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Completed Phase 3 Interventional Results available

Warfarin Versus Aspirin in Reduced Cardiac Ejection Fraction (WARCEF) Trial

ClinicalTrials.gov ID: NCT00041938

Public ClinicalTrials.gov record NCT00041938. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

ClinicalTrials.gov public records Last synced Oct 21, 2026, 12:48 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

The purpose of this study is to determine which of two treatments, Warfarin or aspirin, is better for preventing death and stroke in patients with poor heart function. We are now transitioning into the sub-analysis part of the WARCEF patient data. The study has recently completed data analysis for its Primary Aim. All randomized patients have completed their follow up. All study related procedure as per the protocol has been completed. We are now in the extension phase of the study to obtain more patient data to address further aims of the study. No new procedures are performed and data already in place at the sites will be collected (EKG and echocardiograms). The aims for this study extension are: * To assess progression of cardiac dysfunction over time among heart failure patients * To correlate prognosis with cardiac dysfunction

Study identification

NCT ID
NCT00041938
Recruitment status
Completed
Study type
Interventional
Phase
Phase 3
Lead sponsor
Columbia University
Other
Enrollment
2,305 participants

Conditions and interventions

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Oct 2002 (Type not available)
Primary completion
Aug 2011 (Actual)
Completion
Jul 2014 (Actual)
Last update posted
Sep 5, 2014

2002 – 2014

United States locations

U.S. sites
54
U.S. states
24
U.S. cities
44
Facility City State ZIP Site status
Southern Arizona Veterans Affairs Medical Center Tucson Arizona — —
University of Arizona Health Sciences Center Tucson Arizona — —
Santa Clara Medical Center Santa Clara California — —
West Los Angeles Veterans Affairs Medical Center West Los Angeles California — —
Denver Health Medical Center Denver Colorado — —
Denver Veterans Affairs Medical Center Denver Colorado — —
George Washington University Washington D.C. District of Columbia 20037 —
Mayo Clinic Transplant Center Jacksonville Florida — —
Melbourne Internal Medicine Associates Melbourne Florida — —
Jackson Memorial Hospital/U. of Miami Miami Florida — —
Mercy Research Institute Miami Florida — —
Cardiovascular Consultants of South Florida Tamarac Florida — —
Morehouse School of Medicine Atlanta Georgia — —
Northeast Georgia Heart Center Gainesville Georgia — —
University of Illinois at Chicago Chicago Illinois — —
Methodist Heart, Lung and Vascular Institute Peoria Illinois — —
University of Kentucky Lexington Kentucky — —
Louisville Veterans Affairs Medical Center Louisville Kentucky — —
University of Louisville Louisville Kentucky — —
Gulf Regional Research, LLC Metairie Louisiana — —
LSU Health Sciences Center Shreveport Louisiana — —
Lahey Clinic Burlington Massachusetts — —
Veterans Affairs Medical Center Detroit Michigan — —
Mercy Health Partners Muskegon Michigan — —
Reno Veterans Affairs Medical Center Reno Nevada — —
Concord Hospital Concord New Hampshire — —
UMDNJ - New Brunswick New Brunswick New Jersey — —
University of Medicine and Dentistry of New Jersey Newark New Jersey — —
Albany Medical College Albany New York — —
Buffalo General Hospital Buffalo New York — —
Kaleida Health Millard Fillmore Hospital Buffalo New York — —
Five Towns Neuroscience Research Cedarhurst New York — —
Long Island Jewish Medical Center New Hyde Park New York — —
Columbia University, New York Presbyterian Hospital PH 3-342 New York New York 10032 —
Columbia University Medical Center New York New York — —
Mount Sinai Medical Center New York New York — —
Northport Veterans Affairs Medical Center Northport New York — —
University of Rochester Medical Center Rochester New York — —
University of North Carolina at Chapel Hill Chapel Hill North Carolina — —
MetroHealth Medical Center Cleveland Ohio — —
Oklahoma City Veterans Affairs Medical Center Oklahoma City Oklahoma — —
Lehigh Valley Hospital Allentown Pennsylvania — —
Tri-State Medical Group Cardiology Beaver Pennsylvania — —
Sewickley Valley Medical Group, Cardiology Leetsdale Pennsylvania — —
Albert Einstein Medical Center Philadelphia Pennsylvania — —
Hospital of the University of Pennsylvania Philadelphia Pennsylvania — —
Penn Presbyterian Medical Center Philadelphia Pennsylvania — —
Temple University Hospital Philadelphia Pennsylvania — —
Black Hills Health Care System Fort Meade South Dakota — —
Brooke Army Medical Center MCHE - MDC Cardiology Service Fort Sam Houston Texas — —
Michael E. DeBakey Veterans Affairs Medical Center-MEDVAMC Houston Texas — —
Salem VAMC Salem Virginia — —
Huntington Veterans Affairs Medical Center Huntington West Virginia — —
William S. Middleton Memorial Veterans Hospital Madison Wisconsin — —

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 10 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT00041938, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Sep 5, 2014 · Synced Oct 21, 2026

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Open the official record

The complete public registry record, listed eligibility criteria, and available contact information for NCT00041938 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →