ClinicalTrials.gov record
Doxorubicin and Cyclophosphamide Plus Paclitaxel With or Without Trastuzumab in Treating Women With Node-Positive Breast Cancer That Overexpresses HER2
ClinicalTrials.gov ID: NCT00004067
Public ClinicalTrials.gov record NCT00004067. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized Trial Comparing the Safety and Efficacy of Adriamycin and Cyclophosphamide Followed by Taxol (AC-T) to That of Adriamycin and Cyclophosphamide Followed by Taxol Plus Herceptin (AC-T+H) in Node-Positive Breast Cancer Patients Who Have Tumors That Overexpress HER2
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
RATIONALE: Drugs used in chemotherapy, such as doxorubicin, cyclophosphamide, and paclitaxel, use different ways to stop tumor cells from dividing so they stop growing or die. Monoclonal antibodies such as trastuzumab can locate tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells. It is not yet known whether combination chemotherapy plus trastuzumab is more effective than combination chemotherapy alone for treating breast cancer. PURPOSE: This randomized phase III trial is studying how well giving combination chemotherapy together with trastuzumab works compared to combination chemotherapy alone in treating women with node-positive stage II or stage IIIA breast cancer that overexpresses HER2.
Study identification
- NCT ID
- NCT00004067
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 2,130 participants
Conditions and interventions
Conditions
Interventions
- herceptin Biological
- adriamycin Drug
- cyclophosphamide Drug
- taxol Drug
Biological · Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- Female
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 2000 (Type not available)
- Primary completion
- Mar 2005 (Actual)
- Completion
- Nov 2019 (Actual)
- Last update posted
- Apr 29, 2021
2000 – 2019
United States locations
- U.S. sites
- 141
- U.S. states
- 45
- U.S. cities
- 122
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Comprehensive Cancer Institute | Huntsville | Alabama | 35801 | — |
| Providence Alaska Medical Center | Anchorage | Alaska | 99519-6604 | — |
| CCOP - Western Regional, Arizona | Phoenix | Arizona | 85006-2726 | — |
| City of Hope Comprehensive Cancer Center | Duarte | California | 91010-3000 | — |
| Sutter Health Western Division Cancer Research Group | Greenbrae | California | 94904 | — |
| Scripps Cancer Center at Scripps Clinic | La Jolla | California | 92037 | — |
| Loma Linda University Cancer Institute at Loma Linda University Medical Center | Loma Linda | California | 92354 | — |
| Pacific Shores Medical Group Comprehensive Hematology-Oncology Services - Long Beach | Long Beach | California | 90813 | — |
| CCOP - Bay Area Tumor Institute | Oakland | California | 94609-3305 | — |
| Chao Family Comprehensive Cancer Center at University of California Irvine Medical Center | Orange | California | 92868 | — |
| Comprehensive Cancer Center at Desert Regional Medical Center | Palm Springs | California | 92262 | — |
| Sutter Cancer Center | Sacramento | California | 95816 | — |
| Kaiser Permanente Medical Center/Kaiser Foundation Hospital - San Diego | San Diego | California | 92120 | — |
| CCOP - Santa Rosa Memorial Hospital | Santa Rosa | California | 95403 | — |
| Kaiser Permanente Medical Center - Vallejo | Vallejo | California | 94589 | — |
| University of Colorado Cancer Center at University of Colorado Health Sciences Center | Denver | Colorado | 80010 | — |
