Memory Impairment Study (Mild Cognitive Impairment Study)
Public ClinicalTrials.gov record NCT00000173. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-Blind, Placebo-Controlled Trial of Vitamin E and Donepezil HCL (Aricept) to Delay Clinical Progression From Mild Cognitive Impairment (MCI) to Alzheimer's Disease (AD)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The National Institute on Aging (NIA) is launching a nationwide treatment study targeting individuals with mild cognitive impairment (MCI), a condition characterized by a memory deficit, but not dementia. An NIA-funded study recently confirmed that MCI is different from both dementia and normal age-related changes in memory. Accurate and early evaluation and treatment of MCI individuals might prevent further cognitive decline, including development of Alzheimer's disease (AD). The Memory Impairment Study is the first such AD prevention clinical trial carried out by NIH, and will be conducted at 65-80 medical research institutions located in the United States and Canada. This study will test the usefulness of two drugs to slow or stop the conversion from MCI to AD. The trial will evaluate placebo, vitamin E, and donepezil, an investigational agent approved by the Food and Drug Administration for another use. Vitamin E (alpha-tocopherol) is thought to have antioxidant properties, and was shown in a 1997 study to delay important dementia milestones, such as patients' institutionalization or progression to severe dementia, by about seven months.
Study identification
- NCT ID
- NCT00000173
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- Not listed
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 55 Years to 90 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 1999 (Type not available)
- Primary completion
- Jan 2004 (Actual)
- Completion
- Jan 2004 (Actual)
- Last update posted
- Dec 11, 2009
1999 – 2004
United States locations
- U.S. sites
- 63
- U.S. states
- 30
- U.S. cities
- 56
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Barrow Neurological Group | Phoenix | Arizona | 85013 | — |
| University of Arizona | Tucson | Arizona | 857245023 | — |
| UC Irvine Institute for Brain Aging and Dementia | Irvine | California | 92697-4285 | — |
| University of Southern California | Los Angeles | California | 90033 | — |
| University of California, Los Angeles | Los Angeles | California | 90095-1769 | — |
| East Bay Institute | Martinez | California | 94553 | — |
| Sutter Institute for Medical Research | Sacramento | California | 95816 | — |
| Affiliated Research Instiute | San Diego | California | 92018 | — |
| University of California, San Diego | San Diego | California | 92093-0949 | — |
| University of California, San Francisco | San Francisco | California | 94115 | — |
| Yale University | New Haven | Connecticut | 06520 | — |
| Baumel-Eisner Neuromedical Institute, Boca Raton | Boca Raton | Florida | 33486 | — |
| Baumel-Eisner Neuromedical Institute, Ft. Lauderdale | Fort Lauderdale | Florida | 33321 | — |
| Mayo Clinic Jacksonville | Jacksonville | Florida | 32225 | — |
| Wein Center | Miami Beach | Florida | 33140 | — |
| Baumel-Eisner Neuromedical Institute, MiamiBeach | Miami Beach | Florida | 33154 | — |
| University of Miami | Port Charlotte | Florida | 33952 | — |
| University of South Florida | Tampa | Florida | 33612 | — |
| Premiere Research Institute | West Palm Beach | Florida | 33407 | — |
| Emory University | Atlanta | Georgia | 30329 | — |
| Augusta VA Medical Center | Augusta | Georgia | 30904 | — |
| Northwestern University | Chicago | Illinois | 60611 | — |
| Rush Presbyterian St. Luke's Medical Center | Chicago | Illinois | 60612 | — |
| Southern Illinois University | Springfield | Illinois | 62702 | — |
| Indiana University | Indianapolis | Indiana | 46202-5111 | — |
| University of Kansas Medical Center | Kansas City | Kansas | 66160 | — |
| University of Kentucky | Lexington | Kentucky | 40536-0230 | — |
| Johns Hopkins University | Baltimore | Maryland | 21224 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| University of Michigan | Ann Arbor | Michigan | 48109 | — |
| University of Minnesota | Minneapolis | Minnesota | 55455 | — |
| Mayo Clinic | Rochester | Minnesota | 55901-0144 | — |
| Washington University | St Louis | Missouri | 63110 | — |
| University of Nevada | Las Vegas | Nevada | 89102 | — |
| Dartmouth Hitchcock Medical Center | Lebanon | New Hampshire | 03756 | — |
| Memory Disorders Institute | Lakehurst | New Jersey | 08733 | — |
| Princeton Biomedical Research, PA | Princeton | New Jersey | 08540 | — |
| ClinSearch, Inc. | Summit | New Jersey | 07901 | — |
| Princeton Biomedical - Toms River | Toms River | New Jersey | 08755 | — |
| Alzheimer's Research Corp. | West Long Branch | New Jersey | 07764 | — |
| Univ. of New Mexico | Albuquerque | New Mexico | 89108 | — |
| Maimonides Medical Center | Brooklyn | New York | 11219 | — |
| NYU Medical Center | New York | New York | 10016 | — |
| Mount Sinai Medical Center | New York | New York | 10029 | — |
| Columbia University | New York | New York | 11032 | — |
| Nathan S. Kline Institute for Psychiatric Research | Orangeburg | New York | 10962 | — |
| University of Rochester | Rochester | New York | 14620 | — |
| SUNY Stony Brook | Stony Brook | New York | 11794-8121 | — |
| Burke Medical Research Institute | White Plains | New York | 10605 | — |
| Duke University Medical Center | Durham | North Carolina | 27705 | — |
| University Hospitals of Cleveland | Cleveland | Ohio | 44120-1013 | — |
| Oregon Health Sciences University | Portland | Oregon | 97201-3098 | — |
| University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | — |
| MCP Hahnemann | Philadelphia | Pennsylvania | 19129 | — |
| University of Pittsburgh | Pittsburgh | Pennsylvania | 15213 | — |
| Brown University | Pawtucket | Rhode Island | 02860 | — |
| Medical University of South Carolina | North Charleston | South Carolina | 29406 | — |
| Vanderbilt University Medical Center | Nashville | Tennessee | 37212-8646 | — |
| Baylor College of Medicine | Houston | Texas | 77030 | — |
| Southwestern Vermont Medical Center | Bennington | Vermont | 05201 | — |
| Clinical Neuroscience Research Unit | Burlington | Vermont | 05401 | — |
| University of Washington | Seattle | Washington | 98108 | — |
| Marshfield Clinic | Marshfield | Wisconsin | 54449 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 9 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00000173, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Dec 11, 2009 · Synced Oct 25, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00000173 live on ClinicalTrials.gov.