The Effect of Acyclovir Treatment of the Herpes Simplex Virus (HSV) Infection on HIV Levels in the Blood
Public ClinicalTrials.gov record NCT00001115. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Pilot Study to Determine the Effect of Acyclovir Treatment for Herpes Simplex Virus (HSV) Infection on Peripheral Blood HIV Viral Load.
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Part A: To evaluate the impact of HSV suppression with acyclovir ( ACV ) on HIV burden in patients with asymptomatic HSV infection and at high risk for HSV reactivation. Part B: To characterize the change in plasma HIV RNA levels and other measures of HIV burden during and after a 10 day course of ACV treatment for acute HSV infection. Approximately 70% of patients infected with HIV are concurrently infected with HSV. There is new evidence to suggest that HSV may act as a co-factor in HIV disease progression. This study will attempt to determine if the upregulation of HIV RNA that occurs during symptomatic HSV reactivation also occurs during asymptomatic HSV reactivation and if suppression of HSV will result in decreased levels of HIV RNA. There is a need to determine the patterns of association between HSV and HIV.
Study identification
- NCT ID
- NCT00001115
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Not applicable
- Enrollment
- 75 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 13 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Not listed
- Primary completion
- May 31, 2005
- Completion
- May 31, 2005
- Last update posted
- Oct 30, 2016
Ends 2005
United States locations
- U.S. sites
- 15
- U.S. states
- 9
- U.S. cities
- 13
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| AIDS Research Ctr | Palo Alto | California | 94304 | — |
| Harbor-UCLA Med Ctr | Torrance | California | 90502 | — |
| Yale Univ School of Medicine / AIDS Program | New Haven | Connecticut | 06510 | — |
| North Broward Hosp District | Fort Lauderdale | Florida | 33316 | — |
| Univ of Miami / Jackson Memorial Hosp | Miami | Florida | 331361094 | — |
| Univ of Illinois - Chicago | Chicago | Illinois | 60612 | — |
| Univ of Illinois Chicago / Howard Brown Hlth Ctr | Chicago | Illinois | 60612 | — |
| Johns Hopkins Univ | Baltimore | Maryland | 21205 | — |
| SUNY Brooklyn / SUNY Health Sciences Ctr at Brooklyn | Brooklyn | New York | 11203 | — |
| Community Research Initiative on AIDS | New York | New York | 10001 | — |
| NYU - Bellevue Hosp | New York | New York | 10016 | — |
| New York Med College / Westchester County Med Ctr | Valhalla | New York | 10595 | — |
| Research and Education Group | Portland | Oregon | 97210 | — |
| Univ of Pennsylvania Med Ctr | Philadelphia | Pennsylvania | 19104 | — |
| Brown Univ / The Miriam Hosp | Providence | Rhode Island | 02906 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00001115, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 30, 2016 · Synced Sep 8, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT00001115 live on ClinicalTrials.gov.