ClinicalTrials.gov record
Hormone Therapy Compared With Combination Chemotherapy in Treating Patients With Prostate Cancer
ClinicalTrials.gov ID: NCT00027859
Public ClinicalTrials.gov record NCT00027859. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase III Randomized Trial for Evaluating Second Line Hormonal Therapy (Ketoconazole/Hydrocortisone) Versus Paclitaxel/Estramustine Combination Chemotherapy on Progression Free Survival in Asymptomatic Patients With a Rising PSA After Hormonal Therapy for Prostate Cancer
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
RATIONALE: Androgens can stimulate the growth of prostate cancer cells. Drugs such as ketoconazole may stop the production of androgens. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. It is not yet known whether hormone therapy is more effective than combination chemotherapy in treating prostate cancer. PURPOSE: Randomized phase III trial to compare the effectiveness of hormone therapy with that of combination chemotherapy in treating patients who have prostate cancer that has been previously treated with androgen suppression.
Study identification
- NCT ID
- NCT00027859
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- Not listed
Conditions and interventions
Conditions
Interventions
- docetaxel Drug
- estramustine phosphate sodium Drug
- ketoconazole Drug
- therapeutic hydrocortisone Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years to 120 Years
- Sex
- Male
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 8, 2003 (Actual)
- Primary completion
- Dec 2004 (Actual)
- Completion
- Not listed
- Last update posted
- Jun 15, 2023
Started 2003
United States locations
- U.S. sites
- 98
- U.S. states
- 39
- U.S. cities
- 79
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Comprehensive Cancer Institute | Huntsville | Alabama | 35801 | — |
| CCOP - Mayo Clinic Scottsdale Oncology Program | Scottsdale | Arizona | 85259-5404 | — |
| Veterans Affairs Medical Center - Tucson | Tucson | Arizona | 85723 | — |
| Veterans Affairs Medical Center - Little Rock | Little Rock | Arkansas | 72205 | — |
| City of Hope Comprehensive Cancer Center | Duarte | California | 91010-3000 | — |
| Rebecca and John Moores UCSD Cancer Center | La Jolla | California | 92093-0658 | — |
| Cedars-Sinai Comprehensive Cancer Center at Cedars-Sinai Medical Center | Los Angeles | California | 90048 | — |
| Veterans Affairs Outpatient Clinic - Martinez | Martinez | California | 94553 | — |
| Naval Medical Center - San Diego | San Diego | California | 92134-3202 | — |
| UCSF Comprehensive Cancer Center | San Francisco | California | 94115 | — |
| Medical Center of Aurora - South Campus | Aurora | Colorado | 80012-0000 | — |
| Boulder Community Hospital | Boulder | Colorado | 80301-9019 | — |
| Penrose Cancer Center at Penrose Hospital | Colorado Springs | Colorado | 80933 | — |
| Porter Adventist Hospital | Denver | Colorado | 80210 | — |
| St. Joseph Hospital | Denver | Colorado | 80218-1191 | — |
| Presbyterian - St. Luke's Medical Center | Denver | Colorado | 80218 | — |
| Rocky Mountain Cancer Centers - Denver Rose | Denver | Colorado | 80220 | — |
| Veterans Affairs Medical Center - Denver | Denver | Colorado | 80220 | — |
| CCOP - Colorado Cancer Research Program, Incorporated | Denver | Colorado | 80224 | — |
| Swedish Medical Center | Englewood | Colorado | 80112 | — |
| Sky Ridge Medical Center | Lone Tree | Colorado | 80124 | — |
| Hope Cancer Care Center at Longmont United Hospital | Longmont | Colorado | 80501 | — |
| St. Mary-Corwin Regional Medical Center | Pueblo | Colorado | 81004 | — |
| Rocky Mountain Cancer Centers - Thornton | Thornton | Colorado | 80221 | — |
| Walter Reed Army Medical Center | Washington D.C. | District of Columbia | 20307-5001 | — |
| Memorial Regional Cancer Center at Memorial Regional Hospital | Hollywood | Florida | 33021 | — |
| H. Lee Moffitt Cancer Center and Research Institute at University of South Florida | Tampa | Florida | 33612-9497 | — |
| Veterans Affairs Medical Center - Tampa (Haley) | Tampa | Florida | 33612 | — |
| Veterans Affairs Medical Center - Atlanta (Decatur) | Decatur | Georgia | 30033 | — |
| MBCCOP - Hawaii | Honolulu | Hawaii | 96813 | — |
| University of Chicago Cancer Research Center | Chicago | Illinois | 60637-1470 | — |
| CCOP - Central Illinois | Decatur | Illinois | 62526 | — |
| Decatur Memorial Hospital Cancer Care Institute | Decatur | Illinois | 62526 | — |
| Veterans Affairs Medical Center - Hines | Hines | Illinois | 60141 | — |
| CCOP - Illinois Oncology Research Association | Peoria | Illinois | 61615-7828 | — |
| West Suburban Center for Cancer Care | River Forest | Illinois | 60305 | — |
| CCOP - Carle Cancer Center | Urbana | Illinois | 61801 | — |
| Indiana University Cancer Center | Indianapolis | Indiana | 46202-5289 | — |
| Veterans Affairs Medical Center - Indianapolis (Roudebush) | Indianapolis | Indiana | 46202 | — |
| CCOP - Cedar Rapids Oncology Project | Cedar Rapids | Iowa | 52403-1206 | — |
