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ClinicalTrials.gov record
Completed Phase 3 Interventional Results available

S0016 Combination Chemotherapy With Monoclonal Antibody Therapy in Newly Diagnosed Non-Hodgkin's Lymphoma

ClinicalTrials.gov ID: NCT00006721

Public ClinicalTrials.gov record NCT00006721. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

ClinicalTrials.gov public records Last synced Oct 21, 2026, 4:23 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase III Trial of CHOP Plus Rituximab vs CHOP Plus Iodine-131-Labeled Monoclonal Anti-B1 Antibody (Tositumomab) for Treatment of Newly Diagnosed Follicular Non-Hodgkin's Lymphomas

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

RATIONALE: Drugs used in chemotherapy work in different ways to stop cancer cells from dividing so they stop growing or die. Monoclonal antibodies can locate tumor cells and either kill them or deliver radioactive tumor-killing substances to them without harming normal cells. It is not yet known which monoclonal antibody plus combination chemotherapy regimen is more effective in treating non-Hodgkin's lymphoma. PURPOSE: This randomized phase III trial is comparing 2 different monoclonal antibodies given together with combination chemotherapy to see how well they work in treating patients with newly-diagnosed non-Hodgkin's lymphoma.

Study identification

NCT ID
NCT00006721
Recruitment status
Completed
Study type
Interventional
Phase
Phase 3
Lead sponsor
SWOG Cancer Research Network
Network
Enrollment
571 participants

Conditions and interventions

Conditions

Interventions

Biological · Drug · Radiation

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Mar 2001 (Type not available)
Primary completion
Sep 2011 (Actual)
Completion
Dec 2025 (Actual)
Last update posted
Mar 16, 2026

