Triacetyluridine and Fluorouracil Compared With Gemcitabine in Treating Patients With Unresectable Locally Advanced, or Metastatic Pancreatic Cancer
Public ClinicalTrials.gov record NCT00024427. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
An Open Label, Randomized, Controlled, Phase III, Multi-center, Clinical Trial Of PN401 With High Dose 5-Fluorouracil (5FU) Versus Gemcitabine For Treatment Of Patients With Advanced Pancreatic Cancer
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Giving the drugs in different combinations may kill more tumor cells. Chemoprotective drugs such as triacetyluridine may protect normal cells from the side effects of chemotherapy. It is not yet known which chemotherapy regimen is more effective in treating pancreatic cancer. PURPOSE: Randomized phase III trial to compare the effectiveness of fluorouracil plus triacetyluridine with that of gemcitabine in treating patients who have locally advanced or metastatic pancreatic cancer that cannot be treated with surgery.
Study identification
- NCT ID
- NCT00024427
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 250 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 31, 2001
- Primary completion
- Jan 31, 2006
- Completion
- Not listed
- Last update posted
- Jun 27, 2012
Started 2001
United States locations
- U.S. sites
- 26
- U.S. states
- 14
- U.S. cities
- 25
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Brookwood Medical Center | Birmingham | Alabama | 35209-6804 | — |
| Comprehensive Cancer Center at University of Alabama at Birmingham | Birmingham | Alabama | 35294 | — |
| Providence Saint Joseph Medical Center - Burbank | Burbank | California | 91505 | — |
| City of Hope Comprehensive Cancer Center | Duarte | California | 91010-3000 | — |
| Scripps Cancer Center at Scripps Clinic | La Jolla | California | 92037 | — |
| Northwest Oncology and Hematology Associates | Coral Springs | Florida | 33065 | — |
| Florida Cancer Specialists - World Plaza | Fort Myers | Florida | 33908 | — |
| Memorial Cancer Institute at Memorial Regional Hospital | Hollywood | Florida | 33021 | — |
| Florida Oncology Associates - South Side | Jacksonville | Florida | 32207 | — |
| University of Miami Sylvester Comprehensive Cancer Center | Miami | Florida | 33136 | — |
| Florida Cancer Institute - New Port Richey | New Port Richey | Florida | 34655 | — |
| St. Joseph's Hospital | Savannah | Georgia | 31419 | — |
| Cancer Care Center | New Albany | Indiana | 47150 | — |
| Cancer Center at Greater Baltimore Medical Center | Baltimore | Maryland | 21204-6881 | — |
| Wellstat Therapeutics | Gaithersburg | Maryland | 20878 | — |
| CCOP - Metro-Minnesota | Saint Louis Park | Minnesota | 55416 | — |
| Capitol Comprehensive Cancer Care Clinic | Jefferson City | Missouri | 65109 | — |
| David C. Pratt Cancer Center at St. John's Mercy | St Louis | Missouri | 63141 | — |
| University of New Mexico Cancer Research and Treatment Center | Albuquerque | New Mexico | 87131-5636 | — |
| Queens Medical Associates, PC | Fresh Meadows | New York | 11365 | — |
| New York Weill Cornell Cancer Center at Cornell University | New York | New York | 10021 | — |
| Summit Oncology Associates | Akron | Ohio | 44304 | — |
| Penn State Cancer Institute at Milton S. Hershey Medical Center | Hershey | Pennsylvania | 17033-0850 | — |
| Fox Chase - Temple Cancer Center | Philadelphia | Pennsylvania | 19140 | — |
| Cancer Centers of the Carolinas - Eastside | Greenville | South Carolina | 29615 | — |
| Corpus Christi Cancer Center | Corpus Christi | Texas | 78412 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 3 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00024427, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 27, 2012 · Synced Sep 11, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT00024427 live on ClinicalTrials.gov.