(Ro 24-2027) A Randomized, Double-Blind, Comparative Study of Dideoxycytidine (ddC) Versus Zidovudine (AZT) in Patients With AIDS or Advanced ARC
Public ClinicalTrials.gov record NCT00000679. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
To show that zalcitabine (dideoxycytidine; ddC) is at least as effective as zidovudine (AZT) in the treatment of AIDS or advanced AIDS related complex (ARC), and also that ddC shows a different safety profile than AZT. In clinical studies, ddC shows antiviral activity. Because of the antiviral activity, and because of the low incidence of mild, reversible neurotoxicity and absence of blood-related toxicity with low dose ddC therapy, a long-term Phase II/III study comparing ddC to AZT in patients with AIDS or advanced ARC is now warranted.
Study identification
- NCT ID
- NCT00000679
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 600 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Not listed
- Primary completion
- Jan 31, 1994
- Completion
- Not listed
- Last update posted
- Mar 13, 2011
United States locations
- U.S. sites
- 25
- U.S. states
- 13
- U.S. cities
- 22
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Kaiser Foundation Hosp | Harbor City | California | 90710 | — |
| Kaiser Permanente Med Ctr | Los Angeles | California | 90027 | — |
| UCD Med Ctr | Sacramento | California | 95817 | — |
| Davies Med Ctr | San Francisco | California | 94114 | — |
| Mount Zion Med Ctr | San Francisco | California | 94115 | — |
| San Francisco Veterans Administration Med Ctr | San Francisco | California | 94121 | — |
| Santa Clara Valley Med Ctr | San Jose | California | 95128 | — |
| Georgetown Univ Med Ctr | Washington D.C. | District of Columbia | 20007 | — |
| Ctr for Special Immunology | Fort Lauderdale | Florida | 33308 | — |
| Comprehensive Clinic / Dr Robert Schwartz | Fort Myers | Florida | 33901 | — |
| Med Service | Miami | Florida | 33125 | — |
| AIDS Research Consortium of Atlanta | Atlanta | Georgia | 30308 | — |
| Northwestern Univ Med School | Chicago | Illinois | 60611 | — |
| Rush Presbyterian - Saint Luke's Med Ctr | Chicago | Illinois | 60612 | — |
| New England Med Ctr | Boston | Massachusetts | 02111 | — |
| Henry Ford Hosp | Detroit | Michigan | 48202 | — |
| Saint Michael's Med Ctr | Newark | New Jersey | 07102 | — |
| Albany Med College / AIDS Treatment Ctr | Albany | New York | 12203 | — |
| Sunset Park Health Ctr - Lutheran Med Ctr | Brooklyn | New York | 11220 | — |
| Bowman Gray School of Medicine / North Carolina Baptist Hosp | Winston-Salem | North Carolina | 27103 | — |
| Univ Hosp of Cleveland / Case Western Reserve Univ | Cleveland | Ohio | 44106 | — |
| Graduate Hosp | Philadelphia | Pennsylvania | 19146 | — |
| N Texas Ctr for AIDS & Clin Rsch | Dallas | Texas | 75219 | — |
| Univ TX Galveston Med Branch | Galveston | Texas | 77550 | — |
| Baylor College of Medicine | Houston | Texas | 77030 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00000679, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 13, 2011 · Synced Sep 9, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT00000679 live on ClinicalTrials.gov.