Evaluation of Patients Who Have Not Had Success With Zidovudine
Public ClinicalTrials.gov record NCT00001025. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Study to Evaluate the Short-Term Clinical and Virologic Significance of Zidovudine Resistance
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
To determine the relationship of viral susceptibility to zidovudine (AZT) and baseline viral load (as determined by plasma viremia and quantitative endpoint dilution). To determine the relationship between viral load and susceptibility during different antiretroviral therapy strategies. To correlate measures of viral load and short term clinical and laboratory markers (such as weight, CD4 count, p24 antigenemia, and beta2 microglobulin) on the different therapy arms. High-grade resistance to AZT has been detected in HIV isolates from approximately 25 percent of individuals with AIDS who received AZT for at least 1 year. To elucidate the clinical significance of in vitro AZT resistance, it is necessary to distinguish between clinical failure caused by AZT resistance and clinical decompensation caused by other factors.
Study identification
- NCT ID
- NCT00001025
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 120 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 12 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Not listed
- Primary completion
- Not listed
- Completion
- May 1995 (Actual)
- Last update posted
- Nov 1, 2021
Ends 1995
United States locations
- U.S. sites
- 18
- U.S. states
- 9
- U.S. cities
- 14
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Univ of Alabama at Birmingham | Birmingham | Alabama | 35294 | — |
| San Francisco Gen Hosp | San Francisco | California | 941102859 | — |
| Santa Clara Valley Med Ctr / AIDS Community Rsch Consortium | San Jose | California | 951282699 | — |
| San Mateo AIDS Program / Stanford Univ | Stanford | California | 943055107 | — |
| Kaiser Permanente Franklin Med Ctr | Denver | Colorado | 80262 | — |
| Univ of Colorado Health Sciences Ctr | Denver | Colorado | 80262 | — |
| Children's Mem Hosp Family Cln / Northwestern Univ Med Schl | Chicago | Illinois | 60611 | — |
| Northwestern Univ Med School | Chicago | Illinois | 60611 | — |
| Cook County Hosp | Chicago | Illinois | 60612 | — |
| Rush Presbyterian - Saint Luke's Med Ctr | Chicago | Illinois | 60612 | — |
| Baystate Med Ctr of Springfield | Springfield | Massachusetts | 01199 | — |
| Univ of Minnesota | Minneapolis | Minnesota | 55455 | — |
| Univ of Nebraska Med Ctr | Omaha | Nebraska | 681985130 | — |
| SUNY / Health Sciences Ctr at Brooklyn | Brooklyn | New York | 112032098 | — |
| SUNY / Erie County Med Ctr at Buffalo | Buffalo | New York | 14215 | — |
| Univ of Rochester Medical Center | Rochester | New York | 14642 | — |
| SUNY / State Univ of New York | Syracuse | New York | 13210 | — |
| Univ of Washington | Seattle | Washington | 981224304 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00001025, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Nov 1, 2021 · Synced Oct 26, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00001025 live on ClinicalTrials.gov.