ClinicalTrials.gov record
Comparison of Different Combination Chemotherapy Regimens in Treating Children With Acute Lymphoblastic Leukemia
ClinicalTrials.gov ID: NCT00005945
Public ClinicalTrials.gov record NCT00005945. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Escalating Dose Intravenous Methotrexate Without Leucovorin Rescue Versus Oral Methotrexate and Single Versus Double Delayed Intensification for Children With Standard Risk Acute Lymphoblastic Leukemia
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Giving more than one drug may kill more cancer cells. It is not yet known which combination chemotherapy regimen is more effective in treating childhood acute lymphoblastic leukemia. PURPOSE: This randomized phase III trial is comparing different combination chemotherapy regimens to see how well they work in treating children with acute lymphoblastic leukemia.
Study identification
- NCT ID
- NCT00005945
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 3,054 participants
Conditions and interventions
Conditions
Interventions
- cyclophosphamide Drug
- cytarabine Drug
- daunorubicin hydrochloride Drug
- dexamethasone Drug
- doxorubicin hydrochloride Drug
- mercaptopurine Drug
- methotrexate Drug
- pegaspargase Drug
- thioguanine Drug
- vincristine sulfate Drug
- radiation therapy Radiation
Drug · Radiation
Eligibility (public fields only)
- Age range
- 1 Year to 9 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 2000 (Type not available)
- Primary completion
- Nov 2007 (Actual)
- Completion
- Jun 2008 (Actual)
- Last update posted
- Feb 23, 2016
2000 – 2008
United States locations
- U.S. sites
- 116
- U.S. states
- 35
- U.S. cities
- 95
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Phoenix Children's Hospital | Phoenix | Arizona | 85016 | — |
| Southern California Permanente Medical Group | Downey | California | 90242 | — |
| City of Hope Comprehensive Cancer Center | Duarte | California | 91010-3000 | — |
| Loma Linda University Cancer Institute at Loma Linda University Medical Center | Loma Linda | California | 92354 | — |
| Children's Hospital Los Angeles | Los Angeles | California | 90027-0700 | — |
| Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai Medical Center | Los Angeles | California | 90048 | — |
| Jonsson Comprehensive Cancer Center, UCLA | Los Angeles | California | 90095-1781 | — |
| Children's Hospital Central California | Madera | California | 93638-8762 | — |
| Children's Hospital and Research Center at Oakland | Oakland | California | 94609-1809 | — |
| Chao Family Comprehensive Cancer Center at University of California Irvine Medical Center | Orange | California | 92868 | — |
| Children's Hospital of Orange County | Orange | California | 92868 | — |
| Kaiser Permanente Medical Center - Sacramento | Sacramento | California | 95825 | — |
| Kaiser Permanente Medical Center/Kaiser Foundation Hospital - San Diego | San Diego | California | 92120 | — |
| UCSF Comprehensive Cancer Center | San Francisco | California | 94143 | — |
| Santa Barbara Cottage Hospital | Santa Barbara | California | 93102 | — |
| Kaiser Permanente Medical Center - Santa Clara | Santa Clara | California | 95051-5386 | — |
| General Robert Huyser Cancer Center at David Grant Medical Center | Travis Air Force Base | California | 94535 | — |
| Children's Hospital Cancer Center | Denver | Colorado | 80218 | — |
| Presbyterian - St. Luke's Medical Center | Denver | Colorado | 80218 | — |
| Carole and Ray Neag Comprehensive Cancer Center at the University of Connecticut Health Center | Farmington | Connecticut | 06360-7106 | — |
| Yale Comprehensive Cancer Center | New Haven | Connecticut | 06520-8064 | — |
| Alfred I. duPont Hospital for Children | Wilmington | Delaware | 19899 | — |
| Lombardi Cancer Center at Georgetown University Medical Center | Washington D.C. | District of Columbia | 20007 | — |
| Children's National Medical Center | Washington D.C. | District of Columbia | 20010-2970 | — |
