Combination Chemotherapy Compared With Hormone Therapy in Treating Patients With Recurrent, Stage III, or Stage IV Endometrial Cancer
Public ClinicalTrials.gov record NCT00016341. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Randomized Phase III Crossover Trial of Chemotherapy (Doxorubicin/Cisplatin/Paclitaxel and G-CSF) Versus Hormonal Therapy (Tamoxifen/Megestrol Acetate) in Patients With Stage III & IV or Recurrent Endometrial Cancer
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Estrogen can stimulate the growth of tumor cells. Hormone therapy using tamoxifen and megestrol may fight endometrial cancer by blocking the absorption of estrogen. It is not yet known whether chemotherapy is more effective than hormone therapy in treating endometrial cancer. PURPOSE: Randomized phase III trial to compare the effectiveness of combination chemotherapy with that of hormone therapy in treating patients who have recurrent, stage III, or stage IV endometrial cancer.
Study identification
- NCT ID
- NCT00016341
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- Not listed
Conditions and interventions
Conditions
Interventions
- filgrastim Biological
- cisplatin Drug
- doxorubicin hydrochloride Drug
- megestrol acetate Drug
- paclitaxel Drug
- tamoxifen citrate Drug
Biological · Drug
Eligibility (public fields only)
- Age range
- Not listed
- Sex
- Female
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 2001 (Type not available)
- Primary completion
- Oct 2003 (Actual)
- Completion
- Not listed
- Last update posted
- Apr 11, 2013
Started 2001
United States locations
- U.S. sites
- 49
- U.S. states
- 26
- U.S. cities
- 44
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham Comprehensive Cancer Center | Birmingham | Alabama | 35294-3300 | — |
| Jonsson Comprehensive Cancer Center, UCLA | Los Angeles | California | 90095-1781 | — |
| Community Hospital of Los Gatos | Los Gatos | California | 95032 | — |
| Chao Family Comprehensive Cancer Center | Orange | California | 92868 | — |
| University of Colorado Cancer Center | Denver | Colorado | 80010 | — |
| Walter Reed Army Medical Center | Washington D.C. | District of Columbia | 20307-5000 | — |
| H. Lee Moffitt Cancer Center and Research Institute | Tampa | Florida | 33612-9497 | — |
| Rush-Presbyterian-St. Luke's Medical Center | Chicago | Illinois | 60612 | — |
| University of Chicago Cancer Research Center | Chicago | Illinois | 60637-1470 | — |
| Indiana University Cancer Center | Indianapolis | Indiana | 46202-5289 | — |
| Holden Comprehensive Cancer Center at The University of Iowa | Iowa City | Iowa | 52242-1009 | — |
| Albert B. Chandler Medical Center, University of Kentucky | Lexington | Kentucky | 40536-0084 | — |
| Tufts University School of Medicine | Boston | Massachusetts | 02111 | — |
| University of Massachusetts Memorial Medical Center | Worcester | Massachusetts | 01655 | — |
| Barbara Ann Karmanos Cancer Institute | Detroit | Michigan | 48201-1379 | — |
| University of Minnesota Cancer Center | Minneapolis | Minnesota | 55455 | — |
| Mayo Clinic Cancer Center | Rochester | Minnesota | 55905 | — |
| University of Mississippi Medical Center | Jackson | Mississippi | 39216-4505 | — |
| Ellis Fischel Cancer Center - Columbia | Columbia | Missouri | 65203 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| Cooper Hospital/University Medical Center | Camden | New Jersey | 08103 | — |
| Cancer Center of Albany Medical Center | Albany | New York | 12208 | — |
| State University of New York Health Science Center at Brooklyn | Brooklyn | New York | 11203 | — |
| Roswell Park Cancer Institute | Buffalo | New York | 14263-0001 | — |
| Schneider Children's Hospital at North Shore | Manhasset | New York | 11030 | — |
| Memorial Sloan-Kettering Cancer Center | New York | New York | 10021 | — |
| State University of New York Health Sciences Center - Stony Brook | Stony Brook | New York | 11790-7775 | — |
| Lineberger Comprehensive Cancer Center, UNC | Chapel Hill | North Carolina | 27599-7295 | — |
| Duke Comprehensive Cancer Center | Durham | North Carolina | 27710 | — |
| Comprehensive Cancer Center at Wake Forest University | Winston-Salem | North Carolina | 27157-1082 | — |
| Barrett Cancer Center, The University Hospital | Cincinnati | Ohio | 45267-0502 | — |
| Ireland Cancer Center | Cleveland | Ohio | 44106-5065 | — |
| Cleveland Clinic Taussig Cancer Center | Cleveland | Ohio | 44195 | — |
| Arthur G. James Cancer Hospital - Ohio State University | Columbus | Ohio | 43210-1240 | — |
| University of Oklahoma College of Medicine | Oklahoma City | Oklahoma | 73190 | — |
| Abington Memorial Hospital | Abington | Pennsylvania | 19001 | — |
| Milton S. Hershey Medical Center | Hershey | Pennsylvania | 17033-0850 | — |
| University of Pennsylvania Cancer Center | Philadelphia | Pennsylvania | 19104-4283 | — |
| Kimmel Cancer Center of Thomas Jefferson University - Philadelphia | Philadelphia | Pennsylvania | 19107-5541 | — |
| Fox Chase Cancer Center | Philadelphia | Pennsylvania | 19111 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29425-0721 | — |
| Brookview Research, Inc. | Nashville | Tennessee | 37203 | — |
| Simmons Cancer Center - Dallas | Dallas | Texas | 75235-9154 | — |
| M.D. Anderson CCOP Research Base | Houston | Texas | 77030-4009 | — |
| University of Texas - MD Anderson Cancer Center | Houston | Texas | 77030-4009 | — |
| Fletcher Allen Health Care - Medical Center Campus | Burlington | Vermont | 05401 | — |
| Cancer Center at the University of Virginia | Charlottesville | Virginia | 22908 | — |
| Fred Hutchinson Cancer Research Center | Seattle | Washington | 98109-1024 | — |
| Tacoma General Hospital | Tacoma | Washington | 98405 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 1 non-U.S. site.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00016341, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 11, 2013 · Synced Oct 19, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00016341 live on ClinicalTrials.gov.