ClinicalTrials.gov record
Fludarabine With or Without Cyclophosphamide in Treating Patients With Chronic Lymphocytic Leukemia
ClinicalTrials.gov ID: NCT00003764
Public ClinicalTrials.gov record NCT00003764. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Phase III Randomized Trial of Fludarabine and Cyclophosphamide Versus Fludarabine for Previously Untreated Chronic Lymphocytic Leukemia
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more cancer cells. It is not yet known whether combining cyclophosphamide with fludarabine is more effective than fludarabine alone in treating chronic lymphocytic leukemia. PURPOSE: Randomized phase III trial to study the effectiveness of fludarabine with or without cyclophosphamide in treating patients who have chronic lymphocytic leukemia that has not been treated previously.
Study identification
- NCT ID
- NCT00003764
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 280 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 120 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 8, 2000
- Primary completion
- Oct 31, 2005
- Completion
- Not listed
- Last update posted
- Jun 17, 2023
Started 2000
United States locations
- U.S. sites
- 215
- U.S. states
- 46
- U.S. cities
- 143
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Northeast Alabama Regional Medical Center | Anniston | Alabama | 36207 | — |
| University of Alabama at Birmingham Comprehensive Cancer Center | Birmingham | Alabama | 35294-3300 | — |
| MBCCOP - Gulf Coast | Mobile | Alabama | 36688 | — |
| CCOP - Western Regional, Arizona | Phoenix | Arizona | 85006-2726 | — |
| Veterans Affairs Medical Center - Phoenix (Carl T. Hayden) | Phoenix | Arizona | 85012 | — |
| Veterans Affairs Medical Center - Tucson | Tucson | Arizona | 85723 | — |
| Arizona Cancer Center at University of Arizona Health Sciences Center | Tucson | Arizona | 85724 | — |
| University of Arkansas for Medical Sciences | Little Rock | Arkansas | 72205 | — |
| Veterans Affairs Medical Center - Little Rock (McClellan) | Little Rock | Arkansas | 72205 | — |
| City of Hope Comprehensive Cancer Center | Duarte | California | 91010-0269 | — |
| Rebecca and John Moores UCSD Cancer Center | La Jolla | California | 92093-0658 | — |
| USC/Norris Comprehensive Cancer Center and Hospital | Los Angeles | California | 90033 | — |
| Cedars-Sinai Comprehensive Cancer Center at Cedars-Sinai Medical Center | Los Angeles | California | 90048 | — |
| Jonsson Comprehensive Cancer Center, UCLA | Los Angeles | California | 90095-1781 | — |
| Veterans Affairs Outpatient Clinic - Martinez | Martinez | California | 94553 | — |
| CCOP - Bay Area Tumor Institute | Oakland | California | 94609-3305 | — |
| Chao Family Comprehensive Cancer Center at University of California Irvine Cancer Center | Orange | California | 92868 | — |
| University of California Davis Cancer Center | Sacramento | California | 95817 | — |
| Veterans Affairs Medical Center - San Diego | San Diego | California | 92161 | — |
| Veterans Affairs Medical Center - San Francisco | San Francisco | California | 94121 | — |
| CCOP - Santa Rosa Memorial Hospital | Santa Rosa | California | 95403 | — |
| David Grant Medical Center | Travis Air Force Base | California | 94535 | — |
| University of Colorado Cancer Center at University of Colorado Health Sciences Center | Aurora | Colorado | 80010 | — |
| Medical Center of Aurora - South Campus | Aurora | Colorado | 80012-0000 | — |
| Boulder Community Hospital | Boulder | Colorado | 80301-9019 | — |
| Penrose Cancer Center | Colorado Springs | Colorado | 80933 | — |
| Porter Adventist Hospital | Denver | Colorado | 80210 | — |
| St. Joseph Hospital | Denver | Colorado | 80218-1191 | — |
| Presbyterian-St Luke's Medical Center | Denver | Colorado | 80218 | — |
| Rocky Mountain Cancer Centers - Rose | Denver | Colorado | 80220 | — |
