Down Syndrome - Comparison of Screening Methods in the 1st and 2nd Trimesters
Public ClinicalTrials.gov record NCT00006445. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
First and 2nd Trimester Evaluation of the Risk of Aneuploidy
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Too much or too little genetic information (chromosome material) can cause abnormal development of the fetus or death. Each year approximately 2.5 million pregnant women are screened for Down Syndrome using invasive screening methods (amniocentesis or chorionic villus sampling). This 11 center study of 38,000 women will compare the accuracy of the several non-invasive tests in the first and second trimesters of pregnancy versus amniocentesis or diagnosis at birth to diagnose aneuploidy or Down Syndrome.
Study identification
- NCT ID
- NCT00006445
- Recruitment status
- Not listed
- Study type
- Interventional
- Phase
- Not applicable
- Lead sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
- NIH
- Enrollment
- 38,000 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 16 Years to 45 Years
- Sex
- Female
- Healthy volunteers
- Accepts healthy volunteers
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Not listed
- Primary completion
- Not listed
- Completion
- Not listed
- Last update posted
- Feb 22, 2007
United States locations
- U.S. sites
- 10
- U.S. states
- 8
- U.S. cities
- 9
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Colorado Health Sciences Center | Denver | Colorado | 80262 | — |
| New England Medical Center | Boston | Massachusetts | 02111 | — |
| William Beaumont Hospital Research Institute | Royal Oak | Michigan | 48073-6769 | — |
| New York University School of Medicine | New York | New York | 10016 | — |
| Mount Sinai Medical Center | New York | New York | 10029 | — |
| Montefiore Medical Center | The Bronx | New York | 10461 | — |
| Women and Infants Hospital | Providence | Rhode Island | 02905 | — |
| University of Texas Medical Branch | Galveston | Texas | 77555-0587 | — |
| University of Utah | Salt Lake City | Utah | 84132 | — |
| Swedish Medical Center | Seattle | Washington | 98104-1377 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00006445, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Feb 22, 2007 · Synced Oct 20, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00006445 live on ClinicalTrials.gov.