| CCOP - Colorado Cancer Research Program, Incorporated | Denver | Colorado | 80209-5031 | — |
| Carole and Ray Neag Comprehensive Cancer Center at the University of Connecticut Health Center | Farmington | Connecticut | 06360-7106 | — |
| Helen and Harry Gray Cancer Center at Hartford Hospital | Hartford | Connecticut | 06102-5037 | — |
| CCOP - Christiana Care Health Services | Wilmington | Delaware | 19899 | — |
| Morton Plant Hospital | Clearwater | Florida | 33756 | — |
| Halifax Medical Center | Daytona Beach | Florida | 32114 | — |
| Baptist Cancer Institute - Jacksonville | Jacksonville | Florida | 32207 | — |
| University of Miami Sylvester Comprehensive Cancer Center | Miami | Florida | 33136 | — |
| CCOP - Mount Sinai Medical Center | Miami Beach | Florida | 33140 | — |
| M.D. Anderson Cancer Center - Orlando | Orlando | Florida | 32806 | — |
| Cancer Research Network, Inc. | Plantation | Florida | 33324 | — |
| Florida Cancer Specialists | Sarasota | Florida | 34236 | — |
| Phoebe Cancer Center at Phoebe Putney Memorial Hospital | Albany | Georgia | 31701 | — |
| Winship Cancer Institute of Emory University | Atlanta | Georgia | 30322 | — |
| CCOP - Atlanta Regional | Atlanta | Georgia | 30342-1701 | — |
| MBCCOP-Medical College of Georgia Cancer Center | Augusta | Georgia | 30912-4000 | — |
| Dwight David Eisenhower Army Medical Center | Fort Gordon | Georgia | 30905-5650 | — |
| Cancer Research Center of Hawaii | Honolulu | Hawaii | 96813 | — |
| North Idaho Cancer Center | Coeur d'Alene | Idaho | 83814 | — |
| John H. Stroger, Jr. Hospital of Cook County | Chicago | Illinois | 60612-9985 | — |
| Rush Cancer Institute at Rush University Medical Center | Chicago | Illinois | 60612 | — |
| Creticos Cancer Center at Advocate Illinois Masonic Medical Center | Chicago | Illinois | 60657 | — |
| CCOP - Central Illinois | Decatur | Illinois | 62526 | — |
| CCOP - Evanston | Evanston | Illinois | 60201 | — |
| West Suburban Hospital Medical Center | Oak Park | Illinois | 60302 | — |
| CCOP - Illinois Oncology Research Association | Peoria | Illinois | 61602 | — |
| CCOP - Carle Cancer Center | Urbana | Illinois | 61801 | — |
| Methodist Cancer Center at Methodist Hospital | Indianapolis | Indiana | 46206-1367 | — |
| Community Hospital | Munster | Indiana | 46321 | — |
| CCOP - Northern Indiana CR Consortium | South Bend | Indiana | 46601 | — |
| Genesis Regional Cancer Center at Genesis Medical Center | Davenport | Iowa | 52803 | — |
| CCOP - Iowa Oncology Research Association | Des Moines | Iowa | 50309-1016 | — |
| Holden Comprehensive Cancer Center at University of Iowa | Iowa City | Iowa | 52242-1009 | — |
| CCOP - Wichita | Wichita | Kansas | 67214-3882 | — |
| Markey Cancer Center at University of Kentucky Chandler Medical Center | Lexington | Kentucky | 40536-0093 | — |
| Norton Cancer Center at Norton Hospital | Louisville | Kentucky | 40202-5070 | — |
| Consultants in Blood Disorders and Cancer | Louisville | Kentucky | 40207 | — |
| Stanley S. Scott Cancer Center at Louisiana State University Medical Center - New Orleans | New Orleans | Louisiana | 70112 | — |
| Tulane Cancer Center at Tulane University Hospital and Clinic | New Orleans | Louisiana | 70112 | — |
| CCOP - Ochsner | New Orleans | Louisiana | 70121 | — |
| CancerCare of Maine at Eastern Maine Medial Center | Bangor | Maine | 04401 | — |
| Harry and Jeanette Weinberg Cancer Institute at Franklin Square Hospital Center | Baltimore | Maryland | 21237 | — |
| National Naval Medical Center | Bethesda | Maryland | 20889-5000 | — |