| CCOP - Colorado Cancer Research Program, Incorporated | Denver | Colorado | 80224 | — |
| Swedish Medical Center | Englewood | Colorado | 80110 | — |
| Sky Ridge Medical Center | Lone Tree | Colorado | 80124 | — |
| Longmont United Hospital | Longmont | Colorado | 80501 | — |
| St. Mary-Corwin Regional Medical Center | Pueblo | Colorado | 81004 | — |
| Rocky Mountain Cancer Centers | Thornton | Colorado | 80260 | — |
| CCOP - Christiana Care Health Services | Newark | Delaware | 19713 | — |
| Lombardi Cancer Center at Georgetown University Medical Center | Washington D.C. | District of Columbia | 20007 | — |
| MBCCOP - Howard University Cancer Center | Washington D.C. | District of Columbia | 20060 | — |
| Walter Reed Army Medical Center | Washington D.C. | District of Columbia | 20307-5000 | — |
| Veterans Affairs Medical Center - Washington, DC | Washington D.C. | District of Columbia | 20422 | — |
| Broward General Medical Center | Fort Lauderdale | Florida | 33316 | — |
| Memorial Regional Hospital Comprehensive Cancer Center | Hollywood | Florida | 33021 | — |
| CCOP - Mount Sinai Medical Center | Miami Beach | Florida | 33140 | — |
| Florida Hospital Cancer Institute | Orlando | Florida | 32804 | — |
| H. Lee Moffitt Cancer Center and Research Institute | Tampa | Florida | 33612-9497 | — |
| Palm Beach Cancer Institute | West Palm Beach | Florida | 33401 | — |
| Winship Cancer Institute of Emory University | Atlanta | Georgia | 30322 | — |
| CCOP - Atlanta Regional | Atlanta | Georgia | 30342-1701 | — |
| Veterans Affairs Medical Center - Atlanta (Decatur) | Decatur | Georgia | 30033 | — |
| MBCCOP - Hawaii | Honolulu | Hawaii | 96813 | — |
| Veterans Affairs Medical Center - Lakeside Chicago | Chicago | Illinois | 60611-4494 | — |
| Robert H. Lurie Comprehensive Cancer Center at Northwestern University | Chicago | Illinois | 60611 | — |
| MBCCOP - University of Illinois at Chicago | Chicago | Illinois | 60612 | — |
| Veterans Affairs Medical Center - Chicago (Westside Hospital) | Chicago | Illinois | 60612 | — |
| University of Chicago Cancer Research Center | Chicago | Illinois | 60637-1470 | — |
| Louis A. Weiss Memorial Hospital | Chicago | Illinois | 60640 | — |
| CCOP - Central Illinois | Decatur | Illinois | 62526 | — |
| CCOP - Evanston | Evanston | Illinois | 60201 | — |
| Veterans Affairs Medical Center - Hines (Hines Junior VA Hospital) | Hines | Illinois | 60141 | — |
| Cardinal Bernardin Cancer Center at Loyola University Medical Center | Maywood | Illinois | 60153-5500 | — |
| CCOP - Illinois Oncology Research Association | Peoria | Illinois | 61602 | — |
| West Suburban Center for Cancer Care | River Forest | Illinois | 60305 | — |
| Saint Anthony Medical Center | Rockford | Illinois | 61108 | — |
| CCOP - Carle Cancer Center | Urbana | Illinois | 61801 | — |
| Fort Wayne Medical Oncology and Hematology, Incorporated | Fort Wayne | Indiana | 46885-5099 | — |
| CCOP - Northern Indiana CR Consortium | South Bend | Indiana | 46601 | — |
| Hematology Oncology Associates of the Quad Cities | Bettendorf | Iowa | 52722 | — |
| CCOP - Cedar Rapids Oncology Project | Cedar Rapids | Iowa | 52403-1206 | — |
| Genesis Medical Center | Davenport | Iowa | 52804 | — |
| CCOP - Iowa Oncology Research Association | Des Moines | Iowa | 50309-1016 | — |
| Holden Comprehensive Cancer Center at University of Iowa | Iowa City | Iowa | 52242-1009 | — |
| Kansas Cancer Institute at the University of Kansas Medical Center | Kansas City | Kansas | 66160-7353 | — |
| CCOP - Wichita | Wichita | Kansas | 67214-3882 | — |
| Veterans Affairs Medical Center - Wichita | Wichita | Kansas | 67218 | — |
| Veterans Affairs Medical Center - Lexington | Lexington | Kentucky | 40502-2236 | — |
| Markey Cancer Center at University of Kentucky Chandler Medical Center | Lexington | Kentucky | 40536-0084 | — |
| Baptist Hospital East - Louisville | Louisville | Kentucky | 40207 | — |
