Chemotherapy Plus Monoclonal Antibody Therapy in Treating Women With Stage II or Stage IIIA Breast Cancer That Overexpresses HER2
Public ClinicalTrials.gov record NCT00003992. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Pilot Trial of Paclitaxel-Herceptin Adjuvant Therapy for Early Stage Breast Cancer
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Randomized phase II trial to study the effectiveness of chemotherapy with paclitaxel and the monoclonal antibody trastuzumab followed by chemotherapy in treating women who have stage II or stage IIIA breast cancer that overexpresses HER2. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Monoclonal antibodies can locate tumor cells and deliver tumor-killing substances to them without harming normal cells. Combining monoclonal antibody therapy with chemotherapy may kill more tumor cells.
Study identification
- NCT ID
- NCT00003992
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 200 participants
Conditions and interventions
Conditions
Interventions
- trastuzumab Biological
- cyclophosphamide Drug
- doxorubicin hydrochloride Drug
- paclitaxel Drug
- tamoxifen citrate Drug
Biological · Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- Female
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 1999 (Type not available)
- Primary completion
- Jan 2007 (Actual)
- Completion
- Mar 2009 (Actual)
- Last update posted
- Jun 3, 2013
1999 – 2009
United States locations
- U.S. sites
- 44
- U.S. states
- 22
- U.S. cities
- 38
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Veterans Affairs Medical Center - Palo Alto | Palo Alto | California | 94304 | — |
| Stanford University Medical Center | Stanford | California | 94305-5408 | — |
| CCOP - Colorado Cancer Research Program, Inc. | Denver | Colorado | 80209-5031 | — |
| H. Lee Moffitt Cancer Center and Research Institute | Tampa | Florida | 33612 | — |
| Emory University Hospital - Atlanta | Atlanta | Georgia | 30322 | — |
| Veterans Affairs Medical Center - Atlanta (Decatur) | Decatur | Georgia | 30033 | — |
| Robert H. Lurie Comprehensive Cancer Center, Northwestern University | Chicago | Illinois | 60611 | — |
| Veterans Affairs Medical Center - Chicago (Lakeside) | Chicago | Illinois | 60611 | — |
| CCOP - Central Illinois | Decatur | Illinois | 62526 | — |
| CCOP - Evanston | Evanston | Illinois | 60201 | — |
| CCOP - Illinois Oncology Research Association | Peoria | Illinois | 61602 | — |
| CCOP - Carle Cancer Center | Urbana | Illinois | 61801 | — |
| Veterans Affairs Medical Center - Indianapolis (Roudebush) | Indianapolis | Indiana | 46202 | — |
| CCOP - Cedar Rapids Oncology Project | Cedar Rapids | Iowa | 52403-1206 | — |
| CCOP - Wichita | Wichita | Kansas | 67214-3882 | — |
| CCOP - Ochsner | New Orleans | Louisiana | 70121 | — |
| Johns Hopkins Oncology Center | Baltimore | Maryland | 21231 | — |
| New England Medical Center Hospital | Boston | Massachusetts | 02111 | — |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | — |
| CCOP - Ann Arbor Regional | Ann Arbor | Michigan | 48106 | — |
| CCOP - Kalamazoo | Kalamazoo | Michigan | 49007-3731 | — |
| Mayo Clinic Cancer Center | Rochester | Minnesota | 55905 | — |
| CCOP - Metro-Minnesota | Saint Louis Park | Minnesota | 55416 | — |
| CCOP - Missouri Valley Cancer Consortium | Omaha | Nebraska | 68131 | — |
| Trinitas Hospital - Jersey Street Campus | Elizabeth | New Jersey | 07201 | — |
| Hunterdon Regional Cancer Program | Flemington | New Jersey | 08822 | — |
| CCOP - Northern New Jersey | Hackensack | New Jersey | 07601 | — |
| Hackensack University Medical Center | Hackensack | New Jersey | 07601 | — |
| Morristown Memorial Hospital | Morristown | New Jersey | 07962-1956 | — |
| Veterans Affairs Medical Center - Albany | Albany | New York | 12208 | — |
| Veterans Affairs Medical Center - New York | New York | New York | 10010 | — |
| Kaplan Cancer Center | New York | New York | 10016 | — |
| University of Rochester Cancer Center | Rochester | New York | 14642 | — |
| Albert Einstein Comprehensive Cancer Center | The Bronx | New York | 10461 | — |
| CCOP - Merit Care Hospital | Fargo | North Dakota | 58122 | — |
| Ireland Cancer Center | Cleveland | Ohio | 44106-5065 | — |
| CCOP - Sooner State | Tulsa | Oklahoma | 74136 | — |
| University of Pennsylvania Cancer Center | Philadelphia | Pennsylvania | 19104 | — |
| CCOP - MainLine Health | Wynnewood | Pennsylvania | 19096 | — |
| Vanderbilt Cancer Center | Nashville | Tennessee | 37232-6838 | — |
| Veterans Affairs Medical Center - Madison | Madison | Wisconsin | 53705 | — |
| University of Wisconsin Comprehensive Cancer Center | Madison | Wisconsin | 53792 | — |
| Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
| Veterans Affairs Medical Center - Milwaukee (Zablocki) | Milwaukee | Wisconsin | 53295 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 1 non-U.S. site.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00003992, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 3, 2013 · Synced Nov 1, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00003992 live on ClinicalTrials.gov.