ClinicalTrials.gov record
Doxorubicin Hydrochloride, Cyclophosphamide, and Pacltaxel With or Without Trastuzumab in Treating Women With HER2-Positive Node-Positive or High-Risk Node-Negative Breast Cancer
ClinicalTrials.gov ID: NCT00005970
Public ClinicalTrials.gov record NCT00005970. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Phase III Trial of Doxorubicin and Cyclophosphamide (AC) Followed by Weekly Paclitaxel With or Without Trastuzumab as Adjuvant Treatment for Women With HER-2 Over-Expressing or Amplified Node Positive or High-Risk Node Negative Breast Cancer
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This randomized phase III trial studies doxorubicin hydrochloride, cyclophosphamide, paclitaxel, and trastuzumab to see how well they work compared to combination chemotherapy alone in treating women with breast cancer that is human epidermal growth factor receptor 2 (HER2)-positive and has spread to the lymph nodes or high-risk and has not spread to the lymph nodes. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Monoclonal antibodies such as trastuzumab can locate tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells. It is not yet known whether combination chemotherapy is more effective with or without trastuzumab in treating breast cancer.
Study identification
- NCT ID
- NCT00005970
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 3,436 participants
Conditions and interventions
Conditions
Interventions
- Aromatase Inhibition Therapy Drug
- Cyclophosphamide Drug
- Doxorubicin Hydrochloride Drug
- Laboratory Biomarker Analysis Other
- Paclitaxel Drug
- Tamoxifen Citrate Drug
- Trastuzumab Biological
Drug · Other · Biological
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- Female
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 19, 2000 (Actual)
- Primary completion
- Apr 25, 2005 (Actual)
- Completion
- Jan 27, 2010 (Actual)
- Last update posted
- Aug 14, 2020
2000 – 2010
United States locations
- U.S. sites
- 154
- U.S. states
- 42
- U.S. cities
- 122
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham Cancer Center | Birmingham | Alabama | 35233 | — |
| Western Regional CCOP | Phoenix | Arizona | 85006 | — |
| Mayo Clinic in Arizona | Scottsdale | Arizona | 85259 | — |
| Banner University Medical Center - Tucson | Tucson | Arizona | 85719 | — |
| University of Arkansas for Medical Sciences | Little Rock | Arkansas | 72205 | — |
| Community Cancer Institute | Clovis | California | 93611 | — |
| City of Hope Comprehensive Cancer Center | Duarte | California | 91010 | — |
| Washington Hospital | Fremont | California | 94538 | — |
| Glendale Memorial Hospital and Health Center | Glendale | California | 91204 | — |
| USC / Norris Comprehensive Cancer Center | Los Angeles | California | 90033 | — |
| Memorial Medical Center | Modesto | California | 95355 | — |
| Community Hospital of Monterey Peninsula | Monterey | California | 93940 | — |
| UC Irvine Health/Chao Family Comprehensive Cancer Center | Orange | California | 92868 | — |
| Stanford Cancer Institute Palo Alto | Palo Alto | California | 94304 | — |
| University of California Davis Comprehensive Cancer Center | Sacramento | California | 95817 | — |
| Salinas Valley Memorial | Salinas | California | 93901 | — |
| University of California San Diego | San Diego | California | 92103 | — |
| Naval Medical Center -San Diego | San Diego | California | 92134 | — |
| UCSF Medical Center-Mount Zion | San Francisco | California | 94115 | — |
| The Angeles Clinic and Research Institute - Santa Monica Office | Santa Monica | California | 90404 | — |
| Santa Rosa Memorial Hospital | Santa Rosa | California | 95405 | — |
| University of Colorado Hospital | Aurora | Colorado | 80045 | — |
| MedStar Georgetown University Hospital | Washington D.C. | District of Columbia | 20007 | — |
| Mayo Clinic in Florida | Jacksonville | Florida | 32224-9980 | — |
| AdventHealth Orlando | Orlando | Florida | 32803 | — |
| Moffitt Cancer Center | Tampa | Florida | 33612 | — |
| Emory University Hospital/Winship Cancer Institute | Atlanta | Georgia | 30322 | — |
| Atlanta Regional CCOP | Atlanta | Georgia | 30342 | — |
| Northeast Georgia Medical Center-Gainesville | Gainesville | Georgia | 30501 | — |
| Memorial Health University Medical Center | Savannah | Georgia | 31404 | — |
| University of Hawaii Cancer Center | Honolulu | Hawaii | 96813 | — |
| Northwestern University | Chicago | Illinois | 60611 | — |
| Rush University Medical Center | Chicago | Illinois | 60612 | — |
| University of Illinois | Chicago | Illinois | 60612 | — |
| University of Chicago Comprehensive Cancer Center | Chicago | Illinois | 60637 | — |
| Heartland Cancer Research NCORP | Decatur | Illinois | 62526 | — |
