Shingles Prevention Study
Public ClinicalTrials.gov record NCT00007501. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
CSP #403 - Trial of Varicella Zoster Vaccine for the Prevention of Herpes Zoster and Its Complications
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The incidence and severity of HZ (or shingles), as well as the frequency and severity of its complications, increases markedly with increasing age. More than half of all cases occur in persons over the age of 60. Even without complications, HZ can interfere with an elderly patient's ability to perform essential activities of daily living, resulting in a loss of independence that is emotionally devastating and frequently irreversible. The most common complication of HZ in elderly persons is postherpetic neuralgia (PHN), which frequently results in disordered sleep, chronic fatigue, anxiety and severe depression. Antiviral therapy has a modest impact on the acute phase of HZ. However, it does not appear to prevent the development of PHN. This study is a 5.5 year randomized, double-blind, placebo-controlled, efficacy trial to determine whether vaccination with live-attenuated Oka/Merck varicella-zoster decreases the incidence and/or severity of herpes zoster (HZ) and its complications in adults 60 years of age and older.
Study identification
- NCT ID
- NCT00007501
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 38,456 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 60 Years and older
- Sex
- All
- Healthy volunteers
- Accepts healthy volunteers
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 1998 (Type not available)
- Primary completion
- Apr 2004 (Actual)
- Completion
- Feb 2011 (Actual)
- Last update posted
- Jul 4, 2013
1998 – 2011
United States locations
- U.S. sites
- 22
- U.S. states
- 17
- U.S. cities
- 22
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| VA Medical Center, Birmingham | Birmingham | Alabama | 35233 | — |
| VA Palo Alto Health Care System | Palo Alto | California | 94304-1290 | — |
| VA San Diego Healthcare System, San Diego | San Diego | California | 92161 | — |
| University of Colorado | Denver | Colorado | 80262 | — |
| James A. Haley Veterans Hospital, Tampa | Tampa | Florida | 33612 | — |
| Edward Hines, Jr. VA Hospital | Hines | Illinois | 60141-5000 | — |
| VA Medical Center, Lexington | Lexington | Kentucky | 40502 | — |
| VA Maryland Health Care System, Baltimore | Baltimore | Maryland | 21201 | — |
| NIH-NIAID (Bethesda, MD) | Bethesda | Maryland | 20892 | — |
| VA Medical Center, Jamaica Plain Campus | Boston | Massachusetts | 02130 | — |
| VA Ann Arbor Healthcare System | Ann Arbor | Michigan | 48113 | — |
| VA Medical Center, Minneapolis | Minneapolis | Minnesota | 55417 | — |
| VA Medical Center, St Louis | St Louis | Missouri | 63106 | — |
| New Mexico VA Health Care System, Albuquerque | Albuquerque | New Mexico | 87108-5153 | — |
| New York Harbor HCS | New York | New York | 10010 | — |
| VA Medical Center, Northport | Northport | New York | 11768 | — |
| Rochester, NY (NIH) | Rochester | New York | 14642 | — |
| VA Medical Center, Durham | Durham | North Carolina | 27705 | — |
| Vanderbilt University | Nashville | Tennessee | 37212-2637 | — |
| Baylor University | Houston | Texas | 77030 | — |
| University of Texas at San Antonio | San Antonio | Texas | 78229 | — |
| VA Puget Sound Health Care System, Seattle | Seattle | Washington | 98108 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00007501, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 4, 2013 · Synced Oct 25, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00007501 live on ClinicalTrials.gov.