Study of a Drug [DCVax®-L] to Treat Newly Diagnosed GBM Brain Cancer
Public ClinicalTrials.gov record NCT00045968. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase III Clinical Trial Evaluating DCVax®-L, Autologous Dendritic Cells Pulsed With Tumor Lysate Antigen For The Treatment Of Glioblastoma Multiforme (GBM)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The primary purpose of the study is to determine the efficacy of an investigational therapy called DCVax(R)-L in patients with newly diagnosed GBM for whom surgery is indicated. Patients must enter screening at a participating site prior to surgical resection of the tumor. Patients will receive the standard of care, including radiation and Temodar therapy and two out of three will additionally receive DCVax-L, with the remaining one third receiving a placebo. All patients will have the option to receive DCVax-L in a crossover arm upon documented disease progression. (note: DCVax-L when used for patients with brain cancer is sometimes also referred to as DCVax-Brain)
Study identification
- NCT ID
- NCT00045968
- Recruitment status
- Not listed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 348 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 70 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 2006 (Type not available)
- Primary completion
- Nov 2022 (Estimated)
- Completion
- Not listed
- Last update posted
- May 18, 2022
Started 2006
United States locations
- U.S. sites
- 71
- U.S. states
- 27
- U.S. cities
- 59
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35294 | — |
| University of Arkansas for Medical Sciences | Little Rock | Arkansas | 72205 | — |
| Sutter East Bay Neuroscience Institute-Eden Medical Center | Castro Valley | California | 94546 | — |
| City of Hope | Duarte | California | 91010 | — |
| UCSD Moores Cancer Center | La Jolla | California | 93093 | — |
| Kaiser Permanente - Los Angeles | Los Angeles | California | 90027 | — |
| UCLA Medical Center | Los Angeles | California | 90095 | — |
| Hoag Memorial Hospital Presbyterian | Newport Beach | California | 92663 | — |
| St. Joseph Hospital of Orange | Orange | California | 92868 | — |
| University of California, Irvine Medical Center | Orange | California | 92868 | — |
| Kaiser Permanente - Redwood City | Redwood City | California | 94063 | — |
| Sutter Institute for Medical Research | Sacramento | California | 95816 | — |
| University of Colorado Cancer Center | Aurora | Colorado | 80045 | — |
| Colorado Neurological Institute | Englewood | Colorado | 80113 | — |
| Georgetown University Medical Center | Washington D.C. | District of Columbia | 20057 | — |
| University of Florida | Gainesville | Florida | 32611 | — |
| Memorial Cancer Institute | Hollywood | Florida | 33021 | — |
| Mount Sinai Community Clinical Oncology Program | Miami Beach | Florida | 33140 | — |
| Moffitt Cancer Center | Tampa | Florida | 33612 | — |
| Piedmont Atlanta Hospital | Atlanta | Georgia | 30309 | — |
| Rush University Medical Center | Chicago | Illinois | 60612 | — |
| Illinois Cancer Care | Peoria | Illinois | 61615 | — |
| Cadence Cancer Center | Warrenville | Illinois | 60555 | — |
| IU Simon Cancer Center | Indianapolis | Indiana | 46202 | — |
| University of Kansas Cancer Center | Westwood | Kansas | 66205 | — |
| Markey Cancer Center/University of Kentucky | Lexington | Kentucky | 40536 | — |
| Norton Cancer Institute | Louisville | Kentucky | 40202 | — |
| Tufts Medical Center | Boston | Massachusetts | 02111 | — |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | — |
| University of Michigan Cancer Center | Ann Arbor | Michigan | 48109 | — |
| Henry Ford Hospital | Detroit | Michigan | 48202 | — |
| Spectrum Health | Grand Rapids | Michigan | 49503 | — |
| John Nasseff Neuroscience Institute at Abbott Northwestern Hospital | Minneapolis | Minnesota | 55407 | — |
| St. Luke's Hospital | Kansas City | Missouri | 64111 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| The Brain Tumor Center at JFK Medical Center | Edison | New Jersey | 08818 | — |
| John Theurer Cancer Center at Hackensack University Medical Center | Hackensack | New Jersey | 07601 | — |
| The Valley Hospital | Ridgewood | New Jersey | 07450 | — |
| Overlook Hospital | Summit | New Jersey | 07902 | — |
| Capital Health Regional Medical Center | Trenton | New Jersey | 08638 | — |
| Long Island Brain Tumor Center at Neurological Surgery, P.C. | Lake Success | New York | 11042 | — |
| North Shore University Hospital | Manhasset | New York | 11030 | — |
| New York University Clinical Cancer Center | New York | New York | 10016 | — |
| Mount Sinai Medical Center | New York | New York | 10029-6574 | — |
| Columbia University Medical Center | New York | New York | 10032 | — |
| University of Rochester Medical Center | Rochester | New York | 14642 | — |
| Stony Brook Medicine | Stony Brook | New York | 11794 | — |
| Brain and Spine Surgeons of New York and Northern Westchester Hospital | White Plains | New York | 10604 | — |
| University of North Carolina, Chapel Hill | Chapel Hill | North Carolina | 27514 | — |
| Wake Forest Baptist Medical Center | Winston-Salem | North Carolina | 27157 | — |
| University of Cincinnati Cancer Institute | Cincinnati | Ohio | 45267 | — |
| University Hospitals Seidman Cancer Center | Cleveland | Ohio | 44106 | — |
| Cleveland Clinic Foundation | Cleveland | Ohio | 44195 | — |
| Ohio State University | Columbus | Ohio | 43210 | — |
| OhioHealth | Columbus | Ohio | 43214 | — |
| Oklahoma University Health Science Center | Oklahoma City | Oklahoma | 73104 | — |
| Geisinger Medical Center | Danville | Pennsylvania | 17822 | — |
| Hospital of the University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | — |
| Jefferson Hospital for Neuroscience | Philadelphia | Pennsylvania | 19107 | — |
| Temple University School of Medicine | Philadelphia | Pennsylvania | 19140 | — |
| Rhode Island Hospital | Providence | Rhode Island | 02903 | — |
| Medical University of South Carolina Hospitals and Clinics | Charleston | South Carolina | 29425 | — |
| Saint Thomas Research Institute | Nashville | Tennessee | 37205 | — |
| Vanderbilt Ingram Cancer Center | Nashville | Tennessee | 37232 | — |
| Baylor Research Institute | Dallas | Texas | 75246 | — |
| The Methodist Hospital | Houston | Texas | 77030 | — |
| University of Texas Health Science Center at Houston | Houston | Texas | 77030 | — |
| Cancer Therapy & Research at University of Texas Health Science Center San Antonio | San Antonio | Texas | 78229 | — |
| Benaroya Research Institute at Virginia Mason | Seattle | Washington | 98101 | — |
| Swedish Hospital Neuroscience Research | Seattle | Washington | 98122 | — |
| Aurora Saint Luke's Medical Center | Milwaukee | Wisconsin | 23215 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 15 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00045968, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 18, 2022 · Synced Oct 21, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00045968 live on ClinicalTrials.gov.