Chemotherapy, Imatinib Mesylate, and Peripheral Stem Cell Transplantation in Treating Patients With Newly Diagnosed Acute Lymphoblastic Leukemia
Public ClinicalTrials.gov record NCT00039377. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
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Official title
A Phase II Trial of Sequential Chemotherapy, Imatinib Mesylate (Gleevec, STI571) (NSC # 716051), and Transplantation for Adults With Newly Diagnosed Ph+ Acute Lymphoblastic Leukemia by the CALGB and SWOG
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This phase II trial studies how well giving imatinib mesylate together with chemotherapy and peripheral stem cell transplantation works in treating patients with newly diagnosed acute lymphoblastic leukemia. Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Imatinib mesylate may stop the growth of cancer cells by blocking the enzymes necessary for cancer cell growth. Giving imatinib mesylate together with chemotherapy and peripheral stem cell transplantation may be an effective treatment for acute lymphoblastic leukemia.
Study identification
- NCT ID
- NCT00039377
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 58 participants
Conditions and interventions
Interventions
- imatinib mesylate Drug
- methotrexate Drug
- vincristine sulfate Drug
- leucovorin calcium Drug
- peripheral blood stem cell transplantation Procedure
- autologous hematopoietic stem cell transplantation Procedure
- allogeneic hematopoietic stem cell transplantation Procedure
- total-body irradiation Radiation
- tacrolimus Drug
- filgrastim Biological
- etoposide Drug
- cyclophosphamide Drug
- cytarabine Drug
- laboratory biomarker analysis Other
Drug · Procedure · Radiation + 2 more
Eligibility (public fields only)
- Age range
- 15 Years to 59 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Apr 2002 (Type not available)
- Primary completion
- Apr 2012 (Actual)
- Completion
- Feb 2014 (Actual)
- Last update posted
- Nov 24, 2014
2002 – 2014
United States locations
- U.S. sites
- 97
- U.S. states
- 17
- U.S. cities
- 66
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Blood and Marrow Transplant Group of Georgia | Atlanta | Georgia | 30342 | — |
| Saint Joseph Medical Center | Bloomington | Illinois | 61701 | — |
| Graham Hospital Association | Canton | Illinois | 61520 | — |
| Memorial Hospital | Carthage | Illinois | 62321 | — |
| University of Chicago | Chicago | Illinois | 60637 | — |
| Weiss Memorial Hospital | Chicago | Illinois | 60640 | — |
| Eureka Hospital | Eureka | Illinois | 61530 | — |
| Galesburg Cottage Hospital | Galesburg | Illinois | 61401 | — |
| Illinois CancerCare Galesburg | Galesburg | Illinois | 61401 | — |
| Mason District Hospital | Havana | Illinois | 62644 | — |
| Hopedale Medical Complex - Hospital | Hopedale | Illinois | 61747 | — |
| Mcdonough District Hospital | Macomb | Illinois | 61455 | — |
| Loyola University Medical Center | Maywood | Illinois | 60153 | — |
| Bromenn Regional Medical Center | Normal | Illinois | 61761 | — |
| Community Cancer Center Foundation | Normal | Illinois | 61761 | — |
| Illinois CancerCare-Ottawa Clinic | Ottawa | Illinois | 61350 | — |
| Ottawa Regional Hospital and Healthcare Center | Ottawa | Illinois | 61350 | — |
| Pekin Cancer Treatment Center | Pekin | Illinois | 61554 | — |
| Pekin Hospital | Pekin | Illinois | 61554 | — |
| Methodist Medical Center of Illinois | Peoria | Illinois | 61603 | — |
| Proctor Hospital | Peoria | Illinois | 61614 | — |
| Illinois CancerCare-Peoria | Peoria | Illinois | 61615 | — |
| Illinois Oncology Research Association CCOP | Peoria | Illinois | 61615 | — |
| OSF Saint Francis Medical Center | Peoria | Illinois | 61637 | — |
| Illinois Valley Hospital | Peru | Illinois | 61354 | — |
| Perry Memorial Hospital | Princeton | Illinois | 61356 | — |
| Saint Margaret's Hospital | Spring Valley | Illinois | 61362 | — |
| Fort Wayne Medical Oncology and Hematology Inc-Parkview | Fort Wayne | Indiana | 46845 | — |
| Cancer Center of Kansas - Chanute | Chanute | Kansas | 66720 | — |
| Cancer Center of Kansas - Dodge City | Dodge City | Kansas | 67801 | — |
| Cancer Center of Kansas - El Dorado | El Dorado | Kansas | 67042 | — |
| Providence Medical Center | Kansas City | Kansas | 66112 | — |
| Cancer Center of Kansas-Kingman | Kingman | Kansas | 67068 | — |
| Lawrence Memorial Hospital | Lawrence | Kansas | 66044 | — |
| Cancer Center of Kansas - Newton | Newton | Kansas | 67114 | — |
| Radiation Oncology Center of Olathe | Olathe | Kansas | 66061 | — |
| Radiation Oncology Practice Corporation Southwest | Overland Park | Kansas | 66210 | — |
| Cancer Center of Kansas - Parsons | Parsons | Kansas | 67357 | — |
| Cancer Center of Kansas - Pratt | Pratt | Kansas | 67124 | — |
| Cancer Center of Kansas - Salina | Salina | Kansas | 67401 | — |
| Salina Regional Health Center | Salina | Kansas | 67401 | — |
| Cancer Center of Kansas - Wellington | Wellington | Kansas | 67152 | — |
| Associates In Womens Health | Wichita | Kansas | 67208 | — |
| Cancer Center of Kansas-Wichita Medical Arts Tower | Wichita | Kansas | 67208 | — |
| Cancer Center of Kansas - Main Office | Wichita | Kansas | 67214 | — |
| Via Christi Regional Medical Center | Wichita | Kansas | 67214 | — |
| Wichita CCOP | Wichita | Kansas | 67214 | — |
| Cancer Center of Kansas - Winfield | Winfield | Kansas | 67156 | — |
| Eastern Maine Medical Center | Bangor | Maine | 04401 | — |
| Beverly Hospital | Beverly | Massachusetts | 01915 | — |
| Addison Gilbert Hospital | Gloucester | Massachusetts | 01930 | — |
| Commonwealth Hematology Oncology PC-Worcester | Worcester | Massachusetts | 01605 | — |
| Centerpoint Medical Center LLC | Independence | Missouri | 64057 | — |
| Saint Luke's Cancer Institute | Kansas City | Missouri | 64111 | — |
| Radiation Oncology Practice Corporation South | Kansas City | Missouri | 64114 | — |
| Radiation Oncology Practice Corporation - North | Kansas City | Missouri | 64154 | — |
| Liberty Hospital | Liberty | Missouri | 64068 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| Montana Cancer Consortium CCOP | Billings | Montana | 59101 | — |
| Northern Rockies Radiation Oncology Center | Billings | Montana | 59101 | — |
| Saint Vincent Healthcare | Billings | Montana | 59101 | — |
| Hematology-Oncology Centers of the Northern Rockies PC | Billings | Montana | 59102 | — |
| Billings Clinic | Billings | Montana | 59107-7000 | — |
| Deaconess Medical Center | Billings | Montana | 59107 | — |
| Bozeman Deaconess Cancer Center | Bozeman | Montana | 59715 | — |
| Bozeman Deaconess Hospital | Bozeman | Montana | 59715 | — |
| Internal Medicine of Bozeman | Bozeman | Montana | 59715 | — |
| Saint James Community Hospital and Cancer Treatment Center | Butte | Montana | 59701 | — |
| Berdeaux, Donald MD (UIA Investigator) | Great Falls | Montana | 59405 | — |
| Great Falls Clinic | Great Falls | Montana | 59405 | — |
| Saint Peter's Community Hospital | Helena | Montana | 59601 | — |
| Glacier Oncology PLLC | Kalispell | Montana | 59901 | — |
| Kalispell Medical Oncology | Kalispell | Montana | 59901 | — |
| Kalispell Regional Medical Center | Kalispell | Montana | 59901 | — |
| Community Medical Hospital | Missoula | Montana | 59801 | — |
| Montana Cancer Specialists | Missoula | Montana | 59802 | — |
| Saint Patrick Hospital - Community Hospital | Missoula | Montana | 59802 | — |
| Guardian Oncology and Center for Wellness | Missoula | Montana | 59804 | — |
| Cheshire Medical Center-Dartmouth-Hitchcock Keene | Keene | New Hampshire | 03431 | — |
| Frisbie Hospital | Rochester | New Hampshire | 03867 | — |
| Roswell Park Cancer Institute | Buffalo | New York | 14263 | — |
| North Shore University Hospital | Manhasset | New York | 11030 | — |
| North Shore-LIJ Health System CCOP | Manhasset | New York | 11030 | — |
| Long Island Jewish Medical Center | New Hyde Park | New York | 11040 | — |
| North Shore-LIJ Health System/Center for Advanced Medicine | New Hyde Park | New York | 11040 | — |
| Weill Medical College of Cornell University | New York | New York | 10065 | — |
| Oswego Hospital | Oswego | New York | 13126 | — |
| University of Rochester | Rochester | New York | 14642 | — |
| State University of New York Upstate Medical University | Syracuse | New York | 13210 | — |
| Kinston Medical Specialists PA | Kinston | North Carolina | 28501 | — |
| Wake Forest University Health Sciences | Winston-Salem | North Carolina | 27157 | — |
| Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University Medical Center | Columbus | Ohio | 43210 | — |
| Western Pennsylvania Hospital | Pittsburgh | Pennsylvania | 15224-1791 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| Northeastern | St. Johnsbury | Vermont | 05819 | — |
| Virginia Commonwealth University | Richmond | Virginia | 23298 | — |
| Welch Cancer Center | Sheridan | Wyoming | 82801 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00039377, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Nov 24, 2014 · Synced Nov 4, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00039377 live on ClinicalTrials.gov.