A Randomized, Double-Blind, Four-Arm Study Comparing Combination Nucleoside, Alternating Nucleoside, and Triple-Drug Therapy for the Treatment of Advanced HIV Disease (CD4 <= 50/mm3)
Public ClinicalTrials.gov record NCT00000781. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
To determine the relative clinical efficacy of zidovudine ( AZT ) plus didanosine (ddI), AZT plus zalcitabine ( ddC ), AZT alternating monthly with ddI, and AZT/ddI plus nevirapine in HIV-infected patients with advanced disease. The rapid emergence of resistant HIV strains has been observed in patients receiving monotherapy with a nucleoside analog or non-nucleoside reverse transcriptase inhibitor. Use of combination therapy with two nucleoside drugs or convergent combination therapy with two nucleosides and a non-nucleoside RT inhibitor may minimize the evolution of these resistant HIV strains. Since toxicity is a major problem in patients with advanced disease who are receiving combination nucleoside therapy, alternating the two drugs may provide a way of retaining several benefits of combination therapy while minimizing the increased toxicity.
Study identification
- NCT ID
- NCT00000781
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 1,292 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 13 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Not listed
- Primary completion
- Not listed
- Completion
- Aug 31, 1996
- Last update posted
- Nov 3, 2021
Ends 1996
United States locations
- U.S. sites
- 95
- U.S. states
- 25
- U.S. cities
- 53
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Univ of Alabama at Birmingham | Birmingham | Alabama | 35294 | — |
| Children's Hosp of Los Angeles | Los Angeles | California | 90027 | — |
| Univ of Southern California / LA County USC Med Ctr | Los Angeles | California | 900331079 | — |
| Huntington Memorial Hosp / Children's Hosp of Los Angeles | Pasadena | California | 91105 | — |
| Univ of California / San Diego Treatment Ctr | San Diego | California | 921036325 | — |
| San Francisco AIDS Clinic / San Francisco Gen Hosp | San Francisco | California | 941102859 | — |
| San Francisco Gen Hosp | San Francisco | California | 941102859 | — |
| Stanford at Kaiser / Kaiser Permanente Med Ctr | San Francisco | California | 94115 | — |
| Santa Clara Valley Med Ctr / AIDS Community Rsch Consortium | San Jose | California | 951282699 | — |
| San Mateo AIDS Program / Stanford Univ | Stanford | California | 943055107 | — |
| Stanford Univ Med Ctr | Stanford | California | 943055107 | — |
| Olive View Med Ctr | Sylmar | California | 91342 | — |
| Harbor UCLA Med Ctr | Torrance | California | 90502 | — |
| Denver Dept of Health and Hosps | Denver | Colorado | 80262 | — |
| Mountain States Reg Hemo Ctr / Univ of Colorado | Denver | Colorado | 80262 | — |
| Rose Med Ctr | Denver | Colorado | 80262 | — |
| Univ of Colorado Health Sciences Ctr | Denver | Colorado | 80262 | — |
| Yale Univ / New Haven | New Haven | Connecticut | 065102483 | — |
| HIV Ctr - District of Columbia Gen Hosp | Washington D.C. | District of Columbia | 200072197 | — |
| Whitman - Walker Clinic / Georgetown Univ Med Ctr | Washington D.C. | District of Columbia | 200072197 | — |
| Georgetown Univ Med Ctr | Washington D.C. | District of Columbia | 20007 | — |
| George Washington Univ / Hershey Med Ctr | Washington D.C. | District of Columbia | 20037 | — |
| Howard Univ | Washington D.C. | District of Columbia | 20059 | — |
| Univ of Miami School of Medicine | Miami | Florida | 331361013 | — |
| Univ of South Florida | Tampa | Florida | 33612 | — |
| Univ of Hawaii | Honolulu | Hawaii | 96816 | — |
| Northwestern Univ Med School | Chicago | Illinois | 60611 | — |
| Cook County Hosp | Chicago | Illinois | 60612 | — |
| Rush Presbyterian - Saint Luke's Med Ctr | Chicago | Illinois | 60612 | — |
| Louis A Weiss Memorial Hosp | Chicago | Illinois | 60640 | — |
| Indiana Univ Hosp | Indianapolis | Indiana | 462025250 | — |
| Methodist Hosp of Indiana / Life Care Clinic | Indianapolis | Indiana | 46202 | — |
| Univ of Louisville / East Tennesee Comprehensive Hem Ctr | Louisville | Kentucky | 40202 | — |
| Harvard (Massachusetts Gen Hosp) | Boston | Massachusetts | 02114 | — |
| Boston Med Ctr | Boston | Massachusetts | 02118 | — |
| Beth Israel Deaconess - West Campus | Boston | Massachusetts | 02215 | — |
| Worcester Memorial Hosp / Med Ctr of Cntrl MA-Memorial | Worcester | Massachusetts | 01605 | — |
| Hennepin County Med Clinic | Minneapolis | Minnesota | 55415 | — |