| MBCCOP - LSU Health Sciences Center | New Orleans | Louisiana | 70112 | — |
| Tulane University School of Medicine | New Orleans | Louisiana | 70112 | — |
| Veterans Affairs Medical Center - New Orleans | New Orleans | Louisiana | 70112 | — |
| CCOP - Ochsner | New Orleans | Louisiana | 70121 | — |
| Louisiana State University Health Sciences Center - Shreveport | Shreveport | Louisiana | 71130-3932 | — |
| Veterans Affairs Medical Center - Shreveport | Shreveport | Louisiana | 71130 | — |
| Marlene and Stewart Greenebaum Cancer Center, University of Maryland | Baltimore | Maryland | 21201 | — |
| Veterans Affairs Medical Center - Baltimore | Baltimore | Maryland | 21201 | — |
| Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Baltimore | Maryland | 21231 | — |
| Tufts - New England Medical Center | Boston | Massachusetts | 02111 | — |
| Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute | Boston | Massachusetts | 02115 | — |
| Cancer Research Center at Boston Medical Center | Boston | Massachusetts | 02118 | — |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | — |
| University of Massachusetts Memorial Medical Center - University Campus | Worcester | Massachusetts | 01655 | — |
| Veterans Affairs Medical Center - Ann Arbor | Ann Arbor | Michigan | 48105 | — |
| CCOP - Michigan Cancer Research Consortium | Ann Arbor | Michigan | 48106 | — |
| University of Michigan Comprehensive Cancer Center | Ann Arbor | Michigan | 48109-0912 | — |
| Barbara Ann Karmanos Cancer Institute | Detroit | Michigan | 48201-1379 | — |
| Veterans Affairs Medical Center - Detroit | Detroit | Michigan | 48201-1932 | — |
| Josephine Ford Cancer Center at Henry Ford Hospital | Detroit | Michigan | 48202 | — |
| CCOP - Grand Rapids | Grand Rapids | Michigan | 49503 | — |
| CCOP - Kalamazoo | Kalamazoo | Michigan | 49007-3731 | — |
| CCOP - Beaumont | Royal Oak | Michigan | 48073-6769 | — |
| Lakeland Cancer Care Center at Lakeland Hospital - St. Joseph | Saint Joseph | Michigan | 49085 | — |
| Providence Cancer Institute at Providence Hospital | Southfield | Michigan | 48075 | — |
| Veterans Affairs Medical Center - Minneapolis | Minneapolis | Minnesota | 55417 | — |
| University of Minnesota Cancer Center | Minneapolis | Minnesota | 55455 | — |
| Mayo Clinic Cancer Center | Rochester | Minnesota | 55905 | — |
| CCOP - Metro-Minnesota | Saint Louis Park | Minnesota | 55416 | — |
| Veterans Affairs Medical Center - Biloxi | Biloxi | Mississippi | 39531-2410 | — |
| University of Mississippi Medical Center | Jackson | Mississippi | 39216-4505 | — |
| Veterans Affairs Medical Center - Jackson | Jackson | Mississippi | 39216 | — |
| Veterans Affairs Medical Center - Columbia (Truman Memorial) | Columbia | Missouri | 65201 | — |
| Ellis Fischel Cancer Center at University of Missouri - Columbia | Columbia | Missouri | 65203 | — |
| Veterans Affairs Medical Center - Kansas City | Kansas City | Missouri | 64128 | — |
| CCOP - Kansas City | Kansas City | Missouri | 64131 | — |
| CCOP - Cancer Research for the Ozarks | Springfield | Missouri | 65807 | — |
| Barnes-Jewish Hospital | St Louis | Missouri | 63110 | — |
| St. Louis University Hospital Cancer Center | St Louis | Missouri | 63110 | — |
| Missouri Baptist Cancer Center | St Louis | Missouri | 63131 | — |
| CCOP - St. Louis-Cape Girardeau | St Louis | Missouri | 63141 | — |
| CCOP - Montana Cancer Consortium | Billings | Montana | 59101 | — |
| UNMC Eppley Cancer Center at the University of Nebraska Medical Center | Omaha | Nebraska | 68198-7680 | — |
| CCOP - Southern Nevada Cancer Research Foundation | Las Vegas | Nevada | 89106 | — |
| Veterans Affairs Medical Center - Las Vegas | Las Vegas | Nevada | 89106 | — |
| Norris Cotton Cancer Center at Dartmouth Medical School | Lebanon | New Hampshire | 03756-0002 | — |
