ClinicalTrials.gov record
Erlotinib and Temozolomide With Radiation Therapy in Treating Patients With Glioblastoma Multiforme or Other Brain Tumors
ClinicalTrials.gov ID: NCT00039494
Public ClinicalTrials.gov record NCT00039494. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Pilot and Phase II Study of OSI-774 and Temozolomide in Combination With Radiation Therapy in Glioblastoma Multiforme
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This pilot phase II trial is studying the side effects and best dose of erlotinib when given with temozolomide and radiation therapy and to see how well they work in treating patients with glioblastoma multiforme or other brain tumors. Radiation therapy uses high-energy x-rays to damage tumor cells. Erlotinib may interfere with the growth of tumor cells, slow the growth of the tumor, and make the tumor cells more sensitive to radiation therapy. Drugs used in chemotherapy, such as temozolomide, work in different ways to stop tumor cells from dividing so they stop growing or die. Combining erlotinib and temozolomide with radiation therapy may kill more tumor cells.
Study identification
- NCT ID
- NCT00039494
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 171 participants
Conditions and interventions
Interventions
- erlotinib hydrochloride Drug
- 3-dimensional conformal radiation therapy Radiation
- temozolomide Drug
Drug · Radiation
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 2002 (Type not available)
- Primary completion
- Jul 2007 (Actual)
- Completion
- Not listed
- Last update posted
- Aug 2, 2013
Started 2002
United States locations
- U.S. sites
- 139
- U.S. states
- 15
- U.S. cities
- 85
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Mobile Infirmary Medical Center | Mobile | Alabama | 36607 | — |
| Mayo Clinic in Arizona | Scottsdale | Arizona | 85259 | — |
| Mayo Clinic in Florida | Jacksonville | Florida | 32224-9980 | — |
| Northeast Georgia Cancer Care LLC | Athens | Georgia | 30607 | — |
| Rush - Copley Medical Center | Aurora | Illinois | 60504 | — |
| Saint Joseph Medical Center | Bloomington | Illinois | 61701 | — |
| Graham Hospital Association | Canton | Illinois | 61520 | — |
| Memorial Hospital | Carthage | Illinois | 62321 | — |
| Saint Anthony Memorial Hospital | Effingham | Illinois | 62401 | — |
| Eureka Hospital | Eureka | Illinois | 61530 | — |
| Galesburg Cottage Hospital | Galesburg | Illinois | 61401 | — |
| Illinois CancerCare Galesburg | Galesburg | Illinois | 61401 | — |
| Western Illinois Cancer Treatment Center | Galesburg | Illinois | 61401 | — |
| Mason District Hospital | Havana | Illinois | 62644 | — |
| Hopedale Medical Complex - Hospital | Hopedale | Illinois | 61747 | — |
| Joliet Oncology-Hematology Associates Limited | Joliet | Illinois | 60435 | — |
| Kewanee Hospital | Kewanee | Illinois | 61443 | — |
| Mcdonough District Hospital | Macomb | Illinois | 61455 | — |
| Garneau, Stewart C MD (UIA Investigator) | Moline | Illinois | 61265 | — |
| Porubcin, Michael MD (UIA Investigator) | Moline | Illinois | 61265 | — |
| Sharis, Christine M MD (UIA Investigator) | Moline | Illinois | 61265 | — |
| Stoffel, Thomas J MD (UIA Investigator) | Moline | Illinois | 61265 | — |
| Vigliotti, Antonio, P.G. M.D. (UIA Investigator) | Moline | Illinois | 61265 | — |
| Bromenn Regional Medical Center | Normal | Illinois | 61761 | — |
| Community Cancer Center Foundation | Normal | Illinois | 61761 | — |
| Illinois CancerCare-Ottawa Clinic | Ottawa | Illinois | 61350 | — |
| Ottawa Regional Hospital and Healthcare Center | Ottawa | Illinois | 61350 | — |
| Pekin Cancer Treatment Center | Pekin | Illinois | 61554 | — |
| Pekin Hospital | Pekin | Illinois | 61554 | — |
| Methodist Medical Center of Illinois | Peoria | Illinois | 61603 | — |
| Proctor Hospital | Peoria | Illinois | 61614 | — |
| Illinois CancerCare-Peoria | Peoria | Illinois | 61615 | — |
| Illinois Oncology Research Association CCOP | Peoria | Illinois | 61615 | — |
| OSF Saint Francis Medical Center | Peoria | Illinois | 61637 | — |
| Illinois Valley Hospital | Peru | Illinois | 61354 | — |
| Perry Memorial Hospital | Princeton | Illinois | 61356 | — |
| Saint Margaret's Hospital | Spring Valley | Illinois | 61362 | — |
| Valley Cancer Center | Spring Valley | Illinois | 61362 | — |
| Carle Clinic-Urbana Main | Urbana | Illinois | 61801 | — |
| Saint Anthony Memorial Health Center | Michigan City | Indiana | 46360 | — |
| McFarland Clinic | Ames | Iowa | 50010 | — |
| Constantinou, Costas L MD (UIA Investigator) | Bettendorf | Iowa | 52722 | — |
| Saint Anthony Regional Hospital | Carroll | Iowa | 51401 | — |
| Saint Luke's Hospital | Cedar Rapids | Iowa | 52402 | — |
| Cedar Rapids Oncology Association | Cedar Rapids | Iowa | 52403 | — |
| Mercy Hospital | Cedar Rapids | Iowa | 52403 | — |
| Oncology Associates at Mercy Medical Center | Cedar Rapids | Iowa | 52403 | — |
| Medical Oncology and Hematology Associates-West Des Moines | Clive | Iowa | 50325 | — |
| Alegent Health Mercy Hospital | Council Bluffs | Iowa | 51503 | — |
| Mercy Capitol | Des Moines | Iowa | 50307 | — |
| Iowa Methodist Medical Center | Des Moines | Iowa | 50309 | — |
| Iowa Oncology Research Association CCOP | Des Moines | Iowa | 50309 | — |
| Medical Oncology and Hematology Associates-Des Moines | Des Moines | Iowa | 50309 | — |
| Medical Oncology and Hematology Associates | Des Moines | Iowa | 50314 | — |
| Mercy Medical Center - Des Moines | Des Moines | Iowa | 50314 | — |
| Iowa Lutheran Hospital | Des Moines | Iowa | 50316 | — |
| Community Memorial Hospital | Missouri Valley | Iowa | 51555 | — |
| Burgess Memorial Hospital | Onawa | Iowa | 51040 | — |
| Siouxland Regional Cancer Center | Sioux City | Iowa | 51101-1733 | — |
| Siouxland Hematology Oncology Associates | Sioux City | Iowa | 51101 | — |
| Mercy Medical Center-Sioux City | Sioux City | Iowa | 51104 | — |
| Saint Luke's Regional Medical Center | Sioux City | Iowa | 51104 | — |
| Hospital District Sixth of Harper County | Anthony | Kansas | 67003 | — |
| Cancer Center of Kansas - Chanute | Chanute | Kansas | 66720 | — |
| Cancer Center of Kansas - Dodge City | Dodge City | Kansas | 67801 | — |
| Cancer Center of Kansas - El Dorado | El Dorado | Kansas | 67042 | — |
| Cancer Center of Kansas - Fort Scott | Fort Scott | Kansas | 66701 | — |
| Cancer Center of Kansas-Independence | Independence | Kansas | 67301 | — |
| Cancer Center of Kansas-Kingman | Kingman | Kansas | 67068 | — |
| Lawrence Memorial Hospital | Lawrence | Kansas | 66044 | — |
| Cancer Center of Kansas - Newton | Newton | Kansas | 67114 | — |
| Cancer Center of Kansas - Parsons | Parsons | Kansas | 67357 | — |
| Cancer Center of Kansas - Pratt | Pratt | Kansas | 67124 | — |
| Cancer Center of Kansas - Salina | Salina | Kansas | 67401 | — |
| Cancer Center of Kansas - Wellington | Wellington | Kansas | 67152 | — |
| Associates In Womens Health | Wichita | Kansas | 67208 | — |
| Cancer Center of Kansas-Wichita Medical Arts Tower | Wichita | Kansas | 67208 | — |
| Cancer Center of Kansas - Main Office | Wichita | Kansas | 67214 | — |
| Via Christi Regional Medical Center | Wichita | Kansas | 67214 | — |
| Wesley Medical Center | Wichita | Kansas | 67214 | — |
| Wichita CCOP | Wichita | Kansas | 67214 | — |
| Cancer Center of Kansas - Winfield | Winfield | Kansas | 67156 | — |
| Saint Joseph Mercy Hospital | Ann Arbor | Michigan | 48106-0995 | — |
| Michigan Cancer Research Consortium Community Clinical Oncology Program | Ann Arbor | Michigan | 48106 | — |
| Oakwood Hospital | Dearborn | Michigan | 48124 | — |
| Saint John Hospital and Medical Center | Detroit | Michigan | 48236 | — |
| Hurley Medical Center | Flint | Michigan | 48502 | — |
