A Study to Evaluate the Effects of YM872 on Brain Function and Disability When Administered in Combination With Alteplase (Tissue Plasminogen Activator)
Public ClinicalTrials.gov record NCT00044057. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Multicenter, Stratified, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate Neurologic Function and Disability in Patients With Acute Ischemic Stroke Given Tissue Plasminogen Activator Plus YM872 or Tissue Plasminogen Activator Plus Placebo
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to determine if YM872 in combination with t-PA can reduce disability and brain damage from stroke. YM872 or placebo will be given as a continuous intravenous (iv) infusion for 24 hours. It is important that the study medication, YM872 or placebo, is administered prior to the completion of the t-PA administration. The clinical effects of YM872 in addition to t-PA will be determined by assessing neurological function and disability scores at follow up visits through Day 90 of the study.
Study identification
- NCT ID
- NCT00044057
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- Not listed
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 2000 (Type not available)
- Primary completion
- Not listed
- Completion
- Jan 2003 (Type not available)
- Last update posted
- Apr 3, 2006
2000 – 2003
United States locations
- U.S. sites
- 94
- U.S. states
- 32
- U.S. cities
- 81
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of South Alabama Stroke Center | Mobile | Alabama | — | — |
| Good Samaritan Hospital | Phoenix | Arizona | — | — |
| University of Arizona | Tucson | Arizona | — | — |
| East Bay Region Associates in Neurology | Berkeley | California | — | — |
| Providence St. Joseph's Medical Center | Burbank | California | — | — |
| Mercy San Juan Hospital | Carmichael | California | — | — |
| University of California Davis Medical Center | Davis | California | — | — |
| Scripps Memorial Hospital | Encinitas | California | — | — |
| Grossmont Hospital | La Mesa | California | — | — |
| UCLA Medical Center | Los Angeles | California | — | — |
| Tri-City Medical Center | Oceanside | California | — | — |
| Stanford University Medical Center | Palo Alto | California | — | — |
| Mercy General Hospital | Sacramento | California | — | — |
| Scripps Mercy Hospital | San Diego | California | — | — |
| University of California at San Diego | San Diego | California | — | — |
| Good Samaritan Hospital | San Jose | California | — | — |
| UCLA Medical Center - Santa Monica | Santa Monica | California | — | — |
| John Muir Medical Center | Walnut Creek | California | — | — |
| Mt Diablo Medical Center | Walnut Creek | California | — | — |
| Colorado Neurological Institute | Englewood | Colorado | — | — |
| Bridgeport Hospital | Bridgeport | Connecticut | — | — |
| Columbia JFK Hospital | Atlantis | Florida | — | — |
| Bethesda Memorial Hospital | Boynton Beach | Florida | — | — |
| Lakeland Regional Medical Center | Lakeland | Florida | — | — |
| Holmes Regional Medical Center | Melbourne | Florida | — | — |
| Bay Medical Center | Panama City | Florida | — | — |
| St Joseph's Hospital | Tampa | Florida | — | — |
| Tampa General Hospital | Tampa | Florida | — | — |
| St Francis Hospital | Columbus | Georgia | — | — |
| DNA Research (Dekalb Medical Center) | Decatur | Georgia | — | — |
| Candler Hospital | Savannah | Georgia | — | — |
| St Joseph Hospital | Savannah | Georgia | — | — |
| Queen's Medical Center | Honolulu | Hawaii | — | — |
| OSF St. Francis Medical Center | Peoria | Illinois | — | — |
| Parkview Hospital | Fort Wayne | Indiana | — | — |
| Methodist Hospital | Indianapolis | Indiana | — | — |
| Louisville Neuroscience Research Center | Louisville | Kentucky | — | — |
| Culicchia Neurology Clinic, LLP | Marrero | Louisiana | — | — |
| University of Maryland Medical System | Baltimore | Maryland | — | — |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | — | — |
| New England Medical Center | Boston | Massachusetts | — | — |
| St John's Hospital | Detroit | Michigan | — | — |
| Michigan State University | East Lansing | Michigan | — | — |
| William Beaumont Hospital | Royal Oak | Michigan | — | — |
| Northern Michigan Neurology | Traverse City | Michigan | — | — |
| Bi-County Hospital | Warren | Michigan | — | — |
| Research Medical Center | Kansas City | Missouri | — | — |
| Advanced Neurology Specialists (Benefis Healthcare Hospital) | Great Falls | Montana | — | — |
| Washoe Comprehensive Stroke Center | Reno | Nevada | — | — |
| JFK Medical Center | Edison | New Jersey | — | — |
| Muhlenberg Regional Medical Center | Plainfield | New Jersey | — | — |
| Neurology Group of Bergen County (Valley Hospital) | Ridgewood | New Jersey | — | — |
| University of New Mexico Hospital | Albuquerque | New Mexico | — | — |
| VA Medical Center | Albuquerque | New Mexico | — | — |
| Albany Medical Center | Albany | New York | — | — |
| Buffalo General Hospital | Buffalo | New York | — | — |
| North Shore University Hospital | Manhasset | New York | — | — |
| Long Island Jewish Medical Center | New Hyde Park | New York | — | — |
| Columbia Presbyterian Medical Center | New York | New York | — | — |
| Roosevelt Hospital | New York | New York | — | — |
| St. Luke's Hospital | New York | New York | — | — |
| Rochester General Hospital | Rochester | New York | — | — |
| Ellis Hospital | Schenectady | New York | — | — |
| Stony Brook Hospital | Stony Brook | New York | — | — |
| Forsyth Medical Center | Winston-Salem | North Carolina | — | — |
| Rowan Regional Medical Center | Winston-Salem | North Carolina | — | — |
| Akron General Medical Center | Akron | Ohio | — | — |
| Metrohealth Medical Center | Cleveland | Ohio | — | — |
| Riverside Methodist Hospital | Columbus | Ohio | — | — |
| Medical College of Ohio | Toledo | Ohio | — | — |
| St. Elizabeth Health Center | Youngstown | Ohio | — | — |
| Lehigh Valley Hospital | Allentown | Pennsylvania | — | — |
| Geisinger Medical Center | Danville | Pennsylvania | — | — |
| Westmoreland Regional Hospital | Greensburg | Pennsylvania | — | — |
| Hershey Medical Center | Hershey | Pennsylvania | — | — |
| Albert Einstein Medical Center | Philadelphia | Pennsylvania | — | — |
| Thomas Jefferson University Hospital | Philadelphia | Pennsylvania | — | — |
| University of Pennsylvania Medical Center | Philadelphia | Pennsylvania | — | — |
| University of Pittsburgh Medical Center Stroke Institute | Pittsburgh | Pennsylvania | — | — |
| Crozer Chester Medical Center | Upland | Pennsylvania | — | — |
| Miriam Hospital | Providence | Rhode Island | — | — |
| Roper Hospital | Charleston | South Carolina | — | — |
| Chattanooga Neurology Associates (Erlanger Hospital) | Chattanooga | Tennessee | — | — |
| Chattanooga Neurology Associates (Memorial Hospital) | Chattanooga | Tennessee | — | — |
| St. Thomas Hospital | Nashville | Tennessee | — | — |
| Vanderbilt University Medical Center | Nashville | Tennessee | — | — |
| University of Texas (Houston Medical Center) | Houston | Texas | — | — |
| Neurological Research Center, Inc | Bennington | Vermont | — | — |
| Neurology Associates, Inc. (St. Mary's Hospital) | Richmond | Virginia | — | — |
| Virginia Beach General Hospital | Virginia Beach | Virginia | — | — |
| Stevens Memorial Hospital | Edmonds | Washington | — | — |
| Providence St. Peter Hospital | Olympia | Washington | — | — |
| St. Luke's Medical Center | Milwaukee | Wisconsin | — | — |
| Theda Clark Medical Center | Neenah | Wisconsin | — | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 24 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00044057, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 3, 2006 · Synced Oct 22, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00044057 live on ClinicalTrials.gov.