| AFLAC Cancer Center and Blood Disorders Service of Children's Healthcare of Atlanta - Scottish Rite Campus | Atlanta | Georgia | 30342 | — |
| Medical Center of Central Georgia | Macon | Georgia | 31201 | — |
| Curtis & Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center | Savannah | Georgia | 31405 | — |
| Mountain States Tumor Institute - Boise | Boise | Idaho | 83712 | — |
| University of Chicago Cancer Research Center | Chicago | Illinois | 60601 | — |
| University of Illinois Medical Center | Chicago | Illinois | 60612 | — |
| Lutheran General Cancer Care Center | Park Ridge | Illinois | 60068-1174 | — |
| Southern Illinois University School of Medicine | Springfield | Illinois | 62794-9658 | — |
| Riley Children Cancer Center at Riley Hospital for Children | Indianapolis | Indiana | 46202-5225 | — |
| Blank Children's Hospital | Des Moines | Iowa | 50308 | — |
| Holden Comprehensive Cancer Center at University of Iowa | Iowa City | Iowa | 52242-1009 | — |
| Markey Cancer Center at University of Kentucky Chandler Medical Center | Lexington | Kentucky | 40536-0284 | — |
| Kosair Children's Hospital | Louisville | Kentucky | 40202-3830 | — |
| MBCCOP - LSU Health Sciences Center | New Orleans | Louisiana | 70112 | — |
| Alvin and Lois Lapidus Cancer Institute at Sinai Hospital | Baltimore | Maryland | 21215 | — |
| Baystate Regional Cancer Program at D'Amour Center for Cancer Care | Springfield | Massachusetts | 01107 | — |
| University of Michigan Comprehensive Cancer Center | Ann Arbor | Michigan | 48109-0914 | — |
| Josephine Ford Cancer Center at Henry Ford Health System | Detroit | Michigan | 48202 | — |
| DeVos Children's Hospital | Grand Rapids | Michigan | 49503 | — |
| Bronson Methodist Hospital | Kalamazoo | Michigan | 49007-5364 | — |
| Breslin Cancer Center at Ingham Regional Medical Center | Lansing | Michigan | 48910 | — |
| CCOP - Beaumont | Royal Oak | Michigan | 48073-6769 | — |
| William Beaumont Hospital - Royal Oak | Royal Oak | Michigan | 48073-6769 | — |
| St. Mary's - Duluth Clinic Cancer Center | Duluth | Minnesota | 55805 | — |
| Children's Hospitals and Clinics - Minneapolis/St. Paul | Minneapolis | Minnesota | 55404 | — |
| University of Minnesota Cancer Center | Minneapolis | Minnesota | 55455 | — |
| Mayo Clinic Cancer Center | Rochester | Minnesota | 55905 | — |
| Children's Mercy Hospital | Kansas City | Missouri | 64108 | — |
| Children's Hospital of Omaha | Omaha | Nebraska | 68114 | — |
| UNMC Eppley Cancer Center at the University of Nebraska Medical Center | Omaha | Nebraska | 68198-2168 | — |
| Sunrise Hospital and Medical Center | Las Vegas | Nevada | 89109 | — |
| St. Barnabas Medical Center | Livingston | New Jersey | 07039 | — |
| Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School | New Brunswick | New Jersey | 08903 | — |
| Newark Beth Israel Medical Center | Newark | New Jersey | 07112-2094 | — |
| St. Joseph's Hospital and Medical Center | Paterson | New Jersey | 07503 | — |
| Valerie Fund Children's Center at Atlantic Health | Summit | New Jersey | 07901 | — |
| Cancer Center of Albany Medical Center | Albany | New York | 12208 | — |
| Brooklyn Hospital Center | Brooklyn | New York | 11201-5493 | — |
| SUNY Downstate Medical Center | Brooklyn | New York | 11203 | — |
| Brookdale University Hospital and Medical Center | Brooklyn | New York | 11212 | — |
| Comprehensive Cancer Center at Maimonides Medical Center | Brooklyn | New York | 11219 | — |
| Schneider Children's Hospital | New Hyde Park | New York | 11042 | — |
| Memorial Sloan-Kettering Cancer Center | New York | New York | 10021 | — |
| New York Weill Cornell Cancer Center at Cornell University | New York | New York | 10021 | — |
| Herbert Irving Comprehensive Cancer Center at Columbia University | New York | New York | 10032 | — |
| Long Island Cancer Center at Stony Brook University Hospital | Stony Brook | New York | 11794 | — |
| SUNY Upstate Medical University Hospital | Syracuse | New York | 13210 | — |
| Albert Einstein Cancer Center at Albert Einstein College of Medicine | The Bronx | New York | 10461 | — |