| Loyola University Medical Center | Maywood | Illinois | 60153 | — |
| Carle Cancer Center | Urbana | Illinois | 61801 | — |
| Indiana University/Melvin and Bren Simon Cancer Center | Indianapolis | Indiana | 46202 | — |
| Northern Indiana Cancer Research Consortium | South Bend | Indiana | 46628 | — |
| Iowa-Wide Oncology Research Coalition NCORP | Des Moines | Iowa | 50309 | — |
| University of Iowa/Holden Comprehensive Cancer Center | Iowa City | Iowa | 52242 | — |
| Siouxland Regional Cancer Center | Sioux City | Iowa | 51101 | — |
| Via Christi Hospital-Pittsburg | Pittsburg | Kansas | 66762 | — |
| Kansas City NCI Community Oncology Research Program | Prairie Village | Kansas | 66208 | — |
| Salina Regional Health Center | Salina | Kansas | 67401 | — |
| Cotton O'Neil Cancer Center / Stormont Vail Health | Topeka | Kansas | 66606 | — |
| Saint Francis Hospital and Medical Center - Topeka | Topeka | Kansas | 66606 | — |
| Wichita NCI Community Oncology Research Program | Wichita | Kansas | 67214 | — |
| Tulane University Health Sciences Center | New Orleans | Louisiana | 70112 | — |
| Ochsner Medical Center Jefferson | New Orleans | Louisiana | 70121 | — |
| Louisiana State University Health Sciences Center Shreveport | Shreveport | Louisiana | 71103 | — |
| University of Maryland/Greenebaum Cancer Center | Baltimore | Maryland | 21201 | — |
| Johns Hopkins University/Sidney Kimmel Cancer Center | Baltimore | Maryland | 21287 | — |
| Walter Reed National Military Medical Center | Bethesda | Maryland | 20889-5600 | — |
| Tufts Medical Center | Boston | Massachusetts | 02111 | — |
| Massachusetts General Hospital Cancer Center | Boston | Massachusetts | 02114 | — |
| Boston Medical Center | Boston | Massachusetts | 02118 | — |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | — |
| Dana-Farber Cancer Institute | Boston | Massachusetts | 02215 | — |
| Milford Regional Medical Center | Milford | Massachusetts | 01757 | — |
| Saint Vincent Hospital/Reliant Medical Group | Worcester | Massachusetts | 01608 | — |
| University of Massachusetts Medical School | Worcester | Massachusetts | 01655 | — |
| Michigan Cancer Research Consortium NCORP | Ann Arbor | Michigan | 48106 | — |
| University of Michigan Comprehensive Cancer Center | Ann Arbor | Michigan | 48109 | — |
| Wayne State University/Karmanos Cancer Institute | Detroit | Michigan | 48201 | — |
| Henry Ford Hospital | Detroit | Michigan | 48202 | — |
| Cancer Research Consortium of West Michigan NCORP | Grand Rapids | Michigan | 49503 | — |
| Kalamazoo Center for Medical Studies | Kalamazoo | Michigan | 49008 | — |
| Ascension Providence Hospitals - Southfield | Southfield | Michigan | 48075 | — |
| Essentia Health Cancer Center | Duluth | Minnesota | 55805 | — |
| University of Minnesota/Masonic Cancer Center | Minneapolis | Minnesota | 55455 | — |
| Mayo Clinic | Rochester | Minnesota | 55905 | — |
| Coborn Cancer Center at Saint Cloud Hospital | Saint Cloud | Minnesota | 56303 | — |
| Metro Minnesota Community Oncology Research Consortium | Saint Louis Park | Minnesota | 55416 | — |
| University of Mississippi Medical Center | Jackson | Mississippi | 39216 | — |
| University of Missouri - Ellis Fischel | Columbia | Missouri | 65212 | — |
| Cancer Research for the Ozarks NCORP | Springfield | Missouri | 65804 | — |
| Washington University - Jewish | St Louis | Missouri | 63110 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| Missouri Baptist Medical Center | St Louis | Missouri | 63131 | — |
| Saint Louis-Cape Girardeau CCOP | St Louis | Missouri | 63141 | — |
| Montana Cancer Consortium NCORP | Billings | Montana | 59102 | — |
| CHI Health Good Samaritan | Kearney | Nebraska | 68847 | — |
| Missouri Valley Cancer Consortium | Omaha | Nebraska | 68106 | — |
| University of Nebraska Medical Center | Omaha | Nebraska | 68198 | — |
| University Medical Center of Southern Nevada | Las Vegas | Nevada | 89102 | — |
| New Hampshire Oncology Hematology PA-Hooksett | Hooksett | New Hampshire | 03106 | — |
| Dartmouth Hitchcock Medical Center | Lebanon | New Hampshire | 03756 | — |
| Englewood Hospital and Medical Center | Englewood | New Jersey | 07631 | — |
| Hackensack University Medical Center | Hackensack | New Jersey | 07601 | — |
| Rutgers Cancer Institute of New Jersey | New Brunswick | New Jersey | 08903 | — |
| Roswell Park Cancer Institute | Buffalo | New York | 14263 | — |
| North Shore University Hospital | Manhasset | New York | 11030 | — |
| Long Island Jewish Medical Center | New Hyde Park | New York | 11040 | — |
| Laura and Isaac Perlmutter Cancer Center at NYU Langone | New York | New York | 10016 | — |