| Veterans Affairs Medical Center - Wichita | Wichita | Kansas | 67218 | — |
| Veterans Affairs Medical Center - Lexington | Lexington | Kentucky | 40502-2236 | — |
| MBCCOP - LSU Health Sciences Center | New Orleans | Louisiana | 70112 | — |
| Veterans Affairs Medical Center - New Orleans | New Orleans | Louisiana | 70112 | — |
| CCOP - Ochsner | New Orleans | Louisiana | 70121 | — |
| Veterans Affairs Medical Center - Shreveport | Shreveport | Louisiana | 71101-4295 | — |
| Greenebaum Cancer Center at University of Maryland Medical Center | Baltimore | Maryland | 21201 | — |
| Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Baltimore | Maryland | 21231 | — |
| Veterans Affairs Medical Center - Detroit | Detroit | Michigan | 48201-1932 | — |
| CCOP - Kalamazoo | Kalamazoo | Michigan | 49007-3731 | — |
| West Michigan Cancer Center | Kalamazoo | Michigan | 49007 | — |
| Lakeland Cancer Care Center at Lakeland Hospital - St. Joseph | Saint Joseph | Michigan | 49085 | — |
| Mayo Clinic Cancer Center | Rochester | Minnesota | 55905 | — |
| Veterans Affairs Medical Center - Jackson | Jackson | Mississippi | 39216 | — |
| Ellis Fischel Cancer Center at University of Missouri - Columbia | Columbia | Missouri | 65203 | — |
| CCOP - Kansas City | Kansas City | Missouri | 64131 | — |
| Missouri Baptist Cancer Center | St Louis | Missouri | 63131 | — |
| CCOP - Southern Nevada Cancer Research Foundation | Las Vegas | Nevada | 89106 | — |
| New Hampshire Oncology-Hematology, PA - Hooksett | Hooksett | New Hampshire | 03106 | — |
| Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center | Lebanon | New Hampshire | 03756-0002 | — |
| Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School | New Brunswick | New Jersey | 08903 | — |
| Veterans Affairs Medical Center - Albuquerque | Albuquerque | New Mexico | 87108-5138 | — |
| MBCCOP - University of New Mexico HSC | Albuquerque | New Mexico | 87131 | — |
| Roswell Park Cancer Institute | Buffalo | New York | 14263-0001 | — |
| NYU School of Medicine's Kaplan Comprehensive Cancer Center | New York | New York | 10016 | — |
| Memorial Sloan-Kettering Cancer Center | New York | New York | 10021 | — |
| Mount Sinai Medical Center | New York | New York | 10029 | — |
| Veterans Affairs Medical Center - Syracuse | Syracuse | New York | 13210 | — |
| Cape Fear Valley Health System | Fayetteville | North Carolina | 28302-2000 | — |
| CCOP - Southeast Cancer Control Consortium | Goldsboro | North Carolina | 27534-9479 | — |
| Veterans Affairs Medical Center - Cincinnati | Cincinnati | Ohio | 45220-2288 | — |
| Cleveland Clinic Taussig Cancer Center | Cleveland | Ohio | 44195 | — |
| CCOP - Columbus | Columbus | Ohio | 43206 | — |
| Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University | Columbus | Ohio | 43210-1240 | — |
| Veterans Affairs Medical Center - Dayton | Dayton | Ohio | 45428-1002 | — |
| CCOP - Toledo Community Hospital | Toledo | Ohio | 43623-3456 | — |
| Oklahoma University Medical Center | Oklahoma City | Oklahoma | 73104 | — |
| Veterans Affairs Medical Center - Portland | Portland | Oregon | 97207 | — |
| CCOP - Geisinger Clinic and Medical Center | Danville | Pennsylvania | 17822-2001 | — |
| Abramson Cancer Center at the University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | — |
| Fox Chase Cancer Center | Philadelphia | Pennsylvania | 19111-2497 | — |
| Western Pennsylvania Hospital | Pittsburgh | Pennsylvania | 15224 | — |
| Veterans Affairs Medical Center - Charleston | Charleston | South Carolina | 29401-5799 | — |
| CCOP - Sioux Community Cancer Consortium | Sioux Falls | South Dakota | 57104 | — |
| Vanderbilt-Ingram Cancer Center at Vanderbilt Medical Center | Nashville | Tennessee | 37232-6307 | — |
| Harrington Cancer Center | Amarillo | Texas | 79106 | — |
| Veterans Affairs Medical Center - Amarillo | Amarillo | Texas | 79106 | — |
| Veterans Affairs Medical Center - San Antonio (Murphy) | San Antonio | Texas | 78229 | — |
| Veterans Affairs Medical Center - Temple | Temple | Texas | 76504 | — |
| CCOP - Scott and White Hospital | Temple | Texas | 76508 | — |
| Veterans Affairs Medical Center - Salt Lake City | Salt Lake City | Utah | 84148 | — |
| Martha Jefferson Hospital | Charlottesville | Virginia | 22902 | — |
| Oncology and Hematology Associates of Southwest Virginia, Incorporated - Roanoke | Roanoke | Virginia | 24014 | — |
| Veterans Affairs Medical Center - Seattle | Seattle | Washington | 98108 | — |
| St. Mary's Medical Center | Huntington | West Virginia | 25701 | — |
| CCOP - St. Vincent Hospital Cancer Center, Green Bay | Green Bay | Wisconsin | 54307-3453 | — |
| University of Wisconsin Comprehensive Cancer Center | Madison | Wisconsin | 53792-0001 | — |
| Medical College of Wisconsin Cancer Center | Milwaukee | Wisconsin | 53226-3596 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00027859, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 15, 2023 · Synced Oct 25, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00027859 live on ClinicalTrials.gov.