Hormone Therapy Plus Radiation Therapy With or Without Combination Chemotherapy in Treating Patients With Prostate Cancer
Public ClinicalTrials.gov record NCT00004054. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase III Protocol of Androgen Suppression (AS) and Radiation Therapy (RT) vs AS and RT Followed by Chemotherapy With Paclitaxel, Estramustine, and Etoposide (TEE) for Localized, High-Risk, Prostate Cancer
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
RATIONALE: Hormones can stimulate the production of prostate cancer cells. Hormone therapy may fight prostate cancer by reducing the production of androgens. Radiation therapy uses high-energy x-rays to damage tumor cells. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. It is not yet known whether hormone therapy plus radiation therapy is more effective with or without combination chemotherapy for prostate cancer. PURPOSE: Randomized phase III trial to compare the effectiveness of hormone therapy plus radiation therapy with or without combination chemotherapy in treating patients who have prostate cancer.
Study identification
- NCT ID
- NCT00004054
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 397 participants
Conditions and interventions
Conditions
Interventions
- bicalutamide Drug
- estramustine phosphate sodium Drug
- etoposide Drug
- flutamide Drug
- paclitaxel Drug
- Luteinizing hormone releasing hormone [LHRH] agonist Drug
- Radiation therapy Radiation
- warfarin Drug
Drug · Radiation
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- Male
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 2000 (Type not available)
- Primary completion
- Apr 2010 (Actual)
- Completion
- Nov 2013 (Actual)
- Last update posted
- Oct 22, 2020
2000 – 2013
United States locations
- U.S. sites
- 52
- U.S. states
- 22
- U.S. cities
- 46
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham Comprehensive Cancer Center | Birmingham | Alabama | 35294-3300 | — |
| Foundation for Cancer Research and Education | Phoenix | Arizona | 85013 | — |
| Mount Diablo Medical Center | Concord | California | 94524-4110 | — |
| Sutter Health Western Division Cancer Research Group | Greenbrae | California | 94904 | — |
| CCOP - Santa Rosa Memorial Hospital | Santa Rosa | California | 95403 | — |
| University of Colorado Cancer Center at University of Colorado Health Sciences Center | Denver | Colorado | 80010 | — |
| Baptist Hospital of Miami | Miami | Florida | 33176-2197 | — |
| Lutheran General Cancer Care Center | Park Ridge | Illinois | 60068 | — |
| Methodist Cancer Center at Methodist Hospital | Indianapolis | Indiana | 46206-1367 | — |
| Ball Memorial Hospital Cancer Center | Muncie | Indiana | 47303-3499 | — |
| Markey Cancer Center at University of Kentucky Chandler Medical Center | Lexington | Kentucky | 40536-0293 | — |
| Mary Bird Perkins Cancer Center | Baton Rouge | Louisiana | 70809 | — |
| CCOP - Ochsner | New Orleans | Louisiana | 70121 | — |
| Anne Arundel Oncology Center | Annapolis | Maryland | 21401 | — |
| Greater Baltimore Medical Center and Cancer Center | Baltimore | Maryland | 21204 | — |
| University of Michigan Comprehensive Cancer Center | Ann Arbor | Michigan | 48109-0010 | — |
| West Michigan Cancer Center | Kalamazoo | Michigan | 49007 | — |
| Marquette General Hospital | Marquette | Michigan | 49855 | — |
| CCOP - Metro-Minnesota | Saint Louis Park | Minnesota | 55416 | — |
| Ellis Fischel Cancer Center at University of Missouri - Columbia | Columbia | Missouri | 65203 | — |
| CCOP - Southern Nevada Cancer Research Foundation | Las Vegas | Nevada | 89106 | — |
| Veterans Affairs Medical Center - East Orange | East Orange | New Jersey | 07019 | — |
| Monmouth Medical Center | Long Branch | New Jersey | 07740-6395 | — |
| South Jersey Regional Cancer Center | Millville | New Jersey | 08332 | — |
| Atlantic City Medical Center | Pomona | New Jersey | 08240 | — |
| Fox Chase Cancer Center at St. Francis Medical Center | Trenton | New Jersey | 08629 | — |
| CCOP - North Shore University Hospital | Manhasset | New York | 11030 | — |
| Herbert Irving Comprehensive Cancer Center at Columbia University | New York | New York | 10032 | — |
| Akron General Medical Center | Akron | Ohio | 44302 | — |
| Akron City Hospital | Akron | Ohio | 44304 | — |
| CCOP - Columbus | Columbus | Ohio | 43206 | — |
| Arthur G. James Cancer Hospital - Ohio State University | Columbus | Ohio | 43210-1240 | — |
| CCOP - Dayton | Dayton | Ohio | 45429 | — |
| CCOP - Toledo Community Hospital | Toledo | Ohio | 43623-3456 | — |
| John and Dorothy Morgan Cancer Center at Lehigh Valley Hospital | Allentown | Pennsylvania | 18105 | — |
| St. Luke's Hospital Cancer Center | Bethlehem | Pennsylvania | 18015 | — |
| Delaware County Memorial Hospital | Drexel Hill | Pennsylvania | 19026 | — |
| Kimmel Cancer Center at Thomas Jefferson University - Philadelphia | Philadelphia | Pennsylvania | 19107-5541 | — |
| Fox Chase Cancer Center | Philadelphia | Pennsylvania | 19111 | — |
| Albert Einstein Cancer Center | Philadelphia | Pennsylvania | 19141-3098 | — |
| CCOP - MainLine Health | Wynnewood | Pennsylvania | 19096 | — |
| Wellspan Health - York Cancer Center | York | Pennsylvania | 17403 | — |
| University of Texas - MD Anderson Cancer Center | Houston | Texas | 77030-4009 | — |
| LDS Hospital | Salt Lake City | Utah | 84143 | — |
| Dixie Regional Medical Center | St. George | Utah | 84770 | — |
| University Cancer Center at University of Washington Medical Center | Seattle | Washington | 98195-6043 | — |
| CCOP - St. Vincent Hospital Cancer Center, Green Bay | Green Bay | Wisconsin | 54301 | — |
| St. Vincent Hospital | Green Bay | Wisconsin | 54307-3508 | — |
| Gundersen Lutheran Cancer Center at Gundersen Lutheran Medical Center | La Crosse | Wisconsin | 54601 | — |
| St. Luke's Medical Center | Milwaukee | Wisconsin | 53215 | — |
| Medical College of Wisconsin Cancer Center | Milwaukee | Wisconsin | 53226 | — |
| All Saints Cancer Center at All Saints Healthcare | Racine | Wisconsin | 53405 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 2 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00004054, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 22, 2020 · Synced Oct 20, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00004054 live on ClinicalTrials.gov.