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Mayo Clinic clinical trials

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ClinicalTrials.gov public records Last synced Nov 1, 2026, 1:38 AM EDT

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Mayo Clinic
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Showing 373–384 of 3,667 matching trials for sponsor Mayo Clinic.
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Enrolling by invitation No phase listed Observational Accepts healthy volunteers

Precure Targeted Accrual and Rapid Growth in Enrollment Trial Study

NCT07756320
View directory record Official record
Conditions
Exposure, Environmental, Genetic Predisposition
Interventions
Not listed
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
100,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2035
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 17, 2026 · Synced Nov 1, 2026, 1:38 AM EDT
Recruiting No phase listed Observational

Exosome-based Omic Signatures of Disease Activity in Cardiac Sarcoidosis (EXODACS)

NCT07604220
View directory record Official record
Conditions
Cardiac Sarcoidosis, Sarcoidosis of the Heart, Sarcoidosis With Myocarditis, Sarcoidosis, Cardiac
Interventions
Exosome Analysis
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
115 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 17, 2026 · Synced Nov 1, 2026, 1:38 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

iCCaRE Consortium Pilot Project 1: Feasibility of a Point of Prostate Cancer Diagnosis Intervention for Newly Diagnosed Black Men

NCT06535802
View directory record Official record
Conditions
Prostate Carcinoma
Interventions
Focus group, Clinician Interviews, Intervention testing, Survey, Follow-up Interview, Virtual Health Intervention
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
Up to 80 Years
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Aug 17, 2026 · Synced Nov 1, 2026, 1:38 AM EDT
Recruiting Not applicable Interventional

Ketogenic Intervention for Bipolar Depression

NCT07121894
View directory record Official record
Conditions
Bipolar Depression
Interventions
Ketogenic Diet
Behavioral
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 50 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 17, 2026 · Synced Nov 1, 2026, 1:38 AM EDT
Active, not recruiting Not applicable Interventional

3D DL Ozteo in the Detection of Osseous Changes in Patients With Inflammatory Arthritis

NCT06383585
View directory record Official record
Conditions
Inflammatory Arthritis
Interventions
oZTEo
Device
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 14, 2026 · Synced Nov 1, 2026, 1:38 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Ultrasound With Subharmonic Imaging and Subharmonic Aided Pressure Estimation (SHAPE) to Identify Portal Hypertension

NCT06797193
View directory record Official record
Conditions
Portal Hypertension
Interventions
Electronic Health Record Review, Liver Biopsy, Medical Device Usage and Evaluation, Perflutren Lipid Microspheres, Ultrasound Imaging
Other · Procedure · Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
3
States / cities
Scottsdale, Arizona • Jacksonville, Florida • Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 14, 2026 · Synced Nov 1, 2026, 1:38 AM EDT
Recruiting Not applicable Interventional

App-Based Optimization of Long-Term CPAP Adherence and Quality of Life

NCT06381115
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
SleepWell24 Application
Behavioral
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
2
States / cities
Scottsdale, Arizona • Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 14, 2026 · Synced Nov 1, 2026, 1:38 AM EDT
Completed No phase listed Observational

Gene Expression in Patients With Metastatic Prostate Cancer Receiving CYP-17 Inhibition Therapy

NCT01953640
View directory record Official record
Conditions
Hormone-Resistant Prostate Cancer, Metastatic Prostate Carcinoma, Prostate Adenocarcinoma, Recurrent Prostate Carcinoma
Interventions
Laboratory Biomarker Analysis, Quality-of-Life Assessment
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older · Male only
Enrollment
92 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2023
U.S. locations
3
States / cities
Scottsdale, Arizona • Jacksonville, Florida • Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 14, 2026 · Synced Nov 1, 2026, 1:38 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

CArdioMEtabolic Function and Reserve Capacity in Healthy Adults: The CAMERA Study

NCT06220396
View directory record Official record
Conditions
Healthy
Interventions
Right Heart Catheterization with Hemodynamics and Limited Echocardiogram, Magnetic Resonance Imaging (MRI), Dual X-ray absorptiometry (DEXA) scan
Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
30 Years and older
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2029
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 14, 2026 · Synced Nov 1, 2026, 1:38 AM EDT
Completed Phase 4 Interventional

Cardiac and Metabolic Effects of Semaglutide in Heart Failure With Preserved Ejection Fraction

NCT05371496
View directory record Official record
Conditions
Cardiomyopathy, Heart Failure With Preserved Ejection Fraction (HFpEF), Obesity
Interventions
Semaglutide, Placebo, Counselling on healthy lifestyle intervention
Drug · Behavioral
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
81 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 14, 2026 · Synced Nov 1, 2026, 1:38 AM EDT
Recruiting Phase 3 Interventional

Study of Tadalafil vs. Placebo for Improving Hemodynamics and End-Organ Dysfunction in Fontan Physiology

NCT05206955
View directory record Official record
Conditions
Fontan Palliation
Interventions
Tadalafil, Placebo
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 13, 2026 · Synced Nov 1, 2026, 1:38 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Sleep Restriction and Parental History of Hypertension

NCT06482814
View directory record Official record
Conditions
Hypertension
Interventions
Partial sleep deprivation (sleep restriction), Normal sleep
Behavioral
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 35 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2029
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 13, 2026 · Synced Nov 1, 2026, 1:38 AM EDT

About this Mayo Clinic sponsor directory page

What this page lists
U.S. ClinicalTrials.gov public records where Mayo Clinic is the lead sponsor, including recruiting, not yet recruiting, and active not recruiting trials across phase 1, phase 2, and phase 3.
How to narrow results
Use the filters above to scope by condition, intervention, city, state, recruitment status, phase, study type, healthy volunteer eligibility, sex, age, or NCT ID within Mayo Clinic trials.
Where the data comes from
Records are sourced from the official ClinicalTrials.gov public API. Each result links back to the official study page, which is the source of truth for eligibility, enrollment, and contact information.
What this page does not do
No medical advice, eligibility judgments, sponsor quality scoring, ranking of trials, or AI-generated medical summaries.

Related: all sponsor pages, browse by condition, browse by drug or therapy, browse by U.S. city, trials at Mayo Clinic in Rochester, MN, trials at Mayo Clinic in Jacksonville, FL, trials at Mayo Clinic in Phoenix & Scottsdale, AZ, or open the full search for Mayo Clinic.