2001 – 2025

United States locations

U.S. sites
259
U.S. states
31
U.S. cities
170
Facility City State ZIP Site status
Alaska Regional Hospital Cancer Center Anchorage Alaska 99508 —
Fairbanks Cancer Treatment Center at Fairbanks Memorial Hospital Fairbanks Alaska 99701 —
Hembree Mercy Cancer Center at St. Edward Mercy Medical Center Fort Smith Arkansas 72903 —
Arkansas Cancer Research Center at University of Arkansas for Medical Sciences Little Rock Arkansas 72205 —
Alta Bates Summit Comprehensive Cancer Center Berkeley California 94704 —
Peninsula Medical Center Burlingame California 94010 —
Marin Cancer Institute at Marin General Hospital Greenbrae California 94904 —
Sutter Health - Western Division Cancer Research Group Greenbrae California 94904 —
Desert Regional Medical Center Comprehensive Cancer Center Palm Springs California 92262 —
University of California Davis Cancer Center Sacramento California 95817 —
California Pacific Medical Center - California Campus San Francisco California 94118 —
Stanford Cancer Center Stanford California 94305-5824 —
Sutter Solano Medical Center Vallejo California 94589 —
Helen and Harry Gray Cancer Center at Hartford Hospital Hartford Connecticut 06102-5037 —
Lombardi Comprehensive Cancer Center at Georgetown University Medical Center Washington D.C. District of Columbia 20007 —
Center for Cancer Care and Research at Watson Clinic, LLP Lakeland Florida 33805 —
Sacred Heart Cancer Center at Sacred Heart Hospital Pensacola Florida 32504 —
West Florida Cancer Institute at West Florida Hospital - Pensacola Pensacola Florida 32514 —
Piedmont Hospital Atlanta Georgia 30309 —
Northside Hospital Cancer Center Atlanta Georgia 30342-1611 —
Saint Joseph's Hospital of Atlanta Atlanta Georgia 30342-1701 —
CCOP - Atlanta Regional Atlanta Georgia 30342 —
WellStar Cobb Hospital Austell Georgia 30106 —
Charles B. Eberhart Cancer Center at DeKalb Medical Center Decatur Georgia 30033 —
Dwight David Eisenhower Army Medical Center Fort Gordon Georgia 30905-5650 —
Northeast Georgia Medical Center Gainesville Georgia 30501 —
Gwinnett Medical Center Lawrenceville Georgia 30045 —
Kennestone Cancer Center at Wellstar Kennestone Hospital Marietta Georgia 30060 —
Southern Regional Medical Center Riverdale Georgia 30274-2600 —
Pearlman Comprehensive Cancer Center at South Georgia Medical Center Valdosta Georgia 31603 —
Tripler Army Medical Center Honolulu Hawaii 96859 —
Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center Boise Idaho 83706 —
Mountain States Tumor Institute at St. Luke's Regional Medical Center Boise Idaho 83712 —
Saint Anthony's Hospital at Saint Anthony's Health Center Alton Illinois 62002 —
Rush-Copley Cancer Care Center Aurora Illinois 60504 —
St. Joseph Medical Center Bloomington Illinois 61701 —
Graham Hospital Canton Illinois 61520 —
Memorial Hospital Carthage Illinois 62321 —
University of Illinois Cancer Center Chicago Illinois 60612-7243 —
University of Chicago Cancer Research Center Chicago Illinois 60637-1470 —
Decatur Memorial Hospital Cancer Care Institute Decatur Illinois 62526 —
Eureka Community Hospital Eureka Illinois 61530 —
Galesburg Clinic, PC Galesburg Illinois 61401 —
Galesburg Cottage Hospital Galesburg Illinois 61401 —
Mason District Hospital Havana Illinois 62644 —
Veterans Affairs Medical Center - Hines Hines Illinois 60141 —
Hopedale Medical Complex Hopedale Illinois 61747 —
Joliet Oncology-Hematology Associates, Limited - West Joliet Illinois 60435 —
McDonough District Hospital Macomb Illinois 61455 —
Cardinal Bernardin Cancer Center at Loyola University Medical Center Maywood Illinois 60153 —
Good Samaritan Regional Health Center Mount Vernon Illinois 62864 —
Edward Hospital Cancer Center Naperville Illinois 60540 —
BroMenn Regional Medical Center Normal Illinois 61761 —
Community Cancer Center Normal Illinois 61761 —
Community Hospital of Ottawa Ottawa Illinois 61350 —
Oncology Hematology Associates of Central Illinois, PC - Ottawa Ottawa Illinois 61350 —
Cancer Treatment Center at Pekin Hospital Pekin Illinois 61554 —
Proctor Hospital Peoria Illinois 61614 —
CCOP - Illinois Oncology Research Association Peoria Illinois 61615 —
Oncology Hematology Associates of Central Illinois, PC - Peoria Peoria Illinois 61615 —
Methodist Medical Center of Illinois Peoria Illinois 61636 —
OSF St. Francis Medical Center Peoria Illinois 61637 —
Illinois Valley Community Hospital Peru Illinois 61354 —
