Preventive Treatment Against Tuberculosis (TB) in Patients With Human Immunodeficiency Virus (HIV) Infection and Confirmed Latent Tuberculous Infection
Public ClinicalTrials.gov record NCT00000638. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Prophylaxis Against Tuberculosis (TB) in Patients With Human Immunodeficiency Virus (HIV) Infection and Confirmed Latent Tuberculous Infection
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
To evaluate and compare the safety and effectiveness of a one-year course of isoniazid (INH) versus a two-month course of rifampin plus pyrazinamide for the prevention of reactivation tuberculosis in individuals infected with both HIV and latent (inactive) Mycobacterium tuberculosis. Current guidelines from the American Thoracic Society and the Centers for Disease Control recommend 6 to 12 months of INH for PPD (purified protein derivative)-positive individuals. Although the effectiveness of this treatment is not known for HIV-infected individuals, several studies using INH to prevent tuberculosis in presumably normal hosts have shown 60 to 80 percent effectiveness. Problems with this treatment include compliance, adverse reaction, and the possibility of not preventing disease due to tuberculosis organisms being resistant to INH. A two-month preventive treatment plan should help in increasing compliance. In addition, the use of two drugs (rifampin / pyrazinamide) may help overcome problems with drug resistance. If this study shows equal or greater effectiveness of the two-month rifampin / pyrazinamide treatment, it could alter the approach to tuberculosis prevention for both HIV-positive and HIV-negative individuals.
Study identification
- NCT ID
- NCT00000638
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Not applicable
- Enrollment
- 2,000 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 13 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Not listed
- Primary completion
- Not listed
- Completion
- Sep 1999 (Actual)
- Last update posted
- Nov 2, 2021
Ends 1999
United States locations
- U.S. sites
- 75
- U.S. states
- 20
- U.S. cities
- 42
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Univ of Alabama at Birmingham | Birmingham | Alabama | 35294 | — |
| Children's Hosp of Los Angeles | Los Angeles | California | 90027 | — |
| Univ of Southern California / LA County USC Med Ctr | Los Angeles | California | 900331079 | — |
| Highland Gen Hosp / San Francisco Gen Hosp | Oakland | California | 946021018 | — |
| San Francisco Gen Hosp | San Francisco | California | 941102859 | — |
| Stanford at Kaiser / Kaiser Permanente Med Ctr | San Francisco | California | 94115 | — |
| Santa Clara Valley Med Ctr / AIDS Community Rsch Consortium | San Jose | California | 951282699 | — |
| San Mateo AIDS Program / Stanford Univ | Stanford | California | 943055107 | — |
| Stanford Univ Med Ctr | Stanford | California | 943055107 | — |
| Olive View Med Ctr | Sylmar | California | 91342 | — |
| Harbor UCLA Med Ctr | Torrance | California | 90502 | — |
| Yale Univ / New Haven | New Haven | Connecticut | 065102483 | — |
| HIV Ctr - District of Columbia Gen Hosp | Washington D.C. | District of Columbia | 200072197 | — |
| Whitman - Walker Clinic / Georgetown Univ Med Ctr | Washington D.C. | District of Columbia | 200072197 | — |
| Georgetown Univ Med Ctr | Washington D.C. | District of Columbia | 20007 | — |
| Howard Univ | Washington D.C. | District of Columbia | 20059 | — |
| Univ of Miami School of Medicine | Miami | Florida | 331361013 | — |
| Queens Med Ctr | Honolulu | Hawaii | 96816 | — |
| Univ of Hawaii | Honolulu | Hawaii | 96816 | — |
| Children's Mem Hosp Family Cln / Northwestern Univ Med Schl | Chicago | Illinois | 60611 | — |
| Northwestern Univ Med School | Chicago | Illinois | 60611 | — |
| Rush Presbyterian - Saint Luke's Med Ctr | Chicago | Illinois | 60612 | — |
| Louis A Weiss Memorial Hosp | Chicago | Illinois | 60640 | — |
| Indiana Univ Hosp | Indianapolis | Indiana | 462025250 | — |