| Cancer Research Center at Boston Medical Center | Boston | Massachusetts | 02118 | — |
| Berkshire Medical Center | Pittsfield | Massachusetts | 01201 | — |
| Baystate Regional Cancer Program at D'Amour Center for Cancer Care | Springfield | Massachusetts | 01199 | — |
| UMASS Memorial Cancer Center - University Campus | Worcester | Massachusetts | 01655 | — |
| CCOP - Michigan Cancer Research Consortium | Ann Arbor | Michigan | 48106 | — |
| Josephine Ford Cancer Center at Henry Ford Health System | Detroit | Michigan | 48202 | — |
| Michigan State University | East Lansing | Michigan | 48824 | — |
| CCOP - Grand Rapids | Grand Rapids | Michigan | 49503 | — |
| CCOP - Kalamazoo | Kalamazoo | Michigan | 49007-3731 | — |
| William Beaumont Hospital - Royal Oak | Royal Oak | Michigan | 48073 | — |
| Providence Cancer Institute at Providence Hospital - Southfield Campus | Southfield | Michigan | 48075-9975 | — |
| CCOP - Duluth | Duluth | Minnesota | 55805 | — |
| Hennepin County Medical Center - Minneapolis | Minneapolis | Minnesota | 55415 | — |
| CCOP - Metro-Minnesota | Saint Louis Park | Minnesota | 55416 | — |
| Ellis Fischel Cancer Center at University of Missouri - Columbia | Columbia | Missouri | 65203 | — |
| CCOP - Kansas City | Kansas City | Missouri | 64131 | — |
| CCOP - Cancer Research for the Ozarks | Springfield | Missouri | 65807 | — |
| Saint Louis University Cancer Center | St Louis | Missouri | 63110-0250 | — |
| Missouri Baptist Cancer Center | St Louis | Missouri | 63131 | — |
| CCOP - St. Louis-Cape Girardeau | St Louis | Missouri | 63141 | — |
| CCOP - Montana Cancer Consortium | Billings | Montana | 59101 | — |
| Methodist Hospital Cancer Center at Nebraska Methodist Hospital - Omaha | Omaha | Nebraska | 68114 | — |
| CCOP - Missouri Valley Cancer Consortium | Omaha | Nebraska | 68131 | — |
| CCOP - Southern Nevada Cancer Research Foundation | Las Vegas | Nevada | 89106 | — |
| CCOP - Northern New Jersey | Hackensack | New Jersey | 07601 | — |
| Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School | New Brunswick | New Jersey | 08903 | — |
| Newark Beth Israel Medical Center | Newark | New Jersey | 07112 | — |
| University of New Mexico Cancer Research and Treatment Center | Albuquerque | New Mexico | 87131 | — |
| New York Oncology Hematology, P.C. at Albany Regional Cancer Care | Albany | New York | 12208 | — |
| Charles R. Wood Cancer Center at Glens Falls Hospital | Glens Falls | New York | 12801 | — |
| Nalitt Cancer Institute at Staten Island University Hospital | Staten Island | New York | 10305 | — |
| CCOP - Syracuse Hematology-Oncology Associates of Central New York, P.C. | Syracuse | New York | 13217 | — |
| Lincoln Medical and Mental Health Center | The Bronx | New York | 10451 | — |
| MBCCOP-Our Lady of Mercy Cancer Center | The Bronx | New York | 10466 | — |
| Alamance Cancer Center | Burlington | North Carolina | 27216 | — |
| Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill | Chapel Hill | North Carolina | 27599-7295 | — |
| Leo W. Jenkins Cancer Center at Pitt County Memorial Hospital | Greenville | North Carolina | 27858-4354 | — |
| CCOP - Southeast Cancer Control Consortium | Winston-Salem | North Carolina | 27104-4241 | — |
| Comprehensive Cancer Center at Wake Forest University | Winston-Salem | North Carolina | 27157-1082 | — |
| CCOP - Merit Care Hospital | Fargo | North Dakota | 58122 | — |
| Akron City Hospital at Summa Health System | Akron | Ohio | 44309 | — |