| Genesys Regional Medical Center-West Flint Campus | Flint | Michigan | 48532 | — |
| Allegiance Health | Jackson | Michigan | 49201 | — |
| Sparrow Hospital | Lansing | Michigan | 48912 | — |
| Saint Mary's of Michigan | Saginaw | Michigan | 48601 | — |
| Saint John Macomb-Oakland Hospital | Warren | Michigan | 48093 | — |
| Harris, John Gilbert MD (UIA Investigator) | Alexandria | Minnesota | 56308 | — |
| Medini, Eitan MD (UIA Investigator) | Alexandria | Minnesota | 56308 | — |
| Sanford Clinic North-Bemidgi | Bemidji | Minnesota | 56601 | — |
| Brainerd Medical Center Inc | Brainerd | Minnesota | 56401 | — |
| Essentia Health Saint Joseph's Medical Center | Brainerd | Minnesota | 56401 | — |
| Essentia Health Duluth Clinic CCOP | Duluth | Minnesota | 55805 | — |
| Essentia Health Saint Mary's Medical Center | Duluth | Minnesota | 55805 | — |
| Miller-Dwan Hospital | Duluth | Minnesota | 55805 | — |
| Etzell, Paul S MD (UIA Investigator) | Fergus Falls | Minnesota | 56537 | — |
| Swenson, Wade II, MD (UIA Investigator) | Fergus Falls | Minnesota | 56537 | — |
| Meeker County Memorial Hospital | Litchfield | Minnesota | 55355 | — |
| Virginia Piper Cancer Institute | Minneapolis | Minnesota | 55407 | — |
| Chippewa County - Montevideo Hospital | Montevideo | Minnesota | 56265 | — |
| Mayo Clinic | Rochester | Minnesota | 55905 | — |
| CentraCare Clinic | Saint Cloud | Minnesota | 56303 | — |
| Saint Cloud Hospital | Saint Cloud | Minnesota | 56303 | — |
| Saint Joseph's Hospital - Healtheast | Saint Paul | Minnesota | 55102 | — |
| Adult and Pediatric Urology PLLP | Sartell | Minnesota | 56377 | — |
| Woodwinds Health Campus | Woodbury | Minnesota | 55125 | — |
| Montana Cancer Consortium CCOP | Billings | Montana | 59101 | — |
| Northern Rockies Radiation Oncology Center | Billings | Montana | 59101 | — |
| Saint Vincent Healthcare | Billings | Montana | 59101 | — |
| Hematology-Oncology Centers of the Northern Rockies PC | Billings | Montana | 59102 | — |
| Billings Clinic | Billings | Montana | 59107-7000 | — |
| Deaconess Medical Center | Billings | Montana | 59107 | — |
| Bozeman Deaconess Cancer Center | Bozeman | Montana | 59715 | — |
| Bozeman Deaconess Hospital | Bozeman | Montana | 59715 | — |
| Internal Medicine of Bozeman | Bozeman | Montana | 59715 | — |
| Saint James Community Hospital and Cancer Treatment Center | Butte | Montana | 59701 | — |
| Saint Peter's Community Hospital | Helena | Montana | 59601 | — |
| Glacier Oncology PLLC | Kalispell | Montana | 59901 | — |
| Community Medical Hospital | Missoula | Montana | 59801 | — |
| Montana Cancer Specialists | Missoula | Montana | 59802 | — |
| Saint Patrick Hospital - Community Hospital | Missoula | Montana | 59802 | — |
| Fremont Area Medical Center | Fremont | Nebraska | 68025 | — |
| Bryan LGH Medical Center West | Lincoln | Nebraska | 68502 | — |
| Bryan LGH Medical Center East | Lincoln | Nebraska | 68506 | — |
| Saint Elizabeth Regional Medical Center | Lincoln | Nebraska | 68510 | — |
| Midlands Community Hospital | Papillion | Nebraska | 68046 | — |
| Bismarck Cancer Center | Bismarck | North Dakota | 58501 | — |
| Mid Dakota Clinic | Bismarck | North Dakota | 58501 | — |
| Saint Alexius Medical Center | Bismarck | North Dakota | 58501 | — |
| Sanford Bismarck Medical Center | Bismarck | North Dakota | 58501 | — |
| Sanford Clinic North-Fargo | Fargo | North Dakota | 58122 | — |
| Sanford Medical Center-Fargo | Fargo | North Dakota | 58122 | — |
| University of Virginia | Charlottesville | Virginia | 22908 | — |
| Welch Cancer Center | Sheridan | Wyoming | 82801 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00039494, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 2, 2013 · Synced Oct 1, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00039494 live on ClinicalTrials.gov.