| State of MD Div of Corrections / Johns Hopkins Univ Hosp | Baltimore | Maryland | 212052196 | — |
| Johns Hopkins Hosp | Baltimore | Maryland | 21287 | — |
| Beth Israel Deaconess - West Campus | Boston | Massachusetts | 02215 | — |
| Baystate Med Ctr of Springfield | Springfield | Massachusetts | 01199 | — |
| St Louis Regional Hosp / St Louis Regional Med Ctr | St Louis | Missouri | 63112 | — |
| Univ of Nebraska Med Ctr | Omaha | Nebraska | 681985130 | — |
| Univ of Medicine & Dentistry of New Jersey / Univ Hosp | Newark | New Jersey | 071032714 | — |
| Children's Hosp of New Jersey / UMDNJ - New Jersey Med Schl | Newark | New Jersey | 071072198 | — |
| Adirondack Med Ctr at Saranac Lake | Albany | New York | 122083479 | — |
| Albany Med College / Division of HIV Medicine A158 | Albany | New York | 122083479 | — |
| Mid - Hudson Care Ctr | Albany | New York | 122083479 | — |
| Interfaith Med Ctr | Brooklyn | New York | 112032098 | — |
| SUNY / Health Sciences Ctr at Brooklyn | Brooklyn | New York | 112032098 | — |
| SUNY / Erie County Med Ctr at Buffalo | Buffalo | New York | 14215 | — |
| Nassau County Med Ctr | East Meadow | New York | 11554 | — |
| City Hosp Ctr at Elmhurst / Mount Sinai Hosp | Elmhurst | New York | 11373 | — |
| North Shore Univ Hosp | Manhasset | New York | 11030 | — |
| Beth Israel Med Ctr | New York | New York | 10003 | — |
| Bellevue Hosp / New York Univ Med Ctr | New York | New York | 10016 | — |
| Saint Clare's Hosp and Health Ctr | New York | New York | 10019 | — |
| Cornell Univ Med Ctr | New York | New York | 10021 | — |
| Saint Luke's - Roosevelt Hosp Ctr | New York | New York | 10025 | — |
| Mount Sinai Med Ctr | New York | New York | 10029 | — |
| Columbia Presbyterian Med Ctr | New York | New York | 100323784 | — |
| SUNY - Stony Brook | Stony Brook | New York | 117948153 | — |
| SUNY / State Univ of New York | Syracuse | New York | 13210 | — |
| Bronx Municipal Hosp Ctr/Jacobi Med Ctr | The Bronx | New York | 10461 | — |
| Comprehensive Health Care Ctr / Bronx Municipal Hosp | The Bronx | New York | 10461 | — |
| Montefiore Drug Treatment Ctr / Bronx Municipal Hosp | The Bronx | New York | 10461 | — |
| Montefiore Family Health Ctr / Bronx Municipal Hosp | The Bronx | New York | 10461 | — |
| Samaritan Village Inc / Bronx Municipal Hosp | The Bronx | New York | 10461 | — |
| Jack Weiler Hosp / Bronx Municipal Hosp | The Bronx | New York | 10465 | — |
| Montefiore Med Ctr / Bronx Municipal Hosp | The Bronx | New York | 10467 | — |
| Montefiore Med Ctr Adolescent AIDS Program | The Bronx | New York | 10467 | — |
| North Central Bronx Hosp / Bronx Municipal Hosp | The Bronx | New York | 10467 | — |
| Univ of North Carolina | Chapel Hill | North Carolina | 275997215 | — |
| Moses H Cone Memorial Hosp | Greensboro | North Carolina | 27401 | — |
| Wake County Dept of Health | Raleigh | North Carolina | 27610 | — |
| Univ of Cincinnati | Cincinnati | Ohio | 452670405 | — |
| Univ of Kentucky Lexington | Cincinnati | Ohio | 45267 | — |
| Case Western Reserve Univ | Cleveland | Ohio | 44106 | — |
| MetroHealth Med Ctr | Cleveland | Ohio | 441091998 | — |
| Ohio State Univ Hosp Clinic | Columbus | Ohio | 432101228 | — |
| Girard Med Ctr | Philadelphia | Pennsylvania | 191046073 | — |
| Univ of Pennsylvania at Philadelphia | Philadelphia | Pennsylvania | 19104 | — |
| Thomas Jefferson Univ Hosp | Philadelphia | Pennsylvania | 191075098 | — |
| Med Univ of South Carolina / UNC | Charleston | South Carolina | 29425 | — |
| Julio Arroyo | West Columbia | South Carolina | 29169 | — |
| Meharry Med College | Nashville | Tennessee | 37203 | — |
| Univ of Texas Galveston | Galveston | Texas | 775550435 | — |
| Houston Clinical Research Network | Houston | Texas | 77266 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 1 non-U.S. site.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00000638, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Nov 2, 2021 · Synced Oct 21, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00000638 live on ClinicalTrials.gov.