| Aultman Hospital Cancer Center at Aultman Health Foundation | Canton | Ohio | 44710 | — |
| Cancer Center at Jewish Hospital | Cincinnati | Ohio | 45236 | — |
| Charles M. Barrett Cancer Center at University Hospital | Cincinnati | Ohio | 45267-0502 | — |
| Ireland Cancer Center at University Hospitals of Cleveland and Case Western Reserve University | Cleveland | Ohio | 44106-5065 | — |
| South Pointe Hospital Cancer Care Center | Cleveland | Ohio | 44122 | — |
| CCOP - Columbus | Columbus | Ohio | 43206 | — |
| Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University | Columbus | Ohio | 43210-1240 | — |
| CCOP - Dayton | Kettering | Ohio | 45429 | — |
| Cancer Care Center at Northside Medical Center | Youngstown | Ohio | 44501 | — |
| CCOP - Oklahoma | Tulsa | Oklahoma | 74136 | — |
| CCOP - Columbia River Oncology Program | Portland | Oregon | 97213 | — |
| John and Dorothy Morgan Cancer Center at Lehigh Valley Hospital | Allentown | Pennsylvania | 18103 | — |
| Geisinger Medical Center | Danville | Pennsylvania | 17822-2001 | — |
| Kimmel Cancer Center at Thomas Jefferson University - Philadelphia | Philadelphia | Pennsylvania | 19107-5541 | — |
| Albert Einstein Cancer Center | Philadelphia | Pennsylvania | 19141 | — |
| Allegheny General Hospital | Pittsburgh | Pennsylvania | 15212-4772 | — |
| Hillman Cancer Center at University of Pittsburgh Cancer Institute | Pittsburgh | Pennsylvania | 15213-3489 | — |
| Mercy Hospital Cancer Center - Scranton | Scranton | Pennsylvania | 18501 | — |
| York Cancer Center at Wellspan Health | York | Pennsylvania | 17315 | — |
| Kent County Memorial Hospital | Warwick | Rhode Island | 02886 | — |
| CCOP - Greenville | Greenville | South Carolina | 29615 | — |
| CCOP - Upstate Carolina | Spartanburg | South Carolina | 29303 | — |
| CCOP - Sioux Community Cancer Consortium | Sioux Falls | South Dakota | 57104 | — |
| Medical City Dallas Hospital | Dallas | Texas | 75230 | — |
| Baylor College of Medicine | Houston | Texas | 77030 | — |
| Joe Arrington Cancer Research and Treatment Center | Lubbock | Texas | 79410-1894 | — |
| University of Texas Health Science Center at San Antonio | San Antonio | Texas | 78284-7811 | — |
| CCOP - Scott and White Hospital | Temple | Texas | 76508 | — |
| Utah Valley Regional Medical Center - Provo | Provo | Utah | 84604 | — |
| Vermont Cancer Center at University of Vermont | Burlington | Vermont | 05405-0075 | — |
| Sentara Cancer Institute at Sentara Norfolk General Hospital | Norfolk | Virginia | 23507 | — |
| MBCCOP - Massey Cancer Center | Richmond | Virginia | 23298-0037 | — |
| CCOP - Virginia Mason Research Center | Seattle | Washington | 98101 | — |
| Puget Sound Oncology Consortium | Seattle | Washington | 98109 | — |
| CCOP - Northwest | Tacoma | Washington | 98405-0986 | — |
| David Lee Cancer Center at Charleston Area Medical Center | Charleston | West Virginia | 25304-1297 | — |
| Camden-Clark Memorial Hospital | Parkersburg | West Virginia | 26102 | — |
| St. Vincent Hospital | Green Bay | Wisconsin | 54307-3508 | — |
| CCOP - Marshfield Clinic Research Foundation | Marshfield | Wisconsin | 54449 | — |
| Oncology Alliance, S.C. - Milwaukee | Milwaukee | Wisconsin | 53211-2906 | — |
| Medical College of Wisconsin Cancer Center | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 8 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00004067, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 29, 2021 · Synced Oct 30, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00004067 live on ClinicalTrials.gov.