| New York Medical College | Valhalla | New York | 10595 | — |
| Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill | Chapel Hill | North Carolina | 27599 | — |
| Blumenthal Cancer Center at Carolinas Medical Center | Charlotte | North Carolina | 28232-2861 | — |
| Presbyterian Cancer Center at Presbyterian Hospital | Charlotte | North Carolina | 28233 | — |
| Dakota Cancer Institute at Innovis Health - Dakota Clinic | Fargo | North Dakota | 58103-4940 | — |
| Meritcare Roger Maris Cancer Center | Fargo | North Dakota | 58122 | — |
| Children's Hospital Medical Center of Akron | Akron | Ohio | 44308-1062 | — |
| Cincinnati Children's Hospital Medical Center | Cincinnati | Ohio | 45229-3039 | — |
| Ireland Cancer Center at University Hospitals of Cleveland and Case Western Reserve University | Cleveland | Ohio | 44106-5065 | — |
| Columbus Children's Hospital | Columbus | Ohio | 43205-2696 | — |
| Children's Medical Center - Dayton | Dayton | Ohio | 45404 | — |
| Toledo Children's Hospital | Toledo | Ohio | 43601 | — |
| St. Vincent Mercy Medical Center | Toledo | Ohio | 43608 | — |
| CCOP - Columbia River Oncology Program | Portland | Oregon | 97225 | — |
| Doernbecher Children's Hospital at Oregon Health & Science University | Portland | Oregon | 97239-3098 | — |
| Geisinger Medical Center | Danville | Pennsylvania | 17822-1320 | — |
| Children's Hospital at Milton S. Hershey Medical Center | Hershey | Pennsylvania | 17033 | — |
| Children's Hospital of Philadelphia | Philadelphia | Pennsylvania | 19104 | — |
| Children's Hospital of Pittsburgh | Pittsburgh | Pennsylvania | 15213 | — |
| Rhode Island Hospital | Providence | Rhode Island | 02903 | — |
| Sioux Valley Hospital and University of South Dakota Medical Center | Sioux Falls | South Dakota | 57117-5039 | — |
| East Tennessee State University Cancer Center at Johnson City Medical Center | Johnson City | Tennessee | 37614-0622 | — |
| East Tennessee Children's Hospital | Knoxville | Tennessee | 37901 | — |
| Vanderbilt Children's Hospital | Nashville | Tennessee | 37232-6310 | — |
| Texas Tech University Health Sciences Center School of Medicine | Amarillo | Texas | 79106 | — |
| Children's Hospital of Austin | Austin | Texas | 78701 | — |
| Medical City Dallas Hospital | Dallas | Texas | 75230 | — |
| MD Anderson Cancer Center at University of Texas | Houston | Texas | 77030-4009 | — |
| Covenant Children's Hospital | Lubbock | Texas | 79410 | — |
| MBCCOP - South Texas Pediatrics | San Antonio | Texas | 78229-3900 | — |
| Methodist Cancer Center at Methodist Specialty and Transplant Hospital | San Antonio | Texas | 78229-3902 | — |
| CCOP - Scott and White Hospital | Temple | Texas | 76508 | — |
| Children's Hospital of the King's Daughters | Norfolk | Virginia | 23507 | — |
| Children's Hospital and Regional Medical Center - Seattle | Seattle | Washington | 98105 | — |
| Group Health Central Hospital | Seattle | Washington | 98112 | — |
| Deaconess Medical Center | Spokane | Washington | 99210-0248 | — |
| Mary Bridge Children's Hospital and Health Center | Tacoma | Washington | 98415-0299 | — |
| West Virginia University - Robert C. Byrd Health Sciences Center - Charleston Division | Charleston | West Virginia | 25302 | — |
| Cabell Huntington Hospital | Huntington | West Virginia | 25701 | — |
| Bellin Memorial Hospital | Green Bay | Wisconsin | 54301 | — |
| Gundersen Lutheran Cancer Center at Gundersen Lutheran Medical Center | La Crosse | Wisconsin | 54601 | — |
| University of Wisconsin Comprehensive Cancer Center | Madison | Wisconsin | 53792-6164 | — |
| Marshfield Clinic - Marshfield Center | Marshfield | Wisconsin | 54449-5772 | — |
| CCOP - Marshfield Clinic Research Foundation | Marshfield | Wisconsin | 54449 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 14 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00005945, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Feb 23, 2016 · Synced Oct 23, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00005945 live on ClinicalTrials.gov.