM EDT
Terminated Phase 3 Interventional

Effects of Combination Medical Therapy Followed by BPA on Right Ventricular-PA Coupling and Hemodynamics in CTEPH

NCT05140525
View directory record Official record
Conditions
CTEPH
Interventions
Macitentan Tablets, Riociguat, balloon pulmonary angioplasty
Drug · Device
Lead sponsor
Dr Sudarshan Rajagopal
Other
Eligibility
18 Years and older
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 3, 2026 · Synced Oct 31, 2026, 11:27 PM EDT
Withdrawn Phase 1Phase 2 Interventional

A Feasibility Study of Supplemental Oxygen to Improve Pulmonary Hypertension in People With Intradialytic Hypoxemia

NCT06327373
View directory record Official record
Conditions
Pulmonary Hypertension
Interventions
Oxygen, Room air
Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
11
States / cities
Durham, North Carolina • Henderson, North Carolina • Roxboro, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 3, 2026 · Synced Oct 31, 2026, 11:27 PM EDT
Recruiting Phase 1 Interventional

UCB Transplant of Inherited Metabolic Diseases With Administration of Intrathecal UCB Derived Oligodendrocyte-Like Cells

NCT02254863
View directory record Official record
Conditions
Adrenoleukodystrophy, Batten Disease, Mucopolysaccharidosis II, Leukodystrophy, Globoid Cell, Leukodystrophy, Metachromatic, Neimann Pick Disease, Pelizaeus-Merzbacher Disease, Sandhoff Disease, Tay-Sachs Disease, Brain Diseases, Metabolic, Inborn, Alpha-Mannosidosis, Sanfilippo Mucopolysaccharidoses
Interventions
DUOC-01
Biological
Lead sponsor
Joanne Kurtzberg, MD
Other
Eligibility
1 Week to 22 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2027
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 3, 2026 · Synced Oct 31, 2026, 11:27 PM EDT
Active, not recruiting Phase 1 Interventional

Assessing the Immunogenicity of pING-hHER3FL

NCT03832855
View directory record Official record
Conditions
Advanced Cancer
Interventions
pING-hHER3FL
Biological
Lead sponsor
Herbert Lyerly
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2030
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 2, 2026 · Synced Oct 31, 2026, 11:27 PM EDT
Recruiting Phase 4 Interventional Accepts healthy volunteers

Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults

NCT04262206
View directory record Official record
Conditions
Cognitive Impairment, Mild, Dementia, Cardiovascular Diseases
Interventions
Atorvastatin 40 Mg Oral Tablet, Placebo oral tablet
Drug
Lead sponsor
Duke University
Other
Eligibility
75 Years and older
Enrollment
20,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2026
U.S. locations
104
States / cities
Birmingham, Alabama • Tucson, Arizona • Little Rock, Arkansas + 70 more
Source: ClinicalTrials.gov public record
Updated Sep 1, 2026 · Synced Oct 31, 2026, 11:27 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Intracranial Neurophysiological Signatures of Fear and Anxiety in Humans

NCT05120635
View directory record Official record
Conditions
Fear, GAD, Emotional Memory, PTSD
Interventions
Deep Brain Stimulation, Virtual and augmented reality tasks
Device · Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years to 70 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2027
U.S. locations
2
States / cities
Los Angeles, California • Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 31, 2026 · Synced Oct 31, 2026, 11:27 PM EDT
Recruiting Not applicable Interventional

A Randomized Controlled Trial Testing a Digital, Gamified Early Intervention for Eating Disorders ("FlexED")

NCT07632248
View directory record Official record
Conditions
Eating Disorders, Body Image
Interventions
FlexED, Educational Control
Behavioral
Lead sponsor
Duke University
Other
Eligibility
15 Years to 25 Years
Enrollment
128 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 28, 2026 · Synced Oct 31, 2026, 11:27 PM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Lung Cancer and Aging: Improving Well-being for Older Adults With Lung Cancer

NCT06636721
View directory record Official record
Conditions
Lung Cancer
Interventions
LuCA Behavioral Intervention
Behavioral
Lead sponsor
Duke University
Other
Eligibility
60 Years and older
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 28, 2026 · Synced Oct 31, 2026, 11:27 PM EDT

About this Duke University sponsor directory page

What this page lists
U.S. ClinicalTrials.gov public records where Duke University is the lead sponsor, including recruiting, not yet recruiting, and active not recruiting trials across phase 1, phase 2, and phase 3.
How to narrow results
Use the filters above to scope by condition, intervention, city, state, recruitment status, phase, study type, healthy volunteer eligibility, sex, age, or NCT ID within Duke University trials.
Where the data comes from
Records are sourced from the official ClinicalTrials.gov public API. Each result links back to the official study page, which is the source of truth for eligibility, enrollment, and contact information.
What this page does not do
No medical advice, eligibility judgments, sponsor quality scoring, ranking of trials, or AI-generated medical summaries.

Related: all sponsor pages, browse by condition, browse by drug or therapy, browse by U.S. city, trials at Duke University Medical Center in Durham, NC, or open the full search for Duke University.