| Mount Sinai Hospital | New York | New York | 10029 | — |
| NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center | New York | New York | 10032 | — |
| Memorial Sloan Kettering Cancer Center | New York | New York | 10065 | — |
| NYP/Weill Cornell Medical Center | New York | New York | 10065 | — |
| University of Rochester | Rochester | New York | 14642 | — |
| State University of New York Upstate Medical University | Syracuse | New York | 13210 | — |
| SUNY Upstate Medical Center-Community Campus | Syracuse | New York | 13215 | — |
| Montefiore Medical Center-Weiler Hospital | The Bronx | New York | 10461 | — |
| Mission Hospital Inc-Memorial Campus | Asheville | North Carolina | 28801 | — |
| UNC Lineberger Comprehensive Cancer Center | Chapel Hill | North Carolina | 27599 | — |
| Duke University Medical Center | Durham | North Carolina | 27710 | — |
| Cone Health Cancer Center | Greensboro | North Carolina | 27403 | — |
| Wilson Medical Center | Wilson | North Carolina | 27893 | — |
| Novant Health Forsyth Medical Center | Winston-Salem | North Carolina | 27103 | — |
| Southeast Clinical Oncology Research (SCOR) Consortium NCORP | Winston-Salem | North Carolina | 27104 | — |
| Wake Forest University Health Sciences | Winston-Salem | North Carolina | 27157 | — |
| Sanford Bismarck Medical Center | Bismarck | North Dakota | 58501 | — |
| Sanford Broadway Medical Center | Fargo | North Dakota | 58122 | — |
| Altru Cancer Center | Grand Forks | North Dakota | 58201 | — |
| University of Cincinnati/Barrett Cancer Center | Cincinnati | Ohio | 45219 | — |
| Case Western Reserve University | Cleveland | Ohio | 44106 | — |
| Cleveland Clinic Foundation | Cleveland | Ohio | 44195 | — |
| Ohio State University Comprehensive Cancer Center | Columbus | Ohio | 43210 | — |
| Toledo Community Hospital Oncology Program CCOP | Toledo | Ohio | 43617 | — |
| University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | 73104 | — |
| University of Oregon | Eugene | Oregon | 97403-1217 | — |
| Providence Portland Medical Center | Portland | Oregon | 97213 | — |
| Geisinger Medical Center | Danville | Pennsylvania | 17822 | — |
| Penn State Milton S Hershey Medical Center | Hershey | Pennsylvania | 17033-0850 | — |
| University of Pennsylvania/Abramson Cancer Center | Philadelphia | Pennsylvania | 19104 | — |
| Fox Chase Cancer Center | Philadelphia | Pennsylvania | 19111 | — |
| West Penn Hospital | Pittsburgh | Pennsylvania | 15224 | — |
| University of Pittsburgh Cancer Institute (UPCI) | Pittsburgh | Pennsylvania | 15232 | — |
| Lankenau Medical Center | Wynnewood | Pennsylvania | 19096 | — |
| Memorial Hospital of Rhode Island | Pawtucket | Rhode Island | 02860 | — |
| Rhode Island Hospital | Providence | Rhode Island | 02903 | — |
| Roper Hospital | Charleston | South Carolina | 29401 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| Rapid City Regional Hospital | Rapid City | South Dakota | 57701 | — |
| Sanford NCI Community Oncology Research Program of the North Central Plains | Sioux Falls | South Dakota | 57104 | — |
| Wellmont Holston Valley Hospital and Medical Center | Kingsport | Tennessee | 37660 | — |
| Thompson Cancer Survival Center | Knoxville | Tennessee | 37916 | — |
| University of Tennessee - Knoxville | Knoxville | Tennessee | 37920 | — |
| University of Tennessee Health Science Center | Memphis | Tennessee | 38163 | — |
| Vanderbilt University/Ingram Cancer Center | Nashville | Tennessee | 37232 | — |
| The Don and Sybil Harrington Cancer Center | Amarillo | Texas | 79106 | — |
| Brooke Army Medical Center | Fort Sam Houston | Texas | 78234 | — |
| University of Texas Medical Branch | Galveston | Texas | 77555-0565 | — |
| University of Texas Health Science Center at San Antonio | San Antonio | Texas | 78229 | — |
| Huntsman Cancer Institute/University of Utah | Salt Lake City | Utah | 84112 | — |
| Southwestern Vermont Medical Center | Bennington | Vermont | 05201 | — |
| University of Vermont and State Agricultural College | Burlington | Vermont | 05405 | — |
| Sentara Martha Jefferson Hospital | Charlottesville | Virginia | 22901 | — |
| Virginia Mason Medical Center | Seattle | Washington | 98101 | — |
| Kaiser Permanente Washington | Seattle | Washington | 98112 | — |
| Northwest NCI Community Oncology Research Program | Tacoma | Washington | 98405 | — |
| University of Wisconsin Hospital and Clinics | Madison | Wisconsin | 53792 | — |
| Froedtert and the Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 3 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00005970, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 14, 2020 · Synced Oct 22, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00005970 live on ClinicalTrials.gov.