Thymosin Plus PEG-Interferon in Hepatitis C Patients With Cirrhosis Who Did Not Respond to Interferon or Interferon Plus Ribavirin
Public ClinicalTrials.gov record NCT00039962. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Chronic hepatitis C infection is one of the leading causes of chronic liver disease in the United States. Approximately one-third of patients with hepatitis C infection develop cirrhosis of the liver, which can lead to liver failure or liver cancer. The current treatment for hepatitis C infection in previously untreated patients is successful in only about half of patients. There is no established therapy for non-responders. This is a randomized, double-blinded, multicenter trial to determine the effectiveness of thymosin alpha 1 (thymalfasin) 1.6 mg twice weekly plus PEGinterferon alfa-2a 180 ug/wk compared to placebo plus PEGinterferon alfa-2a in adults with chronic hepatitis C with early cirrhosis or progression to cirrhosis who are non-responders to previous treatment with interferon or interferon plus ribavirin. The definition of non-response requires a positive HCV RNA test at the end of a course of at least 12 weeks of therapy. Patients will receive treatment for 12 months, and will be followed-up for a further 6 months after the end of therapy
Study identification
- NCT ID
- NCT00039962
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 500 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 2002 (Type not available)
- Primary completion
- Not listed
- Completion
- Not listed
- Last update posted
- Jan 15, 2008
Started 2002
United States locations
- U.S. sites
- 54
- U.S. states
- 27
- U.S. cities
- 46
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama - Knollwood Physician's Group | Mobile | Alabama | — | — |
| Mayo Clinic | Scottsdale | Arizona | — | — |
| Advanced Clinical Research Institute | Anaheim | California | — | — |
| Gastroenterology Associates of East Bay Medical Group | Berkeley | California | — | — |
| Scripps Clinic | La Jolla | California | — | — |
| Loma Linda University Medical Center | Loma Linda | California | — | — |
| Huntington Memorial Hospital | Pasadena | California | — | — |
| Kaiser Permanente | Sacramento | California | — | — |
| University of California, Davis Medical Center | Sacramento | California | — | — |
| California Pacific Medical Center | San Francisco | California | — | — |
| San Mateo Medical Center | San Mateo | California | — | — |
| Kaiser Permanente | Santa Clara | California | — | — |
| Arapahoe Gastroenterology | Littleton | Colorado | — | — |
| Walter Reed Army Medical Center | Washington D.C. | District of Columbia | — | — |
| Washington Hospital Center | Washington D.C. | District of Columbia | — | — |
| University of Florida | Gainesville | Florida | — | — |
| Mayo Clinic | Jacksonville | Florida | — | — |
| University Of Miami Center for Liver Diseases | Miami | Florida | — | — |
| Digestive Healthcare of Georgia | Atlanta | Georgia | — | — |
| Center for Digestive and Liver Health | Savannah | Georgia | — | — |
| Idaho Gastroenterology Associates | Meridian | Idaho | — | — |
| University of Chicago Hospital & Clinic | Chicago | Illinois | — | — |
| University of Louisville | Louisville | Kentucky | — | — |
| LSU Healthcare Network | New Orleans | Louisiana | — | — |
| Johns Hopkins University | Baltimore | Maryland | — | — |
| Chevy Chase Clinical Research | Chevy Chase | Maryland | — | — |
| Endoscopic Microsurgery Associates | Towson | Maryland | — | — |
| New England Medical Center | Boston | Massachusetts | — | — |
| William Beaumont Hospital | Royal Oak | Michigan | — | — |
| Mississippi Gastrointestinal Associates | Jackson | Mississippi | — | — |
| Bradley Freilich MD, LLC | Kansas City | Missouri | — | — |
| VAMC | Kansas City | Missouri | — | — |
| North Shore University Hospital | Manhasset | New York | — | — |
| NYU Gastroenterology & Hepatology | New York | New York | — | — |
| VA Harbor HealthCare System | New York | New York | — | — |
| Carolinas Center for Liver Disease | Charlotte | North Carolina | — | — |
| Duke University Medical Center | Durham | North Carolina | — | — |
| University of Cincinnati College of Medicine | Cincinnati | Ohio | — | — |
| Metro Health Medical Ctr. | Cleveland | Ohio | — | — |
| The Cleveland Clinic Foundation | Cleveland | Ohio | — | — |
| Oregon Health Sciences University | Portland | Oregon | — | — |
| Albert Einstein Medical Center | Philadelphia | Pennsylvania | — | — |
| Jefferson University Physicians | Philadelphia | Pennsylvania | — | — |
| University of Pennsylvania | Philadelphia | Pennsylvania | — | — |
| Advanced Clinical Research | Providence | Rhode Island | — | — |
| Medical University of South Carolina | Charleston | South Carolina | — | — |
| University of Tennessee Gastroenterology | Memphis | Tennessee | — | — |
| Austin Gastroenterology PA | Austin | Texas | — | — |
| Baylor University Medical Ctr. | Dallas | Texas | — | — |
| Baylor College of Medicine | Houston | Texas | — | — |
| Baylor, VAMC | Houston | Texas | — | — |
| Metropolitan Research | Fairfax | Virginia | — | — |
| McGuire DVAMC | Richmond | Virginia | — | — |
| Wisconsin Center for Advanced Research | Milwaukee | Wisconsin | — | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 2 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00039962, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jan 15, 2008 · Synced Oct 18, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00039962 live on ClinicalTrials.gov.