Homocysteine Study (HOST)
Public ClinicalTrials.gov record NCT00032435. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
CSP #453 - Homocysteinemia in Kidney and Endstage Renal Disease Study (HOST)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The primary objective of this study is to test the hypothesis that administration of folate, pyridoxine (vitamin B6) and cyanocobalamin (vitamin B12) in high doses to patients with advanced chronic renal failure or end stage renal disease and abnormally high plasma homocysteine levels will lower the homocysteine levels and the death rate compared to patients who receive placebo. The secondary objective is to test the hypothesis that intake of the vitamins compared to placebo decreases the incidence of myocardial infarction, disabling stroke, and amputation of a lower extremity and, in hemodialysis patients, thrombosis of the vascular access.
Study identification
- NCT ID
- NCT00032435
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 2,003 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 21 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 2001 (Type not available)
- Primary completion
- Aug 2006 (Actual)
- Completion
- Sep 2006 (Actual)
- Last update posted
- Oct 15, 2010
2001 – 2006
United States locations
- U.S. sites
- 36
- U.S. states
- 24
- U.S. cities
- 36
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| VA Medical Center, Birmingham | Birmingham | Alabama | 35233 | — |
| Health Economics Resource Center (HERC), Menlo Park | Menlo Park | California | 94025 | — |
| VA Palo Alto Health Care System | Palo Alto | California | 94304-1290 | — |
| VA San Diego Healthcare System, San Diego | San Diego | California | 92161 | — |
| VA Eastern Colorado Health Care System, Denver | Denver | Colorado | 80220 | — |
| VA Connecticut Health Care System (West Haven) | West Haven | Connecticut | 06516 | — |
| VA Medical Center, DC | Washington D.C. | District of Columbia | 20422 | — |
| VA Medical Center, Bay Pines | Bay Pines | Florida | 33708 | — |
| North Florida/South Georgia Veterans Health System | Gainesville | Florida | 32608 | — |
| VA Medical Center, Miami | Miami | Florida | 33125 | — |
| West Palm Beach VA Medical Center | West Palm Beach | Florida | 33410 | — |
| Edward Hines, Jr. VA Hospital | Hines | Illinois | 60141-5000 | — |
| Richard Roudebush VA Medical Center, Indianapolis | Indianapolis | Indiana | 46202-2884 | — |
| Southeast Veterans Healthcare System, New Orleans | New Orleans | Louisiana | 70112 | — |
| VA Medical Center, Jamaica Plain Campus | Boston | Massachusetts | 02130 | — |
| VA Ann Arbor Healthcare System | Ann Arbor | Michigan | 48113 | — |
| John D. Dingell VA Medical Center, Detroit | Detroit | Michigan | 48201 | — |
| VA Medical Center, Minneapolis | Minneapolis | Minnesota | 55417 | — |
| G.V. (Sonny) Montgomery VA Medical Center, Jackson | Jackson | Mississippi | 39216 | — |
| VA Medical Center, Kansas City MO | Kansas City | Missouri | 64128 | — |
| VA Western New York Healthcare System at Buffalo | Buffalo | New York | 14215 | — |
| New York Harbor HCS | New York | New York | 10010 | — |
| VA Medical Center, Northport | Northport | New York | 11768 | — |
| VA Medical Center, Syracuse | Syracuse | New York | 13210 | — |
| VA Medical Center, Bronx | The Bronx | New York | 10468 | — |
| VA Medical Center, Cleveland | Cleveland | Ohio | 44106 | — |
| VA Medical Center, Dayton | Dayton | Ohio | 45428 | — |
| VA Medical Center, Portland | Portland | Oregon | 97201 | — |
| VA Pittsburgh Health Care System | Pittsburgh | Pennsylvania | 15240 | — |
| Ralph H Johnson VA Medical Center, Charleston | Charleston | South Carolina | 29401-5799 | — |
| VA Medical Center, Memphis | Memphis | Tennessee | 38104 | — |
| VA North Texas Health Care System, Dallas | Dallas | Texas | 75216 | — |
| Michael E. DeBakey VA Medical Center (152) | Houston | Texas | 77030 | — |
| Hunter Holmes McGuire VA Medical Center | Richmond | Virginia | 23249 | — |
| VA Puget Sound Health Care System, Seattle | Seattle | Washington | 98108 | — |
| Zablocki VA Medical Center, Milwaukee | Milwaukee | Wisconsin | 53295-1000 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 1 non-U.S. site.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00032435, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 15, 2010 · Synced Nov 3, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00032435 live on ClinicalTrials.gov.