| Univ of Minnesota | Minneapolis | Minnesota | 55455 | — |
| St Paul Ramsey Med Ctr | Saint Paul | Minnesota | 55101 | — |
| St Louis Regional Hosp / St Louis Regional Med Ctr | St Louis | Missouri | 63112 | — |
| Univ of Nebraska Med Ctr | Omaha | Nebraska | 681985130 | — |
| Dartmouth - Hitchcock Med Ctr / Med Ctr Cntrl Massachusetts | Lebanon | New Hampshire | 03756 | — |
| Robert Wood Johnson Med School / Hershey Med Ctr | New Brunswick | New Jersey | 08903 | — |
| Univ of Medicine & Dentistry of New Jersey / Univ Hosp | Newark | New Jersey | 071032714 | — |
| Adirondack Med Ctr at Saranac Lake | Albany | New York | 122083479 | — |
| Albany Med College / Division of HIV Medicine A158 | Albany | New York | 122083479 | — |
| Mid - Hudson Care Ctr | Albany | New York | 122083479 | — |
| SUNY / Health Sciences Ctr at Brooklyn | Brooklyn | New York | 112032098 | — |
| SUNY / Erie County Med Ctr at Buffalo | Buffalo | New York | 14215 | — |
| City Hosp Ctr at Elmhurst / Mount Sinai Hosp | Elmhurst | New York | 11373 | — |
| North Shore Univ Hosp | Manhasset | New York | 11030 | — |
| Beth Israel Med Ctr | New York | New York | 10003 | — |
| Bellevue Hosp / New York Univ Med Ctr | New York | New York | 10016 | — |
| Saint Clare's Hosp and Health Ctr | New York | New York | 10019 | — |
| Cornell Univ Med Ctr | New York | New York | 10021 | — |
| Mem Sloan - Kettering Cancer Ctr | New York | New York | 10021 | — |
| Mount Sinai Med Ctr / Hemophilia Treatment Ctr | New York | New York | 10029 | — |
| Mount Sinai Med Ctr | New York | New York | 10029 | — |
| Columbia Presbyterian Med Ctr | New York | New York | 100323784 | — |
| Harlem Hosp Ctr | New York | New York | 10037 | — |
| Univ of Rochester Medical Center | Rochester | New York | 14642 | — |
| SUNY / State Univ of New York | Syracuse | New York | 13210 | — |
| Bronx Municipal Hosp Ctr/Jacobi Med Ctr | The Bronx | New York | 10461 | — |
| Comprehensive Health Care Ctr / Bronx Municipal Hosp | The Bronx | New York | 10461 | — |
| Montefiore Drug Treatment Ctr / Bronx Municipal Hosp | The Bronx | New York | 10461 | — |
| Montefiore Family Health Ctr / Bronx Municipal Hosp | The Bronx | New York | 10461 | — |
| Samaritan Village Inc / Bronx Municipal Hosp | The Bronx | New York | 10461 | — |
| Jack Weiler Hosp / Bronx Municipal Hosp | The Bronx | New York | 10465 | — |
| Montefiore Med Ctr / Bronx Municipal Hosp | The Bronx | New York | 10467 | — |
| Montefiore Med Ctr Adolescent AIDS Program | The Bronx | New York | 10467 | — |
| North Central Bronx Hosp / Bronx Municipal Hosp | The Bronx | New York | 10467 | — |
| Bronx Veterans Administration / Mount Sinai Hosp | The Bronx | New York | 10468 | — |
| Univ of North Carolina | Chapel Hill | North Carolina | 275997215 | — |
| Moses H Cone Memorial Hosp | Greensboro | North Carolina | 27401 | — |
| Univ of Cincinnati | Cincinnati | Ohio | 452670405 | — |
| Univ of Kentucky Lexington | Cincinnati | Ohio | 45267 | — |
| Case Western Reserve Univ | Cleveland | Ohio | 44106 | — |
| MetroHealth Med Ctr | Cleveland | Ohio | 441091998 | — |
| Columbus Children's Hosp | Columbus | Ohio | 432052696 | — |
| Med College of Ohio | Toledo | Ohio | 43699 | — |
| Milton S Hershey Med Ctr | Hershey | Pennsylvania | 170330850 | — |
| Saint Michael's Med Ctr / Milton S Hershey Med Ctr | Hershey | Pennsylvania | 170330850 | — |
| Girard Med Ctr | Philadelphia | Pennsylvania | 191046073 | — |
| Univ of Pennsylvania at Philadelphia | Philadelphia | Pennsylvania | 19104 | — |
| Thomas Jefferson Univ Hosp | Philadelphia | Pennsylvania | 191075098 | — |
| Med Univ of South Carolina / UNC | Charleston | South Carolina | 29425 | — |
| Julio Arroyo | West Columbia | South Carolina | 29169 | — |
| Univ of Tennessee / E Tennessee Comprehensive Hemophilia Ctr | Knoxville | Tennessee | 37920 | — |
| Meharry Med College | Nashville | Tennessee | 37203 | — |
| Univ of Texas Galveston | Galveston | Texas | 775550435 | — |
| Univ Texas Health Science Ctr / Univ Texas Med School | Houston | Texas | 77030 | — |
| Univ of Washington | Seattle | Washington | 981224304 | — |
| Northern Wisconsin Hemophilia Ctr / Saint Vincent's Hosp | Green Bay | Wisconsin | 54301 | — |
| Great Lakes Hemophilia Foundation | Wauwatosa | Wisconsin | 532130127 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 1 non-U.S. site.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00000781, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Nov 3, 2021 · Synced Sep 28, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT00000781 live on ClinicalTrials.gov.