Phase III Randomized Study of Oral Acyclovir in Infants With Herpes Simplex Virus Infection Limited to Skin, Eyes, and Mouth
Public ClinicalTrials.gov record NCT00006135. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
OBJECTIVES: I. Determine the efficacy of long term suppressive therapy with oral acyclovir in infants with herpes simplex virus infection limited to skin, eyes, and mouth. II. Determine the neurologic outcome in these patients when treated with this regimen. III. Evaluate the significance of a positive cerebrospinal fluid (CSF) polymerase chain reaction (PCR) result when all other CSF parameters remain normal in these patients. IV. Correlate the time to first positive CSF PCR result in the first 12 months of life with clinical neurological assessment in these patients when treated with this regimen. V. Determine whether the continuous administration of this drug suppresses recurrent skin lesions in these patients. VI. Determine the safety of this regimen in these patients.
Study identification
- NCT ID
- NCT00006135
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 66 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 0 Years to 28 Days
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 31, 1997
- Primary completion
- Not listed
- Completion
- Not listed
- Last update posted
- Jun 23, 2005
Started 1997
United States locations
- U.S. sites
- 25
- U.S. states
- 15
- U.S. cities
- 23
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Children's Hospital of Alabama | Birmingham | Alabama | 35233 | — |
| University of Alabama Comprehensive Cancer Center | Birmingham | Alabama | 35294 | — |
| University of Arkansas | Little Rock | Arkansas | 72202 | — |
| University of Arkansas for Medical Sciences | Little Rock | Arkansas | 72205 | — |
| Cedars-Sinai Medical Center | Los Angeles | California | 90048 | — |
| Children's Hospital and Health Center | San Diego | California | 92123-4282 | — |
| Stanford University | Stanford | California | 94305 | — |
| University of Florida Health Science Center - Jacksonville | Jacksonville | Florida | 32209 | — |
| Tulane University Medical Center | New Orleans | Louisiana | 70112 | — |
| Maine Medical Center | Portland | Maine | 04102 | — |
| University of Mississippi Medical Center | Jackson | Mississippi | 39216-4505 | — |
| St. Louis Children's Hospital | St Louis | Missouri | 63110 | — |
| State University of New York - Upstate Medical University | Syracuse | New York | 13210 | — |
| Carolinas Medical Center | Charlotte | North Carolina | 28232-2861 | — |
| Children's Hospital Medical Center - Cincinnati | Cincinnati | Ohio | 45229-3039 | — |
| MetroHealth Medical Center | Cleveland | Ohio | 44109 | — |
| Ohio State University Children's Hospital | Columbus | Ohio | 43205-2696 | — |
| Rhode Island Hospital | Providence | Rhode Island | 02903 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29425-0721 | — |
| University of Tennessee Medical Center at Knoxville | Knoxville | Tennessee | 37920 | — |
| Vanderbilt University | Nashville | Tennessee | 37232-6305 | — |
| University of Texas Southwestern Medical School | Dallas | Texas | 75235-9032 | — |
| Cook Children's Medical Center - Fort Worth | Fort Worth | Texas | 76104 | — |
| Baylor College of Medicine | Houston | Texas | 77030 | — |
| University of Texas Health Science Center at San Antonio | San Antonio | Texas | 78284-7811 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 2 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00006135, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 23, 2005 · Synced Sep 9, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT00006135 live on ClinicalTrials.gov.