Perry Memorial Hospital Princeton Illinois 61356 —
St. Margaret's Hospital Spring Valley Illinois 61362 —
Regional Cancer Center at Memorial Medical Center Springfield Illinois 62781-0001 —
Carle Cancer Center at Carle Foundation Hospital Urbana Illinois 61801 —
CCOP - Carle Cancer Center Urbana Illinois 61801 —
St. Francis Hospital and Health Centers - Beech Grove Campus Beech Grove Indiana 46107 —
Elkhart General Hospital Elkhart Indiana 46515 —
Howard Community Hospital Kokomo Indiana 46904 —
Center for Cancer Therapy at LaPorte Hospital and Health Services La Porte Indiana 46350 —
Saint Anthony Memorial Health Centers Michigan City Indiana 46360 —
Reid Hospital & Health Care Services Richmond Indiana 47374 —
CCOP - Northern Indiana CR Consortium South Bend Indiana 46601 —
Memorial Hospital of South Bend South Bend Indiana 46601 —
Saint Joseph Regional Medical Center South Bend Indiana 46617 —
Siouxland Hematology-Oncology Associates, LLP Sioux City Iowa 51101 —
Mercy Medical Center - Sioux City Sioux City Iowa 51104 —
St. Luke's Regional Medical Center Sioux City Iowa 51104 —
Cancer Center of Kansas, PA - Chanute Chanute Kansas 66720 —
Cancer Center of Kansas, PA - Dodge City Dodge City Kansas 67801 —
Cancer Center of Kansas, PA - El Dorado El Dorado Kansas 67042 —
Cancer Center of Kansas-Independence Independence Kansas 67301 —
Providence Medical Center Kansas City Kansas 66112 —
Cancer Center of Kansas, PA - Kingman Kingman Kansas 67068 —
Lawrence Memorial Hospital Lawrence Kansas 66044 —
Southwest Medical Center Liberal Kansas 67901 —
Cancer Center of Kansas, PA - Newton Newton Kansas 67114 —
Menorah Medical Center Overland Park Kansas 66209 —
Johnson County Radiation Therapy Overland Park Kansas 66210 —
Cancer Center of Kansas, PA - Parsons Parsons Kansas 67357 —
Cancer Center of Kansas, PA - Pratt Pratt Kansas 67124 —
Cancer Center of Kansas, PA - Salina Salina Kansas 67042 —
Tammy Walker Cancer Center at Salina Regional Health Center Salina Kansas 67401 —
Shawnee Mission Medical Center Shawnee Mission Kansas 66204 —
Cotton-O'Neil Cancer Center Topeka Kansas 66606 —
Cancer Center of Kansas, PA - Wellington Wellington Kansas 67152 —
Associates in Womens Health, PA - North Review Wichita Kansas 67208 —
Cancer Center of Kansas, PA - Medical Arts Tower Wichita Kansas 67208 —
Cancer Center of Kansas, PA - Wichita Wichita Kansas 67214 —
CCOP - Wichita Wichita Kansas 67214 —
Via Christi Cancer Center at Via Christi Regional Medical Center Wichita Kansas 67214 —
Wesley Medical Center Wichita Kansas 67214 —
Cancer Center of Kansas, PA - Winfield Winfield Kansas 67156 —
Greenebaum Cancer Center at University of Maryland Medical Center Baltimore Maryland 21201 —
Alvin and Lois Lapidus Cancer Institute at Sinai Hospital Baltimore Maryland 21215 —
Lahey Clinic Medical Center - Burlington Burlington Massachusetts 01805 —
Berkshire Hematology Oncology, PC Pittsfield Massachusetts 01201 —
University of Michigan Comprehensive Cancer Center Ann Arbor Michigan 48109-0942 —
Battle Creek Health System Cancer Care Center Battle Creek Michigan 49017 —
Bay Regional Medical Center Bay City Michigan 48708 —
Mecosta County Medical Center Big Rapids Michigan 49307 —
Barbara Ann Karmanos Cancer Institute Detroit Michigan 48201-1379 —
Josephine Ford Cancer Center at Henry Ford Hospital Detroit Michigan 48202 —
Butterworth Hospital at Spectrum Health Grand Rapids Michigan 49503 —
CCOP - Grand Rapids Grand Rapids Michigan 49503 —
Lacks Cancer Center at Saint Mary's Health Care Grand Rapids Michigan 49503 —
Holland Community Hospital Holland Michigan 49423 —
Borgess Medical Center Kalamazoo Michigan 49001 —
West Michigan Cancer Center Kalamazoo Michigan 49007-3731 —
Bronson Methodist Hospital Kalamazoo Michigan 49007 —
Hackley Hospital Muskegon Michigan 49442 —
Lakeland Regional Cancer Care Center - St. Joseph Saint Joseph Michigan 49085 —
Oncology Care Associates, PLLC Saint Joseph Michigan 49085 —
Munson Medical Center Traverse City Michigan 49684 —
Metro Health Hospital Wyoming Michigan 49519 —
University of Mississippi Cancer Clinic Jackson Mississippi 39216 —
Saint Francis Medical Center Cape Girardeau Missouri 63703 —
Saint Luke's Hospital Chesterfield Missouri 63017 —
Veterans Affairs Medical Center - Columbia (Truman Memorial) Columbia Missouri 65201 —
Ellis Fischel Cancer Center at University of Missouri - Columbia Columbia Missouri 65203 —
