COMBINE (Acamprosate/Naltrexone)
Public ClinicalTrials.gov record NCT00006206. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
COMBINE: Effect of Combined Pharmacotherapies and Behavioral Interventions
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Combine is a multicenter, randomized clinical trial that will evaluate combinations of three interventions for treating alcohol dependence. The goal is to determine whether improvement in treatment outcomes can be achieved by various combinations of drug and behavioral interventions. Two of the interventions will consist of pharmacological treatment with naltrexone (Revia) or acamprosate (Campral). The third intervention is a multicomponent behavioral therapy including such components as motivational enhancement therapy, cognitive behavioral therapy, and referral to self-help groups, including AA. All three interventions will include a component supporting compliance to medications and reduction in drinking.
Study identification
- NCT ID
- NCT00006206
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,375 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 31, 1997
- Primary completion
- Not listed
- Completion
- Apr 30, 2006
- Last update posted
- May 2, 2010
1997 – 2006
United States locations
- U.S. sites
- 12
- U.S. states
- 10
- U.S. cities
- 11
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Substance Abuse Treatment Unit, Yale University | New Haven | Connecticut | 06511 | — |
| University of Miami School of Medicine | Miami | Florida | 33136 | — |
| Harvard University/McLean Hospital | Belmont | Massachusetts | 02478 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| Boston University School of Medicine | Boston | Massachusetts | 02118 | — |
| Center on Alcoholism, Substance Abuse and Addiction, University of New Mexico | Albuquerque | New Mexico | 87106 | — |
| Treatment and Research Center, University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | — |
| Roger Williams Medical Center , Brown University | Providence | Rhode Island | 02908 | — |
| Center for Alcohol Programs, Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| Southwest Texas Addiction Research and Technology Center, University of Texas Health Science Center | San Antonio | Texas | 78229 | — |
| Addictions Treatment Center, University of Washington | Seattle | Washington | 98108 | — |
| University of Wisconsin-Milwaukee | Milwaukee | Wisconsin | 53233 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00006206, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 2, 2010 · Synced Sep 2, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT00006206 live on ClinicalTrials.gov.