The Diabetes Prevention Trial of Type 1 Diabetes (DPT-1)
Public ClinicalTrials.gov record NCT00004984. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The Diabetes Prevention Trial of Type 1 (DPT-1) was a multicenter randomized, controlled clinical trial designed to determine whether it is possible to delay or prevent the clinical onset of type 1 diabetes through daily doses of insulin in individuals determined to be at risk for the disease. Subjects were recruited from study clinics and through media campaigns.First-degree relatives, 3 to 45 years of age, and second-degree relatives, 3 to 20 years of age, of patients with diabetes were screened for islet-cell antibodies. Those individuals found to be at high risk of diabetes were randomized to receive either close observation or low-dose parenteral insulin. Those individuals found to be at intermediate risk of diabetes are randomized to receive insulin orally or to receive placebo. Patients were followed for up to six years.
Study identification
- NCT ID
- NCT00004984
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 711 participants
Conditions and interventions
Conditions
Interventions
- Parenteral Insulin Drug
- Close Observation Other
- Oral Insulin Drug
- Placebo Drug
Drug · Other
Eligibility (public fields only)
- Age range
- 3 Years to 45 Years
- Sex
- All
- Healthy volunteers
- Accepts healthy volunteers
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 1994 (Actual)
- Primary completion
- Jun 2003 (Actual)
- Completion
- Jun 2003 (Actual)
- Last update posted
- Apr 24, 2020
1994 – 2003
United States locations
- U.S. sites
- 14
- U.S. states
- 10
- U.S. cities
- 13
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Childrens Hospital of Los Angeles, Division of Endocrinology | Los Angeles | California | 90027 | — |
| University of California-San Francisco, Milberry Union East RM 405, 500 Parnassus Ave Box 0136 | San Francisco | California | 94143 | — |
| Stanford University | Stanford | California | 94305-5208 | — |
| University of Colorado Barbara Davis Center for Childhood Diabetes | Denver | Colorado | 80262 | — |
| University of Florida Diabetes Research Center | Gainesville | Florida | 32610-0296 | — |
| DPT-1 Operations Coordinating Center | Miami | Florida | 33136 | — |
| University of Miami School of Medicine, Jackson Medical Tower | Miami | Florida | 33136 | — |
| Indiana University, James Whitcomb Riley Hospital for Children, 702 Barnhill Dr, Ste 5960 | Indianapolis | Indiana | 46202 | — |
| Joslin Diabetes Center | Boston | Massachusetts | 02215 | — |
| University of Minnesota | Minneapolis | Minnesota | 55455 | — |
| Naomi Berrie Diabetes Center, Columbia University, 1150 St. Nicholas Ave | New York | New York | 10032 | — |
| Children's Hospital of Pittsburgh, Dept/Pediatric Endocrinology, 3705 5th Ave | Pittsburgh | Pennsylvania | 15213 | — |
| University of Texas, Children's Medical Center, 6300 Harry Hines Ste 1200 | Dallas | Texas | 75235 | — |
| Virginia Mason Research Center, 1201 Ninth Avenue | Seattle | Washington | 98101 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 1 non-U.S. site.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00004984, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 24, 2020 · Synced Oct 19, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00004984 live on ClinicalTrials.gov.