Southeast Missouri Regional Cancer Center at Southeast Missouri Hospital Gape Girardeau Missouri 63701 —
Independence Regional Health Center Independence Missouri 64050 —
Freeman Cancer Institute at Freeman Health System Joplin Missouri 64804 —
St. John's Regional Medical Center Joplin Missouri 64804 —
Truman Medical Center - Hospital Hill Kansas City Missouri 64108 —
Saint Luke's Cancer Institute at Saint Luke's Hospital Kansas City Missouri 64111 —
Kansas City Cancer Center at St. Joseph's Medical Mall Kansas City Missouri 64114 —
St. Joseph Medical Center Kansas City Missouri 64114 —
North Kansas City Hospital Kansas City Missouri 64116 —
Parvin Radiation Oncology Kansas City Missouri 64116 —
CCOP - Kansas City Kansas City Missouri 64131 —
Radiation Oncology Associates of Kansas City at Northland Radiation Oncology Center Kansas City Missouri 64154 —
Heartland Regional Medical Center Saint Joseph Missouri 64506 —
CCOP - Cancer Research for the Ozarks Springfield Missouri 65802 —
St. John's Regional Health Center Springfield Missouri 65804 —
Hulston Cancer Center at Cox Medical Center South Springfield Missouri 65807 —
Midwest Hematology Oncology Group, Incorporated St Louis Missouri 63109 —
Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis St Louis Missouri 63110 —
CCOP - St. Louis-Cape Girardeau St Louis Missouri 63141 —
David C. Pratt Cancer Center at St. John's Mercy St Louis Missouri 63141 —
CCOP - Montana Cancer Consortium Billings Montana 59101 —
Hematology-Oncology Centers of the Northern Rockies - Billings Billings Montana 59101 —
Northern Rockies Radiation Oncology Center Billings Montana 59101 —
St. Vincent Healthcare Cancer Care Services Billings Montana 59101 —
Billings Clinic - Downtown Billings Montana 59107-7000 —
Bozeman Deaconess Cancer Center Bozeman Montana 59715 —
St. James Healthcare Cancer Care Butte Montana 59701 —
Big Sky Oncology Great Falls Montana 59405-5309 —
Great Falls Clinic - Main Facility Great Falls Montana 59405 —
Sletten Cancer Institute at Benefis Healthcare Great Falls Montana 59405 —
Not listed Great Falls Montana 59405 —
St. Peter's Hospital Helena Montana 59601 —
Glacier Oncology, PLLC Kalispell Montana 59901 —
Kalispell Medical Oncology at KRMC Kalispell Montana 59901 —
Kalispell Regional Medical Center Kalispell Montana 59901 —
Community Medical Center Missoula Montana 59801 —
Guardian Oncology and Center for Wellness Missoula Montana 59804 —
Montana Cancer Specialists at Montana Cancer Center Missoula Montana 59807-7877 —
Montana Cancer Center at St. Patrick Hospital and Health Sciences Center Missoula Montana 59807 —
Good Samaritan Cancer Center at Good Samaritan Hospital Kearney Nebraska 68848-1990 —
UNMC Eppley Cancer Center at the University of Nebraska Medical Center Omaha Nebraska 68198-6805 —
Roswell Park Cancer Institute Buffalo New York 14263-0001 —
Tucker Center for Cancer Care at Orange Regional Medical Center Middletown New York 10940-4199 —
New York Weill Cornell Cancer Center at Cornell University New York New York 10021 —
James P. Wilmot Cancer Center at University of Rochester Medical Center Rochester New York 14642 —
Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill Chapel Hill North Carolina 27599-7295 —
Duke Comprehensive Cancer Center Durham North Carolina 27710 —
Wayne Memorial Hospital, Incorporated Goldsboro North Carolina 27534 —
McDowell Cancer Center at Akron General Medical Center Akron Ohio 44307 —
Mary Rutan Hospital Bellefontaine Ohio 43311 —
Adena Regional Medical Center Chillicothe Ohio 45601 —
Good Samaritan Hospital Cancer Treatment Center Cincinnati Ohio 45220 —
Charles M. Barrett Cancer Center at University Hospital Cincinnati Ohio 45267 —
Cleveland Clinic Cancer Center at Fairview Hospital Cleveland Ohio 44111 —
Cleveland Clinic Taussig Cancer Center Cleveland Ohio 44195 —
Riverside Methodist Hospital Cancer Care Columbus Ohio 43214-3998 —
CCOP - Columbus Columbus Ohio 43215 —
Grant Medical Center Cancer Care Columbus Ohio 43215 —
Mount Carmel Health - West Hospital Columbus Ohio 43222 —
Doctors Hospital at Ohio Health Columbus Ohio 43228 —
Grandview Hospital Dayton Ohio 45405 —
Good Samaritan Hospital Dayton Ohio 45406 —
David L. Rike Cancer Center at Miami Valley Hospital Dayton Ohio 45409 —
Samaritan North Cancer Care Center Dayton Ohio 45415 —
Veterans Affairs Medical Center - Dayton Dayton Ohio 45428 —
CCOP - Dayton Dayton Ohio 45429 —
Grady Memorial Hospital Delaware Ohio 43015 —