| Cooper University Hospital | Camden | New Jersey | 08103 | — |
| Veterans Affairs Medical Center - East Orange | East Orange | New Jersey | 07019 | — |
| Cancer Institute of New Jersey | New Brunswick | New Jersey | 08903 | — |
| Veterans Affairs Medical Center - Albuquerque | Albuquerque | New Mexico | 87108-5138 | — |
| MBCCOP - University of New Mexico HSC | Albuquerque | New Mexico | 87131 | — |
| Veterans Affairs Medical Center - Albany | Albany | New York | 12208 | — |
| Veterans Affairs Medical Center - Buffalo | Buffalo | New York | 14215 | — |
| Elmhurst Hospital Center | Elmhurst | New York | 11373 | — |
| Queens Cancer Center of Queens Hospital | Jamaica | New York | 11432 | — |
| CCOP - North Shore University Hospital | Manhasset | New York | 11030 | — |
| North Shore University Hospital | Manhasset | New York | 11030 | — |
| Memorial Sloan-Kettering Cancer Center | New York | New York | 10021 | — |
| New York Weill Cornell Cancer Center at Cornell University | New York | New York | 10021 | — |
| Mount Sinai Medical Center, NY | New York | New York | 10029 | — |
| Herbert Irving Comprehensive Cancer Center at Columbia University | New York | New York | 10032 | — |
| James P. Wilmot Cancer Center at University of Rochester Medical Center | Rochester | New York | 14642 | — |
| University Hospital at State University of New York - Upstate Medical University | Syracuse | New York | 13210 | — |
| Veterans Affairs Medical Center - Syracuse | Syracuse | New York | 13210 | — |
| CCOP - Syracuse Hematology-Oncology Associates of Central New York, P.C. | Syracuse | New York | 13217 | — |
| Albert Einstein Clinical Cancer Center | The Bronx | New York | 10461 | — |
| Veterans Affairs Medical Center - Asheville | Asheville | North Carolina | 28805 | — |
| Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill | Chapel Hill | North Carolina | 27599-7295 | — |
| NorthEast Oncology Associates | Concord | North Carolina | 28025 | — |
| Veterans Affairs Medical Center - Durham | Durham | North Carolina | 27705 | — |
| Duke Comprehensive Cancer Center | Durham | North Carolina | 27710 | — |
| Cape Fear Valley Health System | Fayetteville | North Carolina | 28302-2000 | — |
| Lenoir Memorial Hospital Cancer Center | Kinston | North Carolina | 28503-1678 | — |
| FirstHealth Moore Regional Hospital | Pinehurst | North Carolina | 28374 | — |
| New Hanover Regional Medical Center | Wilmington | North Carolina | 28402-9025 | — |
| CCOP - Southeast Cancer Control Consortium | Winston-Salem | North Carolina | 27104-4241 | — |
| Comprehensive Cancer Center at Wake Forest University | Winston-Salem | North Carolina | 27157-1082 | — |
| Veterans Affairs Medical Center - Fargo | Fargo | North Dakota | 58102 | — |
| CCOP - Merit Care Hospital | Fargo | North Dakota | 58122 | — |
| Veterans Affairs Medical Center - Cincinnati | Cincinnati | Ohio | 45220-2288 | — |
| Charles M. Barrett Cancer Center at University Hospital | Cincinnati | Ohio | 45267-0501 | — |
| MetroHealth Medical Center | Cleveland | Ohio | 44109 | — |
| Cleveland Clinic Taussig Cancer Center | Cleveland | Ohio | 44195-9001 | — |
| CCOP - Columbus | Columbus | Ohio | 43206 | — |
| Arthur G. James Cancer Hospital - Ohio State University | Columbus | Ohio | 43210-1240 | — |
| Veterans Affairs Medical Center - Dayton | Dayton | Ohio | 45428-1002 | — |
| CCOP - Dayton | Dayton | Ohio | 45429 | — |
| Oklahoma University Medical Center at University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | 73104 | — |
| Veterans Affairs Medical Center - Oklahoma City | Oklahoma City | Oklahoma | 73104 | — |
| Cancer Institute at Oregon Health and Science University | Portland | Oregon | 97201-3098 | — |
| Veterans Affairs Medical Center - Portland | Portland | Oregon | 97207 | — |
| CCOP - Columbia River Oncology Program | Portland | Oregon | 97225 | — |
