Anti-HIV Drug Regimens and Treatment-Switching Guidelines in HIV Infected Children
Public ClinicalTrials.gov record NCT00039741. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase II/III Randomized, Open-Label Study of Combination Antiretroviral Regimens and Treatment-Switching Strategies in HIV-1-Infected Antiretroviral Naive Children Between 30 Days and 18 Years of Age
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Little is known about what treatment combinations are best for HIV infected children. This study examined the long-term effectiveness of different anti-HIV drug combinations in children and strategies for switching treatment if the first treatment does not work. The study enrolled children who had not previously taken anti-HIV medication. Participants in this study were recruited in the United States, South America and Europe. Some European children may also enroll in a substudy that will observe changes in body fat in children taking anti-HIV medications.
Study identification
- NCT ID
- NCT00039741
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2, Phase 3
- Enrollment
- 266 participants
Conditions and interventions
Conditions
Interventions
- NRTIs (ABC, FTC, FTC/TDF, 3TC, 3TC/AZT, d4T, TDF, ddC, AZT) Drug
- NNRTIs (EFV, NVP) Drug
- PIs (AMP, IDV, LPV/r, NFV, SQV, RTV) Drug
Drug
Eligibility (public fields only)
- Age range
- 30 Days to 18 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 31, 2002
- Primary completion
- Jul 31, 2009
- Completion
- Feb 28, 2010
- Last update posted
- Nov 4, 2021
2002 – 2010
United States locations
- U.S. sites
- 29
- U.S. states
- 15
- U.S. cities
- 25
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Usc La Nichd Crs | Alhambra | California | 91803 | — |
| Miller Children's Hosp. Long Beach CA NICHD CRS | Long Beach | California | 90806 | — |
| Children's Hospital of Los Angeles NICHD CRS | Los Angeles | California | 90027-6062 | — |
| UCLA-Los Angeles/Brazil AIDS Consortium (LABAC) CRS | Los Angeles | California | 90095-1752 | — |
| Children's Hosp. & Research Ctr. Oakland, Ped. Clinical Research Ctr. & Research Lab. | Oakland | California | 94609 | — |
| Connecticut Children's Med. Ctr. | Hartford | Connecticut | 06106 | — |
| Howard Univ. Washington DC NICHD CRS | Washington D.C. | District of Columbia | 20060 | — |
| South Florida CDTC Ft Lauderdale NICHD CRS | Fort Lauderdale | Florida | 33316 | — |
| Univ. of Florida College of Medicine-Dept of Peds, Div. of Immunology, Infectious Diseases & Allergy | Gainesville | Florida | 32610-0296 | — |
| Univ. of Miami Ped. Perinatal HIV/AIDS CRS | Miami | Florida | 33136 | — |
| USF - Tampa NICHD CRS | Tampa | Florida | 33606 | — |
| Chicago Children's CRS | Chicago | Illinois | 60614 | — |
| Univ. of Chicago - Dept. of Peds., Div. of Infectious Disease | Chicago | Illinois | 60637 | — |
| Tulane Univ. New Orleans NICHD CRS | New Orleans | Louisiana | 70112 | — |
| WNE Maternal Pediatric Adolescent AIDS CRS | Worcester | Massachusetts | 01605 | — |
| Washington University Therapeutics (WT) CRS | St Louis | Missouri | 63110-1010 | — |
| UMDNJ - Robert Wood Johnson Med. School, Div. of Allergy, Immunology & Infectious Diseases | New Brunswick | New Jersey | 08901-1969 | — |
| Rutgers - New Jersey Medical School CRS | Newark | New Jersey | 07103 | — |
| Nyu Ny Nichd Crs | New York | New York | 10016 | — |
| Columbia IMPAACT CRS | New York | New York | 10032 | — |
| Harlem Hosp. Ctr. NY NICHD CRS | New York | New York | 10037 | — |
| SUNY Stony Brook NICHD CRS | Stony Brook | New York | 11794-8111 | — |
| SUNY Upstate Med. Univ., Dept. of Peds. | Syracuse | New York | 13210 | — |
| Jacobi Med. Ctr. Bronx NICHD CRS | The Bronx | New York | 10461 | — |
| UNC at Chapel Hill School of Medicine - Dept. of Peds., Div. of Immunology & Infectious Diseases | Chapel Hill | North Carolina | 27599-7220 | — |
| Oregon Health & Science Univ. - Dept. of Peds., Div. of Infectious Disease | Portland | Oregon | 97239 | — |
| St. Jude/UTHSC CRS | Memphis | Tennessee | 38105 | — |
| Texas Children's Hospital CRS | Houston | Texas | 77030 | — |
| Seattle Children's Hospital CRS | Seattle | Washington | 98105 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 2 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00039741, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Nov 4, 2021 · Synced Sep 1, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT00039741 live on ClinicalTrials.gov.