Blanchard Valley Medical Associates Findlay Ohio 45840 —
Middletown Regional Hospital Franklin Ohio 45005-1066 —
Community Oncology Group at Cleveland Clinic Cancer Center Independence Ohio 44131 —
Charles F. Kettering Memorial Hospital Kettering Ohio 45429 —
Fairfield Medical Center Lancaster Ohio 43130 —
St. Rita's Medical Center Lima Ohio 45801 —
Strecker Cancer Center at Marietta Memorial Hospital Marietta Ohio 45750 —
Licking Memorial Cancer Care Program at Licking Memorial Hospital Newark Ohio 43055 —
Mercy Medical Center Springfield Ohio 45504 —
Community Hospital of Springfield and Clark County Springfield Ohio 45505 —
UVMC Cancer Care Center at Upper Valley Medical Center Troy Ohio 45373-1300 —
Mount Carmel St. Ann's Cancer Center Westerville Ohio 43081 —
Clinton Memorial Hospital Wilmington Ohio 45177 —
Cleveland Clinic - Wooster Wooster Ohio 44691 —
Ruth G. McMillan Cancer Center at Greene Memorial Hospital Xenia Ohio 45385 —
Genesis - Good Samaritan Hospital Zanesville Ohio 43701 —
Legacy Mount Hood Medical Center Gresham Oregon 97030 —
Providence Milwaukie Hospital Milwaukie Oregon 97222 —
Legacy Good Samaritan Hospital & Comprehensive Cancer Center Portland Oregon 97210 —
Providence Cancer Center at Providence Portland Medical Center Portland Oregon 97213-2967 —
Adventist Medical Center Portland Oregon 97216 —
CCOP - Columbia River Oncology Program Portland Oregon 97225 —
Providence St. Vincent Medical Center Portland Oregon 97225 —
Legacy Emanuel Hospital and Health Center and Children's Hospital Portland Oregon 97227 —
Legacy Meridian Park Hospital Tualatin Oregon 97062 —
Roper St. Francis Cancer Center at Roper Hospital Charleston South Carolina 29401 —
Hollings Cancer Center at Medical University of South Carolina Charleston South Carolina 29425 —
Palmetto Health South Carolina Cancer Center Columbia South Carolina 29203 —
CCOP - Greenville Greenville South Carolina 29615 —
Joe Arrington Cancer Research and Treatment Center Lubbock Texas 79410-1894 —
UMC Southwest Cancer and Research Center Lubbock Texas 79415-3364 —
Huntsman Cancer Institute at University of Utah Salt Lake City Utah 84112 —
Lynchburg Hematology-Oncology Clinic Lynchburg Virginia 24501 —
St. Joseph Cancer Center Bellingham Washington 98225 —
Olympic Hematology and Oncology Bremerton Washington 98310 —
St. Francis Hospital Federal Way Washington 98003 —
Columbia Basin Hematology Kennewick Washington 99336 —
Cascade Cancer Center at Evergreen Hospital Medical Center Kirkland Washington 98033 —
Olympic Medical Center Port Angeles Washington 98362 —
Good Samaritan Cancer Center Puyallup Washington 98372 —
Valley Medical Center Renton Washington 98055 —
CCOP - Virginia Mason Research Center Seattle Washington 98101 —
Fred Hutchinson Cancer Research Center Seattle Washington 98104 —
Harborview Medical Center Seattle Washington 98104 —
Minor and James Medical, PLLC Seattle Washington 98104 —
Group Health Central Hospital Seattle Washington 98112 —
Swedish Cancer Institute at Swedish Medical Center - First Hill Campus Seattle Washington 98122-4307 —
Polyclinic First Hill Seattle Washington 98122 —
University Cancer Center at University of Washington Medical Center Seattle Washington 98195-6043 —
Cancer Care Northwest - Spokane South Spokane Washington 99202 —
Franciscan Cancer Center at St. Joseph Medical Center Tacoma Washington 98405-3004 —
Allenmore Hospital Tacoma Washington 98405 —
CCOP - Northwest Tacoma Washington 98405 —
MultiCare Regional Cancer Center at Tacoma General Hospital Tacoma Washington 98405 —
St. Clare Hospital Tacoma Washington 98499 —
Southwest Washington Medical Center Cancer Center Vancouver Washington 98668 —
Wenatchee Valley Medical Center Wenatchee Washington 98801-2028 —
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital Yakima Washington 98902 —
Schiffler Cancer Center at Wheeling Hospital Wheeling West Virginia 26003 —
Welch Cancer Center at Sheridan Memorial Hospital Sheridan Wyoming 82801 —

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT00006721, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Mar 16, 2026 · Synced Oct 21, 2026

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Open the official record

The complete public registry record, listed eligibility criteria, and available contact information for NCT00006721 live on ClinicalTrials.gov.

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