| CCOP - Geisinger Clinic and Medical Center | Danville | Pennsylvania | 17822-2001 | — |
| Penn State Cancer Institute at Milton S. Hershey Medical Center | Hershey | Pennsylvania | 17033-0850 | — |
| Western Pennsylvania Hospital | Pittsburgh | Pennsylvania | 15224 | — |
| Hillman Cancer Center at University of Pittsburgh Cancer Institute | Pittsburgh | Pennsylvania | 15236 | — |
| CCOP - MainLine Health | Wynnewood | Pennsylvania | 19096 | — |
| Lifespan: The Miriam Hospital | Providence | Rhode Island | 02906 | — |
| Veterans Affairs Medical Center - Charleston | Charleston | South Carolina | 29401-5799 | — |
| Hollings Cancer Center at Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| CCOP - Greenville | Greenville | South Carolina | 29615 | — |
| CCOP - Upstate Carolina | Spartanburg | South Carolina | 29303 | — |
| CCOP - Sioux Community Cancer Consortium | Sioux Falls | South Dakota | 57104 | — |
| University of Tennessee Cancer Institute | Memphis | Tennessee | 38103 | — |
| Danville Radiation Therapy Center | Memphis | Tennessee | 38104 | — |
| Harrington Cancer Center | Amarillo | Texas | 79106 | — |
| Veterans Affairs Medical Center - Amarillo | Amarillo | Texas | 79106 | — |
| Veterans Affairs Medical Center - Dallas | Dallas | Texas | 75216 | — |
| Medical City Dallas Hospital | Dallas | Texas | 75230 | — |
| Simmons Cancer Center at University of Texas Southwestern Medical Center - Dallas | Dallas | Texas | 75390 | — |
| Brooke Army Medical Center | Fort Sam Houston | Texas | 78234-6200 | — |
| University of Texas Medical Branch | Galveston | Texas | 77555-0565 | — |
| University of Texas - MD Anderson Cancer Center | Houston | Texas | 77030-4095 | — |
| Veterans Affairs Medical Center - Houston | Houston | Texas | 77030 | — |
| University of Texas Health Science Center at San Antonio | San Antonio | Texas | 78229-3900 | — |
| Veterans Affairs Medical Center - San Antonio (Murphy) | San Antonio | Texas | 78229 | — |
| Veterans Affairs Medical Center - Temple | Temple | Texas | 76504 | — |
| CCOP - Scott and White Hospital | Temple | Texas | 76508 | — |
| Huntsman Cancer Institute | Salt Lake City | Utah | 84112-5550 | — |
| Veterans Affairs Medical Center - Salt Lake City | Salt Lake City | Utah | 84148 | — |
| Green Mountain Oncology Group | Bennington | Vermont | 05201 | — |
| Vermont Cancer Center at University of Vermont | Burlington | Vermont | 05401-3498 | — |
| Veterans Affairs Medical Center - White River Junction | White River Junction | Vermont | 05009 | — |
| Martha Jefferson Hospital | Charlottesville | Virginia | 22902 | — |
| Virginia Oncology Associates - Norfolk | Norfolk | Virginia | 23502 | — |
| MBCCOP - Massey Cancer Center | Richmond | Virginia | 23298-0037 | — |
| Oncology and Hematology Associates of Southwest Virginia, Inc. | Roanoke | Virginia | 24014 | — |
| CCOP - Virginia Mason Research Center | Seattle | Washington | 98101 | — |
| Veterans Affairs Medical Center - Seattle | Seattle | Washington | 98108 | — |
| Puget Sound Oncology Consortium | Seattle | Washington | 98109 | — |
| CCOP - Northwest | Tacoma | Washington | 98405-0986 | — |
| Madigan Army Medical Center | Tacoma | Washington | 98431-5000 | — |
| St. Mary's Medical Center | Huntington | West Virginia | 25701 | — |
| CCOP - St. Vincent Hospital Cancer Center, Green Bay | Green Bay | Wisconsin | 54307-3453 | — |
| University of Wisconsin Comprehensive Cancer Center | Madison | Wisconsin | 53792-0001 | — |
| CCOP - Marshfield Clinic Research Foundation | Marshfield | Wisconsin | 54449 | — |
| Ministry Medical Group - Northern Region | Rhinelander | Wisconsin | 54501 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 3 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00003764, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 17, 2023 · Synced Sep 27, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT00003764 live on ClinicalTrials.gov.